LOCUS       NM_001108489            6158 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus IQ motif containing GTPase activating protein 1
            (Iqgap1), mRNA.
ACCESSION   NM_001108489 XM_001066654 XM_341877
VERSION     NM_001108489.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6158)
  AUTHORS   Zhang,N., Wang,G. and Sun,G.
  TITLE     Actin-binding protein, IQGAP1, regulates LPS-induced RPMVECs
            hyperpermeability and ICAM-1 upregulation via Rap1/Src signalling
            pathway
  JOURNAL   Cell Signal 85, 110067 (2021)
   PUBMED   34147590
  REMARK    GeneRIF: Actin-binding protein, IQGAP1, regulates LPS-induced
            RPMVECs hyperpermeability and ICAM-1 upregulation via Rap1/Src
            signalling pathway.
REFERENCE   2  (bases 1 to 6158)
  AUTHORS   Su,S., Xu,A., Chen,Y., Li,W., Zha,X., Wang,Y. and Sun,G.
  TITLE     Transcriptomic Analysis of Pulmonary Microvascular Endothelial
            Cells with IQGAP1 Knockdown
  JOURNAL   DNA Cell Biol 39 (7), 1127-1140 (2020)
   PUBMED   32364766
  REMARK    GeneRIF: IQGAP1 not only exerts a crucial role in microvascular
            endothelium barrier but also plays an important role in
            inflammation
REFERENCE   3  (bases 1 to 6158)
  AUTHORS   Ashino,T., Kohno,T., Sudhahar,V., Ash,D., Ushio-Fukai,M. and
            Fukai,T.
  TITLE     Copper transporter ATP7A interacts with IQGAP1, a Rac1 binding
            scaffolding protein: role in PDGF-induced VSMC migration and
            vascular remodeling
  JOURNAL   Am J Physiol Cell Physiol 315 (6), C850-C862 (2018)
   PUBMED   30257103
  REMARK    GeneRIF: In cultured rat aortic SMCs, PDGF stimulation rapidly
            promoted ATP7A association with IQGAP1 and Rac1 and their
            translocation to the lipid rafts and leading edge. Cotransfection
            assay revealed that ATP7A directly bound to NH2-terminal domain of
            IQGAP1
REFERENCE   4  (bases 1 to 6158)
  AUTHORS   Liu,J., Liu,W., Yang,L., Wu,Q., Zhang,H., Fang,A., Li,L., Xu,X.,
            Sun,L., Zhang,J., Tang,F. and Wang,X.
  TITLE     The Primate-Specific Gene TMEM14B Marks Outer Radial Glia Cells and
            Promotes Cortical Expansion and Folding
  JOURNAL   Cell Stem Cell 21 (5), 635-649 (2017)
   PUBMED   29033352
REFERENCE   5  (bases 1 to 6158)
  AUTHORS   Vetterkind,S., Lin,Q.Q. and Morgan,K.G.
  TITLE     A novel mechanism of ERK1/2 regulation in smooth muscle involving
            acetylation of the ERK1/2 scaffold IQGAP1
  JOURNAL   Sci Rep 7 (1), 9302 (2017)
   PUBMED   28839270
  REMARK    GeneRIF: These data are consistent with a model in which IQGAP1
            cleavage is regulated by acetylation of the cleavage sites.
            Activation of ERK1/2 by ceramide, known to increase lysine
            acetylation, appears to be mediated by acetylation-dependent
            stabilization of IQGAP1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6158)
  AUTHORS   Skop,A.R., Liu,H., Yates,J. 3rd, Meyer,B.J. and Heald,R.
  TITLE     Dissection of the mammalian midbody proteome reveals conserved
            cytokinesis mechanisms
  JOURNAL   Science 305 (5680), 61-66 (2004)
   PUBMED   15166316
REFERENCE   7  (bases 1 to 6158)
  AUTHORS   Villace,P., Marion,R.M. and Ortin,J.
  TITLE     The composition of Staufen-containing RNA granules from human cells
            indicates their role in the regulated transport and translation of
            messenger RNAs
  JOURNAL   Nucleic Acids Res 32 (8), 2411-2420 (2004)
   PUBMED   15121898
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 6158)
  AUTHORS   Nauert,J.B., Rigas,J.D. and Lester,L.B.
  TITLE     Identification of an IQGAP1/AKAP79 complex in beta-cells
  JOURNAL   J Cell Biochem 90 (1), 97-108 (2003)
   PUBMED   12938160
  REMARK    GeneRIF: Data suggest that cyclic AMP/protein kinase A may be
            coupled with calcium/calmodulin and guanosine triphosphatases
            through an IQGAP1/AKAP79 complex.
REFERENCE   9  (bases 1 to 6158)
  AUTHORS   Mbele,G.O., Deloulme,J.C., Gentil,B.J., Delphin,C., Ferro,M.,
            Garin,J., Takahashi,M. and Baudier,J.
  TITLE     The zinc- and calcium-binding S100B interacts and co-localizes with
            IQGAP1 during dynamic rearrangement of cell membranes
  JOURNAL   J Biol Chem 277 (51), 49998-50007 (2002)
   PUBMED   12377780
  REMARK    GeneRIF: IQGAP1 is a potential target protein of S100B during
            processes of dynamic rearrangement of cell membrane morphology
            [IQGAP1]
REFERENCE   10 (bases 1 to 6158)
  AUTHORS   Natale,D.R. and Watson,A.J.
  TITLE     Rac-1 and IQGAP are potential regulators of E-cadherin-catenin
            interactions during murine preimplantation development
  JOURNAL   Mech Dev 119 Suppl 1, S21-S26 (2002)
   PUBMED   14516655
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473980.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_341877.3, XM_001066654.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..6158
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..6158
                     /gene="Iqgap1"
                     /note="IQ motif containing GTPase activating protein 1"
                     /db_xref="GeneID:361598"
                     /db_xref="RGD:1311884"
     exon            1..154
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..5073
                     /gene="Iqgap1"
                     /codon_start=1
                     /product="ras GTPase-activating-like protein IQGAP1"
                     /protein_id="NP_001101959.2"
                     /db_xref="GeneID:361598"
                     /db_xref="RGD:1311884"
                     /translation="MSAAEEVDGLGVVRPHYGSVLDNERLTAEEMDERRRQNVAYEYL
                     CHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTR
                     YKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLF
                     KLGLAPQIQDLYGKVDFTEEEINNMKIELEKYGIQMPAFSKIGGILANELSVDEAALH
                     AAVIAINEAIDHRVAADTFTALKNPNAMLVNLEEALAPTYQDVLYQAKQDKMTNAKNR
                     TENSDRERDVYEELLTQAEIQGNVNKVNTSSALANINLALEQGCALTLLKALQSVALG
                     LRGLQTQNSDWYLKQLQSDLQQKRQSGQTDPLQKEEVQAGVDAANGAAQQYQRRLAAV
                     AAINAAIQKGIAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQQQSPEHSLTHPEL
                     TVAVEMLSSVALINRALESGDMNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQA
                     HAENNEFVTWNDIQACVDHVNLVVHEEHERILAIGLINEALDEGDAQKTLQALQIPAA
                     KLEGVLPEVAQHYQDTLIRAKREKAQETQDESAVLWLDEIQGGIWQSNKDTQEAQRFA
                     LGIFAINEAVESGDVGRTLSALRSPDVGLYGVIPECGETYQSDLAEAKKKRLAAGDNN
                     SKWVKHWVKGGYHYYHNLETQAGGWAEPPDFVQNSVQLSREEIQSSISGVTAAYNREQ
                     LWLANEGLITKLQACCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDR
                     LAYLHSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYK
                     TLINAEDPPMIVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNLMD
                     IKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKREKLEAY
                     QHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFQTAL
                     QEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIK
                     TDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALSHEEVKTRLDNSIRNMRAVTDKFL
                     SAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAAEDELLKIIGNLLYYRYMNPAIVAPD
                     AFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQKF
                     RRFFQAACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEH
                     NDPIHELLDDLGEVPTIESLIGESCGNSNDPSKEALAKTEVSLTLTNKFDVPGDENAE
                     MDARTILLNTKRLIVDVIRFQPGETLTEILETPATNEQEAEHQRAMQRRAIRDAKTPD
                     KMKKSKPMKEDNNLSLQEKKEKIQTGLKKLTELGTVDPKNRYQELINDIAKDIRNQRR
                     YRQRRKAELVKLQQTYSALNSKATFYGEQVDYYKSYIKTCLDNLASKGKVSKKPREMK
                     GKKSKKISLKYTAARLHEKGVLLEIEDLQANQFKNVIFEIGPTEEVGDFEVKAKFMGV
                     QMETFMLHYQDLLQLQYEGVAVMKLFDRAKVNVNLLIFLLNKKFYGK"
     exon            155..254
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            255..411
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            412..489
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            490..566
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            567..634
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            635..748
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            749..927
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1012
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1176
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1261
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1425
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1586
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1711
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1875
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..1966
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2134
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2277
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2448
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2532
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..2604
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2674
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2883
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..3039
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            3040..3203
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            3204..3428
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            3429..3569
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            3570..3654
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            3655..3887
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            3888..4020
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            4021..4123
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            4124..4259
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            4260..4347
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            4348..4560
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            4561..4727
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            4728..4850
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            4851..4959
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            4960..6158
                     /gene="Iqgap1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgacagcc cgcgcactgg gcaggagttg ctgctgctac ggtcgcccgc gtcttcaagg
       61 tctctgctct tcctcaccgg agaccgggac tcggccgcca tgtccgccgc ggaggaggtc
      121 gatggcctgg gtgtggtccg gccgcactat ggctctgtcc tggataatga gagactcacg
      181 gcagaggaga tggatgagag gaggcgacag aacgtggcct atgagtacct ttgtcatttg
      241 gaagaagcaa agaggtggat ggaagcatgc ctaggggagg acctgccgcc caccacagag
      301 ctggaggagg gccttcggaa tggggtctac cttgccaagc tagggaactt cttctccccc
      361 aaagtggtgt ccctgaagaa aatctacgat cgagagcaga ccagatacaa ggctaccggc
      421 ctacacttca gacacacgga taatgtgatt cagtggctga atgccatgga tgagattgga
      481 ttgcctaaga ttttttatcc agaaaccaca gatatctacg accggaagaa catgccaaga
      541 tgtatctact gtatccacgc cctcagtttg tacctgttca aactgggcct ggctcctcag
      601 attcaagacc tgtatggaaa ggttgacttc acagaggaag aaatcaacaa catgaagatt
      661 gagcttgaga agtacgggat ccagatgcct gccttcagca agataggggg catcctggct
      721 aacgagctct cggtggatga ggctgcatta cacgctgctg tcattgctat taatgaagct
      781 attgatcaca gagttgcagc tgacacgttt acggctctga aaaaccccaa tgccatgctt
      841 gtcaatcttg aagaagcgct ggctcccacc taccaggatg tgctttacca ggccaagcag
      901 gacaagatga caaatgctaa aaacaggacg gaaaactctg acagagaaag ggacgtttat
      961 gaggaactgc tcacacaagc tgaaatccaa gggaatgtaa acaaagtcaa cacatcatct
     1021 gccctggcca acatcaacct ggctttagag cagggctgtg cactgaccct gctcaaggct
     1081 ctgcagtcag tggctctggg cctccgaggg ttgcagaccc agaacagcga ctggtacctg
     1141 aagcagctac agagtgatct gcagcaaaaa cgacagagtg gccagactga ccctctgcag
     1201 aaggaggagg tacaggccgg agtggatgct gccaacggtg ctgcccaaca ataccaacga
     1261 cggttggcag cagtggcagc gatcaatgcg gcgatccaga agggcatcgc cgagaagacc
     1321 gttttggagc taatgaatcc tgaagcccag ctgccccagg tgtatccatt tgcagccgat
     1381 ctttatcaga aggagttggc caccctgcag cagcagagtc ctgagcatag cctcacccat
     1441 cctgaactca ctgttgccgt ggagatgctg tcttctgtgg ccctcatcaa cagggcgctg
     1501 gagtcaggag acatgaacac ggtgtggaag cagctgagca gctccgttac aggccttacc
     1561 aatatcgagg aagaaaactg tcaaaggtat ctggatgagc tgatgaagct gaaggcgcag
     1621 gcacatgcag agaataatga atttgtcacg tggaatgaca tccaggcgtg tgtggaccac
     1681 gtgaacctgg tggtccacga ggaacatgag cggattttgg ccattggttt aattaatgaa
     1741 gccctggatg aaggggacgc tcagaagact ctgcaggccc tgcagatccc tgcagccaag
     1801 ctcgaggggg tccttccaga ggtggcacag cattatcaag acacgctgat cagagcaaag
     1861 agagaaaagg cccaggaaac ccaggatgag tcagctgtgt tatggttgga tgaaattcaa
     1921 ggtggaatct ggcagtccaa caaagacacc caggaagcac agaggtttgc cctaggaatc
     1981 ttcgccatca acgaagcagt agagagtggt gatgttggca gaaccctgag tgcccttcgt
     2041 tctccggacg ttggcttata tggagtgatc cctgagtgtg gggaaacata ccagagtgac
     2101 cttgctgaag ccaagaagaa aagactagca gcaggagaca ataacagcaa gtgggtgaag
     2161 cactgggtga aaggcgggta ccattactac cacaatctgg agacgcaagc aggaggatgg
     2221 gctgaacccc cagacttcgt gcagaattct gtgcagcttt ctcgagagga aatccagagc
     2281 tccatctctg gagtgaccgc tgcgtataac cgagagcagc tttggctggc caacgaaggc
     2341 ttgattacca agctgcaagc ctgctgccgt gggtaccttg ttcgacagga attccgatcc
     2401 cggatgaact ttctgaagaa acagatcccc gccatcacct gcattcagtc acagtggaga
     2461 ggatacaaac agaagaaggc atatcaagat cggctggctt acctgcactc ccataaagac
     2521 gaagttgtga agattcagtc ccttgccagg atgcatcaag ccagaaagcg ctatagagat
     2581 cgcctacagt atttccgaga ccacataaat gacattatca aaatccaggc tttcattcgg
     2641 gcaaacaaag ctcgcgatga ctacaagact ctcatcaatg ctgaggatcc gcctatgatt
     2701 gtggtccgaa agtttgtcca cctcctggac caaagtgatc aggactttca ggaagagctt
     2761 gatcttatga agatgcggga ggaggtcatc accctcatcc gttccaacca gcagctggag
     2821 aatgacctca atctcatgga tatcaaaatc ggcctgctgg taaagaacaa gatcaccctg
     2881 caggatgtgg tttcccatag taaaaaactt accaaaaaga ataaggagca gttgtctgac
     2941 atgatgatga taaacaagca gaagggcggg ctcaaggccc tgagcaagga gaagagggag
     3001 aagctggaag cctatcagca tctcttctat ctgctacaga ccaaccctac ctatctggcc
     3061 aagctgattt ttcagatgcc acagaacaag tccaccaagt tcatggactc tgtgatcttc
     3121 acgctctaca actatgcatc caaccagcgg gaggagtacc tgctgctccg actcttccag
     3181 acggcactgc aggaggagat caagtcaaag gtggatcaga ttcaagaaat cgtgacagga
     3241 aaccctacag ttattaagat ggttgtaagc ttcaaccgtg gtgcccgggg ccagaatgcc
     3301 ctccggcaga tcttggctcc tgttgtgaag gaaattatgg atgacaagtc tctcaacatc
     3361 aaaaccgacc ccgtggacat ttacaagtct tgggttaatc agatggagtc tcagacagga
     3421 gaagcgagca aactgcctta tgatgtgacc cctgagcaag ccttgtctca tgaagaagtg
     3481 aagacgaggt tagacaactc catcaggaac atgagggctg tgacagacaa gttcctttca
     3541 gccatcgtca gctctgtgga caaaatccct tacgggatgc gcttcattgc caaagtgctg
     3601 aaggactctt tgcacgagaa gttcccggat gctgccgagg acgagctgct gaagattatt
     3661 ggtaacctgc tttactaccg atacatgaac ccggccatcg ttgctcctga tgccttcgac
     3721 attattgacc tgtcagcagg aggccagctc accacagacc agcgtagaaa tctgggctcc
     3781 attgcaaaga tgctgcagca cgcggcttcc aacaagatgt ttctgggtga taatgctcac
     3841 ctaagcatca ttaatgaata tctctctcag tcctaccaga aattcagacg gtttttccaa
     3901 gccgcttgcg acgtcccaga gctacaggat aagtttaatg tggatgagta ttccgatcta
     3961 gtcaccctca ccaagccggt tatctacatt tccattggtg agatcatcaa cacccacact
     4021 ctcctgttgg accatcagga cgccattgct ccagagcata acgaccccat ccatgaactg
     4081 ctggatgacc ttggagaggt gcccaccatt gagtccctta taggagaaag ctgtggtaat
     4141 tcaaatgacc ccagcaagga ggcgctggct aagactgaag tgtctctcac actgaccaac
     4201 aagtttgacg tgcctggtga tgagaacgca gagatggatg cgcggaccat cttactgaat
     4261 acaaaacgtt taattgtgga tgtcatccgg ttccagccag gagagacctt gactgaaatc
     4321 ctagaaaccc cagccaccaa tgaacaggaa gctgaacatc agagggccat gcagagacgg
     4381 gctatccgcg atgccaaaac ccctgacaag atgaaaaaat caaagcccat gaaggaggat
     4441 aacaacctca gcctccagga gaagaaagag aagatccaga ctggcctaaa gaagctaacg
     4501 gaacttggga cggtggaccc aaagaacaga taccaggaac tcatcaacga cattgctaag
     4561 gatatccgga atcagcggcg atacaggcag aggaggaagg ctgagctggt aaagctgcag
     4621 cagacctact cggcgctgaa ctcgaaggcc accttttacg gagagcaggt ggattactac
     4681 aagagctaca tcaagacctg cttggataac ttggccagca agggcaaggt ctccaaaaaa
     4741 cctagggaaa tgaaaggcaa aaaaagcaaa aagatttctc tgaagtacac agcagcaaga
     4801 ctgcatgaga agggagtgct tctggaaatt gaggaccttc aagcaaacca atttaaaaat
     4861 gttatcttcg aaattggtcc aacagaagaa gttggagact ttgaagtgaa ggccaagttc
     4921 atgggcgttc agatggagac tttcatgctg cattatcagg acttgctgca gctacagtat
     4981 gaaggggttg cggtcatgaa gttgtttgat agagctaaag tgaatgtcaa cctcctgatc
     5041 ttccttctca acaaaaagtt ctatgggaag taacgggtca cttgccaccc gaggaataaa
     5101 aacaggcaac actccacagc tgtctttcta ggaacctcca ttactcctcg gaagcaaaga
     5161 cctggtccag cagcctcagt tcacactcct gaagcccgtg tttaagtccc ccctcccccg
     5221 acaggctcag tgccctcttc tatatggtga agccggatga cttcccctca gccctgctcc
     5281 cctcattttc tctcatcatg tagaaaagag tggaacccca cccaacccct ttctacgaaa
     5341 gcctcctaag tggtaattac tattttgtaa acattggtgt ttgttttact tagcaataag
     5401 aatggtggaa tccaaattct tgtttagagg taaaagctgt caggttgcta gcaagcatcc
     5461 gattcggcat taagtacggc ccggcccgtg agcagtcaga ggatgaagtc cgtgaagtct
     5521 tccatctgct gcctttgtag gcggagctga tccaagttac tgctctctgt tcaaatgaag
     5581 cagcttcagg agaaaaagag caactacttt tgaattctcc actcaatgtg ggcagtacag
     5641 ttagtgcaga gcccttcctg gtgaaggtga acccccacgg tcatggagac ctgagagact
     5701 gagtgggcag ggcactcacc atccctccca caaagggatg gcttacccta gctcaaaatg
     5761 taactgtttc taaactgtat tccaggagtg ccttaccaaa gtataaattt atttcttaaa
     5821 atgtgagtga taggaatttt aaagatttat ataatgcttt agaatactga gaaagggttg
     5881 tttttttcat tgggttcatc tgtatatctg aattcttgaa gcttttctgt agcctgtact
     5941 gaggtctatc taccaagctg ctgagctaat cctgcttgat tttagcaaca agagacaacc
     6001 cacatcatgc ttgaagttca atccatctct tctctgttac ctacatcatg cttttatcct
     6061 gagaaacctg cacccttaag ctctgactaa caaagacagc tccagacatt gaatttggaa
     6121 acctttgtcc ttggattaaa agtcataaac tttaaaaa
//
