LOCUS       NM_022392               2421 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus insulin induced gene 1 (Insig1), mRNA.
ACCESSION   NM_022392
VERSION     NM_022392.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2421)
  AUTHORS   Tong,X., Christian,P., Zhao,M., Wang,H., Moreau,R. and Su,Q.
  TITLE     Activation of hepatic CREBH and Insig signaling in the
            anti-hypertriglyceridemic mechanism of R-alpha-lipoic acid
  JOURNAL   J Nutr Biochem 26 (9), 921-928 (2015)
   PUBMED   26007286
  REMARK    GeneRIF: Data suggest expression of hepatocyte Insig1/Insig2a and
            Crebh/Creb3l3 (cAMP responsive element-binding protein 3-like 3
            protein) can be up-regulated by dietary factors (here, dietary
            supplementation with hypotriglyceridemic R-alpha-lipoic acid).
REFERENCE   2  (bases 1 to 2421)
  AUTHORS   Boden,G., Salehi,S., Cheung,P., Homko,C., Song,W.,
            Loveland-Jones,C. and Jayarajan,S.
  TITLE     Comparison of in vivo effects of insulin on SREBP-1c activation and
            INSIG-1/2 in rat liver and human and rat adipose tissue
  JOURNAL   Obesity (Silver Spring) 21 (6), 1208-1214 (2013)
   PUBMED   23913732
  REMARK    GeneRIF: INSIG-1 is decreased by insulin in liver and increased in
            fat.
REFERENCE   3  (bases 1 to 2421)
  AUTHORS   Chen,K., Jin,P., He,H.H., Xie,Y.H., Xie,X.Y. and Mo,Z.H.
  TITLE     Overexpression of Insig-1 protects beta cell against
            glucolipotoxicity via SREBP-1c
  JOURNAL   J Biomed Sci 18 (1), 57 (2011)
   PUBMED   21843373
  REMARK    GeneRIF: Overexpression of Insig-1 protects beta cells against
            glucolipotoxicity via SREBP-1c.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2421)
  AUTHORS   Osborne,T.F. and Espenshade,P.J.
  TITLE     Evolutionary conservation and adaptation in the mechanism that
            regulates SREBP action: what a long, strange tRIP it's been
  JOURNAL   Genes Dev 23 (22), 2578-2591 (2009)
   PUBMED   19933148
  REMARK    Review article
REFERENCE   5  (bases 1 to 2421)
  AUTHORS   Palaniappan,M. and Menon,K.M.
  TITLE     Regulation of sterol regulatory element-binding transcription
            factor 1a by human chorionic gonadotropin and insulin in cultured
            rat theca-interstitial cells
  JOURNAL   Biol Reprod 81 (2), 284-292 (2009)
   PUBMED   19299314
REFERENCE   6  (bases 1 to 2421)
  AUTHORS   Wu,X., Pang,S.T., Sahlin,L., Blanck,A., Norstedt,G. and
            Flores-Morales,A.
  TITLE     Gene expression profiling of the effects of castration and estrogen
            treatment in the rat uterus
  JOURNAL   Biol Reprod 69 (4), 1308-1317 (2003)
   PUBMED   12801995
REFERENCE   7  (bases 1 to 2421)
  AUTHORS   Li,J., Takaishi,K., Cook,W., McCorkle,S.K. and Unger,R.H.
  TITLE     Insig-1 'brakes' lipogenesis in adipocytes and inhibits
            differentiation of preadipocytes
  JOURNAL   Proc Natl Acad Sci U S A 100 (16), 9476-9481 (2003)
   PUBMED   12869692
REFERENCE   8  (bases 1 to 2421)
  AUTHORS   Yabe,D., Brown,M.S. and Goldstein,J.L.
  TITLE     Insig-2, a second endoplasmic reticulum protein that binds SCAP and
            blocks export of sterol regulatory element-binding proteins
  JOURNAL   Proc Natl Acad Sci U S A 99 (20), 12753-12758 (2002)
   PUBMED   12242332
REFERENCE   9  (bases 1 to 2421)
  AUTHORS   Yang,T., Espenshade,P.J., Wright,M.E., Yabe,D., Gong,Y.,
            Aebersold,R., Goldstein,J.L. and Brown,M.S.
  TITLE     Crucial step in cholesterol homeostasis: sterols promote binding of
            SCAP to INSIG-1, a membrane protein that facilitates retention of
            SREBPs in ER
  JOURNAL   Cell 110 (4), 489-500 (2002)
   PUBMED   12202038
REFERENCE   10 (bases 1 to 2421)
  AUTHORS   Diamond,R.H., Du,K., Lee,V.M., Mohn,K.L., Haber,B.A., Tewari,D.S.
            and Taub,R.
  TITLE     Novel delayed-early and highly insulin-induced growth response
            genes. Identification of HRS, a potential regulator of alternative
            pre-mRNA splicing
  JOURNAL   J Biol Chem 268 (20), 15185-15192 (1993)
   PUBMED   7686911
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_022392.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L13619.1, BC078827.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-406               JAXUCZ010000004.1  8057364-8057769     c
            407-531             JAXUCZ010000004.1  8055505-8055629     c
            532-698             JAXUCZ010000004.1  8054475-8054641     c
            699-798             JAXUCZ010000004.1  8053947-8054046     c
            799-2421            JAXUCZ010000004.1  8049555-8051177     c
FEATURES             Location/Qualifiers
     source          1..2421
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..2421
                     /gene="Insig1"
                     /note="insulin induced gene 1"
                     /db_xref="GeneID:64194"
                     /db_xref="RGD:708457"
     exon            1..406
                     /gene="Insig1"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..828
                     /gene="Insig1"
                     /note="growth response protein (CL-6); INSIG-1;
                     immediate-early protein CL-6; insulin-induced growth
                     response protein CL-6"
                     /codon_start=1
                     /product="insulin-induced gene 1 protein"
                     /protein_id="NP_071787.1"
                     /db_xref="GeneID:64194"
                     /db_xref="RGD:708457"
                     /translation="MPRLHDHVWSYPSAGAARPYSLPRGMIAAALCPQGPGAPEPEPA
                     PRGQREGTAGFSARPGSWHHDLVQRSLVLFSFGVVLALVLNLLQIQRNVTLFPDEVIA
                     TIFSSAWWVPPCCGTAAAVVGLLYPCIDSHLGEPHKFKREWASVMRCIAVFVGINHAS
                     AKLDFANNVQLSLTLAALSLGLWWTFDRSRSGLGLGITIAFLATLITQFLVYNGVYQY
                     TSPDFLYIRSWLPCIFFSGGVTVGNIGRQLAMGVPEKPHSD"
     exon            407..531
                     /gene="Insig1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..698
                     /gene="Insig1"
                     /inference="alignment:Splign:2.1.0"
     exon            699..798
                     /gene="Insig1"
                     /inference="alignment:Splign:2.1.0"
     exon            799..2421
                     /gene="Insig1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tacgcgtgct ttggtggcgt gcacctctca cggtgtgcct agccgccgat gcccaggctg
       61 cacgatcacg tctggagcta cccaagcgcg ggcgctgcga ggccgtacag cctcccgcga
      121 ggcatgattg cggcggccct ctgtccgcag ggccccggag cccccgagcc cgagcccgcg
      181 ccccggggcc agcgagaggg aaccgcaggc ttcagcgcac gacccggcag ctggcaccac
      241 gacctggtgc agcggagcct cgtgctcttc tcatttggcg tggtcctggc tctggtgctc
      301 aacctgctgc agatccagcg gaatgtcacg ctcttcccgg acgaggtgat agccaccatc
      361 ttctcctccg cctggtgggt gcccccgtgc tgtggcacgg cagccgctgt tgtcggctta
      421 ttgtatccct gtattgacag tcacctggga gaaccacaca agttcaagag agagtgggcc
      481 agtgtcatgc gatgtatcgc ggtgtttgtt ggcatcaacc atgccagtgc caaattagat
      541 ttcgccaata atgtgcagct gtccctgact ctggcagccc tatccttggg cttgtggtgg
      601 acgtttgatc gatcccgaag tggcctgggg ctcgggatca ccatcgcctt cctagccacg
      661 ctgatcactc agtttcttgt ttataatggc gtctaccagt acacgtcccc agatttcctc
      721 tatatccgtt cttggctccc ttgtatattt ttctcaggag gtgtcacagt gggaaacata
      781 ggacgacagt tagctatggg tgttccagaa aagcctcaca gtgactgagt ttgagcacat
      841 gattcagggc ggaagcagaa tgtggagaca ctggtcctgg gtgtggtgaa gaggatcttt
      901 ttctcaatgt tccatttaga ctgggctgat gataaatgac tcctaaagat gcgttcacgt
      961 agtctaaata gcaagtggag gcaaggacta cttacctaaa gtcttacctt gctcacccac
     1021 cctcacacct gtctgcactg gaacattcta tcccaggctg tatgtgagag ttgggtaagg
     1081 gggccggttt cccgagtatt agatttcact catcattcaa agcaaaatgc catatttcaa
     1141 agccttgaat caaaatgaat taccaactag cagttttata tcagtgccca aaggagagag
     1201 gttgatggtg cttaacagag atgaagtatg tgcagtaaga atatttatcc agaattaaaa
     1261 tatagggttg tgtaaagagg ggctaagggc agcagtaagt tggaggaaga tcatgctccc
     1321 cggaggaccc agtgcagcca catctccagg tctcgctcag gctggcgctc acacgtgggt
     1381 ctcatcagtg tgggaactat gctgtttact gacaggaggt ttgtagacaa tcttactgac
     1441 agcccaggac aacacaaagt caggattctg cattgcgatg ctggactttt catctcaatt
     1501 taagtgaagt tttatccaag atctggacca tctaagagtg aatagctgtc tgctgtttca
     1561 gtcgtaatga gccgaaattg tgtctctgtc actccagagt ggagaggact tttccacagc
     1621 cctatggagc ttgcaatctg tgattgcctt gtaaaaggtt gagtgtgcac gtcactgcgt
     1681 tcggtgcgca gtgtcctgtg tgtgttggac agcgtagaac acatgggacc ttgcaagtat
     1741 tgggtcttca acttcaagtg caatgtgtat gaaaccaatc tgagccttgt attctcttaa
     1801 atatttatta ttttttttaa ccgcgcgagc tgttctggag aagggttctc gggtcatttc
     1861 agagctgtgt ggaggcacac tcagcaatac tgtgtcagcc gtgacgctcc ccagtcacac
     1921 cctccactac accctagtcc tctgacatac tccaggtttg taagtttagt gatttttact
     1981 tacaaattta cccttttttg cattctaaaa tgtgtttgtt ttaaattata tggaactgac
     2041 ttggtgaggc agtcattggt ccccgggcag gcagaagctc tgcctgtggg aatcgggttt
     2101 gggttcactc ttgcagggct cctcatagag gctttgctta ttttgttttg aggaaaatgt
     2161 ctggagtaaa cctttgtttt ctgaaactac tttagctaaa agaaaatggg ttgttctaga
     2221 ctttggaatg gttcttaaag tttcctggaa ataaaaataa atgattggca cttcaaagac
     2281 attctttagc caagacttca gtgtctagca gaaaccacaa gtgactagaa gagcaagtga
     2341 tcttggtgat gcacttgatt gtatacaatg agtatttttt ctcttaaact ggaaataaat
     2401 ctgttagaaa taatgtagcc a
//
