LOCUS       NM_022944               4830 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Rattus norvegicus inositol polyphosphate phosphatase-like 1
            (Inppl1), transcript variant 1, mRNA.
ACCESSION   NM_022944
VERSION     NM_022944.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4830)
  AUTHORS   Huber,C., Faqeih,E.A., Bartholdi,D., Bole-Feysot,C.,
            Borochowitz,Z., Cavalcanti,D.P., Frigo,A., Nitschke,P., Roume,J.,
            Santos,H.G., Shalev,S.A., Superti-Furga,A., Delezoide,A.L., Le
            Merrer,M., Munnich,A. and Cormier-Daire,V.
  TITLE     Exome sequencing identifies INPPL1 mutations as a cause of
            opsismodysplasia
  JOURNAL   Am J Hum Genet 92 (1), 144-149 (2013)
   PUBMED   23273569
REFERENCE   2  (bases 1 to 4830)
  AUTHORS   Ijuin,T. and Takenawa,T.
  TITLE     Regulation of insulin signaling and glucose transporter 4 (GLUT4)
            exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3)
            phosphatase, skeletal muscle, and kidney enriched inositol
            polyphosphate phosphatase (SKIP)
  JOURNAL   J Biol Chem 287 (10), 6991-6999 (2012)
   PUBMED   22247557
  REMARK    GeneRIF: Regulation of insulin signaling and glucose transporter 4
            (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate
            (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol
            polyphosphate phosphatase (SKIP).
REFERENCE   3  (bases 1 to 4830)
  AUTHORS   Hasegawa,J., Tokuda,E., Tenno,T., Tsujita,K., Sawai,H., Hiroaki,H.,
            Takenawa,T. and Itoh,T.
  TITLE     SH3YL1 regulates dorsal ruffle formation by a novel
            phosphoinositide-binding domain
  JOURNAL   J Cell Biol 193 (5), 901-916 (2011)
   PUBMED   21624956
REFERENCE   4  (bases 1 to 4830)
  AUTHORS   Mandl,A., Sarkes,D., Carricaburu,V., Jung,V. and Rameh,L.
  TITLE     Serum withdrawal-induced accumulation of phosphoinositide 3-kinase
            lipids in differentiating 3T3-L6 myoblasts: distinct roles for
            Ship2 and PTEN
  JOURNAL   Mol Cell Biol 27 (23), 8098-8112 (2007)
   PUBMED   17893321
  REMARK    GeneRIF: These results reveal the existence of two distinct pools
            of PI3K lipids in myoblasts: a pool dephosphorylated by PTEN,
            capable of activating Akt and promoting myoblast differentiation
            and a stable pool dephosphorylated by Ship2 and unable to activate
            Akt.
REFERENCE   5  (bases 1 to 4830)
  AUTHORS   Aoki,K., Nakamura,T., Inoue,T., Meyer,T. and Matsuda,M.
  TITLE     An essential role for the SHIP2-dependent negative feedback loop in
            neuritogenesis of nerve growth factor-stimulated PC12 cells
  JOURNAL   J Cell Biol 177 (5), 817-827 (2007)
   PUBMED   17535963
  REMARK    GeneRIF: SHIP2-mediated negative feedback on PIP(3) coordinately
            works with the PI3-kinase-mediated positive feedback to maintain
            proper neurite outgrowth.
REFERENCE   6  (bases 1 to 4830)
  AUTHORS   Sasaoka,T., Hori,H., Wada,T., Ishiki,M., Haruta,T., Ishihara,H. and
            Kobayashi,M.
  TITLE     SH2-containing inositol phosphatase 2 negatively regulates
            insulin-induced glycogen synthesis in L6 myotubes
  JOURNAL   Diabetologia 44 (10), 1258-1267 (2001)
   PUBMED   11692174
REFERENCE   7  (bases 1 to 4830)
  AUTHORS   Clement,S., Krause,U., Desmedt,F., Tanti,J.F., Behrends,J.,
            Pesesse,X., Sasaki,T., Penninger,J., Doherty,M., Malaisse,W.,
            Dumont,J.E., Le Marchand-Brustel,Y., Erneux,C., Hue,L. and
            Schurmans,S.
  TITLE     The lipid phosphatase SHIP2 controls insulin sensitivity
  JOURNAL   Nature 409 (6816), 92-97 (2001)
   PUBMED   11343120
  REMARK    Erratum:[Nature. 2004 Oct 14;431(7010):878]
REFERENCE   8  (bases 1 to 4830)
  AUTHORS   Kudo,M., Saito,S., Owada,Y., Suzaki,H. and Kondo,H.
  TITLE     Localization of mRNA for SHIP2, SH2 domain-containing inositol
            polyphosphate 5-phosphatase, in the brain of developing and mature
            rats
  JOURNAL   Brain Res Mol Brain Res 75 (1), 172-177 (2000)
   PUBMED   10648902
REFERENCE   9  (bases 1 to 4830)
  AUTHORS   Ishihara,H., Sasaoka,T., Hori,H., Wada,T., Hirai,H., Haruta,T.,
            Langlois,W.J. and Kobayashi,M.
  TITLE     Molecular cloning of rat SH2-containing inositol phosphatase 2
            (SHIP2) and its role in the regulation of insulin signaling
  JOURNAL   Biochem Biophys Res Commun 260 (1), 265-272 (1999)
   PUBMED   10381377
REFERENCE   10 (bases 1 to 4830)
  AUTHORS   Slama,V. and Dudek,J.
  TITLE     [Stability of diluted solutions of peracetic acid]
  JOURNAL   Cesk Farm 17 (1), 40-41 (1968)
   PUBMED   5668240
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB025794.1, FQ139232.1, CK653108.1, AB011439.1, BQ199460.1 and
            CA506674.1.
            
            On Aug 3, 2012 this sequence version replaced NM_022944.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB025794.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AB025794.1         3-114
            113-252             FQ139232.1         149-288
            253-2846            AB025794.1         251-2844
            2847-2949           CK653108.1         573-675
            2950-3775           AB025794.1         2948-3773
            3776-3836           AB011439.1         3720-3780
            3837-4438           AB025794.1         3835-4436
            4439-4820           BQ199460.1         7-388               c
            4821-4830           CA506674.1         1-10                c
FEATURES             Location/Qualifiers
     source          1..4830
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..4830
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /note="inositol polyphosphate phosphatase-like 1"
                     /db_xref="GeneID:65038"
                     /db_xref="RGD:68396"
     exon            1..82
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            83..469
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..4061
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /EC_number="3.1.3.86"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SHIP-2; INPPL-1; inositol polyphosphate phosphatase-like
                     protein 1; SH2 domain-containing inositol phosphatase 2;
                     protein 51C; SH2-containing inositol phosphatase 2; SH2
                     domain-containing inositol 5'-phosphatase 2;
                     phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2"
                     /codon_start=1
                     /product="phosphatidylinositol 3,4,5-trisphosphate
                     5-phosphatase 2 isoform 1"
                     /protein_id="NP_075233.1"
                     /db_xref="GeneID:65038"
                     /db_xref="RGD:68396"
                     /translation="MASVCGAPSPGGALGSQAPAWYHRDLSRAAAEELLARAGRDGSF
                     LVRDSESVAGAFALCVLYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLY
                     AQPNQGLVCALLLPVEGEREPDPPDDRDASDVEDEKPPLPPRSGSTSISVPAGPSSPL
                     PAPETPTTPAAESTPNGLSTVSHEYLKGSYGLDLEAVRGGASNLPHLTRTLVTSCRRL
                     HSEVDKVLSGLEILSKVFDQQSSPMVTRLLQQQSLPQTGEQELESLVLKLSVLKDFLS
                     GIQKKALKALQDMSSTAPPAPLQPSIRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFT
                     LSVDVEGGRLVLLRRQRDSQEDWTTFTHDRIRQLIKSQRVQNKLGVVFEKEKDRTQRK
                     DFIFVSARKREAFCQLLQLMKNKHSKQDEPDMISVFIGTWNMGSVPPPKNVTSWFTSK
                     GLGKALDEVTVTIPHDIYVFGTQENSVGDREWLDLLRGGLKELTDLDYRPIAMQSLWN
                     IKVAVLVKPEHENRISHVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSG
                     NEKTTRRNQNYLDILRLLSLGDRQLSAFDISLRFTHLFWFGDLNYRLDMDIQEILNYI
                     SRREFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQKPTGV
                     RTNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSDHSPVFGTFEVGVTSQFISKKGL
                     SKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYKKSFENDAQSSDNINFLKVQ
                     WSSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYGECVVALKSMIGSTAQQFLTF
                     LSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDDTGAKSKAPSVLRGSQEHR
                     SGSRKPTSTEASCPLSKLFEEPEKPPPTGRPPAPPRAVPREESLNPRLKSEGTPEQEG
                     VAAPPPKNSFNNPAYYVLEGVPHQLLPLEPTSFARAPIPPTTKNKVAITVPAPQLGRH
                     RTPRVGEGSSSDEDSGGTLPPPDFPPPPLPDSAIFLPPNLDPLSMPVVRGRSVGEARG
                     PPPPKAHPRPPLPPGTSPASTFLEEVASADDRSCSVLQMAKTLSEVDYSPGPGRSALL
                     PNPLELQLPRGPSDYGRPLSFPPPRIRESIQEDLAEEAPCPQGGRASGLGEAGMGAWL
                     RAIGLERYEEGLVHNGWDDLEFLSDITEEDLEEAGVQDPAHKRLLLDTLQLSK"
     exon            470..533
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            534..684
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            685..805
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            806..946
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1040
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1130
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1229
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1380
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1487
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1590
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1787
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1905
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2002
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2141
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2241
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2330
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2412
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..2502
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2616
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..2705
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2793
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            2794..2949
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            2950..3028
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            3029..3169
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            3170..3836
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            3837..3970
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
     exon            3971..4824
                     /gene="Inppl1"
                     /gene_synonym="Ship2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggcggat ggccatctta agtggccgcg gggagtccag ggaggcttcc ccgggctagg
       61 agtcaccaga gtcgccccag agttgaggcc ggcgctgctg gcggcggcgg ctgcgcggag
      121 atcgaggcgg ccggcgcggc caagcgtgga ccccggatac tgggctctct caggctggtg
      181 gatcctcagg cccggaaccc gggcccaggc ccagcctcca ctccaagctt ccctgggcgg
      241 atggcgcgga gcggcaggca tcggcggcgc tgagccctac gcgggccatg gcctcagtgt
      301 gtggggcacc gagtcccggg ggcgcgctag gcagccaggc ccctgcctgg tatcaccgtg
      361 acctgagccg cgcggctgcg gaggagctgc tagctcgggc aggccgcgat ggcagcttcc
      421 tggtgcgaga cagcgagagc gtggcggggg ccttcgcact ctgcgtcctg tatcaaaagc
      481 acgtgcacac ctaccgcatt ctgccagatg gagaggattt cctggctgtg cagacctcac
      541 agggcgttcc tgtgcgccgc ttccagaccc tgggtgagct tataggcctg tatgcccagc
      601 ccaaccaggg tcttgtctgt gctctgctgc tgcctgtaga gggggagaga gagccagatc
      661 caccggatga ccgagatgcc tcagatgtgg aggacgagaa acccccacta cccccgcgct
      721 ctggctctac cagcatttct gtccctgcgg ggcctagcag ccccctgcca gcccctgaga
      781 ctcccacaac tccagcagct gagagcactc ctaatggact cagcactgtg tcacatgagt
      841 atctgaaggg cagctacggg ctggacctgg aggctgtacg aggcggagcc agcaacttgc
      901 cccatctcac ccgaaccctt gtcacctcat gccgtaggct acacagcgag gtggacaagg
      961 tcctgtcagg cctagagatc ctgtcgaagg tgtttgacca gcagagctca cccatggtga
     1021 cccgcctttt gcagcagcag agcctaccac agactggaga gcaagagttg gagagccttg
     1081 tgctgaagct atctgtgcta aaggacttcc tgtcaggcat ccagaagaag gccctaaagg
     1141 cactgcagga catgagctcc acagcacctc cggctccatt gcagccctcc atacgaaagg
     1201 ccaagaccat ccctgtgcaa gcctttgagg tgaagctgga tgtgacactg ggtgacctga
     1261 ccaagatcgg gaagtcccag aagttcacac tgagcgtgga tgtggagggt gggaggctgg
     1321 tactgctgag gagacagcgt gactcccagg aggactggac gaccttcaca cacgaccgga
     1381 tccggcagct cattaaatcc cagcgtgtgc agaacaagct gggtgttgtg tttgaaaagg
     1441 agaaagatcg gacgcagcgc aaggacttca tctttgtcag tgcccggaag cgagaagcct
     1501 tctgccagct tctgcagctc atgaagaaca agcattccaa gcaggatgaa cctgacatga
     1561 tctccgtctt cataggcacc tggaacatgg gaagtgtacc accaccaaaa aacgtgacat
     1621 cttggttcac atcaaaggga ctggggaaag ccctggatga ggtcacagtg actatacccc
     1681 acgatatcta tgtctttggg actcaggaga actcagtggg tgacagagag tggctggatc
     1741 tgctgcgtgg gggcctcaag gagcttacag atctggatta ccgtccgatt gctatgcagt
     1801 cactgtggaa catcaaggtg gccgtgctgg tcaagccaga acatgagaac cgcatcagcc
     1861 acgttagtac gtccagtgtg aagactggta tcgccaatac cctggggaac aagggagctg
     1921 tgggtgtttc cttcatgttc aatggcactt cttttggctt cgtgaattgc catctcacct
     1981 cagggaatga gaagactact cggcggaacc agaattatct ggacatcctg cgtcttctct
     2041 cattgggtga tcggcagctc agtgcctttg acatctcttt gaggttcact catctcttct
     2101 ggtttgggga ccttaactac cgcttagaca tggatatcca ggagatcctg aactacatta
     2161 gtaggagaga gtttgagccc ctgctcaggg tggaccagct caacctggag cgggagaagc
     2221 ataaggtctt ccttcgattt agtgaggagg agatatcttt cccacccacc taccgctacg
     2281 agcggggttc ccgagacaca tatgcttggc acaagcagaa gccaactggg gtccggacca
     2341 atgtgccttc atggtgtgac cggattctat ggaaatccta tcctgaaacc cacatcatct
     2401 gcaattccta tggttgcact gatgacattg ttaccagtga ccattctcct gtgtttggga
     2461 catttgaggt tggagtgact tcccagttca tctccaagaa aggtctctct aagacctcag
     2521 accaggccta cattgagttt gagagcatcg aggccatcgt gaagacggcc agccgcacca
     2581 agttcttcat tgagttctat tctacctgct tggaagagta caagaagagc ttcgagaatg
     2641 acgctcagag cagtgacaac atcaatttcc tcaaggtgca gtggtcctcg cgccagctgc
     2701 ccacgctcaa gccaattctg gctgacattg agtacctgca ggatcagcat ctcctgctca
     2761 cagtcaagtc catggatggc tacgaatcat atggggagtg tgtggttgca ctcaaatcca
     2821 tgattggcag cacggcccag cagttcttga ccttcttgtc ccaccgtgga gaggagacag
     2881 gcaacattcg tggctccatg aaggtgcggg tgcccacaga acgcctgggc acccgtgagc
     2941 ggctctatga atggattagc attgataagg atgacacagg agccaaaagc aaggctcctt
     3001 cagtgttgcg gggcagccag gagcacagat ctgggagccg caagccaact tccacagagg
     3061 cctcctgtcc actgtccaag ttgtttgaag agcctgaaaa gccaccaccg actggcaggc
     3121 ccccagcccc accacgggca gttcctaggg aggagtcctt gaaccccagg ttgaagtcag
     3181 aggggacacc tgaacaggaa ggagtagcag cccctccacc caagaacagc ttcaataacc
     3241 ctgcctacta cgtccttgaa ggggtcccac atcagctgct gcccctggag ccaacctcat
     3301 ttgccagggc ccctatccca cctaccacca agaacaaagt ggccatcaca gtgcctgctc
     3361 ctcagcttgg gcgccaccgg acccctcgtg tgggggaggg aagctcttcg gatgaggact
     3421 ctgggggcac actgcctcct ccagacttcc cacctccacc actgccagac tcagccatct
     3481 tcctgccccc taacctggat cctttatcaa tgccagtggt caggggccga agtgtgggtg
     3541 aggcccgtgg cccaccacct cccaaggccc atccaagacc accactaccg ccgggcacct
     3601 cacctgccag tacttttttg gaagaggttg caagtgcgga tgaccggtct tgctcagtac
     3661 tgcagatggc caagacactc agtgaggtag attattctcc tgggcctgga cgctcagcac
     3721 tcctccccaa ccccttggaa ttgcagcttc cccgagggcc ctcggactac ggacgacccc
     3781 tcagcttccc tccaccccgc atccgggaga gcatccaaga agacttggca gaggaggctc
     3841 cgtgcccgca gggcgggcgg gccagcgggc tgggagaggc gggcatgggt gcctggctgc
     3901 gggccatcgg cttggagcgc tatgaggagg gcctggtgca caatggctgg gacgacctgg
     3961 agtttctcag tgacatcact gaggaagacc tcgaggaagc tggggtgcag gatcctgctc
     4021 acaagcgcct tcttctggac acgctgcagc tcagcaagtg atagcagaga tgccgccgag
     4081 ctgccaaagc agagctggaa gggcacatga aaccaggggt gaaagttttg aggggtgtgg
     4141 cagtgcatct ctgtctattt attggggacc agagttccct actgcccaat tgtttggggc
     4201 gttctagtta gaacatcgtg ctccccacct agcttttagg cccagggtca ggggtttagt
     4261 agcctgtggt aattgtgaag cacggtggtt actccagtgc agacacctcc ctgcctcggt
     4321 tgtgcgtggg gtatggttgg gcacatctgg gtcctcactt ccactgatgt ttccacctcc
     4381 ctccctcggg cctgaactcc aggggaagag ttcctcgtag ctcctactct gggaacgtcc
     4441 gtccgtccgt ccggaaatga aggaagagcc caggaccggg ctggatttat ttaagttttt
     4501 ctgtgtgggt tttgggaagg gagggcacgt taattttatt ggggtggggc aggacctcgg
     4561 ccttaaaatg ccagtttgcc tagttctggc tgttcctctg gttcgaagaa gcgctcttgc
     4621 ccagggaatg cgtggcagcc ggcggatggg gggggggggg cagcctcggg ttgccccggc
     4681 accagaagac agtgcttttg cagtttatcc catcttgggc actcagaaag gttgccggct
     4741 tgatgtcttc aataaattaa gttttatttg gattgagcaa aatcacctta ataaattaca
     4801 cgtttttcaa agaaaaaaaa taaaaaaaaa
//
