LOCUS       NM_001107554            4794 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus inositol polyphosphate-5-phosphatase F (Inpp5f),
            mRNA.
ACCESSION   NM_001107554 XM_001080439 XM_003748994 XM_219372
VERSION     NM_001107554.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4794)
  AUTHORS   Bai D, Zhang Y, Shen M, Sun Y, Xia Q, Zhang Y, Liu X, Wang H and
            Yuan L.
  TITLE     Hyperglycemia and hyperlipidemia blunts the Insulin-Inpp5f negative
            feedback loop in the diabetic heart
  JOURNAL   Sci Rep 6, 22068 (2016)
   PUBMED   26908121
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4794)
  AUTHORS   Zou Y, Stagi M, Wang X, Yigitkanli K, Siegel CS, Nakatsu F,
            Cafferty WB and Strittmatter SM.
  TITLE     Gene-Silencing Screen for Mammalian Axon Regeneration Identifies
            Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal
            Cord Injury
  JOURNAL   J Neurosci 35 (29), 10429-10439 (2015)
   PUBMED   26203138
REFERENCE   3  (bases 1 to 4794)
  AUTHORS   Hsu F, Hu F and Mao Y.
  TITLE     Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2
            regulates endocytic recycling
  JOURNAL   J Cell Biol 209 (1), 97-110 (2015)
   PUBMED   25869669
REFERENCE   4  (bases 1 to 4794)
  AUTHORS   Nakatsu F, Messa M, Nandez R, Czapla H, Zou Y, Strittmatter SM and
            De Camilli P.
  TITLE     Sac2/INPP5F is an inositol 4-phosphatase that functions in the
            endocytic pathway
  JOURNAL   J Cell Biol 209 (1), 85-95 (2015)
   PUBMED   25869668
REFERENCE   5  (bases 1 to 4794)
  AUTHORS   Kim HS, Li A, Ahn S, Song H and Zhang W.
  TITLE     Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3
            activity and suppresses gliomas tumorigenicity
  JOURNAL   Sci Rep 4, 7330 (2014)
   PUBMED   25476455
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4794)
  AUTHORS   Zhu W, Trivedi CM, Zhou D, Yuan L, Lu MM and Epstein JA.
  TITLE     Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac
            hypertrophic responsiveness
  JOURNAL   Circ Res 105 (12), 1240-1247 (2009)
   PUBMED   19875726
REFERENCE   7  (bases 1 to 4794)
  AUTHORS   Trivedi CM, Luo Y, Yin Z, Zhang M, Zhu W, Wang T, Floss T,
            Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber
            PJ and Epstein JA.
  TITLE     Hdac2 regulates the cardiac hypertrophic response by modulating
            Gsk3 beta activity
  JOURNAL   Nat Med 13 (3), 324-331 (2007)
   PUBMED   17322895
REFERENCE   8  (bases 1 to 4794)
  AUTHORS   Minagawa T, Ijuin T, Mochizuki Y and Takenawa T.
  TITLE     Identification and characterization of a sac domain-containing
            phosphoinositide 5-phosphatase
  JOURNAL   J Biol Chem 276 (25), 22011-22015 (2001)
   PUBMED   11274189
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473956.2.
            
            On or before Dec 15, 2013 this sequence version replaced
            XM_003748994.2, XM_219372.4, XM_001080439.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132263,
                              SAMD00132264 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4794
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..4794
                     /gene="Inpp5f"
                     /note="inositol polyphosphate-5-phosphatase F"
                     /db_xref="GeneID:309008"
                     /db_xref="RGD:1305777"
     exon            1..387
                     /gene="Inpp5f"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..3683
                     /gene="Inpp5f"
                     /EC_number="3.1.3.-"
                     /note="phosphatidylinositide phosphatase SAC2-like"
                     /codon_start=1
                     /product="phosphatidylinositide phosphatase SAC2"
                     /protein_id="NP_001101024.2"
                     /db_xref="GeneID:309008"
                     /db_xref="RGD:1305777"
                     /translation="MELFQAKDHYILQQGERALWCSRRDGGLQLRPATDLLLAWNPIC
                     LGLVEGVIGKIQLHSDLPWWLILIRQKALVGKLPGDHEVCKVTKIAVLSLSEMEPQEL
                     ELELCKKHHFGINKPEKIVPSPDDSKFLLKTFTNIKSNVSAPNKKKVKESKEKEKLER
                     RLLEELLKMFMDSESFYYSLTYDLTNSVQRQSTGEKDGRPLWQKVDDRFFWNKYMIQD
                     LSEIGTPDVDFWIIPIIQGFVQIEELVVNYEPSDDDKSSPETPPQEATCVDDIHPRFL
                     VALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHNHTLSFIQTRGSVPVFWS
                     QVGYRYNPRPRLDKSEKETVDCFCAHFEEQLKIYKKQVIVNLVDQAGREKIIGDAYLK
                     QVLLFNNPRLTYVSFDFHEHCRGMKFENVQTLTDAIHDIILDMKWCWVDQAGVICKQE
                     GIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKLGVMPPEQPLPVKCNRTYQIMWANNG
                     DSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLSRFKDAYRQAVIDLMQG
                     IPVTEDLYSIFTKEKEHEALQKETQRSHQELISQLLQSYMQLLLPGDEKFHGGWALID
                     CDPSLTDAAHRDVDVLLLLSNSAYYVAYYDDEVDKVSQYQRRSLEDLEKIEIGPEPTL
                     FGKPKFSCMRLHYTCKEAGGYFHTLRAVPRSPEEDGKDTLQCIAEMLQITKQAMGLHV
                     PIIERKLERKSSKPHEDIIGIRSQNQGSLAQGKSFLMSKFSSLNQKVKQTKSNVNIGN
                     LRKLGNFTKPEVKVNFLKPNLKVNLWKSDSSLETMENPGVMGNKVQGESDGDVSSDND
                     SYHSDELLTNSRSEEGKQLANSLESAGPTDYLLPSCGIIASAPRLGSRSQSASSTDVS
                     IHAPSEATVGHGHELGKGLESPLKKSPSADNIHTLTGFAKPMDVYCQRFVQDAQNKMN
                     ALSEVRAVAQNSEEGNHKTNPVSNEETQSESVEQMPSRPSQLNVSCSVTGPQLLSVEP
                     AHPAVSQKTPGSGSSLLDLEAGLCVTPSSESSSRAVSPFAKIRSSMVQVANITQAGLT
                     HGINLAVAKVQKSPAEPEVVNEIQQNELKNMFTQCQTRIIQI"
     exon            388..468
                     /gene="Inpp5f"
                     /inference="alignment:Splign:2.1.0"
     exon            469..605
                     /gene="Inpp5f"
                     /inference="alignment:Splign:2.1.0"
     exon            606..734
                     /gene="Inpp5f"
                     /inference="alignment:Splign:2.1.0"
     exon            735..902
                     /gene="Inpp5f"
                     /inference="alignment:Splign:2.1.0"
     exon            903..959
                     /gene="Inpp5f"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1155
                     /gene="Inpp5f"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1335
                     /gene="Inpp5f"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1403
                     /gene="Inpp5f"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1528
                     /gene="Inpp5f"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1606
                     /gene="Inpp5f"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1727
                     /gene="Inpp5f"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1856
                     /gene="Inpp5f"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1974
                     /gene="Inpp5f"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2173
                     /gene="Inpp5f"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2245
                     /gene="Inpp5f"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2319
                     /gene="Inpp5f"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2448
                     /gene="Inpp5f"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2536
                     /gene="Inpp5f"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..4794
                     /gene="Inpp5f"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaactata ggaggtggag actcagagta ggggcggagc ctaggtacag gagttgtggg
       61 gggaggggga aaggcctccc gggcctgggc tgtccgagcg tgttctcggc cggcgggtca
      121 ggtcccctag tgcttccccg ccctgttcct ccgtggggtg gttcctcgga gtctcctcga
      181 ggcacgggct ctgtggtcgc ggtggaggag gacgcctgca tcgctcctgg gcgggccgct
      241 gcggtgcctg ggtcggggga ccgccgcctc ccggagcgcg tggggccggc atggagctct
      301 ttcaggccaa ggaccactac atcctgcagc agggcgagcg tgccctgtgg tgcagccggc
      361 gcgacggcgg cctgcagctc cgaccggcca ctgacctact tcttgcctgg aaccccattt
      421 gtttgggatt ggtagaagga gtaattggga agattcaact ccattcagat cttccgtggt
      481 ggcttatttt aattcggcag aaagcattgg tgggcaaact cccaggagac catgaggtct
      541 gtaaagtcac caagattgct gtattgtcac tttctgaaat ggaacctcag gagcttgagc
      601 tggagctctg caagaagcat cattttggaa ttaacaagcc tgagaagatt gtaccatctc
      661 ctgatgactc caagtttcta ctgaagacat tcacaaatat caaatccaat gtgtctgctc
      721 ccaacaaaaa gaaagttaaa gaaagtaaag aaaaggagaa actggagagg cgtttgcttg
      781 aggagttgct gaagatgttc atggactcag agtccttcta ttatagcttg acctatgacc
      841 taaccaactc agtgcagagg cagagcactg gggagaagga tggccgcccc ctgtggcaga
      901 aggttgatga tcgatttttc tggaataagt acatgatcca agacctctct gagattggta
      961 ctccggacgt ggacttctgg atcatcccca ttatccaggg ttttgtgcag attgaagaac
     1021 tggtggttaa ttacgagcca tctgatgatg acaagagcag cccagagacg ccccctcagg
     1081 aggccacttg tgtagatgac attcacccgc gatttctagt ggctcttata tctcgcagga
     1141 gtaggcacag agcaggaatg cggtataaac gaagaggagt ggataaaaat ggaaatgttg
     1201 caaattatgt ggagactgag cagttaattc atgttcataa tcatactctg tcgtttattc
     1261 aaactcgagg ctccgtgccc gtcttttgga gccaggttgg gtatcgctat aatccaagac
     1321 ctcgactaga caaaagtgag aaggagacag tcgactgttt ctgtgcccat tttgaagaac
     1381 aactgaaaat ttacaaaaag caggttattg ttaacttggt ggaccaggct ggaagggaga
     1441 agatcattgg tgatgcttac ctgaagcagg tgctgctctt caacaacccc aggctcacct
     1501 acgtctcctt tgatttccac gagcactgcc gaggaatgaa gtttgagaat gttcaaaccc
     1561 taacggatgc cattcatgac atcatccttg atatgaagtg gtgttgggtt gatcaagctg
     1621 gtgtgatatg taagcaagaa ggaatttttc gagttaattg catggactgc ctggatcgca
     1681 ccaacgtggt ccaagctgcc attgcacgag tggtcatgga acagcagctt aaaaaactag
     1741 gtgtgatgcc ccctgagcag ccactacctg tgaaatgtaa tcggacctac cagataatgt
     1801 gggctaacaa cggcgactcc atcagcagac agtatgctgg cacagctgct ctaaagggcg
     1861 actttacaag aacaggagaa aggaagttgg caggagttat gaaagatgga gttaactcag
     1921 caaataggta ctacctcagc cggttcaagg atgcttacag gcaagctgtc atagatttga
     1981 tgcaaggcat tccagtgacg gaagatcttt attccatatt taccaaggag aaggagcatg
     2041 aagctttgca gaaggagacc cagagaagcc accaagagct catcagccag ctcttacaga
     2101 gctacatgca gttgctgctg ccgggggatg agaagttcca cgggggctgg gccctcattg
     2161 actgtgaccc cagcctcact gatgctgctc acagagatgt ggacgtgcta ctgctgcttt
     2221 ctaattctgc ctactatgtg gcctattatg atgatgaagt tgataaagta agccagtatc
     2281 aacgacggag ccttgaagac ctggaaaaga tagaaatagg tcccgagcct actctttttg
     2341 gcaaaccaaa gttctcctgc atgcggctgc actacacgtg taaagaagca ggtggttact
     2401 tccacacact gagagccgta ccacgcagtc ctgaagaaga cgggaaagat actctccagt
     2461 gcattgcgga gatgctgcag atcaccaagc aggccatggg gctgcatgtg cccataatcg
     2521 agaggaaact cgagaggaag agcagcaagc ctcatgaaga catcattggt atcagatctc
     2581 aaaaccaagg ctctctggcc caggggaaaa gctttttaat gagcaaattt tcatctctaa
     2641 atcaaaaagt aaagcagacc aaatccaatg tgaacattgg caacctacgc aaattaggaa
     2701 actttacaaa gcctgaagtg aaagtgaact ttctaaaacc aaacttaaaa gtcaaccttt
     2761 ggaaatcaga tagtagtctt gagaccatgg agaacccagg agtgatgggt aacaaggtcc
     2821 agggggagtc tgatggggac gtgtcctcag ataatgactc ttaccactct gatgaactcc
     2881 ttacaaactc caggtctgag gaaggcaagc agctagccaa ctctttggag agcgcagggc
     2941 caacagacta ccttctcccg agctgtggca tcatcgcctc agcgcctcgg ttaggcagcc
     3001 ggtcccagtc ggccagcagc accgacgtta gcatccatgc tccctcggaa gctactgttg
     3061 gtcatggaca tgagctcgga aaaggcctgg agtctcccct gaagaaaagc ccttctgctg
     3121 acaacataca cacattgact ggctttgcaa agcccatgga cgtttactgc cagagattcg
     3181 tgcaggatgc acagaacaaa atgaacgcgc tgtcggaggt cagggctgta gctcagaaca
     3241 gcgaggaggg aaatcacaag actaaccctg tttctaatga agaaacccag tcagaatcag
     3301 tggaacagat gccttctcgg ccctctcagt taaatgtctc ttgttctgtg acaggcccac
     3361 agttgttatc agttgaacca gcacatccag cggtatctca gaagaccccc ggctccgggt
     3421 ccagcctgct ggaccttgag gcagggcttt gcgtaactcc ttcttcagag agcagcagca
     3481 gagcagtctc tccctttgca aagatccgca gctccatggt ccaggttgct aatattaccc
     3541 aagctgggct aactcatggg ataaacttgg cagttgccaa agttcagaag agtccagcag
     3601 aacccgaagt ggttaacgaa attcaacaaa atgaacttaa aaatatgttt acacaatgcc
     3661 agacacgaat aattcagatt tagattttag tcagttcttg ggcttttatt taaaagtcca
     3721 agatgaagtt ttcacctctc acctgtgttg agtttaggga tttcaggttc taattatgtt
     3781 tatcggcaat tgttttacaa ggagtctgga ccttagcaaa tttccagctg tgtaagccaa
     3841 ggaccacaag caatcaccct ggattaggga ccagagcggc aaacacacta gagggctttg
     3901 tgcatgtcac tcaggaaggc gcagggaaga aaccaagctg ctgtcaggag ggagatactc
     3961 tgagaagcag atgtagtgtg ggcacccact aaggagttag catttctctg ctctgtcagt
     4021 gcattcctat atcctgcttc tataaaggaa attatgcatt tagattttag tgattctagt
     4081 gtgcattagt atctaaattt ttttttaaag tagtcttgtg gcttaaccat tctctgaagt
     4141 tgagaattaa caatggtgaa aatgtatttt catttgaccc caatctctcc catatttttt
     4201 ttctctctca aattcttaaa tatgggcttg cctaccataa aataacttgc tacaggaaca
     4261 taagatcatg tttattgact ctagggatct ctagaaaagt aatttgaatt ctgtcaaggg
     4321 gacatttagt atctcttgta ggttctagaa ctacagaaaa catacctaaa gtacaggtta
     4381 gactggtttt atgcagtaac taaccaccaa gaacctcttc cgtaacccag agtaagaaag
     4441 tggtagggca cattctagca ggtatcaacg tctctggtgt cccttagagc cttactccag
     4501 ttaactgact ctcagtttaa cattatgtct gttaaaactc tgataagcat tctgcctttg
     4561 ttatttatta caagtgtcaa gtcttgtgac tattaaagta ccactgtaat tcaaacatca
     4621 gtgtatgagg attccttgta taacatttaa tagtaagagt ggctttcaaa gaattcatat
     4681 aagtggtaag tttgctataa ccaaacactt gttctgaact ttcaattaaa atattcttct
     4741 attttaaaaa tgaaagctgt attttaaatc ccagacatta aaaactgaat actg
//
