LOCUS       NM_053778               3606 bp    mRNA    linear   ROD 07-APR-2024
DEFINITION  Rattus norvegicus importin 13 (Ipo13), mRNA.
ACCESSION   NM_053778
VERSION     NM_053778.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3606)
  AUTHORS   Kanno,Y., Miyazaki,Y. and Inouye,Y.
  TITLE     The nuclear import of the constitutive androstane receptor by
            importin/Ran-GTP systems
  JOURNAL   Biochim Biophys Acta 1803 (8), 968-974 (2010)
   PUBMED   20478346
  REMARK    GeneRIF: Data show that nuclear import of CAR is regulated by
            importin/Ran-GTP systems.
REFERENCE   2  (bases 1 to 3606)
  AUTHORS   Tao,T., Lan,J., Lukacs,G.L., Hache,R.J. and Kaplan,F.
  TITLE     Importin 13 regulates nuclear import of the glucocorticoid receptor
            in airway epithelial cells
  JOURNAL   Am J Respir Cell Mol Biol 35 (6), 668-680 (2006)
   PUBMED   16809634
  REMARK    GeneRIF: Findings support a role for IPO13 in promoting nuclear
            occupancy of glucocorticoid receptor in a way that strongly
            potentiates the antiinflammatory effects of glucocorticoids.
REFERENCE   3  (bases 1 to 3606)
  AUTHORS   Kahle,J., Baake,M., Doenecke,D. and Albig,W.
  TITLE     Subunits of the heterotrimeric transcription factor NF-Y are
            imported into the nucleus by distinct pathways involving importin
            beta and importin 13
  JOURNAL   Mol Cell Biol 25 (13), 5339-5354 (2005)
   PUBMED   15964792
REFERENCE   4  (bases 1 to 3606)
  AUTHORS   Zhang,C., Sweezey,N.B., Gagnon,S., Muskat,B., Koehler,D., Post,M.
            and Kaplan,F.
  TITLE     A novel karyopherin-beta homolog is developmentally and hormonally
            regulated in fetal lung
  JOURNAL   Am J Respir Cell Mol Biol 22 (4), 451-459 (2000)
   PUBMED   10745026
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Dec 1, 2020 this sequence version replaced NM_053778.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100658.1, AF110195.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-724               JAXUCZ010000005.1  136738755-136739478 c
            725-1461            JAXUCZ010000005.1  136736329-136737065 c
            1462-1602           JAXUCZ010000005.1  136730034-136730174 c
            1603-1744           JAXUCZ010000005.1  136729770-136729911 c
            1745-1911           JAXUCZ010000005.1  136729495-136729661 c
            1912-2032           JAXUCZ010000005.1  136729211-136729331 c
            2033-2180           JAXUCZ010000005.1  136728977-136729124 c
            2181-2362           JAXUCZ010000005.1  136728394-136728575 c
            2363-2389           JAXUCZ010000005.1  136728292-136728318 c
            2390-2524           JAXUCZ010000005.1  136727971-136728105 c
            2525-2668           JAXUCZ010000005.1  136727667-136727810 c
            2669-2749           JAXUCZ010000005.1  136726118-136726198 c
            2750-2887           JAXUCZ010000005.1  136725475-136725612 c
            2888-2984           JAXUCZ010000005.1  136725204-136725300 c
            2985-3037           JAXUCZ010000005.1  136722365-136722417 c
            3038-3104           JAXUCZ010000005.1  136720263-136720329 c
            3105-3163           JAXUCZ010000005.1  136720119-136720177 c
            3164-3253           JAXUCZ010000005.1  136719901-136719990 c
            3254-3435           JAXUCZ010000005.1  136719464-136719645 c
            3436-3606           JAXUCZ010000005.1  136719204-136719374 c
FEATURES             Location/Qualifiers
     source          1..3606
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3606
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Lgl2"
                     /note="importin 13"
                     /db_xref="GeneID:116458"
                     /db_xref="RGD:620071"
     exon            1..724
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Lgl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             641..3532
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Lgl2"
                     /note="late gestation lung 2 protein"
                     /codon_start=1
                     /product="importin-13"
                     /protein_id="NP_446230.2"
                     /db_xref="GeneID:116458"
                     /db_xref="RGD:620071"
                     /translation="MERREEQLGAAGAGAAPALDFTVENVEKALHQLYYDPNIENKNL
                     AQKWLMQAQVSPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLK
                     AQLFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQAEDSPVDSQ
                     GRCLALLELLTVLPEEFQTSRLPQYRKGLVRASLAVECGAVFPLLEQLLQQPSSPSCV
                     RQKVLKCFSSWVQLEVPLQDCEALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYV
                     NTLLKLIPLVLGLQEQLRQAVQNGDMETSHGICRIAVALGENHSRALLDQVEHWQSFL
                     ALVNMIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDILSFEAEKQAVYQQVYRPVYFQ
                     LVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSNLYDKL
                     GRLLTSSEEPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRISISNVQLADT
                     VMFTIGALSEWLADHPVMINSVLPLVLHALGNPELSVSSVSTLKKICRECKYDLPPYA
                     ANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKL
                     AEEIPNPSNKLAIVHILGLLSNLFTTLDVSHHEDDHEGPELRKLPVPQGPNPVVVVLQ
                     QVFQLIQKVLSKWLSDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTVPQ
                     ASALDLTRQLVHIFAHEPAHFPPIEALFLLVTSVTLSLFQQGPRDHPDIVDSFMQLLA
                     QALKRKPDLFQCERLDVKAVFQCAVLALKFPEAPTVKASCGFFTELLPRCGEIESVGK
                     VVQEDGRMLLIAVLEAIGGQASRSLMDCFADILFALNKHCFSLLSMWIKEALQPPGFP
                     SARLSPEQKDTFSQQILRERVNKRRVKEMVKEFTLLCRGLHGTDYTADY"
     exon            725..1461
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Lgl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1602
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Lgl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1744
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Lgl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1911
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Lgl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2032
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Lgl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2180
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Lgl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2362
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Lgl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2389
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Lgl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2524
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Lgl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2668
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Lgl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..2749
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Lgl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2750..2887
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Lgl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2888..2984
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Lgl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2985..3037
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Lgl2"
                     /inference="alignment:Splign:2.1.0"
     exon            3038..3104
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Lgl2"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3163
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Lgl2"
                     /inference="alignment:Splign:2.1.0"
     exon            3164..3253
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Lgl2"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3435
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Lgl2"
                     /inference="alignment:Splign:2.1.0"
     exon            3436..3606
                     /gene="Ipo13"
                     /gene_synonym="Imp13; Lgl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcactggg gcggaggcag cgaccatagc ggggccaaag ccgggaggcg agcatatcgc
       61 gggccaggag aacggaggga acctagctca gcccctcaac tctaccgact ctgccccaga
      121 ctcacgaaac tgcaaccctg tgcttccttg gatgtctccg tatctcgcga agggctctct
      181 ccagggtgat ctcccagccc cctgacctca cagcatctag aagctcatcc agactagggt
      241 gttatgggta caggccgttg accctgtgac ccctcacggg ccagggcctc tgtttcccct
      301 gtaggccttc ctcccctatg acttttgatt caagggacag agccgtgacc tcccactagg
      361 acccttgtct gagagcacct cactgaggcc tcccttttgg gagccgcctt agcgcggatc
      421 ccctccgaag agcacatctt ttgacctctg caacccccac ccccacccca ctaccaccaa
      481 aggaggtggg caggcctcgg cagccatgcc cgccctgggc atcccctcat cccatcgctt
      541 cctgggtact caagccgggg tctagcaggg ggctgacagc caaaagggct ggggcaagag
      601 agagatcagg gtccacctcc ctgccaggca gggagcaaaa atggagcggc gggaggagca
      661 gctgggggct gcaggggctg gagcagcacc agccttggac ttcactgtgg agaacgtgga
      721 gaaggcgctg caccagctct actacgaccc caatattgag aacaagaacc tggctcagaa
      781 gtggctgatg caggcccagg tctctccaca ggcctggcat ttcagctggc agctactaca
      841 gccagacaag gtgcctgaga tccagtactt tggggccagt gccctgcaca tcaagatctc
      901 tcgctattgg agtgacatcc ccaccgacca gtatgaaagc ctaaaggcgc agctcttcac
      961 ccagatcacc cgctttgcca gtggctccaa aattgtgctg actcggctat gtgtggcgct
     1021 ggcctcactg gctctcagta tgatgcctga cgcttggcca tgtgctgtgg cagatatggt
     1081 ccggctcttc caagctgagg actctccggt ggatagccag ggccgttgtc tggccctgct
     1141 agagttgctg acggtactgc ctgaggagtt tcagaccagt cgcttgcccc agtaccgcaa
     1201 aggtctggta cgggccagcc tggcggtgga gtgtggggct gtcttcccat tgctggagca
     1261 attgctacaa cagcccagct ctcccagctg tgtgcgtcag aaggtgctca agtgcttctc
     1321 cagctgggtg cagctggaag tgcccctgca ggactgtgag gcgctcattc aggccgcctt
     1381 tgctgctctg caggactcgg agctctttga cagcagcgtg gaggccattg tcaatgctat
     1441 ctcccagcca gatgcccaaa ggtatgtgaa cacactcctg aaactcattc cgttggtgct
     1501 gggactgcag gagcaactgc ggcaggcagt gcagaatggg gacatggaga cctcccatgg
     1561 catctgccgc attgctgtgg ccctgggcga gaaccactct cgggccttgc tagatcaagt
     1621 agaacactgg cagagcttcc tggcacttgt caacatgatc atgttctgca caggcatccc
     1681 tggccactat cctgtcaatg agaccaccag ctccctcact ctcaccttct ggtacacact
     1741 gcaggatgac attctgtcct ttgaggcaga gaagcaggct gtgtaccagc aggtgtaccg
     1801 gccagtctac ttccagctgg tggacgtgct tctgcacaag gcccagttcc cctctgatga
     1861 ggaatatgga ttctggtcct cagatgaaaa ggagcagttc cgaatctaca gggtggacat
     1921 ttcagacaca ctcatgtatg tgtatgagat gctgggggct gagctgctta gcaacctcta
     1981 tgacaaactg ggccgtttgc tcaccagctc agaggagccc tactcctggc agcacacaga
     2041 agccctgctc tatggcttcc agtccattgc agagaccatc gatgtcaact actctgatgt
     2101 ggtacccggg ctcattggcc tcatcccacg gatcagcatc agcaacgtgc agctggcaga
     2161 taccgtcatg ttcaccattg gagctctgtc tgaatggctg gctgaccacc ctgtcatgat
     2221 caacagcgtt ctgccccttg tgctgcatgc cctaggcaat cctgagctgt ctgtctcatc
     2281 agtgtcgacc ctcaaaaaga tctgccgaga gtgcaagtat gacctgccgc cctatgctgc
     2341 caacattgta gctgtctccc aggatgtgct gatgaagcag atccacaaga ctagccagtg
     2401 catgtggctg atgcaggcac tgggcttcct gctgtcagcc ctgcaggtag aggagatcct
     2461 gaagaacctg cactcactca tctctcccta catccaacag ctggagaagc tggcagaaga
     2521 gatacctaat ccctccaaca agctggccat tgtccacatc ttggggcttc tttccaacct
     2581 ctttaccaca ctggacgtca gtcatcatga agatgatcac gaaggccctg agctccgaaa
     2641 gctgccagtg ccacagggac ccaacccggt ggtggtcgtg ctgcagcagg tcttccagct
     2701 catccagaag gtgctgagca agtggctgag tgatgcccag gtggtcgagg cggtgtgtgc
     2761 catctttgag aagtctgtta agacactgct ggatgacttt gcccccatgg tgccacagct
     2821 ctgtgagatg ctgggtcgga tgtacagcac cgttccccag gcctctgctc ttgacctcac
     2881 tcgacagttg gtccacatct ttgcccacga gcctgcccac tttcccccaa tagaggccct
     2941 cttcctgctg gtgacctccg tcacactctc tctcttccaa caagggccca gggaccatcc
     3001 tgatattgtt gattcattta tgcaactcct ggcacaggct ttgaagcgga agccagattt
     3061 gttccagtgt gagcgattgg atgtcaaagc tgtgttccag tgtgctgtgc tggccctcaa
     3121 gttccctgag gcacctactg tcaaggcctc ctgtggcttc tttactgagc tgctgcctcg
     3181 atgtggggaa atagaatctg tggggaaagt ggtacaggaa gatggccgta tgctgctcat
     3241 agcagtgctg gaggccatcg ggggccaggc ctcccgtagc ctcatggact gttttgctga
     3301 catcctgttc gccctgaaca aacactgctt cagcctccta agcatgtgga tcaaggaggc
     3361 tctacagcca cctggctttc catctgcccg tctcagccct gagcagaagg acaccttcag
     3421 ccagcagata cttcgtgagc gagtgaacaa gagacgggtg aaggagatgg tgaaggaatt
     3481 tacactgctg tgccgggggc tacatggcac agactacaca gctgactact gagggacacg
     3541 tgtgtcccac ctcacccctt cttacccctt tctgttccca aagagtaaac ctggactctt
     3601 attgct
//
