LOCUS       NM_022212               4997 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus insulin receptor-related receptor (Insrr), mRNA.
ACCESSION   NM_022212 XM_001068054 XM_574972
VERSION     NM_022212.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4997)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   2  (bases 1 to 4997)
  AUTHORS   Deyev,I.E., Sohet,F., Vassilenko,K.P., Serova,O.V., Popova,N.V.,
            Zozulya,S.A., Burova,E.B., Houillier,P., Rzhevsky,D.I.,
            Berchatova,A.A., Murashev,A.N., Chugunov,A.O., Efremov,R.G.,
            Nikol'sky,N.N., Bertelli,E., Eladari,D. and Petrenko,A.G.
  TITLE     Insulin receptor-related receptor as an extracellular alkali sensor
  JOURNAL   Cell Metab 13 (6), 679-689 (2011)
   PUBMED   21641549
REFERENCE   3  (bases 1 to 4997)
  AUTHORS   Vogel,R., Garten,A., Klammt,J., Barnikol-Oettler,A. and Kiess,W.
  TITLE     Activation of Erk1/2 phosphorylation but not of Akt/Pkb through an
            inducible CSF1R/IRR-receptor construct in INS-1E beta-cells
  JOURNAL   Arch Physiol Biochem 116 (3), 128-136 (2010)
   PUBMED   20536329
  REMARK    GeneRIF: the influence of a stimulatable IRR-tyrosine kinase on
            major IR/IGF1R signaling pathways and on proliferation and
            apoptosis of INS-1E beta-cells
REFERENCE   4  (bases 1 to 4997)
  AUTHORS   Nef,S., Verma-Kurvari,S., Merenmies,J., Vassalli,J.D.,
            Efstratiadis,A., Accili,D. and Parada,L.F.
  TITLE     Testis determination requires insulin receptor family function in
            mice
  JOURNAL   Nature 426 (6964), 291-295 (2003)
   PUBMED   14628051
REFERENCE   5  (bases 1 to 4997)
  AUTHORS   Itoh,N., Jobo,K., Tsujimoto,K., Ohta,M. and Kawasaki,T.
  TITLE     Two truncated forms of rat insulin receptor-related receptor
  JOURNAL   J Biol Chem 268 (24), 17983-17986 (1993)
   PUBMED   7688734
REFERENCE   6  (bases 1 to 4997)
  AUTHORS   Kurachi,H., Jobo,K., Ohta,M., Kawasaki,T. and Itoh,N.
  TITLE     A new member of the insulin receptor family, insulin
            receptor-related receptor, is expressed preferentially in the
            kidney
  JOURNAL   Biochem Biophys Res Commun 187 (2), 934-939 (1992)
   PUBMED   1530648
REFERENCE   7  (bases 1 to 4997)
  AUTHORS   Shier,P. and Watt,V.M.
  TITLE     Tissue-specific expression of the rat insulin receptor-related
            receptor gene
  JOURNAL   Mol Endocrinol 6 (5), 723-729 (1992)
   PUBMED   1603082
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473976.2.
            
            On or before Oct 23, 2008 this sequence version replaced
            XM_574972.2, XM_001068054.1, NM_022212.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4997
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..4997
                     /gene="Insrr"
                     /gene_synonym="Sirr"
                     /note="insulin receptor-related receptor"
                     /db_xref="GeneID:60663"
                     /db_xref="RGD:67399"
     exon            1..483
                     /gene="Insrr"
                     /gene_synonym="Sirr"
                     /inference="alignment:Splign:2.1.0"
     CDS             399..4301
                     /gene="Insrr"
                     /gene_synonym="Sirr"
                     /EC_number="2.7.10.1"
                     /note="insulin receptor-related protein; IRR; IR-related
                     receptor"
                     /codon_start=1
                     /product="insulin receptor-related protein precursor"
                     /protein_id="NP_071548.2"
                     /db_xref="GeneID:60663"
                     /db_xref="RGD:67399"
                     /translation="MAVPALWPWGVYLLMSLLSLGSCLDTLEVCPSLDIRSEVTELRR
                     LENCSVVEGHLQILLMFAATGEDFRGLSFPRLTQVTDYLLLFRVYGLESLRDLFPNLA
                     VIRGARLFLGYALIIFEMPHLRDIGLPSLGAVLRGAVRVEKNQELCHLSTIDWGLLQP
                     APGANHIVGNKLGEECADVCPGVLGAAGEPCVRTTFGGHTDYRCWTSSHCQRVCPCPR
                     GLACTVGGECCHSECLGGCSQPEDPRACVACRHLYFQGVCLPTCPPGTYQYESWRCVT
                     AELCGHLREVPGHATAFGIYEGSCLAQCPPGFTRNGSSIFCHKCEGLCPKECKVGTKT
                     IDSVQATQDLVGCTHVEGSLILNLRQGYNLEPELQRNLGLVETITGFLKIKHSFALVT
                     LGFFKNLKLIRGDSMVDGNYTLYVLDNQNLQQLGSWVAAGLTIPVGKIYFAFNPRLCL
                     EHIYQLEEVTGTRGRQSKAEINPRTNGDRAACQTRTLRFVFNLTEEDRILLRWERYEP
                     LEARDLLSFIVYYKESPFQNATEHVGPDACGTQSWNLLDVELPLSRTQEPGVTLAPLK
                     PWTQYAVFVRAITLTTAEDSPHQGAQSPIVYLRTLPAAPTVPQDVISTSNSSSHLLVR
                     WKPPVQRNGNITYYLVLWQRLAEDGDLYINDYCHRGLRLPTSSHDTRFDREDPALEAE
                     PEQGCCPCQHSPPGQALPALEAQEVTFQKKFENFLHHAITIPKAPWKVTSINKNPQRD
                     SERHRRETGLLRLGKNNSDFEIHEDKVPRERAVLSGLRHFTEYRIDIHACNHAAHTVG
                     CSAATFVFARTMPHREADGIPGKVVWKAVGKSSVILHWLEPPDPNGLILKYEIKYRRL
                     GEEATVLCVSRLRYAKVGGVHLALLPPGNYSAKVRATSLAGNGSWTDGVAFYITGPEE
                     EDTGGLRILLTVTPVGFMLLVMLAALGFFYSKKRNSTLYTSVNPEYFSASHMYVPDEW
                     EVPREQIAIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASARERVEFLKE
                     ASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPA
                     LSDMIQMAGEIADGMAYLAAKKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYY
                     RKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKF
                     VMDGGVLEEQEDCPIQLQELMRRCWQHTPRLRPTFVHILDRIQDELRPSFRLCSFYYS
                     PECQRGQASLLPTEAEPDSPPTLNGASDYGPPNGDPGH"
     exon            484..1035
                     /gene="Insrr"
                     /gene_synonym="Sirr"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1339
                     /gene="Insrr"
                     /gene_synonym="Sirr"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1482
                     /gene="Insrr"
                     /gene_synonym="Sirr"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1627
                     /gene="Insrr"
                     /gene_synonym="Sirr"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1842
                     /gene="Insrr"
                     /gene_synonym="Sirr"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1969
                     /gene="Insrr"
                     /gene_synonym="Sirr"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2208
                     /gene="Insrr"
                     /gene_synonym="Sirr"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2376
                     /gene="Insrr"
                     /gene_synonym="Sirr"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2572
                     /gene="Insrr"
                     /gene_synonym="Sirr"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2614
                     /gene="Insrr"
                     /gene_synonym="Sirr"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2835
                     /gene="Insrr"
                     /gene_synonym="Sirr"
                     /inference="alignment:Splign:2.1.0"
     exon            2836..2972
                     /gene="Insrr"
                     /gene_synonym="Sirr"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3135
                     /gene="Insrr"
                     /gene_synonym="Sirr"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3241
                     /gene="Insrr"
                     /gene_synonym="Sirr"
                     /inference="alignment:Splign:2.1.0"
     exon            3242..3294
                     /gene="Insrr"
                     /gene_synonym="Sirr"
                     /inference="alignment:Splign:2.1.0"
     exon            3295..3524
                     /gene="Insrr"
                     /gene_synonym="Sirr"
                     /inference="alignment:Splign:2.1.0"
     exon            3525..3635
                     /gene="Insrr"
                     /gene_synonym="Sirr"
                     /inference="alignment:Splign:2.1.0"
     exon            3636..3795
                     /gene="Insrr"
                     /gene_synonym="Sirr"
                     /inference="alignment:Splign:2.1.0"
     exon            3796..3925
                     /gene="Insrr"
                     /gene_synonym="Sirr"
                     /inference="alignment:Splign:2.1.0"
     exon            3926..4060
                     /gene="Insrr"
                     /gene_synonym="Sirr"
                     /inference="alignment:Splign:2.1.0"
     exon            4061..4997
                     /gene="Insrr"
                     /gene_synonym="Sirr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagggtggag tcctgcgtgt ctccggaccc tgctgccccc cccccccggg gcactcccgg
       61 gggcgctccc ggggcttcca ctctgtcttc cctcctgact gtcccacctc tggatctttg
      121 cgttcagaat cctaggtcaa tttctccctt tggatgcctc tctgaggctt cccctctcct
      181 gtctgcatct ctgttctctg gatcacactg aagctgtctc cagctgccgt cacaggcttt
      241 gtttcctctg atctgaaatt cttttctatc tcccactgtc tctacttgag atttctaatc
      301 cctttgctct tgtgtacccc ttccacactg gaacctgggt ctgactgcat cctcctttct
      361 tcctggagga tacctagaag acaatcaggg ctgaggtcat ggcagtgcct gctctgtggc
      421 cctggggagt atacttgctt atgagcctgc tgtccttggg atcttgcctg gacacactgg
      481 aggtgtgccc cagtcttgac atccgctcgg aggtgacaga gctccgtcgg ctggagaact
      541 gcagtgtggt ggagggtcac ctacagatcc tcctcatgtt tgccgccacg ggagaggact
      601 tccgaggcct cagctttcct cgcctcaccc aggtgactga ctacctgctg ctgttccgag
      661 tctatggcct agagagcctt cgagacctct tccccaacct tgctgtgatc cgaggtgcgc
      721 gcctcttcct gggctatgca cttataatct tcgagatgcc ccacttgagg gacattgggc
      781 tgccgtcgct tggggccgtg ctgcgtgggg ccgttcgtgt ggagaagaac caggaacttt
      841 gccatctctc caccattgac tggggcctgc tgcagcctgc acctggtgcc aaccacattg
      901 ttgggaacaa gctgggtgag gagtgtgctg acgtgtgccc tggtgtgctg ggggctgctg
      961 gtgagccctg tgtgagaacc accttcggtg ggcacaccga ctacaggtgt tggacctcca
     1021 gccactgtca gagagtgtgt ccctgccccc gtgggctggc ctgcacagta ggtggcgagt
     1081 gctgccacag tgaatgtctc gggggctgca gtcagcctga agaccctcga gcctgcgtag
     1141 cttgccgcca cctctacttc caaggagtct gcctccccac ctgccctccg ggcacctacc
     1201 agtatgagtc ttggcggtgt gtcactgcgg agctctgtgg ccatctgcga gaggttcctg
     1261 gacatgccac cgcctttggc atctacgagg gcagctgcct agctcagtgc cctccaggct
     1321 tcacccgtaa tggcagcagc attttctgcc ataagtgtga gggcctgtgc cccaaagagt
     1381 gcaaggttgg gacaaagacc atcgactctg tccaagccac acaggaccta gtgggctgca
     1441 cccatgtgga ggggagcctc atcctcaacc ttcgacaagg ctacaatctg gagccagagc
     1501 ttcaacgcaa cctggggctg gtggagacca tcaccggctt cctcaaaatc aagcactctt
     1561 ttgcactcgt gaccctggga tttttcaaga acctcaaact aatccgggga gattccatgg
     1621 tggatgggaa ctacactctg tacgtgttag acaaccagaa cctgcaacag ttggggtctt
     1681 gggtggccgc agggctcacc attcccgtgg gcaaaatata cttcgccttc aacccacgcc
     1741 tctgcctgga gcacatatac caactggaag aggtgaccgg aaccagaggc cggcaaagca
     1801 aggctgaaat caacccccgg accaatggag atcgtgctgc ctgccagact cgcactctgc
     1861 gctttgtgtt caacctgacc gaggaggacc gcatcctcct gcgctgggag cgctatgagc
     1921 cactggaggc ccgtgacctg ctcagcttca tcgtctatta caaggagtcc ccattccaga
     1981 atgccacaga acacgtgggt ccagacgcct gtggaactca gagctggaat ctgttggatg
     2041 tggaactacc cctcagccgc acccaggagc ccggggtgac cctagccccc ctaaagccct
     2101 ggacgcagta tgctgtgttt gtgcgagcca tcacactgac cacggctgag gacagccccc
     2161 atcagggagc ccagagcccc attgtctacc tgcgaacatt acctgcagca cccacagtac
     2221 cccaggacgt catctccacc tccaattcct cttcacacct cctggtgcgc tggaagccgc
     2281 cggtccagcg caatggaaac atcacctatt acctggtgtt gtggcagcgg ctagcagagg
     2341 acggtgacct ctacatcaat gactactgcc accgcggtct gcggctgccc accagcagcc
     2401 acgacacacg cttcgaccgt gaagacccgg cgctggaggc tgagccggag caaggctgct
     2461 gtccttgcca acactcgcct cctggtcagg ccctgcctgc actggaggca caagaggtca
     2521 ccttccagaa aaagtttgaa aacttcctac accatgccat caccatcccc aaggccccgt
     2581 ggaaagtgac atccatcaac aagaaccccc aaagggattc ggagaggcac cgccgggaaa
     2641 ctgggcttct cagactaggg aaaaacaact cggattttga gattcatgag gacaaggttc
     2701 cccgggagcg agcagtattg agcggcttgc gacacttcac agaatacagg attgacatcc
     2761 atgcctgcaa ccacgcggca cacactgtgg gctgcagcgc tgccaccttc gtctttgcac
     2821 gcaccatgcc acatagagag gccgatggca tcccagggaa agtggtctgg aaggcggttg
     2881 gcaagagcag tgtcatcttg cattggcttg agccacctga ccccaatggg ctcatcctca
     2941 agtatgaaat caagtaccgc cgccttggag aggaggccac agtgctttgt gtgtcccgtc
     3001 ttcgatatgc caaagttggt ggggtccacc tggctctgct gcctcctgga aactactctg
     3061 ctaaagttcg ggccacctca ttggctggca atggctcctg gactgacggt gttgccttct
     3121 acatcaccgg tccagaggaa gaggatactg ggggactgcg catcctcctc actgtcaccc
     3181 ctgtcggctt catgctgctc gtgatgcttg ctgcccttgg tttcttctac agcaaaaaga
     3241 gaaacagcac gctgtacaca tccgtgaacc cggagtattt tagtgcatcc cacatgtatg
     3301 tccccgacga gtgggaggtc cctcgggagc agatagccat catccgcgag ctgggccagg
     3361 gctcttttgg gatggtatat gagggactgg cacgaggact tgaggctgga gaggagtcta
     3421 cacctgtagc cctgaagaca gttaatgagc tggccagcgc tcgggaacgc gttgaattcc
     3481 tcaaggaagc atctgtcatg aaggccttca agtgtcacca tgtggtccgt ctcctgggtg
     3541 tggtgtctca gggccagcca actttggtca tcatggagtt aatgacccgt ggagacctca
     3601 agagccatct ccgatctctg agacctgagg cagagaacaa ccctggcctc ccacagccag
     3661 cactcagtga catgattcag atggctggtg agattgcaga tggcatggcc tatcttgctg
     3721 ccaagaagtt tgtgcaccgg gacctggcag cccgcaactg catggtgtct caggatttta
     3781 ccgtcaaaat tggtgacttc ggaatgactc gggatgtgta cgagacagac tattaccgca
     3841 agggtggaaa ggggctactg cctgtgcgct ggatggcccc tgagtccctc aaagacggaa
     3901 tcttcaccac tcactcagac gtctggtcct ttggtgtggt gctctgggag attgtgaccc
     3961 tagctgaaca accgtaccag ggcctatcaa acgagcaggt gctgaagttt gtcatggacg
     4021 gtggagttct agaggagcaa gaggattgtc caattcagct acaggagctg atgagacgct
     4081 gctggcagca tactccacgc ctgcgcccga ctttcgtcca catcctggat cgcatacagg
     4141 atgaacttcg tccctctttc cggctctgct ccttctacta cagccccgag tgtcagcggg
     4201 gccaggcctc cttgctgcct actgaggcag agcctgactc cccaccaacc ttaaatggag
     4261 cttcagacta tggtccccca aatggggacc caggacactg aagggtcaac ctttcccaac
     4321 ctgactggcc tgccatgggc agggaaggca gaacccaacc ttcatggcca gctgttcccc
     4381 tctcaccccg aatcccccta agacgggtca agaattagct cagcactagc agagagcagg
     4441 tgccagaaag ggaggcatct gaactcatag acgatagcct aacaaactca cagggacagc
     4501 ctgtgggagg gactcacaag gcagaaatgt cctgccctca gagagaagca ctgccaccgg
     4561 ggcagggtcc agagacacgt ccccttcaac ttcaggtgtc aacagcttga aagcgaatga
     4621 gaggcaggcc tggagatctt tctactcccg ttggggtctg gacacaaatg tccacagaca
     4681 attccttctt tccctgtggt agactcctcc tctctgcccc acataccagg accctgagca
     4741 agtgggtctc acacatggcc ctcacttctc tccccctgct ctacccaggg acctcaagct
     4801 tggtgctcct cctttgcctc aagggcatcc cttgatgtgc agtttcccct tctccaggtg
     4861 tcccctggat tgctagccct gaatgctaag gttgcaagag ccttgtctcc ccctctcccc
     4921 ctgtcccttc tcccacacag cctctcccgg gaagactgga gaagactcaa taaataccaa
     4981 ggtctgtttg tatttgg
//
