LOCUS       NM_001107932            5616 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus inversin (Invs), mRNA.
ACCESSION   NM_001107932 XM_001056122 XM_232983
VERSION     NM_001107932.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5616)
  AUTHORS   Li,L., Gao,S., Wang,L., Bu,T., Chu,J., Lv,L., Tahir,A., Mao,B.,
            Li,H., Li,X., Wang,Y., Wu,X., Ge,R. and Cheng,C.Y.
  TITLE     PCP Protein Inversin Regulates Testis Function Through Changes in
            Cytoskeletal Organization of Actin and Microtubules
  JOURNAL   Endocrinology 163 (4) (2022)
   PUBMED   35106541
  REMARK    GeneRIF: PCP Protein Inversin Regulates Testis Function Through
            Changes in Cytoskeletal Organization of Actin and Microtubules.
REFERENCE   2  (bases 1 to 5616)
  AUTHORS   Nakajima,Y., Kiyonari,H., Mukumoto,Y. and Yokoyama,T.
  TITLE     The Inv compartment of renal cilia is an intraciliary
            signal-activating center to phosphorylate ANKS6
  JOURNAL   Kidney Int 93 (5), 1108-1117 (2018)
   PUBMED   29395339
REFERENCE   3  (bases 1 to 5616)
  AUTHORS   Kamijho,Y., Shiozaki,Y., Sakurai,E., Hanaoka,K. and Watanabe,D.
  TITLE     Multiple renal cyst development but not situs abnormalities in
            transgenic RNAi mice against Inv::GFP rescue gene
  JOURNAL   PLoS One 9 (2), e89652 (2014)
   PUBMED   24586938
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5616)
  AUTHORS   Shiba,D., Manning,D.K., Koga,H., Beier,D.R. and Yokoyama,T.
  TITLE     Inv acts as a molecular anchor for Nphp3 and Nek8 in the proximal
            segment of primary cilia
  JOURNAL   Cytoskeleton (Hoboken) 67 (2), 112-119 (2010)
   PUBMED   20169535
REFERENCE   5  (bases 1 to 5616)
  AUTHORS   Tory,K., Rousset-Rouviere,C., Gubler,M.C., Moriniere,V.,
            Pawtowski,A., Becker,C., Guyot,C., Gie,S., Frishberg,Y., Nivet,H.,
            Deschenes,G., Cochat,P., Gagnadoux,M.F., Saunier,S., Antignac,C.
            and Salomon,R.
  TITLE     Mutations of NPHP2 and NPHP3 in infantile nephronophthisis
  JOURNAL   Kidney Int 75 (8), 839-847 (2009)
   PUBMED   19177160
REFERENCE   6  (bases 1 to 5616)
  AUTHORS   Otto,E.A., Schermer,B., Obara,T., O'Toole,J.F., Hiller,K.S.,
            Mueller,A.M., Ruf,R.G., Hoefele,J., Beekmann,F., Landau,D.,
            Foreman,J.W., Goodship,J.A., Strachan,T., Kispert,A., Wolf,M.T.,
            Gagnadoux,M.F., Nivet,H., Antignac,C., Walz,G., Drummond,I.A.,
            Benzing,T. and Hildebrandt,F.
  TITLE     Mutations in INVS encoding inversin cause nephronophthisis type 2,
            linking renal cystic disease to the function of primary cilia and
            left-right axis determination
  JOURNAL   Nat Genet 34 (4), 413-420 (2003)
   PUBMED   12872123
REFERENCE   7  (bases 1 to 5616)
  AUTHORS   Okada,Y., Nonaka,S., Tanaka,Y., Saijoh,Y., Hamada,H. and
            Hirokawa,N.
  TITLE     Abnormal nodal flow precedes situs inversus in iv and inv mice
  JOURNAL   Mol Cell 4 (4), 459-468 (1999)
   PUBMED   10549278
REFERENCE   8  (bases 1 to 5616)
  AUTHORS   Mazziotti,M.V., Willis,L.K., Heuckeroth,R.O., LaRegina,M.C.,
            Swanson,P.E., Overbeek,P.A. and Perlmutter,D.H.
  TITLE     Anomalous development of the hepatobiliary system in the Inv mouse
  JOURNAL   Hepatology 30 (2), 372-378 (1999)
   PUBMED   10421642
REFERENCE   9  (bases 1 to 5616)
  AUTHORS   Morgan,D., Turnpenny,L., Goodship,J., Dai,W., Majumder,K.,
            Matthews,L., Gardner,A., Schuster,G., Vien,L., Harrison,W.,
            Elder,F.F., Penman-Splitt,M., Overbeek,P. and Strachan,T.
  TITLE     Inversin, a novel gene in the vertebrate left-right axis pathway,
            is partially deleted in the inv mouse
  JOURNAL   Nat Genet 20 (2), 149-156 (1998)
   PUBMED   9771707
  REMARK    Erratum:[Nat Genet 1998 Nov;20(3):312]
REFERENCE   10 (bases 1 to 5616)
  AUTHORS   Biben,C. and Harvey,R.P.
  TITLE     Homeodomain factor Nkx2-5 controls left/right asymmetric expression
            of bHLH gene eHand during murine heart development
  JOURNAL   Genes Dev 11 (11), 1357-1369 (1997)
   PUBMED   9192865
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jun 3, 2021 this sequence version replaced NM_001107932.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.19476.1,
                                           SRR26360190.3307136.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               JAXUCZ010000005.1  67406511-67406668
            159-288             JAXUCZ010000005.1  67409878-67410007
            289-455             JAXUCZ010000005.1  67429357-67429523
            456-629             JAXUCZ010000005.1  67503023-67503196
            630-797             JAXUCZ010000005.1  67504471-67504638
            798-978             JAXUCZ010000005.1  67508031-67508211
            979-1088            JAXUCZ010000005.1  67511060-67511169
            1089-1260           JAXUCZ010000005.1  67519169-67519340
            1261-1416           JAXUCZ010000005.1  67520469-67520624
            1417-1646           JAXUCZ010000005.1  67521018-67521247
            1647-1753           JAXUCZ010000005.1  67525621-67525727
            1754-1966           JAXUCZ010000005.1  67529947-67530159
            1967-2238           JAXUCZ010000005.1  67541005-67541276
            2239-2941           JAXUCZ010000005.1  67548797-67549499
            2942-3171           JAXUCZ010000005.1  67553446-67553675
            3172-3246           JAXUCZ010000005.1  67554493-67554567
            3247-5616           JAXUCZ010000005.1  67556981-67559350
FEATURES             Location/Qualifiers
     source          1..5616
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..5616
                     /gene="Invs"
                     /gene_synonym="RGD1563359"
                     /note="inversin"
                     /db_xref="GeneID:313228"
                     /db_xref="RGD:1563359"
     exon            1..158
                     /gene="Invs"
                     /gene_synonym="RGD1563359"
                     /inference="alignment:Splign:2.1.0"
     exon            159..288
                     /gene="Invs"
                     /gene_synonym="RGD1563359"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..3350
                     /gene="Invs"
                     /gene_synonym="RGD1563359"
                     /codon_start=1
                     /product="inversin"
                     /protein_id="NP_001101402.1"
                     /db_xref="GeneID:313228"
                     /db_xref="RGD:1563359"
                     /translation="MNISENVLSTGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKE
                     DQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLT
                     RRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYN
                     NPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDASAVHTVRCILDAAPTESLLNWQD
                     YEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLE
                     RNKSGTVPSDSQGATPLHYAAQSNFAETVKVFLTHPSVRDDSDLEGRTSFMWAAGKGS
                     DDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHT
                     PLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPN
                     VQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLL
                     LDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKIQAVY
                     KGYKVRKAFRDRKNLLMKHEQLRKDAAAKKREEENKRKEAEQKGQPDTDPPRPQVLPC
                     PPSPQNEPSRQSAAPSKQPPASHTVQSPDPEQGRPAGQCPGRASHRDCSSDLQGTASR
                     KPSESPREHCRGASAGVHPRSCEDGDSYRHQGTSSAEKCRGETSGEHQRCEQGPSRAR
                     QPVSTGSAGPAEKGEDSSPAITSASQRDRPRKPSKRQDGAPRSRGASQKRRTHQLRDR
                     CSPAGSSRPGSAKAEVARADQSSVHHDTPRNKVTQDKLVGGVSSDVPLSTEELGSGCQ
                     KLYEDLCASPENNVAHGPRPGQSVNIHLLPVEQRLLIIQRERSRKELFRRKNKAAAVI
                     QRAWRSYQLRKHLSRLLHLKQLGARDVLRCTQLCAALLLQVWRKELELKFPKSISVSR
                     TSKSPSKGMSAAKSARHSVLRQIYGCSQEGKVHHPIRSPKVPPVLHLSSVNSLQSIHL
                     DSSGRSKKFSYNLQPASQSKNKPKL"
     exon            289..455
                     /gene="Invs"
                     /gene_synonym="RGD1563359"
                     /inference="alignment:Splign:2.1.0"
     exon            456..629
                     /gene="Invs"
                     /gene_synonym="RGD1563359"
                     /inference="alignment:Splign:2.1.0"
     exon            630..797
                     /gene="Invs"
                     /gene_synonym="RGD1563359"
                     /inference="alignment:Splign:2.1.0"
     exon            798..978
                     /gene="Invs"
                     /gene_synonym="RGD1563359"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1088
                     /gene="Invs"
                     /gene_synonym="RGD1563359"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1260
                     /gene="Invs"
                     /gene_synonym="RGD1563359"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1416
                     /gene="Invs"
                     /gene_synonym="RGD1563359"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1646
                     /gene="Invs"
                     /gene_synonym="RGD1563359"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1753
                     /gene="Invs"
                     /gene_synonym="RGD1563359"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1966
                     /gene="Invs"
                     /gene_synonym="RGD1563359"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2238
                     /gene="Invs"
                     /gene_synonym="RGD1563359"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2941
                     /gene="Invs"
                     /gene_synonym="RGD1563359"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3171
                     /gene="Invs"
                     /gene_synonym="RGD1563359"
                     /inference="alignment:Splign:2.1.0"
     exon            3172..3246
                     /gene="Invs"
                     /gene_synonym="RGD1563359"
                     /inference="alignment:Splign:2.1.0"
     exon            3247..5616
                     /gene="Invs"
                     /gene_synonym="RGD1563359"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcggccggg agcctcaggc tgcttcttca gagctcctgg gctctagggt cctggggtct
       61 gttcctgtgg gcaaagtggc ctgacttggc gggaggcgcg gcccagtgag ggttgtacct
      121 cctagggcgg ccccgggacg ccagttttgg aggcaggggt cactagggtt gtggagaaaa
      181 ctatgaacat atcagagaat gtgctctcta cggggtcctc attagcatct caggttcatg
      241 ccgctgcagt taatggagat aaaggtgccc ttcagagact cattgttgga aactctgctc
      301 ttaaagacaa agaagaccaa tttgggagaa caccacttat gtattgtgtg ttggcagaca
      361 gattggactg tgcagatgcc cttctaaaag caggggcaga tgtcaacaaa accgaccata
      421 gccggagaac agccctccac cttgcagccc aaaagggaaa ttaccgcttt atgaaactct
      481 tactcactcg cagagcaaac tggatgcaga aggacctaga agagatgacg cctctgcacc
      541 tgagcactcg gcacaggagc cccaagtgtc tagcgctcct gctgaagttt atggcgcccg
      601 gggaggtgga tacacaggac aaaaacaagc aaacagctct gcactggagc gcctactaca
      661 acaatcccga gcatgcgaag ctgctcatca agcatgactc caacatcggg attcctgacg
      721 tggagggcaa gatccccctc cactgggcag ccaaccataa agacgcgagt gccgtgcaca
      781 cagtgagatg catcctggat gccgccccaa cagagtcttt attgaactgg caagactatg
      841 agggccgcac acctctgcac ttcgcagttg ctgatggaaa cctaacggtg gtggatgtct
      901 tgacctccta tgaaagctgc aacataacgt cttatgacaa cttatttcga accccacttc
      961 actgggcagc cttactaggc catgcacaga ttgtccatct ccttctggaa agaaacaagt
     1021 ctggaaccgt cccttccgac agccaagggg caacaccctt gcactatgca gctcagagta
     1081 attttgctga aacagttaag gtgtttttaa cgcatccttc agtgagagat gattctgact
     1141 tggaaggaag aacatctttc atgtgggcag caggaaaagg cagtgacgac gtgctcagaa
     1201 ctatgctcag tttaaaatcg gacatcgaca tcaacatggc ggacaaatat ggaggcacag
     1261 ctttacatgc cgctgccctt tctggccacg tcagcaccgt gaagttgtta ttggacaatg
     1321 atgcccaagt agatgctact gacgtcatga aacacactcc actgttccga gcctgcgaga
     1381 tgggacacag agacgtgatt cagacgctta ttaaaggcgg agcacgagtc gacctggttg
     1441 accaagatgg acattcactt ctacactggg cagcactggg aggaaacgct gacgtctgcc
     1501 agatcctgat agaaaacaag atcaacccaa acgtgcagga ctacgcggga agaaccccac
     1561 ttcagtgcgc tgcatatgga gggtacatca actgcatggc tgtgctcatg gagaacaatg
     1621 cagaccccaa catccaagac aaagagggac gaacagctct gcactggtcc tgtaacaacg
     1681 gctacctcga tgccattaaa ctactgctgg acttcgctgc tttccctaac cagatggaga
     1741 acaatgagga gaggtacaca ccccttgact atgcattgct tggtgagcgc catgaggtga
     1801 tccagttcat gctggaacac ggtgccctgt ccatcgcagc tattcaagac atcgctgcct
     1861 tcaaaatcca agcggtctac aaaggataca aggtcagaaa agccttccga gaccggaaga
     1921 acctcctcat gaagcacgaa cagctgagaa aggacgctgc agctaagaaa cgggaggagg
     1981 aaaacaagcg gaaggaagct gaacagaaag gacagccgga cacagatcct cccaggcccc
     2041 aagtcctccc ctgtccaccc agcccccaga atgagcccag taggcagagc gcagccccta
     2101 gcaaacagcc acctgctagc cacacagtcc agagccccga cccagagcag ggcaggcctg
     2161 caggccaatg tccaggcaga gcctcccaca gggattgttc ctcagacctt cagggaacag
     2221 cctccagaaa gccgagtgaa tcccccaggg agcactgcag aggcgcctct gccggcgtgc
     2281 accccagatc ctgcgaggat ggtgatagct acaggcatca gggaacatcc tctgcggaga
     2341 agtgcagagg tgagaccagt ggcgaacacc agcggtgtga gcagggccca agcagagcca
     2401 ggcagcccgt gtccactggg tcagcggggc ctgccgagaa aggagaggac tccagccctg
     2461 ccattacaag tgcttcccag cgggaccgcc cccggaaacc cagcaagaga caggacgggg
     2521 cgcccaggtc cagaggtgcg tcccagaaaa gacgcaccca tcagctcaga gacaggtgct
     2581 cccccgctgg gtccagccgg cctggcagtg ctaaggcgga agttgcccgc gctgatcaga
     2641 gttctgtcca ccatgacaca ccaagaaaca aggtgaccca ggacaagctt gtaggagggg
     2701 tctcctcgga tgtgccactc agcacagaag agctggggtc aggatgccag aagctttatg
     2761 aggacctgtg tgcatctccg gagaacaatg tggctcacgg cccccgacct ggacagagtg
     2821 tgaatatcca ccttcttccc gtagaacagc gcctgctgat aatccagagg gaacggagca
     2881 ggaaggagct gtttcggaga aaaaacaagg cagcggccgt catccagcga gcttggcgaa
     2941 gctaccagct caggaagcac ctctctcggc ttctgcattt gaagcagctt ggagccagag
     3001 atgtgctcag atgtactcaa ctgtgcgcag ccctgctcct ccaggtttgg aggaaagaac
     3061 tggagctcaa gttcccaaag tccatctcag taagcagaac atcaaagagt ccatccaaag
     3121 gcatgtcggc cgcaaagtcc gccaggcact cagtgctcag gcagatctac ggttgttctc
     3181 aggaagggaa agtacatcat cccatcagat ctcccaaagt ccctcctgtg cttcatctca
     3241 gttcagtgaa cagtttgcag tctatacatc ttgacagcag tggaagatca aagaagtttt
     3301 cttacaatct gcaaccagcc agtcaatcaa aaaacaagcc aaagctttga gcctgaagga
     3361 agatcaaaac cagtgtggac ttcggctctg tgaactctta attaggacac cgaagtcctc
     3421 attccccaac atatgtggtc agaggcagcg ttcagatgtt ttctcctggg tactcctacc
     3481 agcatacttt tccattcctc ttggcacgca ctgaaaagga ccagagcaga gtgcgcggat
     3541 ggaccgccga gctgtgcgcc tcacctcagc cggcgtggct ggagaagaga actgccacgc
     3601 tcctcagtgt aacagacaac acctgcacta aaggagccgt gggccgggat ttctcacagc
     3661 taacctgcac aggcctggcc tcttcaccct aggaaacctg ggcctcagcg gccaccttca
     3721 attctttact tccctggaac atactgtgtg acaaacatca caagagacag tttaaatttt
     3781 agatcgaaat catggcttag tgtttgcatt agaaaccacc cattgtacta aagcggaact
     3841 gaggagtgca ttctggggct tccttacagt tttcagtttc caaattggcc ctggaagacg
     3901 acgcgctgca gctgtgtgct ctccctgact ggggctttca ctgctgagag gcaccgatga
     3961 cagcacagca ccaagaagtc ggtagacagg ttgacagcac aatgcgccaa ccaactctgg
     4021 cttctcttcc cctttgcatc ctgaccaact tgcagaagaa aataaccttc cccaaatgca
     4081 atttcttttg tgaaagtaac ccacattcta gctttctaag aatacttgcc ttaaataaag
     4141 tctagtgatt atggactttt acagaggcag ataacatcag gtcattcctg tgctaacact
     4201 aaaggacagg aatttacgtc atttaatcac aatgactttg gtatagtaaa ttatattcaa
     4261 aattttggag acaggtttat ctagacagga tcacaaagat tcattggtaa gtgaatgaag
     4321 gcaccataga tcactgtatg tcttataaac atttagcttt tatgaaattc acaatgttct
     4381 actgcctgtc cttgtatcat gtgctaatcc acgcaaacag agtgagatca ctaagaactc
     4441 ttaaacctta ttttcccact tttgtaagaa ggaagctcac gaacaacttc tttaaaagtt
     4501 gagtttaatg gcaaatattt gttacatcag tctctcttca aaataaaatg aatgtgcatg
     4561 aacaattaat ttcaaacagg aggtgccatg gtgcttcttt aatacagtgc attcaatata
     4621 ctaggcccct ggggatggcc actgatgtac acactgaagc agtaatgtaa gtctgtaagc
     4681 cactgctcct gaacactgcc actcttcaaa gtctgcagag aaaaacaaaa ggcactttag
     4741 tttgagaact gaactacctg acatttttca tggcctccat aaaagtatcc tcctccacca
     4801 ccagctggag aacatacatg ggctggacct acgcctccct gaacacagta tgcagcagac
     4861 gtgtagcctc atcttcgtgt gggtcctgaa caatgggagc aagggctgtc ccagaaattg
     4921 ttgcctatac atgaaacatg tcctctatag ctgggctccc ttgtctggcc tcagcgggag
     4981 tggagaaacc tatcctccca gaggacttga tgtgccaggg tggaaggata cccaggggtg
     5041 tccccaccca ctcagaggag aaggggatgg gggaggaatt gtgagagggg gtgtaggtag
     5101 gtagggtagt aagcaggaag taaaaagtga gtaagaaata aaagttaaaa aaatattcta
     5161 taaactagaa gaaatcttaa aatataaaac aaaccaatca actattggga gttactatag
     5221 ccagtgaaaa tgcctactct ttacgaaaat ttgaaattat aaatgggccc taaggctttg
     5281 gtatctgaat aatttttccc gagtagtgct gctgtttgga aggttctttg gacagagccc
     5341 acttgtggtc caggctctct acttcctgac tcactgagat ataactccac ccagcaaact
     5401 cccactgccg caaatgtacc ccagccacag tgtttacccc atgacaatag agtgcctgcc
     5461 cgctcaaatt gtcaaataca gtgagtcctt taagttggaa ctgtgatttg gttaatgtga
     5521 caagagaaac agtatgtgcc cctaagaata acaagttctt tgcaaatctg ttccttcctg
     5581 gacatgctgg agactaataa aaaattttat ggacaa
//
