LOCUS       NM_053632               3342 bp    mRNA    linear   ROD 24-APR-2024
DEFINITION  Rattus norvegicus inositol polyphosphate-5-phosphatase E (Inpp5e),
            transcript variant 1, mRNA.
ACCESSION   NM_053632 XM_002726072 XM_002729145
VERSION     NM_053632.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3342)
  AUTHORS   Badgandi,H.B., Hwang,S.H., Shimada,I.S., Loriot,E. and
            Mukhopadhyay,S.
  TITLE     Tubby family proteins are adapters for ciliary trafficking of
            integral membrane proteins
  JOURNAL   J Cell Biol 216 (3), 743-760 (2017)
   PUBMED   28154160
REFERENCE   2  (bases 1 to 3342)
  AUTHORS   Travaglini,L., Brancati,F., Silhavy,J., Iannicelli,M.,
            Nickerson,E., Elkhartoufi,N., Scott,E., Spencer,E., Gabriel,S.,
            Thomas,S., Ben-Zeev,B., Bertini,E., Boltshauser,E., Chaouch,M.,
            Cilio,M.R., de Jong,M.M., Kayserili,H., Ogur,G., Poretti,A.,
            Signorini,S., Uziel,G., Zaki,M.S., Johnson,C., Attie-Bitach,T.,
            Gleeson,J.G. and Valente,E.M.
  CONSRTM   International JSRD Study Group
  TITLE     Phenotypic spectrum and prevalence of INPP5E mutations in Joubert
            syndrome and related disorders
  JOURNAL   Eur J Hum Genet 21 (10), 1074-1078 (2013)
   PUBMED   23386033
REFERENCE   3  (bases 1 to 3342)
  AUTHORS   Bertelli,D.F., Coope,A., Caricilli,A.M., Prada,P.O., Saad,M.J.,
            Velloso,L.A. and Araujo,E.P.
  TITLE     Inhibition of 72 kDa inositol polyphosphate 5-phosphatase E
            improves insulin signal transduction in diet-induced obesity
  JOURNAL   J Endocrinol 217 (2), 131-140 (2013)
   PUBMED   23349329
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3342)
  AUTHORS   Wang,F., Ijuin,T., Itoh,T. and Takenawa,T.
  TITLE     Regulation of IGF-1/PI3K/Akt signalling by the phosphoinositide
            phosphatase pharbin
  JOURNAL   J Biochem 150 (1), 83-93 (2011)
   PUBMED   21436142
  REMARK    GeneRIF: pharbin is an important negative regulator of
            IGF-1/PI3K/Akt signalling and protein synthesis.
REFERENCE   5  (bases 1 to 3342)
  AUTHORS   Jacoby,M., Cox,J.J., Gayral,S., Hampshire,D.J., Ayub,M.,
            Blockmans,M., Pernot,E., Kisseleva,M.V., Compere,P.,
            Schiffmann,S.N., Gergely,F., Riley,J.H., Perez-Morga,D., Woods,C.G.
            and Schurmans,S.
  TITLE     INPP5E mutations cause primary cilium signaling defects, ciliary
            instability and ciliopathies in human and mouse
  JOURNAL   Nat Genet 41 (9), 1027-1031 (2009)
   PUBMED   19668215
REFERENCE   6  (bases 1 to 3342)
  AUTHORS   Kong,A.M., Speed,C.J., O'Malley,C.J., Layton,M.J., Meehan,T.,
            Loveland,K.L., Cheema,S., Ooms,L.M. and Mitchell,C.A.
  TITLE     Cloning and characterization of a 72-kDa inositol-polyphosphate
            5-phosphatase localized to the Golgi network
  JOURNAL   J Biol Chem 275 (31), 24052-24064 (2000)
   PUBMED   10806194
REFERENCE   7  (bases 1 to 3342)
  AUTHORS   Asano,T., Mochizuki,Y., Matsumoto,K., Takenawa,T. and Endo,T.
  TITLE     Pharbin, a novel inositol polyphosphate 5-phosphatase, induces
            dendritic appearances in fibroblasts
  JOURNAL   Biochem Biophys Res Commun 261 (1), 188-195 (1999)
   PUBMED   10405344
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Feb 9, 2013 this sequence version replaced
            XM_002729145.2, XM_002726072.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB026288.1, SRR26360190.1680612.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1414              JAXUCZ010000003.1  29626129-29627542   c
            1415-1538           JAXUCZ010000003.1  29619919-29620042   c
            1539-1636           JAXUCZ010000003.1  29619390-29619487   c
            1637-1761           JAXUCZ010000003.1  29618649-29618773   c
            1762-1881           JAXUCZ010000003.1  29618108-29618227   c
            1882-1989           JAXUCZ010000003.1  29617770-29617877   c
            1990-2151           JAXUCZ010000003.1  29617112-29617273   c
            2152-2267           JAXUCZ010000003.1  29616931-29617046   c
            2268-2404           JAXUCZ010000003.1  29616273-29616409   c
            2405-3342           JAXUCZ010000003.1  29614868-29615805   c
FEATURES             Location/Qualifiers
     source          1..3342
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..3342
                     /gene="Inpp5e"
                     /note="inositol polyphosphate-5-phosphatase E"
                     /db_xref="GeneID:114089"
                     /db_xref="RGD:620478"
     exon            1..1414
                     /gene="Inpp5e"
                     /inference="alignment:Splign:2.1.0"
     CDS             591..2537
                     /gene="Inpp5e"
                     /EC_number="3.1.3.36"
                     /EC_number="3.1.3.86"
                     /note="72 kDa inositol polyphosphate 5-phosphatase;
                     5-phosphatase that induces arborization;
                     phosphatidylinositol-4,5-bisphosphate 5-phosphatase;
                     pharbin; phosphatidylinositol-3,4,5-trisphosphate
                     5-phosphatase"
                     /codon_start=1
                     /product="phosphatidylinositol polyphosphate 5-phosphatase
                     type IV"
                     /protein_id="NP_446084.1"
                     /db_xref="GeneID:114089"
                     /db_xref="RGD:620478"
                     /translation="MPSKSACLRHTEAPGQLEGRMLQGQLSNPEKKLIPTSASLPAAD
                     SQSSQTNSMPPLSMPAKPSNQNLQAKANLITPQPPIRPKLERTLSLDDKGWRRRRFRG
                     SQEDLTVQNGASPCRGSLQDSVAQSPAYSRPLPCLSTSLQEIPKPRRATGSEGGSPSL
                     WSDCLSGMISTSLDLLHREAASGGPHSRLASLRATHTPPAMDLNIASSSLRTANKVDP
                     EHTDYKLRMQNRLVRAHSNLGPSRPRSPLAGDDHSIHSARSSFSLLAPIRTKDIRSRS
                     YLEGSLLASGALLGADELARYFPDRNMALFVATWNMQGQKELPASLDEFLLPTEADYT
                     QDLYVIGVQEGCSDRREWETRLQETLGPQYVLLSSAAHGVLYMSLFIRRDLIWFCSEV
                     EYSTVTTRIVSQIKTKGALGVSFTFFGTSFLFITSHFTSGDGKVAERLLDYNRTIQAL
                     ALPRNVPDTNPYRSSAGDVTTRFDEVFWFGDFNFRLSGGRVAVEAFLKQDPEVDVLAL
                     LQHDQLTREMKKGSIFKGFEEAEIHFLPSYKFDIGKDTYDSTSKQRTPSYTDRVLYKS
                     RHKGDICPMKYSSCPGIKTSDHRPVYGLFRVKVRPGRDNIPLAAGKFDRELYLIGIKR
                     RISKEIQRQEALKSQSSSAVCTVS"
     exon            1415..1538
                     /gene="Inpp5e"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1636
                     /gene="Inpp5e"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1761
                     /gene="Inpp5e"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1881
                     /gene="Inpp5e"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1989
                     /gene="Inpp5e"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2151
                     /gene="Inpp5e"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2267
                     /gene="Inpp5e"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2404
                     /gene="Inpp5e"
                     /inference="alignment:Splign:2.1.0"
     exon            2405..3342
                     /gene="Inpp5e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagagcggg acctgggcca gggtgaccac caactagact gagctggggc gaacccgggg
       61 ccggggcacc gggcagcagt cgttgttcca gccgccaccg tgactgggct aggctcgcca
      121 gcgccgagcc cgcctggatc agaccttggg cgtccggcgg cgggtctgcg gccgaacgga
      181 gggagcaggt gagcctagga cgttgagcgt gttgtcctac tctaccacgg ttgggtggag
      241 gctggtcccg ggtgcttgac agacttatgc agctccgtga agtgcagccc cgacccccag
      301 tgcctgttct cacgaggtca ctcttaggct tcggggagct aagagatttt tctgagtttc
      361 cttaggcatc atcagtgtga actcaagtct ccggccatgc agctacaggc cctgatccaa
      421 aaggaccgcc ccatgccaca aagagagcca cccgagtttt catggcatcc ggctggcggc
      481 ctctgacgtg catccttgac aacaagagtt gcttgttaat ctcccaggga ggatcccttt
      541 ccttatagga gggccaggct gagtgggtca gggctggccg tgtccggact atgccgtcca
      601 agtccgcttg cctgcgtcac acggaggcac ctgggcagct agaaggcaga atgctccagg
      661 gacagctttc gaaccccgaa aagaagctca tcccaacatc agcctcctta ccagctgctg
      721 actctcagag ttcacagaca aactccatgc ctcctttaag catgccagca aaaccaagca
      781 accagaacct acaagccaag gcaaacctca tcaccccaca gccacccatt agacccaagt
      841 tggagagaac cctgtccctc gatgacaagg gctggagaag gaggcgtttc cggggtagtc
      901 aggaggatct gaccgtccag aatggggcca gtccctgcag gggttccttg caggactcag
      961 tagcccagtc tcctgcctac agtcgtcccc tgccctgcct cagtacatcc ttacaggaga
     1021 tacctaagcc ccgaagggcc acaggcagcg agggagggag cccatccttg tggagtgact
     1081 gtctttctgg aatgatcagc acctccttgg acctcctgca cagagaggct gcctcaggtg
     1141 ggccccactc caggctggca agtttgcgtg ctacacacac accgccagct atggacctca
     1201 acatagcctc cagctccctg agaacagcaa acaaggttga ccctgagcac acggactaca
     1261 agctccgcat gcagaacaga ctggtcaggg cccacagcaa cctgggccct agcagacccc
     1321 ggagtcccct ggctggtgac gaccactcca ttcactcagc cagatcctct ttcagccttc
     1381 tggcccccat ccgcaccaag gacatcagga gcaggagcta tctggaggga agtcttctgg
     1441 ccagtggggc cctgctagga gcagacgagc tggccaggta cttcccagac cgaaacatgg
     1501 ctcttttcgt ggctacctgg aacatgcagg gccagaagga gcttccggca agcctggatg
     1561 agtttctgct tcccaccgag gctgactaca cacaggacct gtatgtcatt ggcgttcagg
     1621 agggctgctc tgacaggcgg gaatgggaga cacgcttgca ggagacactg ggccctcagt
     1681 atgtactgct gtcatcagca gcacatgggg tcctgtacat gtccctgttt atccgtaggg
     1741 acctcatctg gttctgctca gaggtcgagt actccacagt aactacacgc atcgtgtctc
     1801 agatcaagac caaaggggcc ctgggcgtca gcttcacctt ttttggcacc tccttcctct
     1861 tcatcacatc tcacttcacc tctggagatg ggaaggtagc agagcggcta ctggactaca
     1921 acagaaccat ccaagccctc gccttgcccc ggaatgtgcc agacacaaac ccctaccgct
     1981 ctagtgcagg ggatgtcact acccggtttg atgaggtctt ctggtttggg gacttcaact
     2041 tccgcctaag tggtggacga gtggctgtgg aggccttcct gaagcaggac ccagaggtgg
     2101 atgtgctggc actcctgcaa catgaccagc tcacccggga gatgaagaaa gggtccatct
     2161 tcaagggctt tgaggaggca gaaattcact ttctcccatc ctacaagttt gacattggga
     2221 aggacaccta cgacagcacc tccaagcaaa ggacaccctc ctacacagac cgagtcctat
     2281 acaaaagccg tcacaagggt gacatctgtc ccatgaagta ttcctcttgt cctgggatca
     2341 agacttcaga ccaccgtcct gtgtatggct tgttccgggt gaaagtgagg ccaggacgag
     2401 acaacatccc gttagctgcc ggcaagtttg accgagaact gtacttgata ggaattaaaa
     2461 gacgaatttc gaaagagatt cagagacaag aagcactgaa gagtcagagc tccagtgctg
     2521 tgtgcactgt gtcttgaagt taccagacca ggactggcca actgcatctg agggaccaag
     2581 gtcacggcaa agagatgggc ttgttcgcca atgctcctgt aatgctgggt tctaaccaac
     2641 cacagacccc acccctcagg actgtcagta gtgggctgtg gccaggacaa gcctcttcta
     2701 tatcatgctc ccacaggcac atggcagggg tttggtgaga gggacgtgtg gacaccaagc
     2761 cagattcaca ccgtgcagca gtcctgactt cttgcccttg agcactacag tcttttcaac
     2821 cttttattcc tgttctcgtg ctagagccca ggttctaggt ctgtatccta atagctcctt
     2881 tcctccaggg aaagatcaga ccacctctgg tatcttagat gctcagtgcc tagaacctgc
     2941 caggactaga attcttggat attccccaca gacattttga taggctttga ggttctgcac
     3001 cctggtccca ggctcccaac ccacagttga gtagggacct ctcctctctg caggctaagc
     3061 ccagctctat cgactcagtt cctaggagct tcggagcatt tgcttttgtg ttgctcgtct
     3121 caggaaagca ggcactggaa ttgtgttgct aggcagcact ttgctgggtc tcactccttg
     3181 aagaaagctt aggtctcatc cttccttacc ccatcttacc ccatccctca gagacatagc
     3241 cttgaatgta cagacaccta agggcatcca ctctagtctt ctaaattatt tatttttcca
     3301 tatttatatt tttcaataaa taaggatata ttcaactgta aa
//
