LOCUS       NP_001013881             446 aa            linear   ROD 26-FEB-2024
DEFINITION  inositol polyphosphate 5-phosphatase K [Rattus norvegicus].
ACCESSION   NP_001013881 XP_213384
VERSION     NP_001013881.1
DBSOURCE    REFSEQ: accession NM_001013859.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 446)
  AUTHORS   Wiessner M, Roos A, Munn CJ, Viswanathan R, Whyte T, Cox D, Schoser
            B, Sewry C, Roper H, Phadke R, Marini Bettolo C, Barresi R,
            Charlton R, Bonnemann CG, Abath Neto O, Reed UC, Zanoteli E, Araujo
            Martins Moreno C, Ertl-Wagner B, Stucka R, De Goede C, Borges da
            Silva T, Hathazi D, Dell'Aica M, Zahedi RP, Thiele S, Muller J,
            Kingston H, Muller S, Curtis E, Walter MC, Strom TM, Straub V,
            Bushby K, Muntoni F, Swan LE, Lochmuller H and Senderek J.
  TITLE     Mutations in INPP5K, Encoding a Phosphoinositide 5-Phosphatase,
            Cause Congenital Muscular Dystrophy with Cataracts and Mild
            Cognitive Impairment
  JOURNAL   Am J Hum Genet 100 (3), 523-536 (2017)
   PUBMED   28190456
REFERENCE   2  (residues 1 to 446)
  AUTHORS   Ijuin T, Hatano N and Takenawa T.
  TITLE     Glucose-regulated protein 78 (GRP78) binds directly to PIP3
            phosphatase SKIP and determines its localization
  JOURNAL   Genes Cells 21 (5), 457-465 (2016)
   PUBMED   26940976
REFERENCE   3  (residues 1 to 446)
  AUTHORS   Ijuin T and Takenawa T.
  TITLE     Regulation of insulin signaling by the phosphatidylinositol
            3,4,5-triphosphate phosphatase SKIP through the scaffolding
            function of Pak1
  JOURNAL   Mol Cell Biol 32 (17), 3570-3584 (2012)
   PUBMED   22751929
REFERENCE   4  (residues 1 to 446)
  AUTHORS   Ijuin T and Takenawa T.
  TITLE     Regulation of insulin signaling and glucose transporter 4 (GLUT4)
            exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3)
            phosphatase, skeletal muscle, and kidney enriched inositol
            polyphosphate phosphatase (SKIP)
  JOURNAL   J Biol Chem 287 (10), 6991-6999 (2012)
   PUBMED   22247557
  REMARK    GeneRIF: Regulation of insulin signaling and glucose transporter 4
            (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate
            (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol
            polyphosphate phosphatase (SKIP).
REFERENCE   5  (residues 1 to 446)
  AUTHORS   Pernot E, Terryn S, Cheong SC, Markadieu N, Janas S, Blockmans M,
            Jacoby M, Pouillon V, Gayral S, Rossier BC, Beauwens R, Erneux C,
            Devuyst O and Schurmans S.
  TITLE     The inositol Inpp5k 5-phosphatase affects osmoregulation through
            the vasopressin-aquaporin 2 pathway in the collecting system
  JOURNAL   Pflugers Arch 462 (6), 871-883 (2011)
   PUBMED   21938401
REFERENCE   6  (residues 1 to 446)
  AUTHORS   Hung CS, Lin YL, Wu CI, Huang CJ and Ting LP.
  TITLE     Suppression of hepatitis B viral gene expression by
            phosphoinositide 5-phosphatase SKIP
  JOURNAL   Cell Microbiol 11 (1), 37-50 (2009)
   PUBMED   18774950
REFERENCE   7  (residues 1 to 446)
  AUTHORS   Ijuin T, Yu YE, Mizutani K, Pao A, Tateya S, Tamori Y, Bradley A
            and Takenawa T.
  TITLE     Increased insulin action in SKIP heterozygous knockout mice
  JOURNAL   Mol Cell Biol 28 (17), 5184-5195 (2008)
   PUBMED   18573875
REFERENCE   8  (residues 1 to 446)
  AUTHORS   Gurung R, Tan A, Ooms LM, McGrath MJ, Huysmans RD, Munday AD,
            Prescott M, Whisstock JC and Mitchell CA.
  TITLE     Identification of a novel domain in two mammalian
            inositol-polyphosphate 5-phosphatases that mediates membrane ruffle
            localization. The inositol 5-phosphatase skip localizes to the
            endoplasmic reticulum and translocates to membrane ruffles
            following epidermal growth factor stimulation
  JOURNAL   J Biol Chem 278 (13), 11376-11385 (2003)
   PUBMED   12536145
REFERENCE   9  (residues 1 to 446)
  AUTHORS   Ijuin T and Takenawa T.
  TITLE     SKIP negatively regulates insulin-induced GLUT4 translocation and
            membrane ruffle formation
  JOURNAL   Mol Cell Biol 23 (4), 1209-1220 (2003)
   PUBMED   12556481
REFERENCE   10 (residues 1 to 446)
  AUTHORS   Ijuin T, Mochizuki Y, Fukami K, Funaki M, Asano T and Takenawa T.
  TITLE     Identification and characterization of a novel inositol
            polyphosphate 5-phosphatase
  JOURNAL   J Biol Chem 275 (15), 10870-10875 (2000)
   PUBMED   10753883
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083572.1.
            
            On Apr 1, 2005 this sequence version replaced XP_213384.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083572.1, SRR8487226.87136.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     Protein         1..446
                     /product="inositol polyphosphate 5-phosphatase K"
                     /EC_number="3.1.3.36"
                     /note="putative phosphoinositide 5-phosphatase type II;
                     C62; skeletal muscle and kidney enriched inositol
                     phosphatase"
                     /calculated_mol_wt=51721
     Region          17..317
                     /region_name="EEP"
                     /note="Exonuclease-Endonuclease-Phosphatase (EEP) domain
                     superfamily; cl00490"
                     /db_xref="CDD:469791"
     Site            order(25,57,152,195,197,272,307..308)
                     /site_type="active"
                     /note="putative catalytic site [active]"
                     /db_xref="CDD:197328"
     Site            order(57,307)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:197328"
     Site            order(152,197,308)
                     /site_type="other"
                     /note="putative phosphate binding site [ion binding]"
                     /db_xref="CDD:197328"
     Region          328..428
                     /region_name="SKICH"
                     /note="SKICH domain; pfam17751"
                     /db_xref="CDD:465482"
     CDS             1..446
                     /gene="Inpp5k"
                     /gene_synonym="Skip"
                     /coded_by="NM_001013859.1:111..1451"
                     /db_xref="GeneID:287533"
                     /db_xref="RGD:1359130"
ORIGIN      
        1 mttaslrkps apkelmlsih vvtwnvasaa ptvdlsdllq lnnedlnldi yiiglqemny
       61 giisllsdaa fedpwssffm dmlsplnlvk isqvrmqgll llvfakyqhl pyiqiistks
      121 iptglygywg nkgginiclk lygyyvsivn chlpphmynn dqrlehfdri lesltfegyd
      181 vpnildhdli lwfgdmnfri edfgllfvqe citkkrykel wekdqlfiak kqdqllrefq
      241 egpllfppty kfdrhsnnyd tsekkrkpaw tdrilwrlkr qpakanpsgf lltqkdyvsh
      301 mtysisdhkp vtgtfdleln plmsvplitm mpeylwtken dmlinytstp eflsspwdwi
      361 glykvgmrhi ndyvsyvwvg dnqvsrgnnp nqvyinisai pdteeqfllc yysnnlhsiv
      421 gisqpfkips gfflredtls elepql
//
