LOCUS       NM_021660               1894 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus inositol hexakisphosphate kinase 2 (Ip6k2), mRNA.
ACCESSION   NM_021660 XM_001075731 XM_001075757 XM_001075802 XM_001075818
            XM_001075835 XM_001075856 XM_576471
VERSION     NM_021660.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1894)
  AUTHORS   Gu,C., Stashko,M.A., Puhl-Rubio,A.C., Chakraborty,M.,
            Chakraborty,A., Frye,S.V., Pearce,K.H., Wang,X., Shears,S.B. and
            Wang,H.
  TITLE     Inhibition of Inositol Polyphosphate Kinases by Quercetin and
            Related Flavonoids: A Structure-Activity Analysis
  JOURNAL   J Med Chem 62 (3), 1443-1454 (2019)
   PUBMED   30624931
REFERENCE   2  (bases 1 to 1894)
  AUTHORS   Saiardi,A., Nagata,E., Luo,H.R., Snowman,A.M. and Snyder,S.H.
  TITLE     Identification and characterization of a novel inositol
            hexakisphosphate kinase
  JOURNAL   J Biol Chem 276 (42), 39179-39185 (2001)
   PUBMED   11502751
REFERENCE   3  (bases 1 to 1894)
  AUTHORS   Morrison,B.H., Bauer,J.A., Kalvakolanu,D.V. and Lindner,D.J.
  TITLE     Inositol hexakisphosphate kinase 2 mediates growth suppressive and
            apoptotic effects of interferon-beta in ovarian carcinoma cells
  JOURNAL   J Biol Chem 276 (27), 24965-24970 (2001)
   PUBMED   11337497
REFERENCE   4  (bases 1 to 1894)
  AUTHORS   Saiardi,A., Erdjument-Bromage,H., Snowman,A.M., Tempst,P. and
            Snyder,S.H.
  TITLE     Synthesis of diphosphoinositol pentakisphosphate by a newly
            identified family of higher inositol polyphosphate kinases
  JOURNAL   Curr Biol 9 (22), 1323-1326 (1999)
   PUBMED   10574768
REFERENCE   5  (bases 1 to 1894)
  AUTHORS   Katai,K., Miyamoto,K., Kishida,S., Segawa,H., Nii,T., Tanaka,H.,
            Tani,Y., Arai,H., Tatsumi,S., Morita,K., Taketani,Y. and Takeda,E.
  TITLE     Regulation of intestinal Na+-dependent phosphate co-transporters by
            a low-phosphate diet and 1,25-dihydroxyvitamin D3
  JOURNAL   Biochem J 343 Pt 3 (Pt 3), 705-712 (1999)
   PUBMED   10527952
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083574.1.
            
            [WARNING] On Jul 19, 2024 this sequence was replaced by
            NM_021660.3.
            
            On or before Oct 12, 2007 this sequence version replaced
            XM_001075757.1, XM_001075802.1, XM_001075818.1, XM_001075835.1,
            XM_001075856.1, XM_001075731.1, XM_576471.1, NM_021660.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083574.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1894
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1894
                     /gene="Ip6k2"
                     /gene_synonym="Ihpk2; Pius"
                     /note="inositol hexakisphosphate kinase 2"
                     /db_xref="GeneID:59268"
                     /db_xref="RGD:620529"
     exon            1..27
                     /gene="Ip6k2"
                     /gene_synonym="Ihpk2; Pius"
                     /inference="alignment:Splign:2.1.0"
     exon            28..84
                     /gene="Ip6k2"
                     /gene_synonym="Ihpk2; Pius"
                     /inference="alignment:Splign:2.1.0"
     exon            85..458
                     /gene="Ip6k2"
                     /gene_synonym="Ihpk2; Pius"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..1534
                     /gene="Ip6k2"
                     /gene_synonym="Ihpk2; Pius"
                     /EC_number="2.7.4.21"
                     /note="P(i)-uptake stimulator; InsP6 kinase 2; inositol
                     hexaphosphate kinase 2"
                     /codon_start=1
                     /product="inositol hexakisphosphate kinase 2"
                     /protein_id="NP_067692.2"
                     /db_xref="GeneID:59268"
                     /db_xref="RGD:620529"
                     /translation="MSPAFRTMDVEPRTKGILLEPFVHQVGGHSCVLRFNETTLCKPL
                     VPREHQFYETLPAEMRRFTPQYKGVVSVRFEEDEDRNLCLIAYPLKGDHGPVDIVDNS
                     DCEPKSKLLRWTNKKHHVLETEKSPKDWVRQHRKEEKMKSHKLEEEFEWLKKSEVLYY
                     SVEKKGTVSSQLKHYNPWSMKCHQQQLQRMKENAKHRNQYKFILLENLTCRYEVPCVL
                     DLKMGTRQHGDDASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGTGQLMFMNKYHG
                     RKLSVQGFKEALFQFFHNGRYLRRELLGPVLKKLTELKAVLERQESYRFYSSSLLVIY
                     DGKEWPEVTLDSDAEDLEDLSEESADESAGAYAYKPLGASSVDVRMIDFAHTTCRLYG
                     EDSVVHEGQDAGYIFGLQSLIDIVTEISEESGE"
     exon            459..681
                     /gene="Ip6k2"
                     /gene_synonym="Ihpk2; Pius"
                     /inference="alignment:Splign:2.1.0"
     exon            682..857
                     /gene="Ip6k2"
                     /gene_synonym="Ihpk2; Pius"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1033
                     /gene="Ip6k2"
                     /gene_synonym="Ihpk2; Pius"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1812
                     /gene="Ip6k2"
                     /gene_synonym="Ihpk2; Pius"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgcctctg atgtgccagg attagagagt gctgaagaca agaagttttg gagttgtgag
       61 tgaatcccgg tactcaaaaa tgaggctact tccaaacctc atgtcattgt gtttgcttcc
      121 gccagtgtgt gctggcctgc acagaccgag gagcagagat caaacaggcg gctgtaagga
      181 cagacagtaa acggaggacg agctggcctc tggatcccgc tgcctcccct ttctccctgc
      241 tgcctgtgtc cggaggatga gcccagcctt caggaccatg gacgtagagc cccgtaccaa
      301 gggcatcctg ctggagccct ttgtccacca ggttgggggg cactcatgcg ttctccggtt
      361 caatgagaca accctgtgca agcccctggt tccgagggag catcagttct acgagaccct
      421 cccagctgag atgcgcagat tcactcccca gtacaaaggt gtggtatcag tacgctttga
      481 agaagatgaa gacaggaact tgtgtttaat agcatatcca ttaaaggggg accatggacc
      541 tgtggatatt gtagacaatt cagactgtga accaaaaagt aagctgctga gatggacaaa
      601 caaaaaacat cacgtcctag aaacagaaaa gagtcccaag gactgggtgc gccagcaccg
      661 aaaagaggag aagatgaaga gccataagtt agaagaagaa tttgagtggc taaagaagtc
      721 tgaagtctta tactacagtg tagaaaaaaa gggaactgta agctcccagc tcaaacacta
      781 caacccttgg agcatgaagt gtcatcagca gcagctacag aggatgaagg agaacgcgaa
      841 gcaccggaac cagtacaaat tcatcttgct ggagaacctg acttgccgct atgaggtgcc
      901 ttgtgtcctg gacctcaaga tgggcacacg ccagcatggc gacgatgctt cagaggaaaa
      961 agcagctaac cagatccgaa aatgtcagca gagcacatct gcagtcattg gcgttcgagt
     1021 gtgtggcatg caggtgtacc aggcaggcac tgggcagctc atgttcatga acaagtacca
     1081 tggacggaag ctttcagtgc agggcttcaa ggaggcgctt ttccagttct ttcacaatgg
     1141 gcggtacctg cgccgtgagc tcctgggccc tgtgctcaag aagctaactg agcttaaggc
     1201 cgtgttggag cgacaggaat cctaccgctt ctattcaagt tccctactgg tcatttatga
     1261 tggcaaggaa tggccagagg tgaccctgga ctcagatgct gaggacttgg aggacctctc
     1321 agaagagtcg gctgatgagt ctgctggtgc ctatgcctac aagcctctcg gtgccagctc
     1381 agtggacgtg cgcatgatcg actttgcaca caccacctgc aggctctatg gcgaggacag
     1441 tgtggtgcat gagggccagg atgctggcta tatctttggg ctgcagagcc tgatagacat
     1501 tgtcacagag ataagtgagg agagtgggga gtgagcttgc tggctagtcc agtacctgag
     1561 agacgctttg tgtcccccta cagctgtgct gtcgggaagc aggccagtat ggctaggtgt
     1621 tggcctctgc agcctggagc tgatagacag tggcccctgt aacccccccc cccccagcct
     1681 gagccagccc cagatggctc agagcctttt atttatttta actatttctt caacattcca
     1741 catttgatga tgcagatacc tctttcttcc ctgagtgtaa atgttctaat acagatcttt
     1801 ttgtttattg taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1861 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
