LOCUS       NM_001107092            2844 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus IQ motif containing B1 (Iqcb1), mRNA.
ACCESSION   NM_001107092 XM_001062923 XM_221420
VERSION     NM_001107092.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2844)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   2  (bases 1 to 2844)
  AUTHORS   Fahim,A.T., Bowne,S.J., Sullivan,L.S., Webb,K.D., Williams,J.T.,
            Wheaton,D.K., Birch,D.G. and Daiger,S.P.
  TITLE     Polymorphic variation of RPGRIP1L and IQCB1 as modifiers of
            X-linked retinitis pigmentosa caused by mutations in RPGR
  JOURNAL   Adv Exp Med Biol 723, 313-320 (2012)
   PUBMED   22183348
REFERENCE   3  (bases 1 to 2844)
  AUTHORS   Wang,X., Wang,H., Cao,M., Li,Z., Chen,X., Patenia,C., Gore,A.,
            Abboud,E.B., Al-Rajhi,A.A., Lewis,R.A., Lupski,J.R., Mardon,G.,
            Zhang,K., Muzny,D., Gibbs,R.A. and Chen,R.
  TITLE     Whole-exome sequencing identifies ALMS1, IQCB1, CNGA3, and MYO7A
            mutations in patients with Leber congenital amaurosis
  JOURNAL   Hum Mutat 32 (12), 1450-1459 (2011)
   PUBMED   21901789
REFERENCE   4  (bases 1 to 2844)
  AUTHORS   Sang,L., Miller,J.J., Corbit,K.C., Giles,R.H., Brauer,M.J.,
            Otto,E.A., Baye,L.M., Wen,X., Scales,S.J., Kwong,M.,
            Huntzicker,E.G., Sfakianos,M.K., Sandoval,W., Bazan,J.F.,
            Kulkarni,P., Garcia-Gonzalo,F.R., Seol,A.D., O'Toole,J.F., Held,S.,
            Reutter,H.M., Lane,W.S., Rafiq,M.A., Noor,A., Ansar,M., Devi,A.R.,
            Sheffield,V.C., Slusarski,D.C., Vincent,J.B., Doherty,D.A.,
            Hildebrandt,F., Reiter,J.F. and Jackson,P.K.
  TITLE     Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy
            disease genes and pathways
  JOURNAL   Cell 145 (4), 513-528 (2011)
   PUBMED   21565611
REFERENCE   5  (bases 1 to 2844)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   6  (bases 1 to 2844)
  AUTHORS   Stone,E.M., Cideciyan,A.V., Aleman,T.S., Scheetz,T.E., Sumaroka,A.,
            Ehlinger,M.A., Schwartz,S.B., Fishman,G.A., Traboulsi,E.I.,
            Lam,B.L., Fulton,A.B., Mullins,R.F., Sheffield,V.C. and
            Jacobson,S.G.
  TITLE     Variations in NPHP5 in patients with nonsyndromic leber congenital
            amaurosis and Senior-Loken syndrome
  JOURNAL   Arch Ophthalmol 129 (1), 81-87 (2011)
   PUBMED   21220633
REFERENCE   7  (bases 1 to 2844)
  AUTHORS   Fahim,A.T., Bowne,S.J., Sullivan,L.S., Webb,K.D., Williams,J.T.,
            Wheaton,D.K., Birch,D.G. and Daiger,S.P.
  TITLE     Allelic heterogeneity and genetic modifier loci contribute to
            clinical variation in males with X-linked retinitis pigmentosa due
            to RPGR mutations
  JOURNAL   PLoS One 6 (8), e23021 (2011)
   PUBMED   21857984
REFERENCE   8  (bases 1 to 2844)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   9  (bases 1 to 2844)
  AUTHORS   Otto,E.A., Helou,J., Allen,S.J., O'Toole,J.F., Wise,E.L.,
            Ashraf,S., Attanasio,M., Zhou,W., Wolf,M.T. and Hildebrandt,F.
  TITLE     Mutation analysis in nephronophthisis using a combined approach of
            homozygosity mapping, CEL I endonuclease cleavage, and direct
            sequencing
  JOURNAL   Hum Mutat 29 (3), 418-426 (2008)
   PUBMED   18076122
REFERENCE   10 (bases 1 to 2844)
  AUTHORS   Otto,E.A., Loeys,B., Khanna,H., Hellemans,J., Sudbrak,R., Fan,S.,
            Muerb,U., O'Toole,J.F., Helou,J., Attanasio,M., Utsch,B.,
            Sayer,J.A., Lillo,C., Jimeno,D., Coucke,P., De Paepe,A.,
            Reinhardt,R., Klages,S., Tsuda,M., Kawakami,I., Kusakabe,T.,
            Omran,H., Imm,A., Tippens,M., Raymond,P.A., Hill,J., Beales,P.,
            He,S., Kispert,A., Margolis,B., Williams,D.S., Swaroop,A. and
            Hildebrandt,F.
  TITLE     Nephrocystin-5, a ciliary IQ domain protein, is mutated in
            Senior-Loken syndrome and interacts with RPGR and calmodulin
  JOURNAL   Nat Genet 37 (3), 282-288 (2005)
   PUBMED   15723066
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473967.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_221420.4, XM_001062923.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2844
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..2844
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ motif containing B1"
                     /db_xref="GeneID:303915"
                     /db_xref="RGD:1310069"
     exon            1..33
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            34..103
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            104..215
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1789
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /note="IQ calmodulin-binding motif containing 1;
                     nephrocystin 5"
                     /codon_start=1
                     /product="IQ calmodulin-binding motif-containing protein
                     1"
                     /protein_id="NP_001100562.1"
                     /db_xref="GeneID:303915"
                     /db_xref="RGD:1310069"
                     /translation="MKPAGTDPRILSLAAEVAKSPEQNVPVILLKLKEIINNTPLGSS
                     ELKKVKQDIYCYDLIQYCLLVLSQDSSRIQGGWSTISQLTQILSHCCVGLEPGEDGEE
                     FYKELLPSAAENFLVLGRRLQTCFINATKGEEQDKLLHFFQIVTDSLFWLLGGHIQLI
                     QNVLQSDHFLHLLQTDNVQIGATVMTLLQNILQINSGNLLKIEGKALHSILDEILFKL
                     LSTPSPVIRSTATKLLLVLAESHQEILILLRLSACYKGLRSLLNKQETLTEFSRELRQ
                     LVDLLTPKIQQEVEEQKLHKAACLIQAYWKGFQTRKRLKKLPSAVIALQRSFRAKRTK
                     MLLELNRQKEEEDLRLRLQLQKQRAMRLSRESRLSMLEIIHPGQVEKYNREIEEKSAL
                     TIQKHWRGYRERKNFRQQRPSLTEYKAAVTLQRAVLKFLAKCRKKKKLFASWHGLQEL
                     TDARRVELKQQVDDYVKRHPGSQMSDVASRELHAQAQERLQHYFMGRAIEERAQQHRE
                     ALMAQISTNIEQLMSMLYICLCFINGITHARDVASKIFRSATNSLYSSP"
     exon            216..378
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            379..508
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            509..602
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            603..702
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            703..881
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            882..991
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1101
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1244
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1393
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1525
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..2844
                     /gene="Iqcb1"
                     /gene_synonym="NPHP5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcacacagc tcggcgaagg ccgccacgct gagtgattcc tggaagcagt gaagggcacg
       61 gccttgggat tcttgattcc tcaaaggtca gcctagcaac agggtggtag aaaaaatgaa
      121 gccagcgggt acagacccaa ggatcttgtc tttagctgct gaagtagcga aaagtcctga
      181 acaaaatgtc cctgttatat tattgaagtt aaaagaaata ataaacaaca cccctttggg
      241 aagctcagag ttaaagaaag tcaagcaaga tatatattgt tatgacctca ttcaatactg
      301 tctattggtc ctcagtcaag attcttctcg aatccagggt ggttggtcta caatttccca
      361 gctgacacag atactaagcc attgctgtgt gggattagag ccaggagaag atggagaaga
      421 attttacaag gaattacttc catcagctgc cgaaaatttt cttgtcctgg gaagacgatt
      481 gcaaacatgt tttatcaatg caactaaggg tgaagagcaa gataaattac tacatttttt
      541 ccaaattgtg actgattctc tcttctggct attgggaggt catattcaac tcatacagaa
      601 tgtactgcag agtgatcatt tcttgcacct actgcaaact gacaatgttc aaataggagc
      661 tacagtcatg actctgcttc agaatatact acagatcaac agtggtaatt tactcaaaat
      721 agaaggaaaa gccctgcatt ctattttaga tgaaattctt ttcaagcttt tgtcaactcc
      781 tagtccagtc ataagaagta ctgctacaaa gctcctactg gtattggctg aatcccatca
      841 ggaaattttg attttactga gactaagtgc ctgctataaa ggacttagaa gtctgctaaa
      901 taaacaggaa actcttacag aatttagtcg agaacttaga cagctcgttg atcttttaac
      961 ccctaagatc caacaggaag tagaagaaca gaaactacat aaagcagctt gcttgattca
     1021 agcctattgg aaaggtttcc agaccagaaa aagattaaag aagcttccgt ctgctgtgat
     1081 tgccttgcag aggagtttca gagctaaacg aacaaagatg ttgttggagc taaataggca
     1141 gaaggaagaa gaagacctca gattaagatt gcaacttcaa aaacagagag ccatgaggct
     1201 ttcccgagag tcacgcttga gtatgcttga aataattcat ccaggtcaag tggagaaata
     1261 caatagggaa atagaagaga aatctgcatt gactatccag aaacattgga gagggtacag
     1321 ggaaaggaag aattttcgcc aacagaggcc atctctcaca gagtataaag cagctgtcac
     1381 acttcagaga gcagttctta aattcctagc aaagtgccgt aagaaaaaga aactctttgc
     1441 ctcttggcat ggactccaag aactcactga tgcacgccga gttgaactga agcaacaagt
     1501 ggatgactat gtcaaaagac atccgggctc tcagatgtca gatgtggcca gcagagagct
     1561 ccacgcacaa gcacaagaac gacttcaaca ctattttatg ggaagagcca tagaagagcg
     1621 agcccagcaa cacagggaag cattgatggc tcagatcagc accaatattg agcagttgat
     1681 gagtatgctc tacatctgtc tttgtttcat aaatggaata acccatgcaa gagacgtggc
     1741 atccaaaatc tttagaagtg ccacaaatag tctttattcc agtccttagg aaatcttaca
     1801 tcatcccagt tttcaactgt atacattcca tttgttataa attcaaatat ttcaactcca
     1861 tccaaattac taattttaaa gatgctgtgc tcttctacac acattctgcc taaacttttt
     1921 aaattttttt ttgtatttta gaattagata atgacagcag ttacagtaca gtgacctttt
     1981 caaaaataac atttaatgat tttttactga agttttgctc tctttaagct atctaacaca
     2041 acttactgtt tttctcttct aaaagactta aaaagactgg aagttgccag ggattggggt
     2101 tgttgctgtc acccacatct gtaacttttt actagacacc taccttcata gttagcagtg
     2161 acagcatagt cagagttaga gcccatcctg tcctgtcctg tcctaactgt agctaggctc
     2221 cagctctgct ggttccaagt ctgcttgcct ggcgtccttc cactgaccca tttactttct
     2281 gtttgctgca gaggcaccaa gtctgaagga ggcggaagga aaggagcctg agcagttcct
     2341 gagtagatct aggcctgtgg cagccaaagc caagcaggcc caccttacca ccctgaagca
     2401 catacaggcc ccctggtgga agaagctcgg agaggaacca ggggatgaga tggatgttcc
     2461 aaaggacgag cttagtatag atttagggac tttatttatt ggtggaacca agcctcccta
     2521 gagagttact gggaaagccg gcattcttac cttttaagag attgttggtt ttgcctctgg
     2581 catgcaggaa gactaggtct atgccagtgg ctttccagag catcttcttc atgaacactt
     2641 ggaagcaaag agcagagcat tgcctacctc actctcagtt ctttccccat ctctacaccc
     2701 tgtctgtagt cacaaacaga tttgtgggct tttaattgtg ggacagaact caatgtgaaa
     2761 ttttattgtt aatttgaaat ttctttcatt ctgttttctg actaaaagtt gttttgtttt
     2821 tgtttttaaa taaatattgt ttct
//
