LOCUS       NM_001400882            5484 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus importin 8 (Ipo8), mRNA.
ACCESSION   NM_001400882 XM_039108920
VERSION     NM_001400882.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5484)
  AUTHORS   Jiang,Y., Wu,C., Boye,A., Wu,J., Wang,J., Yang,X. and Yang,Y.
  TITLE     MAPK inhibitors modulate Smad2/3/4 complex cyto-nuclear
            translocation in myofibroblasts via Imp7/8 mediation
  JOURNAL   Mol Cell Biochem 406 (1-2), 255-262 (2015)
   PUBMED   25968067
  REMARK    GeneRIF: MAPK-specific inhibitors blocked nuclear translocation of
            Smad2/3/4 complex through inhibition of Imp7/8 protein expression.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jan 28, 2022 this sequence version replaced XM_039108920.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.20191.1,
                                           SRR26360176.104358.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-300               JAXUCZ010000004.1  183524220-183524519 c
            301-382             JAXUCZ010000004.1  183518091-183518172 c
            383-539             JAXUCZ010000004.1  183515056-183515212 c
            540-698             JAXUCZ010000004.1  183511105-183511263 c
            699-855             JAXUCZ010000004.1  183509737-183509893 c
            856-945             JAXUCZ010000004.1  183505601-183505690 c
            946-1040            JAXUCZ010000004.1  183504324-183504418 c
            1041-1125           JAXUCZ010000004.1  183503513-183503597 c
            1126-1260           JAXUCZ010000004.1  183500177-183500311 c
            1261-1360           JAXUCZ010000004.1  183497704-183497803 c
            1361-1437           JAXUCZ010000004.1  183491767-183491843 c
            1438-1554           JAXUCZ010000004.1  183491338-183491454 c
            1555-1644           JAXUCZ010000004.1  183490053-183490142 c
            1645-1810           JAXUCZ010000004.1  183489528-183489693 c
            1811-1971           JAXUCZ010000004.1  183488665-183488825 c
            1972-2097           JAXUCZ010000004.1  183486501-183486626 c
            2098-2164           JAXUCZ010000004.1  183481168-183481234 c
            2165-2290           JAXUCZ010000004.1  183479592-183479717 c
            2291-2388           JAXUCZ010000004.1  183478795-183478892 c
            2389-2484           JAXUCZ010000004.1  183476290-183476385 c
            2485-2705           JAXUCZ010000004.1  183474118-183474338 c
            2706-2911           JAXUCZ010000004.1  183472147-183472352 c
            2912-3112           JAXUCZ010000004.1  183467015-183467215 c
            3113-3229           JAXUCZ010000004.1  183464423-183464539 c
            3230-5484           JAXUCZ010000004.1  183460583-183462837 c
FEATURES             Location/Qualifiers
     source          1..5484
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..5484
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /note="importin 8"
                     /db_xref="GeneID:686774"
                     /db_xref="RGD:1593688"
     exon            1..300
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..3246
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /codon_start=1
                     /product="importin-8"
                     /protein_id="NP_001387811.1"
                     /db_xref="GeneID:686774"
                     /db_xref="RGD:1593688"
                     /translation="MDLNRIIQALKGTIDPKLRIAAETELNQSYKIINFAPSLLRIIV
                     SDHVEFPVRQAAAIYLKNMVTQYWPDREPPPGEVIFPFNIHENDRQQIRDNIVEGIIR
                     SPDLVRVQLTMCLRVIIRHDFPGHWPAVVDKIDYYLKSPNSGNWLGSLLCLYQLVKTY
                     EYKKAEEREPLLAAMQIFLPRIQQQILQLLPDASHYSVLLQKQILKIFYALVQYALPL
                     QLVNHQTMTTWMEIFRTIIDRTVPPETLQIDEDDRPELVWWKCKKWALHIVTRLFERY
                     GSPGNVTKEYFEFSEFFLKTYAVGIQQVLLKILDQYRQKEYIAPRVLQQALNYLNQGV
                     VHAVTWKQMKPHMQNISEDVIFSVMCYKDEDEELWQEDPYEYIRVKFDIFEDYASPTT
                     AAQTLLYTAAKKRKEVLPKMMAFCYQILTDPNFDPRKKDGALHVIGSLAEILLKKSLF
                     KDQIELFLQNHVFPLILSNLGYLRARSCWVLHAFSSLKFHNELNLRNAVELAKKSLIE
                     DLEMPVKVEAALALQSLISNQTQAKEYMKPYVRFIMQELLHIVKETESDDVTNVIQKL
                     ICEYSHDMASIAVDITQHLAEIFGKVLQSDEYEEIEDKTVMAMGILHTIDTILTVVED
                     HPEIIQQLENICLRIIDLVLQKHVIEFYEEILSLAYNLTCHAISPQMWQLLGILFEVF
                     QQDCFEYFTDMMPLLHNYVTVDTNALLSNPKHLEVLFTMCRKVLCGESGEDAECYAAK
                     LLEVIILQCKGRGIDQCIPLFIQLVLERLTRGVKTSELRTMCLQVAIAALYYSPELLF
                     HTLERVQLPHNPGPVTSQFINQWMSDTDYFLGHHDRKMCIIGLSVLLELQNRPPAVDA
                     VAAQILPSILFLFLGLKQVCATRQTVNRENHSKAEKADIEENEEISSEEEEETSVNAQ
                     AMQSQICRGEEEEDDDWDEEVVEETALEGFSTPLDLDNSVDEYQFFTQALLTVQNRDA
                     AWYQLLVAPLSEDQKRKLQEVYTLAEHRRTLAGQFHI"
     exon            301..382
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /inference="alignment:Splign:2.1.0"
     exon            383..539
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /inference="alignment:Splign:2.1.0"
     exon            540..698
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /inference="alignment:Splign:2.1.0"
     exon            699..855
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /inference="alignment:Splign:2.1.0"
     exon            856..945
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1040
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1125
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1260
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1360
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1437
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1554
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1644
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1810
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1971
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2097
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2164
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2290
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2388
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2484
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2705
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2911
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3112
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3113..3229
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3230..5484
                     /gene="Ipo8"
                     /gene_synonym="AABR07062570.1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaaggtgaa tggagagaga gttgtggagg ggaaaggagg gaggacaggg ggcgcggagt
       61 cagagtggcg cagcaagtag ctgcaggagg cggtggcagc ggcagggggt gggggtaagg
      121 tagtcccctg aggcggaggc ggctgaaagg ggccaggaag catccgggct gcaacccggc
      181 ctgctggctc taggaccgga gctcccgctc gtggacatgg acctcaatcg gatcatccag
      241 gcgctgaagg gcactatcga cccaaagctg aggattgctg ccgagacgga gctcaaccag
      301 tcctacaaga ttattaattt tgcccccagc ttgcttcgga tcatagtctc tgaccatgtg
      361 gagttccctg tgcgtcaggc agctgccatc tacctgaaga atatggtgac acagtactgg
      421 ccagacaggg agcctccacc aggggaagtg atattcccat ttaatatcca cgagaatgac
      481 cggcagcaga ttcgtgacaa cattgtggaa gggataattc ggtctccaga tctggtgaga
      541 gtccagctaa caatgtgtct ccgagtcata attagacatg atttccctgg tcattggcct
      601 gcagtggtgg acaagataga ctactacttg aagtcaccaa acagtgggaa ctggctcggc
      661 agtttactgt gcttgtatca gctggtgaag acctatgaat ataaaaaagc ggaagaaaga
      721 gagcctctcc tggcagccat gcagatattt ctgcctagaa ttcagcagca aatcctgcag
      781 ctgcttccgg atgcttccca ttactctgtg ttgctgcaga agcagattct gaagatcttc
      841 tatgctctcg ttcagtacgc actgcccctt cagctggtga atcaccagac catgactacg
      901 tggatggaga tctttcggac catcatcgat aggacggtcc ctccggagac tcttcaaata
      961 gatgaggatg accggccgga gctggtgtgg tggaagtgta agaagtgggc tctgcatatt
     1021 gtcactcgtc tctttgaacg gtatggaagt ccaggaaatg tcacaaaaga gtacttcgaa
     1081 ttttctgaat tttttttgaa aacctatgca gtgggaattc agcaggtact actaaaaatt
     1141 ttagaccaat accgacagaa agagtatata gcgccccgtg ttcttcagca agctctcaac
     1201 tacctgaacc aaggggttgt ccatgcagtg acgtggaaac agatgaagcc acacatgcag
     1261 aatatctctg aagacgtcat tttttccgtg atgtgttaca aagacgagga tgaagagctg
     1321 tggcaagaag acccgtacga gtacatcagg gtgaaattcg atatttttga agattatgct
     1381 tcacccacca cagcggccca gaccctcctg tacacagctg caaagaaaag gaaagaggta
     1441 ttgccaaaaa tgatggcgtt ctgttatcag atactaacag acccgaactt tgaccccagg
     1501 aagaaagatg gagccctgca tgtgattggt tccctggctg agattttgtt gaagaagagt
     1561 ttattcaagg accaaattga gttgttcctg cagaatcatg tatttccatt aatattgtct
     1621 aacctgggat atcttcgagc tagatcctgc tgggtgcttc atgcatttag ttctttgaag
     1681 tttcacaatg agctcaacct cagaaatgca gtagagttag caaagaagag cctgattgaa
     1741 gacttggaga tgcccgtcaa ggtggaagct gcccttgcac tgcagtcgct gatctccaac
     1801 cagacacaag ccaaggagta catgaaacca tacgtgagat tcatcatgca ggagcttctg
     1861 cacattgtca aagagacgga gagtgatgat gtcactaacg tcatccagaa gctcatatgt
     1921 gagtacagtc acgacatggc ctccatcgct gtggacataa cccagcactt ggctgagata
     1981 tttggtaaag ttcttcaaag tgacgagtat gaggaaattg aagacaaaac tgtcatggcc
     2041 atgggaattt tacacactat cgacactatc ttaaccgttg tggaagacca tccagagatt
     2101 atacagcagc tggagaacat ctgtctacga atcattgatc ttgtcctaca gaagcatgtt
     2161 attgaattct atgaggaaat cctttctctg gcatacaatt taacctgcca tgccatctcc
     2221 ccgcagatgt ggcagctcct gggcatttta tttgaagttt tccagcagga ttgcttcgag
     2281 tacttcacag acatgatgcc tctcctgcat aattacgtga ccgtggacac caacgcgctg
     2341 ctgtccaatc caaagcactt agaagtcttg ttcacaatgt gcaggaaggt gctgtgtgga
     2401 gagtcagggg aggatgccga gtgctacgct gcaaaactct tggaagtcat cattcttcag
     2461 tgcaaaggaa ggggaattga tcagtgtatc ccactgttca ttcaactcgt cttggagagg
     2521 ttaacccgcg gggtcaagac gagtgagctg cgcacaatgt gtcttcaggt ggccattgcg
     2581 gccctttact acagccctga actgctgttc cacacactgg agcgagtcca gctgccacac
     2641 aacccaggac ctgtcacgtc gcagtttata aaccagtgga tgagcgacac cgattacttc
     2701 cttggacacc atgaccggaa gatgtgtata ataggactaa gcgtgctctt ggagctgcag
     2761 aaccgacctc ctgccgtgga tgctgtggct gcacagatcc tcccctccat tctcttcctt
     2821 ttccttggcc tgaagcaggt ctgtgctaca cgacaaacag taaaccgtga aaatcactca
     2881 aaggcagaga aagctgacat agaggaaaat gaggagattt ccagtgagga ggaggaggag
     2941 acaagtgtaa acgctcaagc tatgcagtca cagatctgca gaggcgagga ggaggaggat
     3001 gacgactggg atgaagaagt ggtggaggag acagccctcg agggcttcag caccccactg
     3061 gacctcgaca acagcgtgga tgagtaccag tttttcacac aagctctgct gactgtgcag
     3121 aatcgggatg ctgcctggta ccagctgctg gtggcaccac tcagtgagga tcagaagaga
     3181 aagctacagg aggtgtacac gttggcagag caccgaagga cactggcagg gcagttccac
     3241 atttgaggac aggagcatct tctctgcatt taattttgga gctgcgccca gcaacacccg
     3301 gaaggcgcgt ccaccgtgca ccgatcggcg tcaccgctgc tgcttagtac acgggttgag
     3361 ggccaagagg gaaacaaggg actgagtcgt cggcatcagg cggccacgga cctgttctcc
     3421 ctttccttga cccttctcac cctggaatat atatattttt aacagctact gtaatgtatg
     3481 aaattttaaa aaagcagaat cattgattgg aaaggacaga gcgtccgctc tgaaggctga
     3541 acgctgaggg tttagagttc tgtattggcg catgtctcag gtttttgcca tgaagaatca
     3601 gtggatttat gcagataaca gtgccttctg ttgtacatga ataatcagaa aacaattttt
     3661 ttggagtgca ttgcaatttt ttttaaagca taaaacatat ttctagatat cctgtaaacc
     3721 ttggttatgt catttcattc tgcatttttc tctgtgagtt gaccgtcagg cagttagtgc
     3781 aggtctcact ctggcttcag aagcatccct gcacccttgg accaccctgt gcccaaaggc
     3841 ttccttcaag ggtcggaact caggcagtgg ctctggtttt acctaagaca tctgtggcta
     3901 tcctaagaac tgtctggttt tcctaagaca tctgtggcta tcctaagaac tgtctggttt
     3961 tcctaagaca tctgtggcta tcctaagaac tgtctgattt tccctaagac atctgcggca
     4021 tcctaagaac tgttaaattc agtttcccac cacattttct ctctgagggg gatgatgatt
     4081 ctttcaggat cgaaagtgta ttgataatat tgacaacctg ctaatttcag gcttcacccg
     4141 cctcttggca gccagcagca gggacttgtc agtcactggg cttagcagaa agactgacgg
     4201 tcttatgggt catgtgttta agtaatactg caggggttgt gggcatccca atatgaaagc
     4261 acactgaagt tctaagcaga aggtgactcc tgggtggggg ctcggtcagt agttaccatt
     4321 ccaaccatgt tggacagggc ccaaagcatt ttataatttt tttcctttct ccattcaacc
     4381 ctcccttctt tctttgtgag agagagagac aatttctgta tgcaacccag gttgacctca
     4441 agattgcagt cctcctgagt cagccccatg gctgttaaca cacccagccg gtgggttttg
     4501 ctacgtagtt ctggctggac tggaactcac tctgtggctt aggctgacct cagacttgca
     4561 gcagtcctcc ctcagcttcc cagggcttgg agttacagcc gttacaaatg gtagacgtct
     4621 tttcatttag taagaagacc cgacagctct aacctaacaa tctgctcttc acggtctgaa
     4681 gtctctccag cctgacttgg cttagtcttt attacggctc agttgctttt tcataaattc
     4741 ctcaagggtt ggtctcttgg ccagctgggt ttacaggtga gtgatgacgt cactgtcgca
     4801 gatggctttt cccgaactgt tcaaaagcag actatgaacc actgtgcttt cattcggcaa
     4861 aatgaaaata tgttatcagg actcgaaata tttctggatg tgatacagat tttgtttgtg
     4921 tgaaatacct gcagcttaaa tttccatcag caactggcag gattttccgg gtgattcctg
     4981 aattgtcaat ccttacttgt attctttttt ttttttttaa tttaggttat ttaatttttt
     5041 ttcagaagta gctttgaaaa gccatgtgtt tcagagtgaa atcaccctgt attttgccgt
     5101 ctctcatttt tcagggcacc aaagctgcgt gtcccccagc agttagaagg ggaagattgc
     5161 attgcggggg ctttagagct ctgaagtggt ccgtttttct cccatgtctt atgtggttta
     5221 attgtaacat aggtagtatg ccttcacact ggatcccggg ggcatgggct ttggagatct
     5281 tacttcgtgg tgaattgcca tctgcagtat tgaagggaag acatattcct gcgcatcacc
     5341 ataccttgtt tttaaagcca gagtcattgt atgattttta ttacctgaag tgctcaccgg
     5401 aatgtgatct ggttaccttg gaaatgcagg aacttttatg aatgtactgt aaaataaaat
     5461 gtgggctaat ccccaggagc tgaa
//
