LOCUS       NM_001013859            1701 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus inositol polyphosphate-5-phosphatase K (Inpp5k),
            mRNA.
ACCESSION   NM_001013859 XM_213384
VERSION     NM_001013859.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1701)
  AUTHORS   Wiessner M, Roos A, Munn CJ, Viswanathan R, Whyte T, Cox D, Schoser
            B, Sewry C, Roper H, Phadke R, Marini Bettolo C, Barresi R,
            Charlton R, Bonnemann CG, Abath Neto O, Reed UC, Zanoteli E, Araujo
            Martins Moreno C, Ertl-Wagner B, Stucka R, De Goede C, Borges da
            Silva T, Hathazi D, Dell'Aica M, Zahedi RP, Thiele S, Muller J,
            Kingston H, Muller S, Curtis E, Walter MC, Strom TM, Straub V,
            Bushby K, Muntoni F, Swan LE, Lochmuller H and Senderek J.
  TITLE     Mutations in INPP5K, Encoding a Phosphoinositide 5-Phosphatase,
            Cause Congenital Muscular Dystrophy with Cataracts and Mild
            Cognitive Impairment
  JOURNAL   Am J Hum Genet 100 (3), 523-536 (2017)
   PUBMED   28190456
REFERENCE   2  (bases 1 to 1701)
  AUTHORS   Ijuin T, Hatano N and Takenawa T.
  TITLE     Glucose-regulated protein 78 (GRP78) binds directly to PIP3
            phosphatase SKIP and determines its localization
  JOURNAL   Genes Cells 21 (5), 457-465 (2016)
   PUBMED   26940976
REFERENCE   3  (bases 1 to 1701)
  AUTHORS   Ijuin T and Takenawa T.
  TITLE     Regulation of insulin signaling by the phosphatidylinositol
            3,4,5-triphosphate phosphatase SKIP through the scaffolding
            function of Pak1
  JOURNAL   Mol Cell Biol 32 (17), 3570-3584 (2012)
   PUBMED   22751929
REFERENCE   4  (bases 1 to 1701)
  AUTHORS   Ijuin T and Takenawa T.
  TITLE     Regulation of insulin signaling and glucose transporter 4 (GLUT4)
            exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3)
            phosphatase, skeletal muscle, and kidney enriched inositol
            polyphosphate phosphatase (SKIP)
  JOURNAL   J Biol Chem 287 (10), 6991-6999 (2012)
   PUBMED   22247557
  REMARK    GeneRIF: Regulation of insulin signaling and glucose transporter 4
            (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate
            (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol
            polyphosphate phosphatase (SKIP).
REFERENCE   5  (bases 1 to 1701)
  AUTHORS   Pernot E, Terryn S, Cheong SC, Markadieu N, Janas S, Blockmans M,
            Jacoby M, Pouillon V, Gayral S, Rossier BC, Beauwens R, Erneux C,
            Devuyst O and Schurmans S.
  TITLE     The inositol Inpp5k 5-phosphatase affects osmoregulation through
            the vasopressin-aquaporin 2 pathway in the collecting system
  JOURNAL   Pflugers Arch 462 (6), 871-883 (2011)
   PUBMED   21938401
REFERENCE   6  (bases 1 to 1701)
  AUTHORS   Hung CS, Lin YL, Wu CI, Huang CJ and Ting LP.
  TITLE     Suppression of hepatitis B viral gene expression by
            phosphoinositide 5-phosphatase SKIP
  JOURNAL   Cell Microbiol 11 (1), 37-50 (2009)
   PUBMED   18774950
REFERENCE   7  (bases 1 to 1701)
  AUTHORS   Ijuin T, Yu YE, Mizutani K, Pao A, Tateya S, Tamori Y, Bradley A
            and Takenawa T.
  TITLE     Increased insulin action in SKIP heterozygous knockout mice
  JOURNAL   Mol Cell Biol 28 (17), 5184-5195 (2008)
   PUBMED   18573875
REFERENCE   8  (bases 1 to 1701)
  AUTHORS   Gurung R, Tan A, Ooms LM, McGrath MJ, Huysmans RD, Munday AD,
            Prescott M, Whisstock JC and Mitchell CA.
  TITLE     Identification of a novel domain in two mammalian
            inositol-polyphosphate 5-phosphatases that mediates membrane ruffle
            localization. The inositol 5-phosphatase skip localizes to the
            endoplasmic reticulum and translocates to membrane ruffles
            following epidermal growth factor stimulation
  JOURNAL   J Biol Chem 278 (13), 11376-11385 (2003)
   PUBMED   12536145
REFERENCE   9  (bases 1 to 1701)
  AUTHORS   Ijuin T and Takenawa T.
  TITLE     SKIP negatively regulates insulin-induced GLUT4 translocation and
            membrane ruffle formation
  JOURNAL   Mol Cell Biol 23 (4), 1209-1220 (2003)
   PUBMED   12556481
REFERENCE   10 (bases 1 to 1701)
  AUTHORS   Ijuin T, Mochizuki Y, Fukami K, Funaki M, Asano T and Takenawa T.
  TITLE     Identification and characterization of a novel inositol
            polyphosphate 5-phosphatase
  JOURNAL   J Biol Chem 275 (15), 10870-10875 (2000)
   PUBMED   10753883
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083572.1.
            
            On Apr 1, 2005 this sequence version replaced XM_213384.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083572.1, SRR8487226.87136.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1701
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..1701
                     /gene="Inpp5k"
                     /gene_synonym="Skip"
                     /note="inositol polyphosphate-5-phosphatase K"
                     /db_xref="GeneID:287533"
                     /db_xref="RGD:1359130"
     exon            1..163
                     /gene="Inpp5k"
                     /gene_synonym="Skip"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1451
                     /gene="Inpp5k"
                     /gene_synonym="Skip"
                     /EC_number="3.1.3.36"
                     /note="putative phosphoinositide 5-phosphatase type II;
                     C62; skeletal muscle and kidney enriched inositol
                     phosphatase"
                     /codon_start=1
                     /product="inositol polyphosphate 5-phosphatase K"
                     /protein_id="NP_001013881.1"
                     /db_xref="GeneID:287533"
                     /db_xref="RGD:1359130"
                     /translation="MTTASLRKPSAPKELMLSIHVVTWNVASAAPTVDLSDLLQLNNE
                     DLNLDIYIIGLQEMNYGIISLLSDAAFEDPWSSFFMDMLSPLNLVKISQVRMQGLLLL
                     VFAKYQHLPYIQIISTKSIPTGLYGYWGNKGGINICLKLYGYYVSIVNCHLPPHMYNN
                     DQRLEHFDRILESLTFEGYDVPNILDHDLILWFGDMNFRIEDFGLLFVQECITKKRYK
                     ELWEKDQLFIAKKQDQLLREFQEGPLLFPPTYKFDRHSNNYDTSEKKRKPAWTDRILW
                     RLKRQPAKANPSGFLLTQKDYVSHMTYSISDHKPVTGTFDLELNPLMSVPLITMMPEY
                     LWTKENDMLINYTSTPEFLSSPWDWIGLYKVGMRHINDYVSYVWVGDNQVSRGNNPNQ
                     VYINISAIPDTEEQFLLCYYSNNLHSIVGISQPFKIPSGFFLREDTLSELEPQL"
     exon            164..271
                     /gene="Inpp5k"
                     /gene_synonym="Skip"
                     /inference="alignment:Splign:2.1.0"
     exon            272..380
                     /gene="Inpp5k"
                     /gene_synonym="Skip"
                     /inference="alignment:Splign:2.1.0"
     exon            381..497
                     /gene="Inpp5k"
                     /gene_synonym="Skip"
                     /inference="alignment:Splign:2.1.0"
     exon            498..673
                     /gene="Inpp5k"
                     /gene_synonym="Skip"
                     /inference="alignment:Splign:2.1.0"
     exon            674..785
                     /gene="Inpp5k"
                     /gene_synonym="Skip"
                     /inference="alignment:Splign:2.1.0"
     exon            786..895
                     /gene="Inpp5k"
                     /gene_synonym="Skip"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1064
                     /gene="Inpp5k"
                     /gene_synonym="Skip"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1202
                     /gene="Inpp5k"
                     /gene_synonym="Skip"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1286
                     /gene="Inpp5k"
                     /gene_synonym="Skip"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1391
                     /gene="Inpp5k"
                     /gene_synonym="Skip"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1662
                     /gene="Inpp5k"
                     /gene_synonym="Skip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaacaatcc ggagggagct gtgctgctga gaccggagac caagggctgc tccggctcgc
       61 agtagctgca gcgctgagac acgaacctac agcattacca cgaaggaata atgacgactg
      121 cgagtctaag gaagccgagc gcaccaaaag agcttatgct cagcatacac gttgtaacat
      181 ggaatgtggc ctctgcagcc cccactgtgg acctcagtga cctacttcaa ctgaacaacg
      241 aagacctgaa tctggacata tatatcattg gtttgcagga aatgaattat gggatcataa
      301 gccttctttc tgatgctgcc tttgaggacc catggagcag tttcttcatg gatatgcttt
      361 ctccactgaa ccttgtcaag atctctcaag tccgtatgca ggggcttctc ttactggtct
      421 ttgccaagta tcagcatttg ccctacatcc agatcatctc tacaaaatcc attcctactg
      481 gcctctacgg gtactggggg aacaaagggg gaatcaacat ctgtctgaag ctttacggct
      541 actatgtcag catcgtcaac tgccacctgc ctccccacat gtacaacaat gaccagcgcc
      601 tggagcactt tgaccgcatc ttggagagtc tgacttttga gggatatgat gtccccaaca
      661 tcctggacca tgacctcatt ctgtggtttg gagacatgaa ctttcgaatc gaggactttg
      721 ggctgctctt tgttcaggag tgtataacaa agaagcgcta caaagagctg tgggagaaag
      781 atcagctctt cattgccaag aaacaggacc agctgctccg ggagttccag gaaggcccac
      841 tgctcttccc acccacctac aagtttgaca ggcactccaa caactatgac accagtgaga
      901 aaaaacgcaa gcctgcgtgg actgaccgaa tcctgtggag gttgaagcgg cagccagcca
      961 aggccaaccc ctccggcttc ttgttgacac agaaggacta tgtcagccac atgacataca
     1021 gcatcagtga ccataagcct gtcactggca ccttcgactt ggagctgaac ccactgatgt
     1081 ctgtcccact gatcactatg atgcctgaat acctgtggac caaggagaac gacatgctga
     1141 tcaactacac ctccacccca gagttcctca gcagcccctg ggactggatc ggactataca
     1201 aggtggggat gcgacacatt aatgactatg tatcctatgt ctgggtcggt gacaaccaag
     1261 tctcccgtgg taacaaccca aaccaggtgt atatcaacat cagtgctatc cctgacacgg
     1321 aggagcagtt tcttctctgt tactatagca acaacctgca ctctatagtg gggataagtc
     1381 aacccttcaa gatcccgtcc ggcttctttt tgagagagga cacactgtct gagcttgaac
     1441 cacagctctg agcccagatg ggagtgaatg aatccagggc ggaggctaga gctggaagcc
     1501 agctgtgctt cagcactgcc agcagcgctg ggtctggccc agcccctgag gaggcatctg
     1561 agtttcctcc agctccccac ctcccagggg agctcagcca acctcctctg ctctctctag
     1621 tccagatgaa ctggcccttt aatacaggtt ttttattaca gaaaaaaaaa aaaaaaaaaa
     1681 aaaaaaaaaa aaaaaaaaaa a
//
