LOCUS       NM_001399746            2934 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus INSM transcriptional repressor 1 (Insm1), mRNA.
ACCESSION   NM_001399746 XM_006235176
VERSION     NM_001399746.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2934)
  AUTHORS   Osipovich,A.B., Long,Q., Manduchi,E., Gangula,R., Hipkens,S.B.,
            Schneider,J., Okubo,T., Stoeckert,C.J. Jr., Takada,S. and
            Magnuson,M.A.
  TITLE     Insm1 promotes endocrine cell differentiation by modulating the
            expression of a network of genes that includes Neurog3 and Ripply3
  JOURNAL   Development 141 (15), 2939-2949 (2014)
   PUBMED   25053427
REFERENCE   2  (bases 1 to 2934)
  AUTHORS   Welcker,J.E., Hernandez-Miranda,L.R., Paul,F.E., Jia,S., Ivanov,A.,
            Selbach,M. and Birchmeier,C.
  TITLE     Insm1 controls development of pituitary endocrine cells and
            requires a SNAG domain for function and for recruitment of
            histone-modifying factors
  JOURNAL   Development 140 (24), 4947-4958 (2013)
   PUBMED   24227653
REFERENCE   3  (bases 1 to 2934)
  AUTHORS   Zhang,T., Liu,W.D., Saunee,N.A., Breslin,M.B. and Lan,M.S.
  TITLE     Zinc finger transcription factor INSM1 interrupts cyclin D1 and
            CDK4 binding and induces cell cycle arrest
  JOURNAL   J Biol Chem 284 (9), 5574-5581 (2009)
   PUBMED   19124461
REFERENCE   4  (bases 1 to 2934)
  AUTHORS   Wang,H.W., Muguira,M., Liu,W.D., Zhang,T., Chen,C., Aucoin,R.,
            Breslin,M.B. and Lan,M.S.
  TITLE     Identification of an INSM1-binding site in the insulin promoter:
            negative regulation of the insulin gene transcription
  JOURNAL   J Endocrinol 198 (1), 29-39 (2008)
   PUBMED   18417529
  REMARK    GeneRIF: INSM1 is a new zinc-finger transcription factor that
            modulates insulin gene transcription during early pancreas
            development.
REFERENCE   5  (bases 1 to 2934)
  AUTHORS   Wildner,H., Gierl,M.S., Strehle,M., Pla,P. and Birchmeier,C.
  TITLE     Insm1 (IA-1) is a crucial component of the transcriptional network
            that controls differentiation of the sympatho-adrenal lineage
  JOURNAL   Development 135 (3), 473-481 (2008)
   PUBMED   18094025
REFERENCE   6  (bases 1 to 2934)
  AUTHORS   Gierl,M.S., Karoulias,N., Wende,H., Strehle,M. and Birchmeier,C.
  TITLE     The zinc-finger factor Insm1 (IA-1) is essential for the
            development of pancreatic beta cells and intestinal endocrine cells
  JOURNAL   Genes Dev 20 (17), 2465-2478 (2006)
   PUBMED   16951258
REFERENCE   7  (bases 1 to 2934)
  AUTHORS   Liu,W.D., Wang,H.W., Muguira,M., Breslin,M.B. and Lan,M.S.
  TITLE     INSM1 functions as a transcriptional repressor of the neuroD/beta2
            gene through the recruitment of cyclin D1 and histone deacetylases
  JOURNAL   Biochem J 397 (1), 169-177 (2006)
   PUBMED   16569215
REFERENCE   8  (bases 1 to 2934)
  AUTHORS   Mellitzer,G., Bonne,S., Luco,R.F., Van De Casteele,M.,
            Lenne-Samuel,N., Collombat,P., Mansouri,A., Lee,J., Lan,M.,
            Pipeleers,D., Nielsen,F.C., Ferrer,J., Gradwohl,G. and Heimberg,H.
  TITLE     IA1 is NGN3-dependent and essential for differentiation of the
            endocrine pancreas
  JOURNAL   EMBO J 25 (6), 1344-1352 (2006)
   PUBMED   16511571
REFERENCE   9  (bases 1 to 2934)
  AUTHORS   Xie,J., Cai,T., Zhang,H., Lan,M.S. and Notkins,A.L.
  TITLE     The zinc-finger transcription factor INSM1 is expressed during
            embryo development and interacts with the Cbl-associated protein
  JOURNAL   Genomics 80 (1), 54-61 (2002)
   PUBMED   12079283
REFERENCE   10 (bases 1 to 2934)
  AUTHORS   Breslin,M.B., Zhu,M., Notkins,A.L. and Lan,M.S.
  TITLE     Neuroendocrine differentiation factor, IA-1, is a transcriptional
            repressor and contains a specific DNA-binding domain:
            identification of consensus IA-1 binding sequence
  JOURNAL   Nucleic Acids Res 30 (4), 1038-1045 (2002)
   PUBMED   11842116
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jan 13, 2022 this sequence version replaced XM_006235176.4.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR22582416.1301412.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2934              JAXUCZ010000003.1  154093310-154096243
FEATURES             Location/Qualifiers
     source          1..2934
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..2934
                     /gene="Insm1"
                     /note="INSM transcriptional repressor 1"
                     /db_xref="GeneID:100912563"
                     /db_xref="RGD:6486258"
     exon            1..2934
                     /gene="Insm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1737
                     /gene="Insm1"
                     /note="insulinoma-associated protein 1-like;
                     insulinoma-associated 1"
                     /codon_start=1
                     /product="insulinoma-associated protein 1"
                     /protein_id="NP_001386675.1"
                     /db_xref="GeneID:100912563"
                     /db_xref="RGD:6486258"
                     /translation="MPRGFLVKRSKKSTPVSYRVRGGEDCDRALLLSPGCGGARAEPP
                     VPSPGPLPPPPPPALAERAHAALAAALACAPGPPPPPPGPRAAHFGNPEAAHPAPLYS
                     PTRPVSREHEKHKYFERSFNLGSPVSAESFPTPAALLAGGGGGANGAGGGGGGTCGGD
                     ALLFAPAELKMGTAFSAGAEAARGPGPGPPLSPAAALRPPGKRPAAPAAVAAEPPAKA
                     AKAPSAKKPKAIRKLHFEDEVTTSPVLGLKIKEGPVEAPRGRAGGATRPLGEFICQLC
                     KEEYADPFALAQHKCSRIVRVEYRCPECAKVFSCPANLASHRRWHKPRPAPAAARAPE
                     PEAATRAEAREAAGGGGSSDRDTPSPGGVSESGSEDGLYECHHCAKKFRRQAYLRKHL
                     LAHHQALQAKGAPPPPPPPPPPPAEDILAFYAGPDEKAPQEASGDGEAVGVLGLSAAT
                     ECHLCPVCGETFPSKGAQERHLRLLHAAQVFPCKYCPATFYSSPGLTRHINKCHPSEN
                     RQVILLQVPVRPAC"
ORIGIN      
        1 gacagggacg cgtgtgcgga gcgcagagcc gggccagcag ccgcgggcac cgcgcgagtc
       61 ccgaagccgc cgcgtgcagg cgatgggctg ggggcactga gggccgccag ggccaagcac
      121 ggaggtggga cccagccagt gcgtcgtcgc cctttgcacc gcgccaacat gccccgcggg
      181 ttcctggtga agcgcagcaa gaagtccacg cccgtgtcct accgggtccg cggcggcgag
      241 gactgtgacc gcgcgctgct gctgtcaccc ggctgcgggg gcgcccgcgc cgagcccccc
      301 gtgcccagcc ccgggccgct accgccacct ccgccgccgg cgctcgccga gcgcgcccat
      361 gctgcgctcg ccgccgctct tgcctgcgcg ccgggcccac cgccaccccc tccggggccg
      421 cgggccgcgc acttcggcaa cccggaggct gcgcaccccg cgcctctcta cagccccacg
      481 cggccggtga gtcgcgagca cgagaagcac aagtacttcg agcgcagctt caacctgggc
      541 tcgccggtgt ctgccgagtc cttccctacg cccgctgcac tgctcgcagg gggaggcggc
      601 ggcgccaacg gcgctggcgg cggcggtggc ggcacctgcg gcggagacgc gctgctcttc
      661 gcgccggccg agctcaagat gggcactgcg ttctccgccg gcgccgaggc ggctcggggt
      721 cctgggcccg gtcctccact gtcccccgcc gcggccctgc ggccccccgg caagcgaccc
      781 gcggcccctg ccgctgtcgc tgcagagcct cccgccaagg cagccaaggc cccgagcgcc
      841 aaaaagccta aggccatccg caagctgcac ttcgaggacg aggtgaccac gtcgccggtg
      901 ctggggctca agatcaagga gggtccggtg gaggcgccgc ggggccgcgc ggggggcgcg
      961 acccgacccc tgggcgagtt catctgccag ctgtgcaagg aggagtacgc cgatccgttc
     1021 gcgctggcgc agcacaagtg ctcgcgcatc gtgcgcgtgg agtaccgctg ccccgaatgc
     1081 gccaaggtct tcagctgccc ggccaacctg gcctcgcacc gccgctggca caaaccgcgg
     1141 ccggcgcccg cggcggcccg cgctccagag ccagaagccg ccaccagggc ggaggcgcgc
     1201 gaggctgcgg gcggcggcgg cagcagcgat cgggacacgc cgagccctgg cggcgtatcc
     1261 gagtcaggct ccgaggacgg gctctacgag tgccaccact gcgccaagaa gttccgtcgt
     1321 caggcctatc tgcgtaagca cctgctggca catcaccagg cgctgcaggc caaaggcgcg
     1381 ccgccgcccc cgccgccgcc gccgccgccc cctgccgagg acatcctggc tttctacgcg
     1441 gggcccgacg aaaaggcgcc ccaggaggcc tcgggggacg gcgaggcggt cggcgtgctg
     1501 ggcctgagtg cggccaccga gtgccacctg tgcccagtgt gcggggagac cttccccagc
     1561 aagggcgccc aggagcgcca cctgcgcctg ctgcacgctg cccaggtgtt cccctgcaag
     1621 tactgcccgg ccaccttcta cagctccccc ggcctgacgc ggcacatcaa caagtgccac
     1681 ccgtctgaga atagacaggt gatcctcctt caggtgcccg tgcgtccggc ctgctagagt
     1741 gcgccctcgg tccgggcccc tagaactgtg ccttcacttg gagacccaca aagagagcgc
     1801 gcgtcccatg cctgatctgg ggggccccta cccccaatcc gggatgaaag tgtcgtcttc
     1861 gcttctcttg gtgcggcgtg acggtaaccc tggtcttctc gctgtgactc ctttggaccc
     1921 cacccccttt gcgttgtgtc ccctaccccc aatcccatgg cgcaacagga gtccgtctct
     1981 gtacagggga gaaaaaaaat gctgtatacg tttatctcgt ggttggacgc ctctctttga
     2041 ggggtgaagc tgtttttctt gctagtattc actgtgttca tggtctagaa aatgcggttt
     2101 gctctgccta ccaatctctg ctctcaatgt ctgtagcgta cgggttgttt tgggtgaatc
     2161 ttgaggaata aatgccttta tatttcacag gctgtaaatt gaacttccca cacgattagc
     2221 tttattatgg cttgtgaact gctggagtct ggctttacct ttttgtatgt gaacaaatca
     2281 aattgcttaa aaaagagttt tctttagtat agccacaaat gccttgacct gttgtctgtt
     2341 ggggattgtt ttttgggggt gggaggagtt ttaacgagat gctgtagtaa ctgccttagt
     2401 atttcacgga agacttttgg tttgatcatc tttgttgagg tagaactatt gagttccctt
     2461 tacgtgtata tgttgattta tgcctaattg ttatttattc tttatttatt tatattaatt
     2521 atgaagatta tgatattatt tgattgcaga ttcttctctt tttccttttc tttctttctt
     2581 tcttttcttt tcttttcttt tttcttttct ttcttttttt ttttttttgt gagctttccc
     2641 cctgccacct ttgacatttc actgtgcatt ttaggaaaga acctttttgc tagaggggcc
     2701 tgctgaaagt ttttaacttt tctatctatc gagggaatta cagacaacgt accattttat
     2761 tctgcttgag gggccccaag gcccttgtac aaccgacagc tcttactttt aaatgcaatc
     2821 tcttttctac atacattatt ttcttaattg ttagctattt atagaaagct tcgatagaac
     2881 tgtttcaact gtataaatat ttactattca aataaaatat tttcaaagtc aaaa
//
