LOCUS       NM_001100630            5915 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus integrator complex subunit 2 (Ints2), mRNA.
ACCESSION   NM_001100630 XM_001081099 XM_340870
VERSION     NM_001100630.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5915)
  AUTHORS   Jodoin,J.N., Sitaram,P., Albrecht,T.R., May,S.B., Shboul,M.,
            Lee,E., Reversade,B., Wagner,E.J. and Lee,L.A.
  TITLE     Nuclear-localized Asunder regulates cytoplasmic dynein localization
            via its role in the integrator complex
  JOURNAL   Mol Biol Cell 24 (18), 2954-2965 (2013)
   PUBMED   23904267
REFERENCE   2  (bases 1 to 5915)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 5915)
  AUTHORS   Baillat,D., Hakimi,M.A., Naar,A.M., Shilatifard,A., Cooch,N. and
            Shiekhattar,R.
  TITLE     Integrator, a multiprotein mediator of small nuclear RNA
            processing, associates with the C-terminal repeat of RNA polymerase
            II
  JOURNAL   Cell 123 (2), 265-276 (2005)
   PUBMED   16239144
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Sep 15, 2012 this sequence version replaced NM_001100630.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.42409.1,
                                           SRR26643429.38179.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-336               JAXUCZ010000010.1  71576118-71576453   c
            337-643             JAXUCZ010000010.1  71574900-71575206   c
            644-782             JAXUCZ010000010.1  71574260-71574398   c
            783-885             JAXUCZ010000010.1  71571321-71571423   c
            886-999             JAXUCZ010000010.1  71569915-71570028   c
            1000-1130           JAXUCZ010000010.1  71567892-71568022   c
            1131-1304           JAXUCZ010000010.1  71567484-71567657   c
            1305-1531           JAXUCZ010000010.1  71563222-71563448   c
            1532-1657           JAXUCZ010000010.1  71561864-71561989   c
            1658-1729           JAXUCZ010000010.1  71557398-71557469   c
            1730-1844           JAXUCZ010000010.1  71557190-71557304   c
            1845-1913           JAXUCZ010000010.1  71555430-71555498   c
            1914-2048           JAXUCZ010000010.1  71553629-71553763   c
            2049-2225           JAXUCZ010000010.1  71552242-71552418   c
            2226-2334           JAXUCZ010000010.1  71551209-71551317   c
            2335-2439           JAXUCZ010000010.1  71548451-71548555   c
            2440-2604           JAXUCZ010000010.1  71545914-71546078   c
            2605-2806           JAXUCZ010000010.1  71544297-71544498   c
            2807-2932           JAXUCZ010000010.1  71541016-71541141   c
            2933-3131           JAXUCZ010000010.1  71536032-71536230   c
            3132-3383           JAXUCZ010000010.1  71533940-71534191   c
            3384-3491           JAXUCZ010000010.1  71533533-71533640   c
            3492-3597           JAXUCZ010000010.1  71533296-71533401   c
            3598-3774           JAXUCZ010000010.1  71531248-71531424   c
            3775-5915           JAXUCZ010000010.1  71529025-71531165   c
FEATURES             Location/Qualifiers
     source          1..5915
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..5915
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /note="integrator complex subunit 2"
                     /db_xref="GeneID:360589"
                     /db_xref="RGD:1305547"
     exon            1..336
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /inference="alignment:Splign:2.1.0"
     exon            337..643
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /inference="alignment:Splign:2.1.0"
     CDS             348..3944
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /codon_start=1
                     /product="integrator complex subunit 2"
                     /protein_id="NP_001094100.2"
                     /db_xref="GeneID:360589"
                     /db_xref="RGD:1305547"
                     /translation="MMPECTSLQFVSPCAFEAMQKVDVVRLASLSDPELRLLLPCLVR
                     MALCAPADQSQSWAQDKKLILRLLSGVEAVNSIVALLSVDFHALEQDASKEQQLRHKL
                     GGGSGESILVSQLQHGLTLEFEHSDSPRRLRLVLSELLAIMNKVSECSGEFFFKSSEL
                     FESAVYLEEAADVLCILQAELPSLLPIVDVAEALLHVRNGAWFLCLLVANVPDSFNEV
                     CRGLIKNGERQDEESLGGRRRTDALRFLCRMNPSQALKVRGMVVEECHLPGLGVALTL
                     DHTKTEACEDGVSDLVCFVSGLLLGTNAKVRTWFGTFIRNGQQRRRENSGSVLWQMRR
                     QLLLELMGILPTVRSTRIVEEADVEMEPTVSVYSGLKEEHVVKASALLRLYCALMGIA
                     GLKPTEEEAEQLLQLMTSRPPATPAGVRFVSLSFCMLLAFSTLVSTPEQEQLMVVWLS
                     WMIKEEAYFESTSGVSASFGEMLLLVAMYFHSNQLSAIIDLVCSTLGMKIVIKPSSLS
                     RMKTIFTQEIFTEQVVTAHAVRVPVTSNLSANITGFLPIHCIYQLLRSRSFTKHKVSI
                     KDWIYRQLCETSTPLHPQLLPLIDVYINSILTPASKSNPEATNQPVTEQEILNIFQEV
                     IGGDSVRLNQRFSITAQLLVLYYILSYEEALLANTKTLASMQRKPKSYSSSLMDQIPI
                     KFLIRQAQGLQQELGGLHSALLRLLATNYPHLCIVDDWICEEEITGTDALLRRMLLTS
                     NAKTHSPKQLQEAFSAVPVSHTQVMQIMEHLTLLSASELIPYAEVLTSNMNQLLNSGV
                     PRRILQTVNKLWMVLNTVMPRRLWVMTVNALQPSIKFIRQQKYTQNDLMIDPLIVLRC
                     DRRVHRCPPLMDVTLHMLNGYLLASKAYLSAHLKETAEQDRPSPNNTVGLVGQTDAPE
                     VTREELKNALLAAQDSAAVQILLEICLPTEEEKAKAANSDISLRNTQGVITIGTPNKD
                     TEEGEDSLLCNLREVQCLICCLLHQMYIADPNIAKLVHFQGYPCELLPLTVAGIPSMH
                     ICLDFIPELIAQPELEKQIFAIQLLSHLCIQYALPKSLSVARLAVNVMGTLLTVLTQA
                     KRHSFFMPTLPSLVSFCRAFPPLYEDVMSLLVQIGQVCASDVATQTRDIDPIITRLQQ
                     IKEKPSGWSQIYKDASYKHGSRDTGSMDPDVQLCHCIESTVIEIINMSVSGI"
     exon            644..782
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /inference="alignment:Splign:2.1.0"
     exon            783..885
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /inference="alignment:Splign:2.1.0"
     exon            886..999
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1130
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1304
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1531
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1657
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1729
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1844
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..1913
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2048
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2225
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2334
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2439
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2604
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2806
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /inference="alignment:Splign:2.1.0"
     exon            2807..2932
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /inference="alignment:Splign:2.1.0"
     exon            2933..3131
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /inference="alignment:Splign:2.1.0"
     exon            3132..3383
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /inference="alignment:Splign:2.1.0"
     exon            3384..3491
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /inference="alignment:Splign:2.1.0"
     exon            3492..3597
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /inference="alignment:Splign:2.1.0"
     exon            3598..3774
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /inference="alignment:Splign:2.1.0"
     exon            3775..5915
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggctcggg ccagaagctt gggatgaatg gaagtgcagg gtgcaggttg aattaactct
       61 ctgcttttcc ctctctcccg gttgcttctg ccttttcttt ttttttcttt ttttcctttt
      121 tgcagtgttc ccattctgat ccccgctctg tcgacgaccc ggttggtcca gcgtcagagt
      181 tcttggtgcc cgagtcgacc ccgggcatag ccggtgttta gggatccgga taatcgccta
      241 ggcccaactt cggaccgcgt tctcgatttc tgccccgtcc ggcgctcgga cgcggtatcc
      301 gagaaggtct cttgaggctg gaggcttgat ctcaaggatc gagagagatg atgcctgagt
      361 gcacaagcct tcagtttgtc agcccttgtg cttttgaagc catgcagaag gtggacgtcg
      421 ttcgcctggc atctttaagt gatccagaac taagacttct cttgccctgc ttggtgagga
      481 tggctctttg tgctcctgcc gaccagagcc aaagctgggc tcaggataaa aaacttatac
      541 ttcgccttct gtctggagtg gaagctgtca actccattgt tgcactgctg tctgtggact
      601 tccacgccct ggaacaagat gccagcaaag aacaacagct caggcataaa cttggaggag
      661 gcagtggaga gagcatcctg gtatcacagc ttcagcatgg actgactcta gaatttgaac
      721 acagtgattc ccctcgtcga ttgcggcttg tgctgagtga attgttggca attatgaaca
      781 aggtgtcgga gtgcagtggg gagtttttct tcaagtcttc tgagctcttt gagagcgccg
      841 tgtacttgga ggaggctgcg gatgtccttt gtatcttaca agcagagctc ccttccttgc
      901 ttcctatagt ggatgtggct gaagccttgc tacatgtaag aaatggtgcc tggttcttgt
      961 gtctcttggt agccaacgtt cctgatagtt ttaatgaagt ttgtaggggc ctgatcaaaa
     1021 atggagaacg gcaggatgaa gaaagccttg gagggaggcg caggacagac gccttacgct
     1081 tcttatgcag aatgaatcct tctcaggccc tgaaggtccg gggcatggtg gtggaagaat
     1141 gtcacttgcc aggccttggg gtagctttga cattggatca taccaaaact gaagcttgtg
     1201 aagatggagt gagtgacttg gtttgctttg tcagtggctt gcttcttgga acaaatgcaa
     1261 aagtcaggac ttggtttgga accttcattc gaaatggaca acagagaaga agggagaaca
     1321 gcggctcggt gctttggcag atgagaaggc agcttcttct ggagttgatg ggcattctcc
     1381 ccacagtgag gagcacccgt attgtggagg aagccgatgt ggagatggag cctactgtgt
     1441 cggtgtactc ggggctgaaa gaagagcatg tcgtcaaagc cagcgcactc ctacgtctat
     1501 actgtgcctt gatggggatt gctggactca agccaactga agaggaagcc gagcagctgc
     1561 tgcagctgat gaccagccgg cctcccgcca cgcccgccgg ggttcgcttc gtttcgctgt
     1621 ccttctgtat gctgctggcc ttctccacac ttgtcagcac gccggagcag gagcagctga
     1681 tggtcgtgtg gctcagctgg atgatcaaag aagaagccta cttcgagagt acatcaggtg
     1741 tctcggcatc ttttggggag atgttgttat tggtggccat gtatttccac agcaaccagc
     1801 ttagtgctat cattgactta gtctgctcca ctttggggat gaagatcgtg attaagccaa
     1861 gctccttgag caggatgaag accatcttca cacaggagat ctttacagag caggttgtca
     1921 cagcccatgc agtgcgagtt cctgtcacca gcaacctgag tgccaatatt actgggtttt
     1981 tgcccattca ttgtatttac caacttctca ggagtcgatc gtttaccaag cacaaagtgt
     2041 caataaaaga ctggatttat agacagctgt gtgaaacttc cactccactg cacccgcagc
     2101 tgcttcctct gattgatgtg tacataaact ctatacttac tcctgcatct aaatctaacc
     2161 ctgaagccac aaaccagccg gtcactgagc aggagatact caacatcttc caggaagtca
     2221 tcgggggtga cagcgtccgc cttaaccagc gcttcagcat cacagcgcag cttctggtgc
     2281 tctattatat cctgtcctac gaggaagctc tcctggcaaa cacaaagacg ttagcatcca
     2341 tgcagaggaa gcccaagtcg tattcttctt ctctaatgga tcagattcct atcaagtttc
     2401 tcattcggca ggctcaagga ctacagcagg agttgggagg gctgcattca gctttactcc
     2461 gtcttctagc aactaattac ccccatttgt gtatcgtgga tgactggatc tgtgaggagg
     2521 agatcacagg gacggatgct ctgttaaggc gaatgctcct gactagtaat gccaaaaccc
     2581 actctccgaa acagctgcag gaagcatttt cagctgtccc tgtaagtcac acacaagtga
     2641 tgcagattat ggagcacttg actctacttt ctgccagtga gcttatacca tatgcagaag
     2701 ttttaacgtc caatatgaat cagcttctga attctggtgt tccacggaga attcttcaaa
     2761 ctgtcaacaa gttatggatg gttcttaata ctgtgatgcc aagaaggctg tgggtaatga
     2821 cggttaatgc actccaacct tccataaagt ttatacgaca acagaaatat acccagaatg
     2881 atttgatgat agatcctctc attgtcttga ggtgtgaccg aagggtccac aggtgtcctc
     2941 cactaatgga tgttacttta cacatgctga atgggtatct ccttgcctct aaagcttacc
     3001 ttagtgccca tctgaaggaa acagcagagc aggatagacc ttccccgaat aatacagtag
     3061 gcttggttgg acagactgat gccccagaag tgaccagaga agaactgaaa aatgcattac
     3121 tggctgctca ggacagtgcg gctgtccaga ttctcttaga gatttgtttg cctactgaag
     3181 aggaaaaggc aaaggctgcc aattcagaca tctccctcag gaacactcag ggtgtcatta
     3241 ccattggcac cccaaataaa gacacagaag aaggagaaga cagtttgctt tgcaaccttc
     3301 gagaagttca gtgccttatc tgttgcctgt tgcaccaaat gtacattgct gatcccaaca
     3361 ttgctaaact tgttcacttt cagggctatc catgtgaact tctgcctcta acagtcgcag
     3421 ggatcccatc tatgcacatc tgtttggact tcataccgga gcttattgcc cagccggaac
     3481 ttgaaaaaca gatatttgct atacagctgc tttctcactt gtgtatccag tatgcattac
     3541 cgaagtcact aagtgtggct cgcttagctg tcaatgtcat ggggactttg ctaacagttc
     3601 taacacaagc taagcggcat tcttttttca tgccgactct tccaagtttg gtctcctttt
     3661 gccgagcatt tcctccactg tatgaggatg ttatgtcttt gctcgttcaa ataggacaag
     3721 tgtgtgcctc tgatgttgcc actcagacaa gagacattga tccgatcatt acccgtcttc
     3781 aacaaataaa ggagaaacct agcggatggt ctcaaattta taaagatgca tcttacaaac
     3841 atggatccag ggacactgga agcatggatc ctgatgtcca gctctgtcat tgtattgaaa
     3901 gcacagtaat tgaaataata aacatgagtg ttagtgggat ttaaaaaaag acaggtttta
     3961 aatgcagcca tttgctgcat atactgaaca ggattctgga ctttatgaga actctaaact
     4021 gaatgagaac agtgagatct tggaattgct gaagtgattc agttcagcag agtataattt
     4081 agaactctct gagaatttac ttgtttgttt gattggcata tctttggatc tgctctgatg
     4141 gtatgtttat attgaagcag ctgaacttct tttccattgg gcacacttta agaaacttgt
     4201 ccctggttca tgttctcagc tgtttgacgt gaagacagtg ccaggctttt catttaatct
     4261 cttaaaaacg agcctgtgga tagccctcat atttgtgagc ttttaacaat ttcaacagag
     4321 aggagaggaa ggagaaagag ggatgaaggg caggaataat ttagaaaaaa ataccactta
     4381 agtacgtaga aatcatacag acttgtaatg caagaaacag tattacaggt tgaagttcta
     4441 atttgttaaa aataatagta agatggctta aaggaaaaaa aaaaaggcag ttaagccagg
     4501 tgtagcagag catgccttaa atcccagcct gagggagaaa gggagcaagt agatctctgt
     4561 cccaggccag cctgctttac atagtgagtt ccaggaaagt cagagctaca tagtgagacc
     4621 ctgtccaaaa acaataagta aataaactat taaatgactg ccttggaatt acagatgaag
     4681 atagaaggat ttcacaaatc tgcttcaact tttcctaata tatgaagcca tatgtttaaa
     4741 gagatacttg aataatttga aattttaaga tactgattat agttacagaa acatctttgt
     4801 tttgtgcaaa gaagaacctg aagtgaattt catttattct ttttaaaatt tatttttata
     4861 atactctatt atctaattct cagaggagca gacatgtatc caattaaatg aactttagag
     4921 caacaacctc aactgtgctc tcggttcgtc gccaggattg taattcacat tttactctga
     4981 ggagaatttg taagaaaata cagtgtttga acctcaggaa aacgatagtg tggtaaatgc
     5041 tgtgttgctg acttttgcag ccctctgtta ggagcttcac gatgaaggag atgcattcag
     5101 ataaccataa tcatttttta aattaagtag ccaatgtaga aggtacttct ttgctgtgtg
     5161 agaaatacct cagtcatttg ccaccccact caaagcagac ctctggttaa aacaggtagt
     5221 aagctaaaag ggaagtttgt ttttttacaa aaaaaaactt tagcttcatc ctttccacgt
     5281 ggacatagtc acatctcatt ttccttttca ctcctgaccc tacctcatgt aggtattcta
     5341 ttaaagacac gtttatagct gtttccaatc atgaagtgca tagtgtgcat ggtggaatat
     5401 atatgtatat atatatatac atatatatat ataacttttt attagatgct taatgttcaa
     5461 ttaagtgatt ttgatgtgaa gagtaagaat atgctttaaa gatagaccac aggaatttca
     5521 tattttcaat gagacagttt tgtagtctct taactgctcc tgttttgttt ttaaatgagg
     5581 cctttctgga atattttgtg tgaatagtag aatcctttag gaattctgaa atgtttgaag
     5641 tatgttttgt aatgaaatac agtacacatt ttgtggatca attttccaag actagtcata
     5701 acctactgtg ttaaagtaat aacatagcct atttttcatc tgatttgttg atgatgtaaa
     5761 taaaatgtgt aaataatatt agtaaatgtt aatattcatg tatcttaagt taaggttata
     5821 aactttgtca caatgtgatt ttttttttat tccagtcaaa acagatgtgt gcaactattt
     5881 tggatattga tttataaaca ttcattcttt atcaa
//
