LOCUS       NM_001008556            2779 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus inositol-pentakisphosphate 2-kinase (Ippk), mRNA.
ACCESSION   NM_001008556 XM_225201
VERSION     NM_001008556.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2779)
  AUTHORS   Brehm,M.A., Wundenberg,T., Williams,J., Mayr,G.W. and Shears,S.B.
  TITLE     A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate
            2-kinase in the synthesis of ribosomal RNA
  JOURNAL   J Cell Sci 126 (Pt 2), 437-444 (2013)
   PUBMED   23203802
REFERENCE   2  (bases 1 to 2779)
  AUTHORS   Fujii,M. and York,J.D.
  TITLE     A role for rat inositol polyphosphate kinases rIPK2 and rIPK1 in
            inositol pentakisphosphate and inositol hexakisphosphate production
            in rat-1 cells
  JOURNAL   J Biol Chem 280 (2), 1156-1164 (2005)
   PUBMED   15528195
REFERENCE   3  (bases 1 to 2779)
  AUTHORS   Verbsky,J.W., Wilson,M.P., Kisseleva,M.V., Majerus,P.W. and
            Wente,S.R.
  TITLE     The synthesis of inositol hexakisphosphate. Characterization of
            human inositol 1,3,4,5,6-pentakisphosphate 2-kinase
  JOURNAL   J Biol Chem 277 (35), 31857-31862 (2002)
   PUBMED   12084730
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Sep 30, 2022 this sequence version replaced NM_001008556.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.39086.1,
                                           SRR26643298.68716.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               JAXUCZ010000017.1  15435776-15436000   c
            226-273             JAXUCZ010000017.1  15427349-15427396   c
            274-369             JAXUCZ010000017.1  15425866-15425961   c
            370-436             JAXUCZ010000017.1  15424380-15424446   c
            437-558             JAXUCZ010000017.1  15422660-15422781   c
            559-648             JAXUCZ010000017.1  15421398-15421487   c
            649-707             JAXUCZ010000017.1  15416163-15416221   c
            708-780             JAXUCZ010000017.1  15414829-15414901   c
            781-1054            JAXUCZ010000017.1  15411980-15412253   c
            1055-1205           JAXUCZ010000017.1  15410196-15410346   c
            1206-1308           JAXUCZ010000017.1  15409467-15409569   c
            1309-1388           JAXUCZ010000017.1  15400819-15400898   c
            1389-2779           JAXUCZ010000017.1  15396691-15398081   c
FEATURES             Location/Qualifiers
     source          1..2779
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..2779
                     /gene="Ippk"
                     /gene_synonym="C9orf12; RGD1311271; rIpk1"
                     /note="inositol-pentakisphosphate 2-kinase"
                     /db_xref="GeneID:306808"
                     /db_xref="RGD:1311271"
     exon            1..225
                     /gene="Ippk"
                     /gene_synonym="C9orf12; RGD1311271; rIpk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1614
                     /gene="Ippk"
                     /gene_synonym="C9orf12; RGD1311271; rIpk1"
                     /EC_number="2.7.1.158"
                     /note="insP5 2-kinase; ins(1,3,4,5,6)P5 2-kinase;
                     inositol-1,3,4,5,6-pentakisphosphate 2-kinase; inositol
                     polyphosphate kinase 1"
                     /codon_start=1
                     /product="inositol-pentakisphosphate 2-kinase"
                     /protein_id="NP_001008556.2"
                     /db_xref="GeneID:306808"
                     /db_xref="RGD:1311271"
                     /translation="MEEGKMDENEWSYHGEGNKSLVVAHAQRCVVLRFLKFPPNKKKT
                     SEEILQHLQNIVDFGKNVMKDFLGENYVHCGEVVQLPLEFVKQLCLKIQCERPESRCD
                     KDLDTLSGYAMCLPNLTRLQTFPFAEHRPILCVEIKPKCGFIPFSNGVTHEMKHKVCR
                     YCMHQHLKVATGKWKKISKYCPLDLYSGNKQRMHFALKSLLQEAQNNLRIFKNGELIY
                     GCADARSPVADLKALAHHLKPFFFPSNGLASGPQCTRAVIRELVHVITRVLLSTSDKG
                     RAGALRLGLQGARVCEASPFSRSLHHQGKNTPEHSGLPKGCLLYKTLQVQMLDQLDIE
                     GLYPLYNRVEQYLEEFPEERKTLQIDGPYDEVFYQKLLDLSTEDDGTVAFALTKVQQY
                     RVAMTAKDCSIMIALSPCLRGASSDQRPVIPSSRSRLAFSVSVLDLDLKPYESIPHQY
                     KLDSKIVSYYSKTVHAKDDTVRSTRFKEHEDCTLVLHKV"
     exon            226..273
                     /gene="Ippk"
                     /gene_synonym="C9orf12; RGD1311271; rIpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            274..369
                     /gene="Ippk"
                     /gene_synonym="C9orf12; RGD1311271; rIpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            370..436
                     /gene="Ippk"
                     /gene_synonym="C9orf12; RGD1311271; rIpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            437..558
                     /gene="Ippk"
                     /gene_synonym="C9orf12; RGD1311271; rIpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            559..648
                     /gene="Ippk"
                     /gene_synonym="C9orf12; RGD1311271; rIpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            649..707
                     /gene="Ippk"
                     /gene_synonym="C9orf12; RGD1311271; rIpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            708..780
                     /gene="Ippk"
                     /gene_synonym="C9orf12; RGD1311271; rIpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..1054
                     /gene="Ippk"
                     /gene_synonym="C9orf12; RGD1311271; rIpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1205
                     /gene="Ippk"
                     /gene_synonym="C9orf12; RGD1311271; rIpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1308
                     /gene="Ippk"
                     /gene_synonym="C9orf12; RGD1311271; rIpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1388
                     /gene="Ippk"
                     /gene_synonym="C9orf12; RGD1311271; rIpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..2779
                     /gene="Ippk"
                     /gene_synonym="C9orf12; RGD1311271; rIpk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agactgcaag ttgccgcggc tgagagcgca ggcggcagct gacaggcgct tttcttcaga
       61 ctgctgcggc gggagcccag cgaggcgggc gcctccagct ctcgtcccag cgtcccggcc
      121 cgcgaagttc cagggcgccg gggcatggaa gaggggaaaa tggacgagaa tgaatggagt
      181 taccatggcg aaggcaacaa gagccttgtg gtggcccacg cgcagcgctg tgtagttctg
      241 cgctttctga agtttcctcc aaataagaag aagacctcag aagagatact tcagcatctg
      301 cagaacatag tggactttgg caaaaatgtc atgaaagact ttttgggaga gaactatgtt
      361 cattgtgggg aggttgttca gctgccttta gagtttgtga aacaactgtg tttaaagata
      421 cagtgtgaaa gaccagagtc ccgttgtgac aaggacctgg acacactcag tggttatgct
      481 atgtgccttc ccaatttgac cagacttcag accttcccct ttgcagagca ccgaccaatt
      541 ctgtgtgtgg agattaagcc aaaatgtggg tttattcctt tctcaaatgg tgtcacccac
      601 gagatgaagc acaaggtgtg ccggtactgc atgcaccagc acctcaaggt agcgactgga
      661 aagtggaaga aaatcagtaa atactgtccc cttgacctct actcaggaaa taagcagcgt
      721 atgcactttg ccttgaagag tcttctgcag gaggcgcaga ataaccttag gatatttaag
      781 aatggagagc tgatttatgg ctgtgctgat gcccggagcc ccgtggctga cttgaaggcg
      841 cttgcacacc acctgaagcc cttcttcttc ccttccaatg gcctggccag tgggcctcag
      901 tgcacgaggg ctgtgatccg ggagctggtg catgttatca ccagggtgct gctcagcacc
      961 tcagacaaag gccgagcggg tgccttgagg cttgggctcc agggcgcacg agtctgtgaa
     1021 gccagcccat tcagcaggag cctacatcac caaggaaaaa acaccccaga gcactcgggg
     1081 ttaccgaagg gctgtcttct gtacaaaacc ctccaggtgc agatgttgga ccagctggac
     1141 atcgaaggcc tctaccctct gtacaaccgg gttgagcaat acctggagga gtttcctgag
     1201 gagaggaaaa cattacagat agatgggcct tatgatgaag tattttacca gaaactgctt
     1261 gatctatcca ctgaggatga tgggacagtg gcctttgcat taacaaaggt gcagcagtac
     1321 cgagtagcca tgaccgccaa ggactgttcc atcatgatcg cactttcccc ttgtctacgg
     1381 ggcgccagct ctgaccagag gcctgttatc ccttcgtcaa gatcccggct ggccttctct
     1441 gtgtctgtac tggacctcga cctcaagccc tatgagagca ttcctcacca gtataaacta
     1501 gacagcaaga tagtcagcta ttactcaaag actgtgcatg ccaaagatga cactgtgagg
     1561 tccactcggt tcaaggaaca tgaagactgc acattagttc tccataaggt ctaacttctc
     1621 ccctgggatg tctttgaaac ttgaatgtga aagttgaatg gcagagctat tttcggttgt
     1681 gttgggtgac ttggctgtga atgtttttgc ttttaatccc tgctgaggat agactgcctc
     1741 tcagagacaa ggaattgaag agccctataa tcttctagga caaggaatgt aggacgtgag
     1801 tgctgtgtcc cagcaagcca tctgttttct tagagtggaa gtgtccgtta agcccaggta
     1861 aacaccctgg gaagttcttc taaacagagc tcacgtccgg ttctctaata caaaaagcct
     1921 tattattagg acccaaggtt tggatctcct atcaccagac cattgacaca gaaaacttga
     1981 acagtttgga ttttcacaaa aacatggata ctactggaac tttcccagct gttaactggt
     2041 cgcttgttca atgcaagtca cacatcaaca caggctttgg ctggtcccct gctgccgagc
     2101 ggtcaggggt tagttagtgt ggacattggt tctgagggat ttagactcag gtccctgtgg
     2161 aggtactgaa gcccatagct ttgtataggg cagcagcagg gaacaaacac aggactcagg
     2221 tcaggatggt caccactcgc atgagcatca ctttttaaaa tccttcttta tgattttaac
     2281 tctaggggaa gctgaggcgt ttttttccta cctgaaattg ctgctgtaga ggctggaggc
     2341 agagccgtaa ttcagagctg ctgaggtctg ctgggtgggt gttcctatca gcccagagtt
     2401 ttcctggcac tctggtgact tgggttagct ctgaggtata ctgcgtattt gggtctaggg
     2461 ccttactgtt ctcatcaggg ctagatagaa ggctcctggc tggcactgag cattctattg
     2521 gggtcaccag aagtgtgcct ggctgctatg aatcattggg aggtttgtct tcattttttt
     2581 ttatcctatg gtaggctgta cagactgatt atttatatca tccttttgag agactaatga
     2641 aggcttattg taacatagta gtaaaaccat ggaactgtat gaaaaatact acatgaaaaa
     2701 tgaagaaaat attttgctga ttgtaaactt ttgtgggaaa ttttgtgata atttgagaat
     2761 tatacttgtt tgaatcaag
//
