LOCUS       NM_001421108            5905 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Rattus norvegicus inturned planar cell polarity protein (Intu),
            mRNA.
ACCESSION   NM_001421108 XM_039103629
VERSION     NM_001421108.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5905)
  AUTHORS   Yang,N., Leung,E.L., Liu,C., Li,L., Eguether,T., Jun Yao,X.J.,
            Jones,E.C., Norris,D.A., Liu,A., Clark,R.A., Roop,D.R.,
            Pazour,G.J., Shroyer,K.R. and Chen,J.
  TITLE     INTU is essential for oncogenic Hh signaling through regulating
            primary cilia formation in basal cell carcinoma
  JOURNAL   Oncogene 36 (35), 4997-5005 (2017)
   PUBMED   28459465
REFERENCE   2  (bases 1 to 5905)
  AUTHORS   Toriyama,M., Lee,C., Taylor,S.P., Duran,I., Cohn,D.H., Bruel,A.L.,
            Tabler,J.M., Drew,K., Kelly,M.R., Kim,S., Park,T.J., Braun,D.A.,
            Pierquin,G., Biver,A., Wagner,K., Malfroot,A., Panigrahi,I.,
            Franco,B., Al-Lami,H.A., Yeung,Y., Choi,Y.J., Duffourd,Y.,
            Faivre,L., Riviere,J.B., Chen,J., Liu,K.J., Marcotte,E.M.,
            Hildebrandt,F., Thauvin-Robinet,C., Krakow,D., Jackson,P.K. and
            Wallingford,J.B.
  CONSRTM   University of Washington Center for Mendelian Genomics
  TITLE     The ciliopathy-associated CPLANE proteins direct basal body
            recruitment of intraflagellar transport machinery
  JOURNAL   Nat Genet 48 (6), 648-656 (2016)
   PUBMED   27158779
  REMARK    Erratum:[Nat Genet. 2016 Jul 27;48(8):970. doi:
            10.1038/ng0816-970b.. PMID: 27463398]
REFERENCE   3  (bases 1 to 5905)
  AUTHORS   Yasunaga,T., Hoff,S., Schell,C., Helmstadter,M., Kretz,O.,
            Kuechlin,S., Yakulov,T.A., Engel,C., Muller,B., Bensch,R.,
            Ronneberger,O., Huber,T.B., Lienkamp,S.S. and Walz,G.
  TITLE     The polarity protein Inturned links NPHP4 to Daam1 to control the
            subapical actin network in multiciliated cells
  JOURNAL   J Cell Biol 211 (5), 963-973 (2015)
   PUBMED   26644512
REFERENCE   4  (bases 1 to 5905)
  AUTHORS   Chang,R., Petersen,J.R., Niswander,L.A. and Liu,A.
  TITLE     A hypomorphic allele reveals an important role of inturned in mouse
            skeletal development
  JOURNAL   Dev Dyn 244 (6), 736-747 (2015)
   PUBMED   25774014
REFERENCE   5  (bases 1 to 5905)
  AUTHORS   Dai,D., Li,L., Huebner,A., Zeng,H., Guevara,E., Claypool,D.J.,
            Liu,A. and Chen,J.
  TITLE     Planar cell polarity effector gene Intu regulates cell
            fate-specific differentiation of keratinocytes through the primary
            cilia
  JOURNAL   Cell Death Differ 20 (1), 130-138 (2013)
   PUBMED   22935613
REFERENCE   6  (bases 1 to 5905)
  AUTHORS   Lundby,A., Secher,A., Lage,K., Nordsborg,N.B., Dmytriyev,A.,
            Lundby,C. and Olsen,J.V.
  TITLE     Quantitative maps of protein phosphorylation sites across 14
            different rat organs and tissues
  JOURNAL   Nat Commun 3, 876 (2012)
   PUBMED   22673903
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5905)
  AUTHORS   Heydeck,W. and Liu,A.
  TITLE     PCP effector proteins inturned and fuzzy play nonredundant roles in
            the patterning but not convergent extension of mammalian neural
            tube
  JOURNAL   Dev Dyn 240 (8), 1938-1948 (2011)
   PUBMED   21761479
REFERENCE   8  (bases 1 to 5905)
  AUTHORS   Zeng,H., Hoover,A.N. and Liu,A.
  TITLE     PCP effector gene Inturned is an important regulator of cilia
            formation and embryonic development in mammals
  JOURNAL   Dev Biol 339 (2), 418-428 (2010)
   PUBMED   20067783
REFERENCE   9  (bases 1 to 5905)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On May 10, 2023 this sequence version replaced XM_039103629.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.7889.1,
                                           SRR26643293.11741.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-247               JAXUCZ010000002.1  125537773-125538019
            248-795             JAXUCZ010000002.1  125551228-125551775
            796-881             JAXUCZ010000002.1  125562428-125562513
            882-1085            JAXUCZ010000002.1  125571583-125571786
            1086-1201           JAXUCZ010000002.1  125574382-125574497
            1202-1291           JAXUCZ010000002.1  125578968-125579057
            1292-1369           JAXUCZ010000002.1  125579572-125579649
            1370-1559           JAXUCZ010000002.1  125583274-125583463
            1560-1613           JAXUCZ010000002.1  125593825-125593878
            1614-1676           JAXUCZ010000002.1  125596728-125596790
            1677-1898           JAXUCZ010000002.1  125597735-125597956
            1899-2369           JAXUCZ010000002.1  125598621-125599091
            2370-2467           JAXUCZ010000002.1  125600161-125600258
            2468-2657           JAXUCZ010000002.1  125606511-125606700
            2658-2815           JAXUCZ010000002.1  125608557-125608714
            2816-5905           JAXUCZ010000002.1  125610206-125613295
FEATURES             Location/Qualifiers
     source          1..5905
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..5905
                     /gene="Intu"
                     /gene_synonym="Pdzk6"
                     /note="inturned planar cell polarity protein"
                     /db_xref="GeneID:108348166"
                     /db_xref="RGD:1309446"
     exon            1..247
                     /gene="Intu"
                     /gene_synonym="Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..2927
                     /gene="Intu"
                     /gene_synonym="Pdzk6"
                     /note="PDZ domain-containing protein 6; PDZ domain
                     containing 6; inturned planar cell polarity effector
                     homolog"
                     /codon_start=1
                     /product="protein inturned"
                     /protein_id="NP_001408037.1"
                     /db_xref="GeneID:108348166"
                     /db_xref="RGD:1309446"
                     /translation="MADPARRDPRGRAPELPGDLSSQEEEEEESDSDAGASSLGSCSS
                     ASSDTDLEPEWLDSVQRNGELFYLELSEDEEESLLPETQTVNHVNHVRFSEKEVIIEE
                     DDSRERKKYEPKLRRFTKILKSKSLLPKRHHKKKSSNTGPVSILKHQSTQRTGVTVQQ
                     RYKDVTVYINPKKLTAIKAREQAKLLEVLVGVIHQTKWSWKRSGKQADGERLVVHGLV
                     PGGSAMKSGQVLVGDVLVAVNDVDVTSENIERVLSCIPGPMQVKLTFENAYAVKKETA
                     QPKKKKAQSSTNDLVKLLCGSEADATQHSTLSIPHITMYLTLQLQSEVAREEEMLYHY
                     PVSEASQKLKSVRGIFLTLCDMLESVTGTQVTSSSLHVNGKQIHVAYLKESDKLLLIG
                     LPAEEVPLPQLRNMTEDVAQTLKFMYGSLDSAFCQVENTPRLDHFFSLFFERALRPGK
                     LHLSASPSAQQYDAASAVLLDNLPGVRWLLLPQELKVELDTALSDLEAADFQELSEDY
                     YDMRRLYTILGSSLFYKGYMVCSHLPKDDVVEIAAYCRQYCLLPLAAQQRIGQLIIWR
                     EVFPQHHLQPATDSDPEAFQEPEGRYFLLIVGLRHYMLCVLLEAGGCASKATGNPGPD
                     CIYVDQARATLHQLEGVESRIEEQLAATPGPCLSCADWFLAAPREKADSLTTSPILGR
                     LQGPSKTAASPTCRRTFFSDYSFKARKPSPSRIGGGREPGEGEENVGLSPHTTPDTVR
                     KQRESEGSDDNVALLKLARKKSTLPNPFHLGTSKKELSEKELEVYNMMKLTSGPENTL
                     FHYVALETVQGIFITPTHEEVAQLGGSVHSQLIKNFHRCCLTIRAVFQQTLKVEKKKA
                     LSDGDHLESANSVSSLSPVKEHGVLFECSPENWTDQKKTPPVMSYWVVGRLFLNPKPQ
                     ELYVCFHDSVSEIAIEMAFRLFFGLTL"
     exon            248..795
                     /gene="Intu"
                     /gene_synonym="Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            796..881
                     /gene="Intu"
                     /gene_synonym="Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1085
                     /gene="Intu"
                     /gene_synonym="Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1201
                     /gene="Intu"
                     /gene_synonym="Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1291
                     /gene="Intu"
                     /gene_synonym="Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1369
                     /gene="Intu"
                     /gene_synonym="Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1559
                     /gene="Intu"
                     /gene_synonym="Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1613
                     /gene="Intu"
                     /gene_synonym="Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1676
                     /gene="Intu"
                     /gene_synonym="Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1898
                     /gene="Intu"
                     /gene_synonym="Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2369
                     /gene="Intu"
                     /gene_synonym="Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2467
                     /gene="Intu"
                     /gene_synonym="Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2657
                     /gene="Intu"
                     /gene_synonym="Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2815
                     /gene="Intu"
                     /gene_synonym="Pdzk6"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..5905
                     /gene="Intu"
                     /gene_synonym="Pdzk6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcacgtgac ccggcctggc aaaatggcgg agctgctgaa ggcagggctg gcgggctcta
       61 gagtctgatt tttctccccg ggagctctcg cgaccgaaag gatggcggac cctgcgagga
      121 gagacccgcg aggtcgcgcg cccgagctcc ctggagacct gtcctcacag gaagaggaag
      181 aggaggaaag cgactccgac gccggggcca gcagcttggg ctcctgctcc tcagccagca
      241 gcgacactga tctggagccc gagtggctgg acagtgtgca gaggaacgga gaactgttct
      301 acctggagct gagtgaggat gaggaggaga gcctccttcc agaaacccag actgtgaacc
      361 atgtgaacca cgtcaggttc agtgagaagg aggtcatcat tgaagaggac gattccagag
      421 aaagaaagaa gtatgagccc aagctcagac gcttcaccaa gatcttgaaa agcaaaagcc
      481 ttttacctaa gcgtcaccac aaaaagaaaa gcagtaacac tggacctgtg tccattctga
      541 agcatcagtc cacccagagg actggagtca ctgtgcagca gcggtacaag gatgtgactg
      601 tctacatcaa ccccaaaaag ctaacggcca tcaaagccag ggagcaggcc aaactcctgg
      661 aagtgctggt gggagtcatc catcagacca aatggagctg gaaaaggagc gggaagcagg
      721 cagatggaga gaggctcgtg gtgcatggcc tggtgcccgg tggctctgct atgaagagcg
      781 gtcaggtact ggttggcgat gtccttgttg ctgtgaatga tgtagatgtg acttctgaaa
      841 acatagaaag agttctgtcc tgcatccctg ggccaatgca ggtaaagctg acatttgaaa
      901 atgcatatgc cgtgaaaaag gaaacagccc aaccaaaaaa gaaaaaggca cagtcgagca
      961 caaatgattt ggtgaaactc ctctgtgggt cagaggctga tgctacccag cacagtaccc
     1021 tgagcatccc acacatcact atgtacctca cgctgcagct ccagtcagag gtagcccggg
     1081 aggaggaaat gctttaccat taccctgtgt ctgaagcatc tcagaaactc aagagtgtga
     1141 gggggatttt tctcacactc tgtgacatgc tggaaagtgt aactgggaca caagtcacaa
     1201 gctcatccct ccatgtaaat gggaaacaaa ttcatgttgc ttacttgaaa gagtctgaca
     1261 agttgctgtt aattggcctg cctgctgaag aagttcctct cccccagcta aggaacatga
     1321 cagaggacgt cgcccaaacc ctaaagttca tgtatggttc tttagacagt gccttttgcc
     1381 aggttgagaa cacacctcgt ctggaccatt tcttcagctt gttcttcgaa cgagctcttc
     1441 ggcccgggaa attacatctc agcgccagcc ccagtgccca gcagtacgat gcagccagtg
     1501 ctgtgctttt ggacaacctc cctggagtcc gttggctcct acttccacag gaacttaagg
     1561 tagaactgga cacagcactg agtgaccttg aggccgccga cttccaagaa ctgtccgagg
     1621 actactatga catgagacgg ctgtatacaa ttttggggtc ttctctgttt tacaagggtt
     1681 atatggtgtg cagccatctg cctaaggacg atgttgttga gatcgctgcg tactgtcgcc
     1741 agtactgcct gctgccttta gcagcacagc aaaggattgg ccagctgata atatggagag
     1801 aagtgttccc acaacaccac ctccagcccg ctacagactc agaccctgag gccttccagg
     1861 aaccagaagg gagatatttc ttactaatcg tcgggttgcg acattacatg ttgtgtgtgc
     1921 tgttagaagc tggaggctgt gcatctaaag ctactgggaa ccctggtcca gattgcatct
     1981 atgtcgatca ggccagagca acccttcacc agctggaagg agtggagtcc cgcatagagg
     2041 aacagctagc tgcaaccccg gggccctgct tgtcctgtgc tgactggttc cttgctgcac
     2101 cacgcgaaaa ggcagatagt ttgaccactt cgcctatcct cggtaggctg caggggcctt
     2161 ccaaaacagc agcctctcca acatgcagaa gaaccttttt cagtgactat tcattcaagg
     2221 cacggaagcc cagcccctca cggattggtg gaggacgtga acctggtgaa ggggaagaaa
     2281 atgttggtct gagcccacac actaccccag acactgtacg gaagcaaaga gaatctgaag
     2341 gttcagacga caatgtggcc ttgcttaagc ttgctagaaa gaagtcaaca cttccaaatc
     2401 cgtttcattt gggaacttcg aaaaaagaac tttcagaaaa agaattggaa gtctataaca
     2461 tgatgaaatt gacctccggt cctgagaata cactcttcca ctatgttgcc ttagaaacag
     2521 tgcaaggcat cttcatcact cccacccatg aagaggtagc tcagctaggt ggttccgtcc
     2581 actctcaact aataaagaat ttccatcgat gttgtctcac catccgtgca gttttccagc
     2641 agacgttgaa ggtggagaaa aagaaagcgc taagtgacgg agatcatttg gagtctgcaa
     2701 actcagtgtc ttctctgagt cctgtgaaag aacacggtgt actgtttgaa tgctcacctg
     2761 aaaactggac tgaccagaaa aagacaccac cagttatgtc gtactgggta gtagggaggc
     2821 ttttccttaa cccaaaacct caggaactat atgtctgttt tcacgactca gtctcagaaa
     2881 ttgccattga aatggcattt agattgttct ttgggttaac gttgtagctg tgtttgtaag
     2941 atacagagca acacacagat ggaccacagg acagcattgg aatggctgaa gtcatgcaga
     3001 gaagaggctc attaccgccg ttgttcatga ttgtactcgt tagatactga gatgtagtag
     3061 tactgttggg ttggtgcatc agttcatgtg tggtagcata taagacatct gagctgatac
     3121 ttgatcaaaa tacagagaca agattgctaa cttattgcca tttttggtat accatgctaa
     3181 tttattgaat agttttaagt aatgtgaatt ctttaataaa gattaatata ggagatgttt
     3241 atttggggag ggtcacattt aaatcattgt ttgttttcat aaaacccaat actgactgac
     3301 tgataccctg tgaaggaatc ctgacttgaa gagacaacaa ggttctgtag tcagtgagtg
     3361 ctgtgctgtg agcgagccct tgtatcagtt agacctcaca gtatgtgcgg actaatcaca
     3421 ttattattgc attgggattt tgaaatgccc agttaagaaa aatgcgttgt ttgcttattg
     3481 gtcaatatct aaatttacaa tgcctgtgtt ctggtttctt agcaaatcaa aagcctccac
     3541 actggtttaa gtatcttagt agatactcca ctactgaggc ggagcgaaag atgacagttt
     3601 atatttattt gattctcttt attcttcatg gtaaacttaa tttagattag ggtacacatt
     3661 tgcaatcatc tgtaaacttc cattgctttc ttcctggttc atatacattt atatcaactc
     3721 ttatcaaatc atatttaaaa cactaaaatg gggatagagc gatggctcag aggtcaggag
     3781 cgaattcccc attggaagag acctgagttc agctcccaca tccatgttag gcagctcaaa
     3841 accacctgta actccaggga atcctttggt ctttgcaggt accccacaca caattagaaa
     3901 ataaagctct ttttaaaaaa ctggagcggg ggcaggggga gaacaggcta aaactacctt
     3961 atattaactt cttctataaa atactaattt ttgtcttaca aatcagtatc agtctgtatt
     4021 gggttttccc aaaggagagg gctcgctttc cccaactgta gctaatgtga gcttcagcgg
     4081 gacagaatct gacaagacag attttctatg gctgtgagaa ttcggtgtat gctacaggct
     4141 caatatccct cacactttac agtcctgagt aatttctccc tcagggatta tgtatgttgg
     4201 aagacatgct gtctaaaacc aatctaaagt ttgtctttac attttccctc cctcaaacat
     4261 aagccctcca gcttaaaact agaagacatc caagtgtacc cctggccatt tggtcttata
     4321 aaaaatatgg ttaccttggc catcactgta agattctcat cgaggcctgg gtgacagaca
     4381 gcagctgttt atatcattag tgacttctgg gccttaattt cgactttcaa gtcagatagg
     4441 aaaattatgc gccttaaaat gtagaaaaca gtttgaaaca cttccccact taactgagtc
     4501 aaatcagtta agactctctt ctgtcttaat ctgtgttcta gtatttctaa aacggtattt
     4561 attagatgtc ttaaacttct ggatatgccc tcaaatcctg agctgttcta gtgctgatca
     4621 ttaggatgaa tgtagcagtt gatcactcag cgttcaagca gagcaaacta agacttggga
     4681 tttaataggg agaacatttt tcccattgaa agttcgatct gttggtgctt cccttgtgtc
     4741 agatggccat aagcaacact gttccaaatg tggtgtaaaa gacaaacata gcacaatggt
     4801 aaagatgggc cattggcagt gctgtgcttg tgcactgcac attacataag tccatgttga
     4861 aaagccattg catttttaag gaattaatat tgccttccct ttcatttcca agtgaatatt
     4921 gaaggcaaac gtagctgacc atgtctgtaa ataaattcac actcacatct gaaagtcaat
     4981 cagtctgacc gttggacagt agagtccctg tctgtctcgt ttttggggag ggaacaaagt
     5041 gtcaagtgca gataggagaa acctccttga gtcagatttt atccacatcc tggtagtaat
     5101 gttctgtatg aaagtaacat gcttagagct gttatgtcag gcttagaatt cctagacacc
     5161 agtgttcagg gggctgaggc agagggatat agtaagttca agggcgggct gggctttgtg
     5221 acaagaccct atctataaca aaaaacaaaa ccacaagtac tttcctacta ctgtctcgtg
     5281 cttcttagcc ccaaagaaac tctagactct cgctttttct ttccctcttc tctctcctct
     5341 ttccttagct ttctttgttt ctgtcttgtc agagaactgt gcctaggagg gtaggtagtg
     5401 tctcactttt ttgtgccaag acgctgtgga gaatgataca tacctaacaa aatggtaatt
     5461 gtaaaacaat cttttaaata tttctgacac aaattggaaa aactgtgaaa ccagtctact
     5521 aagttttgtc tgcctgaacc attgttcatt tctgtatgct ctccctaacc catggttgcc
     5581 acatattgtg acctgaagca gaagccgtgg atgcctttgt catcattaag tggccactgc
     5641 ttgagaacca aaagggcaca gttcagtcta ccacagcata acaacagtga tctgagaaga
     5701 ttacttcaca ctatagtttt cagaataagg atttatattt tggacttttt ttgaactggt
     5761 aagttctgtt aaagcttgaa cctacacacc aaaccatatg tactaattta attatgaaga
     5821 gttttatttc tgtatgtaat taaaactatt tttctacatt atccagagtt tcaaataaaa
     5881 atgttttgga ggtttgtttg cagta
//
