LOCUS       NM_019311               4925 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus inositol polyphosphate-5-phosphatase D (Inpp5d),
            mRNA.
ACCESSION   NM_019311
VERSION     NM_019311.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4925)
  AUTHORS   Xiong,D., Xiao,S., Guo,S., Lin,Q., Nakatsu,F. and Wu,M.
  TITLE     Frequency and amplitude control of cortical oscillations by
            phosphoinositide waves
  JOURNAL   Nat Chem Biol 12 (3), 159-166 (2016)
   PUBMED   26751515
  REMARK    Erratum:[Nat Chem Biol. 2016 Apr;12(4):304. doi:
            10.1038/nchembio0416-304b.. PMID: 26991087]
REFERENCE   2  (bases 1 to 4925)
  AUTHORS   Downes,C.P., Leslie,N.R., Batty,I.H. and van der Kaay,J.
  TITLE     Metabolic switching of PI3K-dependent lipid signals
  JOURNAL   Biochem Soc Trans 35 (Pt 2), 188-192 (2007)
   PUBMED   17371235
REFERENCE   3  (bases 1 to 4925)
  AUTHORS   Lesourne,R., Fridman,W.H. and Daeron,M.
  TITLE     Dynamic interactions of Fc gamma receptor IIB with filamin-bound
            SHIP1 amplify filamentous actin-dependent negative regulation of Fc
            epsilon receptor I signaling
  JOURNAL   J Immunol 174 (3), 1365-1373 (2005)
   PUBMED   15661894
REFERENCE   4  (bases 1 to 4925)
  AUTHORS   Takeshita,S., Namba,N., Zhao,J.J., Jiang,Y., Genant,H.K.,
            Silva,M.J., Brodt,M.D., Helgason,C.D., Kalesnikoff,J., Rauh,M.J.,
            Humphries,R.K., Krystal,G., Teitelbaum,S.L. and Ross,F.P.
  TITLE     SHIP-deficient mice are severely osteoporotic due to increased
            numbers of hyper-resorptive osteoclasts
  JOURNAL   Nat Med 8 (9), 943-949 (2002)
   PUBMED   12161749
REFERENCE   5  (bases 1 to 4925)
  AUTHORS   Xu,R., Abramson,J., Fridkin,M. and Pecht,I.
  TITLE     SH2 domain-containing inositol polyphosphate 5'-phosphatase is the
            main mediator of the inhibitory action of the mast cell
            function-associated antigen
  JOURNAL   J Immunol 167 (11), 6394-6402 (2001)
   PUBMED   11714805
  REMARK    GeneRIF: SH2 domain-containing inositol polyphosphate
            5'-phosphatase is the primary enzyme responsible for mediating mast
            cell function-associated antigen (MAFA) inhibition of the Fc
            epsilon RI stimulus-response-coupling cascade in mast cells.
REFERENCE   6  (bases 1 to 4925)
  AUTHORS   Helgason,C.D., Kalberer,C.P., Damen,J.E., Chappel,S.M.,
            Pineault,N., Krystal,G. and Humphries,R.K.
  TITLE     A dual role for Src homology 2 domain-containing
            inositol-5-phosphatase (SHIP) in immunity: aberrant development and
            enhanced function of b lymphocytes in ship -/- mice
  JOURNAL   J Exp Med 191 (5), 781-794 (2000)
   PUBMED   10704460
REFERENCE   7  (bases 1 to 4925)
  AUTHORS   Helgason,C.D., Damen,J.E., Rosten,P., Grewal,R., Sorensen,P.,
            Chappel,S.M., Borowski,A., Jirik,F., Krystal,G. and Humphries,R.K.
  TITLE     Targeted disruption of SHIP leads to hemopoietic perturbations,
            lung pathology, and a shortened life span
  JOURNAL   Genes Dev 12 (11), 1610-1620 (1998)
   PUBMED   9620849
REFERENCE   8  (bases 1 to 4925)
  AUTHORS   Kang,A.D., Wong,P.M., Chen,H., Castagna,R., Chung,S.W. and
            Sultzer,B.M.
  TITLE     Restoration of lipopolysaccharide-mediated B-cell response after
            expression of a cDNA encoding a GTP-binding protein
  JOURNAL   Infect Immun 64 (11), 4612-4617 (1996)
   PUBMED   8890215
REFERENCE   9  (bases 1 to 4925)
  AUTHORS   Lioubin,M.N., Algate,P.A., Tsai,S., Carlberg,K., Aebersold,A. and
            Rohrschneider,L.R.
  TITLE     p150Ship, a signal transduction molecule with inositol
            polyphosphate-5-phosphatase activity
  JOURNAL   Genes Dev 10 (9), 1084-1095 (1996)
   PUBMED   8654924
REFERENCE   10 (bases 1 to 4925)
  AUTHORS   Damen,J.E., Liu,L., Rosten,P., Humphries,R.K., Jefferson,A.B.,
            Majerus,P.W. and Krystal,G.
  TITLE     The 145-kDa protein induced to associate with Shc by multiple
            cytokines is an inositol tetraphosphate and phosphatidylinositol
            3,4,5-triphosphate 5-phosphatase
  JOURNAL   Proc Natl Acad Sci U S A 93 (4), 1689-1693 (1996)
   PUBMED   8643691
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 26, 2020 this sequence version replaced NM_019311.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U55192.1, SRR26360176.1117744.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-333               JAXUCZ010000009.1  95735533-95735865
            334-397             JAXUCZ010000009.1  95751710-95751773
            398-548             JAXUCZ010000009.1  95785178-95785328
            549-720             JAXUCZ010000009.1  95787674-95787845
            721-861             JAXUCZ010000009.1  95789533-95789673
            862-949             JAXUCZ010000009.1  95795075-95795162
            950-1030            JAXUCZ010000009.1  95801219-95801299
            1031-1102           JAXUCZ010000009.1  95801421-95801492
            1103-1226           JAXUCZ010000009.1  95802817-95802940
            1227-1333           JAXUCZ010000009.1  95809428-95809534
            1334-1436           JAXUCZ010000009.1  95813459-95813561
            1437-1633           JAXUCZ010000009.1  95815209-95815405
            1634-1751           JAXUCZ010000009.1  95815827-95815944
            1752-1848           JAXUCZ010000009.1  95818181-95818277
            1849-1987           JAXUCZ010000009.1  95818784-95818922
            1988-2096           JAXUCZ010000009.1  95820296-95820404
            2097-2185           JAXUCZ010000009.1  95820533-95820621
            2186-2267           JAXUCZ010000009.1  95822390-95822471
            2268-2357           JAXUCZ010000009.1  95825650-95825739
            2358-2471           JAXUCZ010000009.1  95827156-95827269
            2472-2554           JAXUCZ010000009.1  95828618-95828700
            2555-2642           JAXUCZ010000009.1  95830031-95830118
            2643-2792           JAXUCZ010000009.1  95830971-95831120
            2793-2889           JAXUCZ010000009.1  95832139-95832235
            2890-3165           JAXUCZ010000009.1  95833978-95834253
            3166-3760           JAXUCZ010000009.1  95837588-95838182
            3761-4925           JAXUCZ010000009.1  95839420-95840584
FEATURES             Location/Qualifiers
     source          1..4925
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..4925
                     /gene="Inpp5d"
                     /note="inositol polyphosphate-5-phosphatase D"
                     /db_xref="GeneID:54259"
                     /db_xref="RGD:2914"
     exon            1..333
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..3763
                     /gene="Inpp5d"
                     /EC_number="3.1.3.56"
                     /EC_number="3.1.3.36"
                     /EC_number="3.1.3.86"
                     /note="SHIP-1; SH2 domain-containing inositol phosphatase
                     1; Inositol polyphosphate-5-phosphatase, 145 kDa; SH2
                     domain-containing inositol 5'-phosphatase 1;
                     phosphatidylinositol-4,5-bisphosphate 5-phosphatase"
                     /codon_start=1
                     /product="phosphatidylinositol 3,4,5-trisphosphate
                     5-phosphatase 1"
                     /protein_id="NP_062184.2"
                     /db_xref="GeneID:54259"
                     /db_xref="RGD:2914"
                     /translation="MPAMVPGWNHGNITRSKAEELLSRAGKDGSFLVRASESIPRAYA
                     LCVLFRNCVYTYRILPNEDDKFTVQASEGVPMRFFTKLDQLIEFYKKENMGLVTHLQF
                     PVPLEEEDAIDEPEEDTESVMSPPELPPRNIPVSAGPCEAKDLPLPTENPRAPEVTRL
                     SLSETLFQRLQSMDTSGLPEEHLKAIQDYLSTQLMLDSDFLKTGSSNLPHLKKLTSLL
                     CKELHGEVIRTLPSLESLQRLFDQQLSPGLRPRPQVPGEANPITMVAKLSQLTSLLSS
                     IEDKVKALLHEGSESTNRRSLIPPVTFEVKSESLGIPQKMHLKVDVESGKLIIKKSRD
                     GSEDKFYSHKKILQLIKSQKFLNKLVILVETEKEKILRKEYVFSDSKKREGFCQLLQQ
                     MKNKHSEQSEPDMITIFIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYIPHDIYV
                     IGTQEDPLGEKEWLEILRHSLQEVTSMTFKTVAIHTLWNIRIVVLAKPEHENRISHIC
                     TDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLA
                     LGDKKLSPFNITHRFTHLFWLGDLNYRVELPTWEAEAIIQKIKQQQYSDLLAHDQLLL
                     ERKEQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKSY
                     PLVHVVCQSYGSTSDIMTSDHSPVFATFEAGVTSQFVSKNGPGAVDSQGQIEFLACYA
                     TLKTKSQTKFYLELHSSCLESFVKSQEGENEEGDEGELVVRFGETLPKLKPIISDPEY
                     LLDQHILISIKSSDSDESYGEGCIALRLETTESQLPIYTPLTHHGEMTGHFRGEIKLQ
                     TSEGKMREKLYDFVKTERDESSGMKCLKNLTSHDPMRQWEPAGRVPACGISSLNEIIN
                     PNYIGMGPFGQPLHGKSTLSPDQQLTAWSYDQLPKDSSLGPGRGEGPPTPPSQPPLSP
                     KKFSSSTANRGSCPRVQETRPGDLGKVEALPQEDLPLTKPEMFENPLYGSVSPFPKLV
                     PRKEQESPKMMRKEPPPCPDPGVSSPSIMLPKAQEVENVKGTSKQAPVPVFGPTPRIR
                     SFTCSSSAEGRMPSGDKSQGKPKAPASSQAPVPVKRPVKPSRSEMSQQTTPIPAPRPP
                     LPVKSPAVLQLQHSKGRDYRDNTELPHHGKHRQEESLLGRTAMQ"
     exon            334..397
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
     exon            398..548
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
     exon            549..720
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
     exon            721..861
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
     exon            862..949
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1030
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1102
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1226
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1333
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1436
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1633
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1751
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1848
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1987
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2096
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2185
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2267
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2357
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2471
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2554
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..2642
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2792
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
     exon            2793..2889
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..3165
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..3760
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
     exon            3761..4925
                     /gene="Inpp5d"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagttctct gcagctcagt ttcctctccc tcgctgagcg cctgaaacag gaagtcagtc
       61 agttaagctg gtagtagcag cagaggcagc ttctgagagg ccacaggcgg caggtctcag
      121 cctagggccc ttaactgctt tgctggagtg tccgtcctgg gagtggctgc tgacccagcc
      181 caggagaccc atgcctgcca tggtccctgg gtggaaccat ggcaacatca cccgatccaa
      241 ggcagaggag ctactttcca gagctggcaa ggacgggagc ttccttgtgc gtgccagcga
      301 gtccatcccc cgggcctacg cgctctgcgt gctgttccgg aattgcgttt acacttacag
      361 gattctgccc aatgaggacg ataaattcac tgttcaggca tccgaaggtg tgcccatgag
      421 gttcttcacg aagttggacc agctcatcga gttttacaag aaagaaaaca tggggctggt
      481 gacccacctg cagttccctg tgcctctgga ggaggaggat gctattgatg agcctgaaga
      541 ggacacagaa agtgtcatgt caccacctga gctgcctccc agaaacatcc ctgtgtctgc
      601 tgggccctgc gaggccaagg accttcctct tccaacagag aacccccgag cccctgaggt
      661 cacccggctg agtctctccg agacactgtt tcagcgtcta cagagtatgg ataccagtgg
      721 gctcccggag gagcacctga aagccatcca ggattatctg agcactcagc tcatgctgga
      781 ctctgacttt ctgaagacag gctccagcaa cctccctcac ctgaagaagc tgacttcact
      841 cctctgcaag gaactccatg gagaagtcat caggaccctc ccgtccctgg agtctctgca
      901 gaggttgttt gaccagcagc tctccccagg ccttcgccca cgacctcagg tgcccggaga
      961 ggccaatccc atcaccatgg tggccaaact gagtcaattg acaagtctgc tgtcttccat
     1021 tgaagataag gtcaaggcct tgctgcatga gggctctgag tctaccaaca ggcgttccct
     1081 tatccctccg gtcacctttg aggtgaagtc agagtccctg ggcattcctc agaaaatgca
     1141 tctcaaagta gacgtcgagt ctgggaaact gatcattaag aagtccagag atggttctga
     1201 ggacaagttc tacagccaca aaaaaattct gcagctcatt aagtcccaga agtttctgaa
     1261 caagctggtg attttggtgg agacggagaa ggagaaaatc ctgaggaagg agtatgtgtt
     1321 ttctgactct aaaaagagag aaggcttctg ccagctcctg cagcagatga agaacaagca
     1381 ctcggagcag tcagagcctg acatgatcac catcttcatt ggcacttgga acatgggtaa
     1441 tgcaccccct cccaagaaga tcacgtcctg gtttctctcc aaggggcagg gaaagacacg
     1501 ggacgactct gctgactata tcccccatga catctacgtg attggcaccc aggaggaccc
     1561 cctgggagag aaggagtggc tggagatact caggcactcc ctgcaagaag tcaccagcat
     1621 gacatttaaa acagttgcca tccacaccct ctggaacatt cgcatagtgg tgctcgccaa
     1681 gccggagcat gagaaccgga tcagccacat ctgcactgac aatgtgaaga caggcatcgc
     1741 gaacaccctg ggaaacaaag gagctgtggg agtgtccttc atgttcaatg gaacctcctt
     1801 ggggttcgtc aacagtcact tgacttctgg aagtgaaaaa aaactcaggc gaaatcaaaa
     1861 ctatatgaac atcctgcggt tcctggccct gggagacaag aagctaagcc catttaacat
     1921 cacccaccgc ttcacccacc tcttctggct tggggatctc aactaccgtg tggagctgcc
     1981 cacctgggag gcagaggcca tcatccagaa gattaagcag cagcagtact cagatcttct
     2041 ggcccacgac caactgctcc tggagaggaa ggagcagaaa gtcttcctgc actttgagga
     2101 ggaggagatc accttcgccc ccacctatcg atttgaaaga ctgacccggg acaagtacgc
     2161 ttacacgaag cagaaagcca cagggatgaa gtacaatttg ccatcctggt gcgaccgagt
     2221 cctctggaag tcttacccgc tggtgcatgt ggtctgtcag tcctacggca gtaccagtga
     2281 catcatgacg agtgaccaca gccctgtctt tgccacgttt gaagcaggag tcacatcgca
     2341 gttcgtctcc aagaatggtc ctggcgccgt ggacagccaa gggcagattg agtttcttgc
     2401 atgctacgcc acactgaaga ccaagtccca gactaagttc tacttggagc tccactcaag
     2461 ctgcttagag agttttgtca aaagtcagga aggagaaaac gaagagggag atgaaggaga
     2521 actggtggta cggtttggag agactcttcc caagctaaag cccattatct ctgaccctga
     2581 gtacttactg gaccagcaca ttctgatcag cattaaatct tctgacagtg acgagtccta
     2641 tggtgaaggc tgcattgccc ttcgtctgga gaccacagag agtcagcttc ccatctacac
     2701 acctctcacc caccacgggg agatgactgg ccacttcagg ggagagatta agctgcagac
     2761 ctctgagggc aagatgagag agaagctcta tgactttgtg aagacagagc gggatgagtc
     2821 cagtggaatg aagtgcttga agaacctcac cagccatgac cccatgaggc agtgggagcc
     2881 tgctggcagg gtccctgcat gtggtatctc cagcctcaat gagatcatca atccaaacta
     2941 tattggtatg gggccttttg gacagcccct gcatgggaaa tcaaccctgt ccccagacca
     3001 gcaactcaca gcctggagtt atgaccagct ccccaaggac tcctccctgg ggcccgggag
     3061 gggagagggt cctcccaccc ctccctccca gccacctctg tcaccaaaga agttttcatc
     3121 ctctacagcc aaccgaggtt cctgccccag ggtgcaagaa acaagacctg gcgatctggg
     3181 aaaggtggaa gccctgccgc aggaggacct gccgctgacg aagcccgaga tgtttgagaa
     3241 cccactgtat gggtccgtga gtcccttccc taagctggtg cccaggaaag agcaggagtc
     3301 tcccaagatg atgcgcaagg agcccccgcc ctgcccagac ccaggagtct cttcacccag
     3361 catcatgctc cccaaagccc aagaggtgga gaatgtcaag gggacgagca aacaggcccc
     3421 tgtgcctgtc tttggcccca caccccggat ccgttccttt acctgttcct cctctgctga
     3481 gggcaggatg cccagtgggg acaagagcca agggaagccc aaggccccag ccagttccca
     3541 agccccagtg ccagtcaaga ggcccgtcaa gccttccagg tcagaaatga gccagcagac
     3601 aacgcccatc ccagctccac ggccacccct gccagtcaag agtcctgcag tcttgcagct
     3661 gcagcattcc aaaggcagag actaccgtga caacacagaa ctcccccacc atggcaagca
     3721 ccgccaggag gagagtctgc ttggcagaac tgccatgcag tgaagtcctc ggggagccgc
     3781 tggtgatggg agcctggagg aacagcacaa agcagatcta cgcctctctg gggatgcctc
     3841 ttggaggacc tcctgctagc tcttcttgcc tagcctagct tcaagtccaa ggctgtgcat
     3901 ttcttcagga aacggcctcc cctctctgtg gtccaaggag tgtgctggct gccatactgt
     3961 gtggcggatg ctgaagctga atgggaagca caagccgtgt ggacaacaga gagccgcacc
     4021 ggggtctcag aactcggact ccagagcctc cttccagtcg ccgtttaaaa gaaaggaact
     4081 gagctgctca tccatggatg aagatataaa taataatatt attaataata ataatggtca
     4141 ggtgccatgt gctgtattaa gtgctttatg aacatttgtt aggctggcct ccggagctga
     4201 ggttccagtc aacctgaacc ctaagcccag acccaccgat cccaaatggc gggtcctgag
     4261 atgtttaaac aaagcattaa ggaaaccagc agtctcctag agctagccgg atggactcta
     4321 atgcagggac ctgaacagac tgcacagcta atggcacagg aggccggccc tgtccagctt
     4381 cagagatata agctgcttta gctggggttc tgtcacaggc ctgagcctct tggtttctac
     4441 tgggttttga atctaccaga gtcagagatc agctccaact tggcagtgca gagatctggc
     4501 ctcaatctaa gccagccact tcagacccct gctgatcctg tggaccaatt aacactccct
     4561 gtgccactag aggtggcacc ataccctggg ttgggccaag cccaccccac taacctgcag
     4621 cacttctgat gtactgagga agaatatcca ccatcgtccc cagtgactga gctctctggg
     4681 cctgctctca gggaaggcgg gccttggtcc caggctctca aaaatagtgt accctcttct
     4741 tctcaagctc tgtggtgcag ccctgtgtcc ttggttacta ggagactagt gtggtgatgt
     4801 ctttaattgt cttgcttttt gatatataag gattaatgta ggaaactaga cctaggttat
     4861 tcaggagggc aggtatatac cctgtgtttc ctagtatgtg tgaccaataa attgtggctt
     4921 tctaa
//
