LOCUS       NM_053316               1620 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus inositol hexakisphosphate kinase 1 (Ip6k1), mRNA.
ACCESSION   NM_053316
VERSION     NM_053316.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1620)
  AUTHORS   Zhu,Q., Ghoshal,S., Rodrigues,A., Gao,S., Asterian,A.,
            Kamenecka,T.M., Barrow,J.C. and Chakraborty,A.
  TITLE     Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity
            by enhancing AMPK-mediated thermogenesis
  JOURNAL   J Clin Invest 126 (11), 4273-4288 (2016)
   PUBMED   27701146
REFERENCE   2  (bases 1 to 1620)
  AUTHORS   Yang,S.N., Shi,Y., Yang,G., Li,Y., Yu,L., Shin,O.H., Bacaj,T.,
            Sudhof,T.C., Yu,J. and Berggren,P.O.
  TITLE     Inositol hexakisphosphate suppresses excitatory neurotransmission
            via synaptotagmin-1 C2B domain in the hippocampal neuron
  JOURNAL   Proc Natl Acad Sci U S A 109 (30), 12183-12188 (2012)
   PUBMED   22778403
  REMARK    GeneRIF: InsP6 suppresses excitatory neurotransmission via
            inhibition of the presynaptic synaptotagmin-1 C2B domain-mediated
            fusion via an interaction with the synaptotagmin Ca2+-binding
            sites.
REFERENCE   3  (bases 1 to 1620)
  AUTHORS   Saiardi,A., Nagata,E., Luo,H.R., Snowman,A.M. and Snyder,S.H.
  TITLE     Identification and characterization of a novel inositol
            hexakisphosphate kinase
  JOURNAL   J Biol Chem 276 (42), 39179-39185 (2001)
   PUBMED   11502751
REFERENCE   4  (bases 1 to 1620)
  AUTHORS   Luo,H.R., Saiardi,A., Nagata,E., Ye,K., Yu,H., Jung,T.S., Luo,X.,
            Jain,S., Sawa,A. and Snyder,S.H.
  TITLE     GRAB: a physiologic guanine nucleotide exchange factor for Rab3A,
            which interacts with inositol hexakisphosphate kinase
  JOURNAL   Neuron 31 (3), 439-451 (2001)
   PUBMED   11516400
REFERENCE   5  (bases 1 to 1620)
  AUTHORS   Saiardi,A., Erdjument-Bromage,H., Snowman,A.M., Tempst,P. and
            Snyder,S.H.
  TITLE     Synthesis of diphosphoinositol pentakisphosphate by a newly
            identified family of higher inositol polyphosphate kinases
  JOURNAL   Curr Biol 9 (22), 1323-1326 (1999)
   PUBMED   10574768
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078702.1.
            
            On Jun 10, 2007 this sequence version replaced NM_053316.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078702.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1620
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1620
                     /gene="Ip6k1"
                     /gene_synonym="Ihpk1; Itpk6"
                     /note="inositol hexakisphosphate kinase 1"
                     /db_xref="GeneID:50560"
                     /db_xref="RGD:71025"
     exon            1..29
                     /gene="Ip6k1"
                     /gene_synonym="Ihpk1; Itpk6"
                     /inference="alignment:Splign:2.1.0"
     exon            30..377
                     /gene="Ip6k1"
                     /gene_synonym="Ihpk1; Itpk6"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1456
                     /gene="Ip6k1"
                     /gene_synonym="Ihpk1; Itpk6"
                     /EC_number="2.7.4.21"
                     /note="inositol hexaphosphate kinase 1; insP6 kinase 1;
                     inositol hexakisphosphate kinase 6"
                     /codon_start=1
                     /product="inositol hexakisphosphate kinase 1"
                     /protein_id="NP_445768.1"
                     /db_xref="GeneID:50560"
                     /db_xref="RGD:71025"
                     /translation="MCVCQTMEVGQYGKNASRAGDRGVLLEPFIHQVGGHSSMMRYDD
                     HTVCKPLISREQRFYESLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYVESETV
                     EQDDTPEREQPRRKHSRRSLHRSGSGSDHKEEKASLSFETSESSQETKSPKVELHSHS
                     DVPFQMLDSNSGLSSEKISYNPWSLRCHKQQLSRMRSESKDRKLYKFLLLENVVHHFK
                     YPCVLDLKMGTRQHGDDASAEKAARQMRKCEQSTSASLGVRVCGMQVYQLDTGHYLCR
                     NKYYGRGLSIEGFRNALYQYLHNGLDLRRDLFEPILSKLRGLKAVLERQASYRFYSSS
                     LLVIYDGKECRSELRLKHVDMGLPEVPPLCGPSTSPSNTSLEAGPSSPPKVDVRMIDF
                     AHSTFKGFRDDPTVHDGPDRGYVFGLENLISIMEQMRDENQ"
     exon            378..588
                     /gene="Ip6k1"
                     /gene_synonym="Ihpk1; Itpk6"
                     /inference="alignment:Splign:2.1.0"
     exon            589..770
                     /gene="Ip6k1"
                     /gene_synonym="Ihpk1; Itpk6"
                     /inference="alignment:Splign:2.1.0"
     exon            771..946
                     /gene="Ip6k1"
                     /gene_synonym="Ihpk1; Itpk6"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1589
                     /gene="Ip6k1"
                     /gene_synonym="Ihpk1; Itpk6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtggagacc aaggctgcat cattttgacg acagaacaat aagctaagca gactctgacc
       61 attggcctcc cactagccag gatcgaccta gctctccttt tgtggtccat gtgctgcatc
      121 gtctgctgtc agtgtgtaac cggcccccaa cgcaatgtgt gtttgtcaaa ccatggaagt
      181 ggggcagtat ggcaagaacg caagtcgggc gggagaccga ggagtcctcc tggagccctt
      241 tatccatcag gtgggcggac acagcagcat gatgcggtac gacgatcaca cggtgtgcaa
      301 acctctcatc tctcgggaac agcgcttcta cgagtctctc cctcccgaaa tgaaggaatt
      361 caccccagaa tacaaaggtg tggtttctgt ctgttttgag ggagacagtg acggttacat
      421 caacctggta gcctaccctt atgtggagag tgaaactgta gagcaagacg acacacctga
      481 gcgggagcaa cctcggcgca aacactcccg ccggagcctg catcggtctg gcagtggtag
      541 tgaccacaag gaggagaaag ccagcctgtc ctttgagacc tctgaaagct cccaggagac
      601 aaagagtcca aaggtggagc tgcacagcca ctcagatgtc cctttccaga tgctagacag
      661 caatagcggg ctgagctctg agaagatcag ctacaacccc tggagcctgc gctgccacaa
      721 gcagcagctg agccgcatgc gctccgagtc caaggaccga aaactctaca agttcctcct
      781 gcttgagaat gtggttcacc acttcaagta cccctgtgtg ttggacttga agatgggtac
      841 ccgacagcat ggggatgatg cttcagctga gaaggcagcc cggcagatga ggaagtgtga
      901 gcagagcaca tcggcctcgc tgggggtcag ggtctgtggc atgcaggtgt accagctgga
      961 cacaggtcat tacctctgta ggaataagta ctatggtcgt ggactctcca tcgaaggctt
     1021 ccgcaatgcc ctgtatcagt acctgcacaa tggcttggac ctgcgacgtg acctttttga
     1081 gcctatcctg agcaaactgc gaggcctcaa agctgtgctg gagcggcagg cctcctaccg
     1141 cttctactcc agttccctgc ttgtcatcta tgatggcaag gagtgccggt ctgagctacg
     1201 tctcaagcac gtggacatgg ggctccctga ggtgccacca ctctgtggtc ccagcaccag
     1261 ccctagcaac accagtcttg aggctggccc ctcttctccg cccaaggtgg atgtccgcat
     1321 gattgacttt gcacatagca cattcaaggg cttccgggat gaccccactg ttcacgatgg
     1381 gccagacaga ggctatgtgt ttggcttgga gaatcttatc agcatcatgg agcagatgcg
     1441 ggatgagaac cagtaagccc agttctgggc cctaggaccc cttcctctcc acccacaggc
     1501 agggaccatt gctctgaact tgctgtgagg acacagactt gcttttaaag ggttatattt
     1561 ctctttggtg taaactaaaa gaaatgttta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
