LOCUS       NM_001191709            5795 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus IQ motif containing GTPase activating protein 3
            (Iqgap3), mRNA.
ACCESSION   NM_001191709 XM_227396
VERSION     NM_001191709.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5795)
  AUTHORS   Leone,M., Musa,G. and Engel,F.B.
  TITLE     Cardiomyocyte binucleation is associated with aberrant mitotic
            microtubule distribution, mislocalization of RhoA and IQGAP3, as
            well as defective actomyosin ring anchorage and cleavage furrow
            ingression
  JOURNAL   Cardiovasc Res 114 (8), 1115-1131 (2018)
   PUBMED   29522098
  REMARK    GeneRIF: Naturally occurring cytokinesis failure in primary
            cardiomyocytes is due to an aberrant mitotic microtubule apparatus
            and mislocalization of RhoA and IQGAP3 resulting in inefficient
            anchorage of the actomyosin ring to the plasma cell membrane.
REFERENCE   2  (bases 1 to 5795)
  AUTHORS   Atcheson,E., Hamilton,E., Pathmanathan,S., Greer,B., Harriott,P.
            and Timson,D.J.
  TITLE     IQ-motif selectivity in human IQGAP2 and IQGAP3: binding of
            calmodulin and myosin essential light chain
  JOURNAL   Biosci Rep 31 (5), 371-379 (2011)
   PUBMED   21299499
REFERENCE   3  (bases 1 to 5795)
  AUTHORS   Nojima,H., Adachi,M., Matsui,T., Okawa,K., Tsukita,S. and
            Tsukita,S.
  TITLE     IQGAP3 regulates cell proliferation through the Ras/ERK signalling
            cascade
  JOURNAL   Nat Cell Biol 10 (8), 971-978 (2008)
   PUBMED   18604197
REFERENCE   4  (bases 1 to 5795)
  AUTHORS   Wang,S., Watanabe,T., Noritake,J., Fukata,M., Yoshimura,T.,
            Itoh,N., Harada,T., Nakagawa,M., Matsuura,Y., Arimura,N. and
            Kaibuchi,K.
  TITLE     IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite
            outgrowth
  JOURNAL   J Cell Sci 120 (Pt 4), 567-577 (2007)
   PUBMED   17244649
  REMARK    GeneRIF: Iqgap3, a novel effector of Rac1 and Cdc42, regulates
            neurite outgrowth.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jul 17, 2010 this sequence version replaced XM_227396.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.8128.1,
                                           SRR26643292.9281.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                JAXUCZ010000002.1  175840001-175840037
            38-125              JAXUCZ010000002.1  175841764-175841851
            126-282             JAXUCZ010000002.1  175844447-175844603
            283-360             JAXUCZ010000002.1  175845322-175845399
            361-437             JAXUCZ010000002.1  175848880-175848956
            438-505             JAXUCZ010000002.1  175849765-175849832
            506-619             JAXUCZ010000002.1  175849920-175850033
            620-798             JAXUCZ010000002.1  175850212-175850390
            799-877             JAXUCZ010000002.1  175850788-175850866
            878-1041            JAXUCZ010000002.1  175851536-175851699
            1042-1129           JAXUCZ010000002.1  175852746-175852833
            1130-1293           JAXUCZ010000002.1  175855424-175855587
            1294-1451           JAXUCZ010000002.1  175857215-175857372
            1452-1573           JAXUCZ010000002.1  175858705-175858826
            1574-1737           JAXUCZ010000002.1  175859102-175859265
            1738-1828           JAXUCZ010000002.1  175860854-175860944
            1829-1996           JAXUCZ010000002.1  175861927-175862094
            1997-2136           JAXUCZ010000002.1  175862180-175862319
            2137-2307           JAXUCZ010000002.1  175862400-175862570
            2308-2391           JAXUCZ010000002.1  175864694-175864777
            2392-2463           JAXUCZ010000002.1  175864922-175864993
            2464-2533           JAXUCZ010000002.1  175865086-175865155
            2534-2742           JAXUCZ010000002.1  175867681-175867889
            2743-2895           JAXUCZ010000002.1  175868539-175868691
            2896-3059           JAXUCZ010000002.1  175869029-175869192
            3060-3284           JAXUCZ010000002.1  175869467-175869691
            3285-3425           JAXUCZ010000002.1  175870633-175870773
            3426-3510           JAXUCZ010000002.1  175872836-175872920
            3511-3743           JAXUCZ010000002.1  175873121-175873353
            3744-3876           JAXUCZ010000002.1  175873629-175873761
            3877-3979           JAXUCZ010000002.1  175873878-175873980
            3980-4106           JAXUCZ010000002.1  175874476-175874602
            4107-4194           JAXUCZ010000002.1  175875451-175875538
            4195-4407           JAXUCZ010000002.1  175876240-175876452
            4408-4574           JAXUCZ010000002.1  175877054-175877220
            4575-4676           JAXUCZ010000002.1  175877475-175877576
            4677-4785           JAXUCZ010000002.1  175877967-175878075
            4786-5795           JAXUCZ010000002.1  175880790-175881799
FEATURES             Location/Qualifiers
     source          1..5795
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..5795
                     /gene="Iqgap3"
                     /note="IQ motif containing GTPase activating protein 3"
                     /db_xref="GeneID:310621"
                     /db_xref="RGD:1305951"
     CDS             1..4899
                     /gene="Iqgap3"
                     /codon_start=1
                     /product="ras GTPase-activating-like protein IQGAP3"
                     /protein_id="NP_001178638.1"
                     /db_xref="GeneID:310621"
                     /db_xref="RGD:1305951"
                     /translation="MESCTAGQARTAYDRLTAEEMDEQRRQNVAYQYLCRLEEAKRWM
                     EVCLKEELPSPVELEESLRNGVLLAKLGHCFAPSVVPLKKIYDMEQLRYQATGLHFRH
                     TDNINFWLSAVAHIGLPSTFLPETTDIYDKKNMPRVIYCIHALSLFLFRLGLAPQIHD
                     LYGKVKFTAEELSNIASELAKYGLQLPAFSKIGGILANEFSADEAAVHAAILAINDAV
                     ERGVVEDTLVALQNPNALLGNLREPLAAVYQELLALAKMEKAANARNHDDGQDQDIYE
                     SCLTQAEIQGHINLANVQGALEVVDDALERQSPEALLEALRDPVLALQGVRQAFADWY
                     LEQLTSDREQKSQELGLVRLLEKEEIQAGVAAANEKGDQEQAMLRAVWKINKAIQRGV
                     AADTVKELMCPEAQLPQVYPFASAVYQQELALLQKQQQGELDQEELFVAVEMLSAVVL
                     INRALEAGDACTFWDNLVNPATGLAQVEEENAQRYFDALVKVQQLRGTHRGFLSWNDL
                     QAAVSQVNAQVQEETDQVLAISLINEALDQGCPEKTLSALLLPAAGLEDVSLPVAPRY
                     HHLLVAAKRQKAQKTGDPGAVLWLEEIRQGVARANEDTNTAQRIALGVAAINQAIKEG
                     KAAQTERVLRNPNVALRGIVPDCAKSYQQALEGAAAKKHRPGDTAFWVPRDMKDGTAY
                     YFHLQTFQGTWERPPSRHLNASHLTWEEIQSVITKVTAAHDRQLLWKANVGFVIKLQA
                     RLRGFLVRQKFAESSHFLRTLLPAVIKIQAHWRGYRQRKTYQERLQYFKANLNAIITI
                     QAWARMWAARRQYLRRLRYFQKNVDSVVKIQAFFRARKARDDYRMLVHARHPPLSVVR
                     KFAHLLNQSQEDFSAEAELLRLQEEVVRKIRSNQQLEQDLNLMDIKIGLLVKNRITLQ
                     EVVSHCKKLTKKNKEQLSDMMILDKQKGLKSLSREKRQKLEAYQHLFYLLQTQPIYLA
                     KLIFQMPQNKTTKFMEGVIFSLYNYASNRREAYLLLQLFRTALQEEIKSKVEQPQDVV
                     TGNPTVVRLVVRFYRNGRGQSALQEILGKVIQDVLEDRSVSIHTDPVHIYKSWINQVE
                     AQTGQRSHLPYDVTPEQALSHSEVQRRLDISLRNLLAMTEKFFVAISSSVDHIPYGIR
                     YMAKVLKTTLETKFPNATERDIYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAGSSLAA
                     PQRHALGAVAQLLQHAAAGKVFSGESRHLRILNGYLEDLHHKFRKFICRACRVPEPEE
                     RFAIDEYSDMVAVAKPMVYITVGELIGTHRLLLEHQDQLAPGHQDPLHQLLEDLGEPP
                     TITDLIGDHVATDGHEDLSRLEVSLTLTNKFEGLETDADHNSTQSLLLSTKQMLADLI
                     QFHPGDSLEEILTSSAPREHEEAHHRLMCWRQACDTQKPEPLQRRHSLMAHSLLPLAE
                     KQQRVLRNLRRLQGLGLVRANDCYQGLVDELAKDICNQRRHRQRRKAEMLRLRATLQG
                     LDAKTIFYEEQGDYYNQYTQACLDHLAPNPRSSGKGKKQPSLHYTAAQLLEKGVLVEI
                     EDLPVSHFRNVIFDITPGDEAGRFAVNAKFLGVDMEKFQLHYQDLLQLQYEGVAVMKL
                     FNKAKVNVNLLIFLLNKKFLRK"
     exon            1..37
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            38..125
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            126..282
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            283..360
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            361..437
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            438..505
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            506..619
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            620..798
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            799..877
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1041
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1129
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1293
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1451
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1573
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1737
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1828
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1996
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2136
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2307
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2391
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2463
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2533
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2742
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..2895
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..3059
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            3060..3284
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            3285..3425
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            3426..3510
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            3511..3743
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            3744..3876
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            3877..3979
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            3980..4106
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            4107..4194
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            4195..4407
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            4408..4574
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            4575..4676
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            4677..4785
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
     exon            4786..5795
                     /gene="Iqgap3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagtctt gcacggcagg ccaggctcgg acagcctatg atcgtctcac agctgaggag
       61 atggatgagc agaggcgaca gaatgtcgcc taccagtacc tgtgccggct ggaggaagcc
      121 aagcgctgga tggaggtgtg cttgaaggag gagcttcctt cccctgtgga gctggaggag
      181 agcctccgga atggagtgct tctggccaag ctgggccact gttttgcacc ctctgtggtc
      241 cccctgaaga agatctatga catggaacag ctacgatacc aggcgaccgg cttgcatttc
      301 cggcacacgg acaacatcaa cttctggctt tctgcggtag cccacatcgg tctgccttcg
      361 accttcctcc cagagaccac agacatctat gacaaaaaga acatgcctcg ggtgatctac
      421 tgcattcatg ctctcagtct cttcctcttc cggctgggat tggcccctca gatccacgac
      481 ttgtatggaa aagtgaaatt cacagctgag gaactcagca acatcgcctc tgaactggcc
      541 aaatatggcc tccagttacc ggccttcagc aaaatcgggg gcatcctggc caatgagttt
      601 tcagccgatg aggctgcagt ccatgcagct attctggcca tcaatgacgc agtggagcga
      661 ggggtggtgg aagacactct ggtggccttg cagaatccca atgctcttct ggggaatctt
      721 cgggaacctt tggcagctgt ctaccaagag ctgttggccc tagccaagat ggagaaggct
      781 gccaatgcca ggaatcatga cgatggtcag gaccaggaca tctatgagtc ctgcctcacc
      841 caggcagaga tccagggcca catcaacctc gccaatgtcc agggggctct ggaagttgtt
      901 gatgacgctc tggagaggca gagccctgag gccttgcttg aggcccttcg tgaccctgtc
      961 ctggccctac aaggggtgag acaagccttt gctgactggt acctggaaca gctgacttca
     1021 gacagggagc agaaatcaca ggagctgggc ctggtgaggc ttctagaaaa ggaggagatc
     1081 caggctggtg tggctgcagc caatgagaag ggtgatcaag agcaggctat gctccgagct
     1141 gtgtggaaga tcaacaaagc catccagagg ggagtggccg ctgacaccgt gaaggagctc
     1201 atgtgccctg aagcccagct gccccaagta tacccctttg cctctgctgt gtaccagcag
     1261 gagctggctc tcctccagaa gcagcaacag ggggaactgg accaggagga gctctttgtg
     1321 gctgtggaga tgctctcagc cgtggttctg attaaccgtg ctctggaagc tggagatgcc
     1381 tgtacctttt gggacaatct ggtgaacccc gcaactggcc tggcccaggt tgaagaagaa
     1441 aatgcccaac gttactttga tgccctggtg aaggtgcagc agcttcgagg aacgcataga
     1501 ggcttcctga gctggaatga cctgcaggcg gctgtgagtc aagtcaatgc acaggtccag
     1561 gaagaaactg atcaggttct cgccatcagc ctcatcaatg aggctctgga ccagggctgt
     1621 cctgaaaaga ctctgtctgc cctgctgctt cctgcagctg gcctggaaga tgtcagcctt
     1681 cctgttgcac cccggtacca tcaccttctt gtggctgcca agaggcagaa agcacagaaa
     1741 acgggagatc ctggagctgt gctatggctg gaggagatcc gccagggagt ggccagagcc
     1801 aacgaggaca caaacacagc tcaaagaata gcccttggtg tggctgctat caaccaggcc
     1861 atcaaggagg gcaaggcagc ccagacagag cgtgtgttga ggaaccccaa tgtggccctc
     1921 cgagggatag ttcctgactg cgctaaaagc taccaacagg ccctggaagg cgcagcggca
     1981 aagaagcacc gtcctgggga cacagccttc tgggttccac gtgacatgaa ggatggcacc
     2041 gcctactact tccatctgca gacctttcag gggacctggg agcgtcctcc cagccgccac
     2101 ctcaatgcct cccatctcac ctgggaggag attcagtctg tcatcaccaa ggtcaccgct
     2161 gcccacgacc gccagctgct ctggaaggcc aacgttggct ttgtcatcaa gctccaggct
     2221 cgccttcgtg gcttcctcgt tcgccagaag tttgctgagt cttcccactt cctcaggacc
     2281 ttgctgccag ccgtcatcaa gatccaggcc cactggcggg gttatagaca acggaagact
     2341 taccaggagc ggctgcagta ttttaaagca aacctgaatg ctattatcac gatccaggcc
     2401 tgggcccgaa tgtgggcagc acgaaggcag tacctcaggc gtctgcgata cttccagaag
     2461 aacgttgact ccgttgtgaa gattcaagca tttttccgag ccaggaaggc ccgtgatgac
     2521 tacaggatgt tagtgcacgc acgccaccct cccctctctg tggtccggaa attcgctcac
     2581 ctcttgaacc agagtcagga ggacttctcg gctgaggcgg agctgctgag gctgcaggaa
     2641 gaagtggtca ggaagatccg ctctaatcag cagctggagc aggacctcaa cctcatggac
     2701 atcaagattg gcctgctggt caagaaccgg atcaccctgc aggaggtagt ctcccactgc
     2761 aagaagctga ccaagaagaa taaggagcaa ctgtcagaca tgatgatcct ggacaaacag
     2821 aagggattaa agtcactgag cagagagaaa cggcagaagc tagaagccta ccagcacctc
     2881 ttctacctgc tgcagactca gcccatctat ttggccaaac tgatctttca aatgccccag
     2941 aacaaaacca ccaagttcat ggaaggcgtg attttcagtc tgtacaacta tgcctccaac
     3001 cgccgggagg cctaccttct gctccagctg ttcagaacgg cactgcagga ggaaatcaag
     3061 tcaaaggtgg aacagcccca ggatgtggtg acaggcaacc caacagtagt gagactggtg
     3121 gtgaggttct accgcaatgg gcggggacag agcgctctgc aggagatcct tggcaaggtc
     3181 atccaggatg tgctcgaaga caggtcagtc agcatccaca cagatcctgt ccacatctat
     3241 aagagctgga tcaaccaggt ggaggcccag actggacagc gcagccatct cccctatgac
     3301 gtcacccccg agcaggctct gagccactct gaagtgcaga gacgattaga catctccctg
     3361 cgcaatctcc tcgccatgac tgaaaagttc ttcgttgcca tcagttcatc ggtggaccac
     3421 attccgtatg ggattcggta tatggccaaa gtcctgaaaa caaccctaga gacaaagttc
     3481 cccaatgcca cggagaggga catctataag gtggttggaa acctcctgta ctaccgcttc
     3541 ctgaaccctg ctgtggtagc tcctgacgcc tttgacattg tggccatggc agcaggcagc
     3601 agcctggccg ccccacagcg ccatgcgcta ggagctgtgg ctcagctcct acagcatgcg
     3661 gctgctggca aggtcttctc cggggagagc cggcaccttc gaatcctgaa tggctacctg
     3721 gaggacttgc atcacaagtt caggaagttc atctgcagag catgccgggt accagagccc
     3781 gaggagcgct tcgccataga tgaatactca gacatggtgg ctgtggccaa acccatggtg
     3841 tacatcaccg taggggagtt gatcggcaca cacaggctct tgctggaaca ccaagaccag
     3901 ctggccccag gtcaccagga cccactgcac cagctcctgg aggaccttgg ggagccaccc
     3961 accatcactg acctcatcgg ggaccatgta gccaccgatg ggcatgagga tctgagcagg
     4021 ctcgaagtgt ccctgacact caccaacaag ttcgaagggc tggagacaga tgctgaccac
     4081 aacagcaccc aaagtctgct tctgagcacc aaacagatgc tggccgacct catccagttc
     4141 caccctgggg actccctgga ggagatcctg acctcctcag ctcccaggga gcatgaagag
     4201 gcccatcatc ggttgatgtg ttggcgccaa gcctgtgaca cccagaaacc agagccgctt
     4261 caacgacgac actcactgat ggcacactcc ctcctgccac tggcagagaa gcagcaacgc
     4321 gtcctgcgga acctgcgtcg gctacagggc ctggggctgg tcagggccaa cgactgctac
     4381 cagggacttg tggacgagct ggccaaggac atctgcaacc agcgcaggca ccgacagcgg
     4441 cggaaggcag agatgctgag gctccgggcc acgctacagg gcctagatgc aaaaaccatc
     4501 ttctatgagg aacagggcga ctactacaac cagtacaccc aggcctgcct tgaccacctg
     4561 gcccccaacc ccaggagttc tgggaagggg aagaagcagc cgtctcttca ctacacagcc
     4621 gcccagctcc tggaaaaggg tgtcttggtg gaaattgaag atctccctgt ctctcacttc
     4681 agaaacgtca tctttgacat cactcctgga gatgaggcag gaaggttcgc cgtcaatgcc
     4741 aagttcctgg gtgtagacat ggagaagttt cagctccact accaggacct cttgcagctg
     4801 cagtatgagg gtgtggctgt catgaaactc tttaacaaag ccaaagtcaa cgtcaatctc
     4861 ctcatcttcc tgctcaacaa gaagttcctt cggaagtgac ggaagtgacg gggcagcctc
     4921 tcaactgact ggctgctgtg cttctccatt aaccagctct ggtccccgct gaccagagct
     4981 caggtcacag tgcttgaccc tcccacccaa gaggaattgt cctacttgac tgaagtgggc
     5041 catgcgtccc ggtccagcta ggtggctttt accacatccc tgtgaaccag caacctgcac
     5101 tcagtcctgg agaggaccat ggttttgtgt cactattgct ttcgcgtggt caccaccgtg
     5161 tctgccagta cttctagcac tgcccagcag ccttatctcc cttccttttc acagacttcc
     5221 aaagccaggg ccagactgtc tgtccctcct ccccttcata agccatgggc gttgctgtcc
     5281 cctacagccc aagtcccccc catgctgtgc cccccagcaa cctcttaccc ctcatcacat
     5341 cccagtatct gacttgggtg cagcatttgc tgatgtccat gatggctatg cacacctcga
     5401 atctcctttc tccatttgtg ctgtttctta tgtgggtcac cagagtattt attctaacct
     5461 gattgttgtg tggtcttaat catgatttta attctcactt tctgaactca gagagttctc
     5521 attcctccac tggaactact gcacattcca ctgtctccct ttagctagag tcaagtctct
     5581 tggggtccga gcagggaggc cccagctgaa gaactcctta cctcagctca cttcaggaca
     5641 aagagcagtc ttgccatctt cttgtcacct caactgactt ccaggtggtt cccatagatc
     5701 tgccttggcc actctctgtc caccccacat cttccatctc cctgcctcgc caccctctag
     5761 atttcctatt aataaaatgt catttcctat gttaa
//
