LOCUS       NP_001094100            1198 aa            linear   ROD 31-MAR-2024
DEFINITION  integrator complex subunit 2 [Rattus norvegicus].
ACCESSION   NP_001094100 XP_001081099 XP_340871
VERSION     NP_001094100.2
DBSOURCE    REFSEQ: accession NM_001100630.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1198)
  AUTHORS   Jodoin,J.N., Sitaram,P., Albrecht,T.R., May,S.B., Shboul,M.,
            Lee,E., Reversade,B., Wagner,E.J. and Lee,L.A.
  TITLE     Nuclear-localized Asunder regulates cytoplasmic dynein localization
            via its role in the integrator complex
  JOURNAL   Mol Biol Cell 24 (18), 2954-2965 (2013)
   PUBMED   23904267
REFERENCE   2  (residues 1 to 1198)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (residues 1 to 1198)
  AUTHORS   Baillat,D., Hakimi,M.A., Naar,A.M., Shilatifard,A., Cooch,N. and
            Shiekhattar,R.
  TITLE     Integrator, a multiprotein mediator of small nuclear RNA
            processing, associates with the C-terminal repeat of RNA polymerase
            II
  JOURNAL   Cell 123 (2), 265-276 (2005)
   PUBMED   16239144
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Sep 15, 2012 this sequence version replaced NP_001094100.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.42409.1,
                                           SRR26643429.38179.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1198
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     Protein         1..1198
                     /product="integrator complex subunit 2"
                     /calculated_mol_wt=133412
     Region          27..1131
                     /region_name="INTS2"
                     /note="Integrator complex subunit 2; pfam14750"
                     /db_xref="CDD:464296"
     CDS             1..1198
                     /gene="Ints2"
                     /gene_synonym="RGD1305547"
                     /coded_by="NM_001100630.2:348..3944"
                     /db_xref="GeneID:360589"
                     /db_xref="RGD:1305547"
ORIGIN      
        1 mmpectslqf vspcafeamq kvdvvrlasl sdpelrlllp clvrmalcap adqsqswaqd
       61 kklilrllsg veavnsival lsvdfhaleq daskeqqlrh klgggsgesi lvsqlqhglt
      121 lefehsdspr rlrlvlsell aimnkvsecs gefffkssel fesavyleea advlcilqae
      181 lpsllpivdv aeallhvrng awflcllvan vpdsfnevcr glikngerqd eeslggrrrt
      241 dalrflcrmn psqalkvrgm vveechlpgl gvaltldhtk teacedgvsd lvcfvsglll
      301 gtnakvrtwf gtfirngqqr rrensgsvlw qmrrqlllel mgilptvrst riveeadvem
      361 eptvsvysgl keehvvkasa llrlycalmg iaglkpteee aeqllqlmts rppatpagvr
      421 fvslsfcmll afstlvstpe qeqlmvvwls wmikeeayfe stsgvsasfg emlllvamyf
      481 hsnqlsaiid lvcstlgmki vikpsslsrm ktiftqeift eqvvtahavr vpvtsnlsan
      541 itgflpihci yqllrsrsft khkvsikdwi yrqlcetstp lhpqllplid vyinsiltpa
      601 sksnpeatnq pvteqeilni fqeviggdsv rlnqrfsita qllvlyyils yeeallantk
      661 tlasmqrkpk syssslmdqi pikflirqaq glqqelgglh sallrllatn yphlcivddw
      721 iceeeitgtd allrrmllts nakthspkql qeafsavpvs htqvmqimeh ltllsaseli
      781 pyaevltsnm nqllnsgvpr rilqtvnklw mvlntvmprr lwvmtvnalq psikfirqqk
      841 ytqndlmidp livlrcdrrv hrcpplmdvt lhmlngylla skaylsahlk etaeqdrpsp
      901 nntvglvgqt dapevtreel knallaaqds aavqilleic lpteeekaka ansdislrnt
      961 qgvitigtpn kdteegedsl lcnlrevqcl iccllhqmyi adpniaklvh fqgypcellp
     1021 ltvagipsmh icldfipeli aqpelekqif aiqllshlci qyalpkslsv arlavnvmgt
     1081 lltvltqakr hsffmptlps lvsfcrafpp lyedvmsllv qigqvcasdv atqtrdidpi
     1141 itrlqqikek psgwsqiykd asykhgsrdt gsmdpdvqlc hciestviei inmsvsgi
//
