LOCUS       NM_001408959            6321 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus IQ motif and Sec7 domain ArfGEF 1 (Iqsec1),
            transcript variant 1, mRNA.
ACCESSION   NM_001408959 XM_039108755
VERSION     NM_001408959.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6321)
  AUTHORS   Elagabani,M.N., Brisevac,D., Kintscher,M., Pohle,J., Kohr,G.,
            Schmitz,D. and Kornau,H.C.
  TITLE     Subunit-selective N-Methyl-d-aspartate (NMDA) Receptor Signaling
            through Brefeldin A-resistant Arf Guanine Nucleotide Exchange
            Factors BRAG1 and BRAG2 during Synapse Maturation
  JOURNAL   J Biol Chem 291 (17), 9105-9118 (2016)
   PUBMED   26884337
  REMARK    GeneRIF: both Arf6 activation through GluN2B-BRAG1 during early
            development and the transition from BRAG1- to BRAG2-dependent Arf6
            signaling induced by the GluN2 subunit switch are critical for the
            development of mature glutamatergic synapses.
REFERENCE   2  (bases 1 to 6321)
  AUTHORS   Yue,J., Xie,M., Gou,X., Lee,P., Schneider,M.D. and Wu,X.
  TITLE     Microtubules regulate focal adhesion dynamics through MAP4K4
  JOURNAL   Dev Cell 31 (5), 572-585 (2014)
   PUBMED   25490267
REFERENCE   3  (bases 1 to 6321)
  AUTHORS   Oka,S., Uramoto,H., Shimokawa,H., Yamada,S. and Tanaka,F.
  TITLE     Epidermal growth factor receptor-GEP100-Arf6 axis affects the
            prognosis of lung adenocarcinoma
  JOURNAL   Oncology 86 (5-6), 263-270 (2014)
   PUBMED   24902879
REFERENCE   4  (bases 1 to 6321)
  AUTHORS   Sakagami,H., Katsumata,O., Hara,Y., Tamaki,H., Watanabe,M.,
            Harvey,R.J. and Fukaya,M.
  TITLE     Distinct synaptic localization patterns of brefeldin A-resistant
            guanine nucleotide exchange factors BRAG2 and BRAG3 in the mouse
            retina
  JOURNAL   J Comp Neurol 521 (4), 860-876 (2013)
   PUBMED   22886754
REFERENCE   5  (bases 1 to 6321)
  AUTHORS   Dmitriev,A.A., Kashuba,V.I., Haraldson,K., Senchenko,V.N.,
            Pavlova,T.V., Kudryavtseva,A.V., Anedchenko,E.A., Krasnov,G.S.,
            Pronina,I.V., Loginov,V.I., Kondratieva,T.T., Kazubskaya,T.P.,
            Braga,E.A., Yenamandra,S.P., Ignatjev,I., Ernberg,I., Klein,G.,
            Lerman,M.I. and Zabarovsky,E.R.
  TITLE     Genetic and epigenetic analysis of non-small cell lung cancer with
            NotI-microarrays
  JOURNAL   Epigenetics 7 (5), 502-513 (2012)
   PUBMED   22491060
REFERENCE   6  (bases 1 to 6321)
  AUTHORS   Xie,C.G., Wei,S.M., Chen,J.M., Xu,X.F., Cai,J.T., Chen,Q.Y. and
            Jia,L.T.
  TITLE     Down-regulation of GEP100 causes increase in E-cadherin levels and
            inhibits pancreatic cancer cell invasion
  JOURNAL   PLoS One 7 (5), e37854 (2012)
   PUBMED   22662237
REFERENCE   7  (bases 1 to 6321)
  AUTHORS   Menju,T., Hashimoto,S., Hashimoto,A., Otsuka,Y., Handa,H.,
            Ogawa,E., Toda,Y., Wada,H., Date,H. and Sabe,H.
  TITLE     Engagement of overexpressed Her2 with GEP100 induces autonomous
            invasive activities and provides a biomarker for metastases of lung
            adenocarcinoma
  JOURNAL   PLoS One 6 (9), e25301 (2011)
   PUBMED   21966491
REFERENCE   8  (bases 1 to 6321)
  AUTHORS   Scholz,R., Berberich,S., Rathgeber,L., Kolleker,A., Kohr,G. and
            Kornau,H.C.
  TITLE     AMPA receptor signaling through BRAG2 and Arf6 critical for
            long-term synaptic depression
  JOURNAL   Neuron 66 (5), 768-780 (2010)
   PUBMED   20547133
REFERENCE   9  (bases 1 to 6321)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   10 (bases 1 to 6321)
  AUTHORS   Morishige,M., Hashimoto,S., Ogawa,E., Toda,Y., Kotani,H.,
            Hirose,M., Wei,S., Hashimoto,A., Yamada,A., Yano,H., Mazaki,Y.,
            Kodama,H., Nio,Y., Manabe,T., Wada,H., Kobayashi,H. and Sabe,H.
  TITLE     GEP100 links epidermal growth factor receptor signalling to Arf6
            activation to induce breast cancer invasion
  JOURNAL   Nat Cell Biol 10 (1), 85-92 (2008)
   PUBMED   18084281
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jul 5, 2022 this sequence version replaced XM_039108755.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760475, SAMN12840107
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               JAXUCZ010000004.1  124827406-124827602 c
            198-489             JAXUCZ010000004.1  124758625-124758916 c
            490-1736            JAXUCZ010000004.1  124753594-124754840 c
            1737-1898           JAXUCZ010000004.1  124744807-124744968 c
            1899-2021           JAXUCZ010000004.1  124742220-124742342 c
            2022-2188           JAXUCZ010000004.1  124740863-124741029 c
            2189-2328           JAXUCZ010000004.1  124738452-124738591 c
            2329-2358           JAXUCZ010000004.1  124738067-124738096 c
            2359-2484           JAXUCZ010000004.1  124736706-124736831 c
            2485-2584           JAXUCZ010000004.1  124735619-124735718 c
            2585-2746           JAXUCZ010000004.1  124734965-124735126 c
            2747-2923           JAXUCZ010000004.1  124734195-124734371 c
            2924-2973           JAXUCZ010000004.1  124730336-124730385 c
            2974-6321           JAXUCZ010000004.1  124725917-124729264 c
FEATURES             Location/Qualifiers
     source          1..6321
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..6321
                     /gene="Iqsec1"
                     /note="IQ motif and Sec7 domain ArfGEF 1"
                     /db_xref="GeneID:686590"
                     /db_xref="RGD:1596313"
     exon            1..197
                     /gene="Iqsec1"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..3474
                     /gene="Iqsec1"
                     /note="isoform 1 is encoded by transcript variant 1; IQ
                     motif and SEC7 domain-containing protein 1; IQ motif and
                     Sec7 domain 1"
                     /codon_start=1
                     /product="IQ motif and SEC7 domain-containing protein 1
                     isoform 1"
                     /protein_id="NP_001395888.1"
                     /db_xref="GeneID:686590"
                     /db_xref="RGD:1596313"
                     /translation="MKGDGGAVWGLMWKYCISVRTLSVEGEAPSSETGTSLDSPSAYH
                     QGPLVPGSSLSPDHYEHTSVGAYGLYAGPGPQQRTRRPRLQHSTSVLRKQAEEEAIKR
                     SRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSS
                     MSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGALVPSECGDLS
                     DPALKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHSEEVPASDTARAR
                     DTEPKPGLHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLR
                     SGGAAQDYWALAHKEDKADTDTSCRSTPSLERPEPRLRVEHLPLLTIEPPSDSSVELS
                     DRSDRSSLKRQSAYERSLGGQQGSPKHGPHGGPPKGLPREEPELRPRPPRPLESHLAI
                     NGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKET
                     RNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKGIQYLIERGFVPDTPVGVAHFLLQRK
                     GLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSAMELDEALRKFQAHIRVQGEAQKVE
                     RLIEAFSQRYCVCNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFV
                     KNLRGVDDGEDIPRETLIGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHHG
                     LGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVT
                     YSFRQSFSLYGMQVLLFENQYYPNGIRLTSAVPGADIKVLINFNAPNPQDRKKFTDDL
                     RESVAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGE
                     GLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEGSIISSPHMRRRATSTRECPSRPP
                     QPVPNSSSLLGSLFGSRRGKPPPQAHPPSAPPPAPPHAHHPGPSEGPLHGHHAQYCHA
                     QQNPPPYHHHHHYHPPPHLQHTHQYHHGPHSGHPPYGAHAHSHPPLPTAHPGHAGHSA
                     HHHGQPPAPPPPTSSKAKPSGISTVV"
     exon            198..489
                     /gene="Iqsec1"
                     /inference="alignment:Splign:2.1.0"
     exon            490..1736
                     /gene="Iqsec1"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1898
                     /gene="Iqsec1"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2021
                     /gene="Iqsec1"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2188
                     /gene="Iqsec1"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2328
                     /gene="Iqsec1"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2358
                     /gene="Iqsec1"
                     /inference="alignment:Splign:2.1.0"
     exon            2359..2484
                     /gene="Iqsec1"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2584
                     /gene="Iqsec1"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2746
                     /gene="Iqsec1"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..2923
                     /gene="Iqsec1"
                     /inference="alignment:Splign:2.1.0"
     exon            2924..2973
                     /gene="Iqsec1"
                     /inference="alignment:Splign:2.1.0"
     exon            2974..6321
                     /gene="Iqsec1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcctcatgaa gaaggaagtg acctgagagc tcaagacaag agccatccct tgactgggag
       61 gaggcccagg gtccacggca gtggcaagga ccccctaccc cccagccact gcacctcact
      121 gatccaggca tgaagggtga tggtggtgct gtgtggggcc tcatgtggaa gtactgcatc
      181 tccgtgagga ccctcagtgt tgagggcgag gctcccagca gcgagactgg cacatcgctg
      241 gacagcccgt cagcctacca tcagggtccc ctggtacctg gttccagcct gagtccagac
      301 cactacgagc acacgtcagt gggcgcctat gggctgtacg cagggccagg accacaacag
      361 cgcacacgga ggcctcggct gcagcactcg acctcagtcc tgcgcaagca ggctgaggag
      421 gaggccatca agcgctctcg gtcactctct gagagctatg agctctcttc agatctgcaa
      481 gacaagcagg tggaaatgct agaacgcaag tatgggggac gcctcgtgac ccgccatgca
      541 gcccgcacca tccagacggc gttccgccag taccagatga acaagaactt tgagcgcctg
      601 cgtagctcca tgtcggagaa ccgcatgtca cgccgcattg tgctgtccaa catgaggatg
      661 cagttctcct tcgagggccc cgagaaggtg cacagctcct acttcgaggg aaaacaggtt
      721 tctgtgacca atgatggctc ccagctgggg gccctggtgc catcagaatg tggagacctt
      781 agtgacccag ccctcaagtc tccagccccc tccagtgact ttgcagatgc catcacggaa
      841 ctggaggatg ccttctccag gcaggtgaaa tccctggctg aatccattga tgatgccctt
      901 aattgccgca gcctacacag tgaggaggtg ccagcctcag acacggcccg ggctcgggac
      961 actgagccca aaccaggcct gcatggcatg gaccaccgca aattggatga gatgacagcc
     1021 tcgtatagtg atgtcaccct ctacattgat gaggaagagc tgtcaccgcc tctaccactc
     1081 tcacaggctg gtgatcggcc ttctagcacc gagtcggacc tgcggctgag gtctgggggt
     1141 gcagcccagg actactgggc cttggcccac aaagaggaca aggctgacac ggacacaagc
     1201 tgccgaagca caccttcact ggagcggcca gagccacggc tgcgggtgga gcacctgccc
     1261 ctgcttacca ttgagccgcc cagtgatagc tccgtggaac tcagtgaccg ctcggatcgc
     1321 agctcactca agaggcagag tgcctatgag cgcagcctcg gtgggcagca gggcagcccc
     1381 aagcacggcc cccacggtgg cccccccaaa ggcctccccc gggaggaacc tgaattgcga
     1441 cctcgacccc ccagacctct tgagagtcac ctagccatca atggttcagc caaccggcag
     1501 agcaaatctg agtctgacta ctcagacggg gacaatgaca gcatcaacag cacgtccaac
     1561 tccaatgaca ccataaactg cagctccgag tcctcatctc gggacagcct gcgggaacag
     1621 acactcagca agcagacata ccacaaggag acccgcaaca gctgggactc gccagctttc
     1681 agcaatgatg tcatccgtaa gaggcattac cgaattggcc tgaacctctt caacaagaag
     1741 cctgagaagg gcatccagta tctcattgag cgcggcttcg tgcccgacac gccagtggga
     1801 gtggcccact tcctgctgca gcgcaagggc ctcagccgcc agatgatcgg tgagttcctg
     1861 ggaaaccggc agaagcagtt caaccgtgat gtactcgact gtgttgtgga cgagatggac
     1921 ttctccgcca tggagctaga tgaagccctc cggaagttcc aggcacacat ccgagtccaa
     1981 ggggaggctc agaaagtgga gcggctcatc gaggcattca gccagcggta ctgtgtctgc
     2041 aatcctgggg tggtgcgaca gttccggaac ccagacacca tcttcatcct ggccttcgcc
     2101 atcatcctgc tcaacacaga catgtacagc cccaatgtca agccagagcg caaaatgaag
     2161 ctggaggact ttgtcaagaa cctccgaggt gttgatgacg gtgaagacat tccccgggag
     2221 acactaattg ggatctatga gcggatccgt aagcgagaac tgaagaccaa cgaggaccac
     2281 gtgtcccagg tgcagaaggt tgagaagctc atcgtgggca aaaagccgat tggatccttg
     2341 catcatggtc ttggctgtgt gctctctctt ccccatcgac gactggtctg ctactgccgg
     2401 ctttttgaag ttcctgaccc caacaaaccc cagaagctgg gactgcacca gcgagagatc
     2461 ttcctgttca atgacctcct ggtggtcacc aagatcttcc agaagaagaa gaactcggtg
     2521 acgtacagct tccggcagtc cttctccctc tacggcatgc aggtcctgct cttcgagaac
     2581 cagtactacc ccaatggcat ccggctgacg tctgctgtcc ctggagcaga tatcaaagtg
     2641 ctaataaact tcaacgctcc caatcctcag gaccggaaga agttcactga tgacctacgg
     2701 gagtctgtcg ctgaagtgca agagatggag aaacaccgga tagagtcgga gctcgagaag
     2761 cagaaaggtg tcgtgcggcc cagcatgtca caatgttcca gcctcaaaaa ggagtcaggc
     2821 aacgggacac tgagcagagc ttgcctggat gacagctatg ccagtggcga gggcctcaag
     2881 cgcagcgccc tcagcagctc actgagagac ctctcagaag cggggaagcg agggcgtcgc
     2941 agcagtgcgg gatcgctaga gagcaatgtg gaaggctcca tcattagcag tcctcacatg
     3001 cgccggagag cgacctcaac acgagagtgc ccatctcgcc ccccccagcc cgtgcctaac
     3061 tcctcctctc tcctgggttc tttgtttggg agcaggagag ggaagccccc tccccaggcc
     3121 cacccaccct cagcccctcc cccagcaccc cctcacgccc atcaccctgg gccctcagaa
     3181 ggcccactgc atgggcatca cgcccagtac tgccatgcgc agcagaaccc cccgccctat
     3241 caccaccacc accactacca cccgcccccc cacctgcagc acacccacca gtaccaccat
     3301 ggcccacaca gcgggcaccc cccatatggg gcccatgcac acagccaccc gcctctgccc
     3361 acagctcatc ctggtcatgc agggcactca gcgcatcacc atgggcagcc ccctgcccca
     3421 ccgcccccca ccagcagcaa ggccaagccc agcggcatca gcacagttgt gtagacagcc
     3481 taggcagccg cctcccacac accaggcaca cgaaggccta ccaggcacca gcctcagacc
     3541 agcccaaggc accactgttt ccactccctc taccctcata gcctgggtgg gcccatgggc
     3601 ttgccttcca tggagcagag ctcccactcc ggcttagccc tggcaccccg tcctccctca
     3661 gcccaaggct gggcctcagc caccataggc cttgacatgg cgctgaccaa ggagaagtgg
     3721 aactgcctcc caccctgtag gccctcagcc cctgactcta cacacatctg aaaacccatc
     3781 ttagcaaaga aaacatagaa aagtcagaca aaacaaccaa ccccagaccg gctatgttat
     3841 tgttctgtta ttggcagtgg gcaaaacaat aataataata ataataagta gacctgatat
     3901 gggtgatgaa aatacgtaag taaactttat ataatataaa tatataaata tataaataca
     3961 tatatacata ctgtataggt agtgtttgtg tgtggaagat aagcatttca tccacaaagc
     4021 tagcactagg gacctcctaa ggactgccac ttaagtgaca ggaagtcagt ctagataaat
     4081 gtgtgagtag accaaaaacc ccactagaac aaacccagat ccttccatat tttcatacga
     4141 agagactccc cctagcctgg ctgaaacctt acatgctcat gactcactgt gccaagtaac
     4201 acagcacctg actgtctaat accccactct gctctgtata gccccctatt ttattaacag
     4261 agtactattc taagtaacca gtattataac tgctgttatc tccagtaagc aactaggcaa
     4321 agtgcagtca actctaccct agtacttggg gcaaccagtc tagagctggc tgtctcagat
     4381 ctcagcccca cagatcccta gacactttct actggctgcc ataactttga tcttccatgc
     4441 tctacattcc ttccctctgt acatggtgag ccacgatcct cccccctccc acaatcctcc
     4501 cagggcacac ttggcagagg gattccatcc caacacaatg accactcatc ttccataact
     4561 ccctcatcca gttcccagcc ccagcaggcg ggtggcgtga gcgctgggcg gcccagggcg
     4621 gtgtgtgtgt ccccgtgttg tgttctgagt ggcaacagca atcactgtaa ttccatgcag
     4681 ccatgtgctc gtgacccctg tgtcatcatt gcacctggcc aatgagtgct tggccctggc
     4741 caggtgaagc ccccactgct ctcatggtcc agtgagctgc caggccccac atgccccagc
     4801 tgtgttctcg ttgcttccat gtgtgacacc atgcactccc ctggggccac atgctgccca
     4861 tgttcctgtg cctgagtcac ccatgggctg tactttacag tttcagccct tccagccatc
     4921 acagcctcca gtgctgtgct cctaagccta ggacctgagg actgcctgtg gtctctgcct
     4981 gcgcggaggc cctttcagaa tggaaggagc tgccgcctga ccgtgggctg cgtctaggac
     5041 ctcatgagcc accggggcct gcccaaccac aagagagatc aggagccctc tctggcccat
     5101 catcactctg ctggcctgct tgggtcaccc atctccctcc ccttcatgtc gtcatcatcg
     5161 aggtcacgta ccagcagatc tgcaaactga gcactttgta tccctgcaga gagcaaatcc
     5221 tgcaacgtgg aggtcagcct tctgactcac agtggctcga cccgcctgcc ccatcctctg
     5281 tcagcatggt tcatctttcc cttgtcatct gcacagaaag aactgaccac catagtgtat
     5341 ctgactgggg ccagctggcg aggagctgcc cgcttcacag tgcccgaatc ccttgcttac
     5401 gctccacgta ctgtctgtcc ttagttaaag acactgtctg acagggaaga ggaactgtgc
     5461 tgcatgtgac ctggcaccag tcatgagggg ctgtgctctc tgtattgtac attgacaaaa
     5521 tataccagtg ttactgttgg caaatagttg gagtggtaac attaaatatg ccggctttct
     5581 ttttcaccct cttctgagcc agtggtaagt taaccgtgac cttgagattg ttctgaaaaa
     5641 gacacggctg ttagatatac actctcactc tttttgaagg gacaccactc aggaacaaac
     5701 tcaaaaggcg gcctgattta cctggtgggg tggagccggg cctccctctt tccagtgtcc
     5761 tgcactctca tggctagcca gctctgggct gctcccatgc tgccttccat gtgtcctaga
     5821 gacaagctga gggtagtggg tgggttctcg gggatcaggc ttctaagcat acacagtctt
     5881 tctctgcgtt cctaactcta aaggttatcg tgtcagggtg atgaccctgt gttgttttac
     5941 agatagggac gtcttcatag gatgtgcctg ggcctgcttg gaaagcataa actactagtg
     6001 tactgtgtcc ctcgttgcct gttactcagc tatggcattg aggcactgtg gtccttgact
     6061 gaggagaggg gagataagaa gaggcagagg ccctgagtat acacttctgt ttaccactgt
     6121 caggatacac ttagggcctt cactagttac ctgagttaat ctggttgtct gtggaactgg
     6181 tgacagatgg gataccttag gggaggcagc tggtaacatc acaaagggct ttccagggac
     6241 aacagtgaag ttgtggattt gtattttttg aagctcccaa gtgagttgta atgtgaaaat
     6301 aaagttcacc ctaatgtgcc a
//
