LOCUS       NM_001100755            3827 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus inositol polyphosphate-5-phosphatase B (Inpp5b),
            mRNA.
ACCESSION   NM_001100755 XM_001056372 XM_342909
VERSION     NM_001100755.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3827)
  AUTHORS   Bernard,D.J. and Nussbaum,R.L.
  TITLE     X-inactivation analysis of embryonic lethality in Ocrl wt/-;
            Inpp5b-/- mice
  JOURNAL   Mamm Genome 21 (3-4), 186-194 (2010)
   PUBMED   20195868
REFERENCE   2  (bases 1 to 3827)
  AUTHORS   Hellsten,E., Evans,J.P., Bernard,D.J., Janne,P.A. and Nussbaum,R.L.
  TITLE     Disrupted sperm function and fertilin beta processing in mice
            deficient in the inositol polyphosphate 5-phosphatase Inpp5b
  JOURNAL   Dev Biol 240 (2), 641-653 (2001)
   PUBMED   11784089
REFERENCE   3  (bases 1 to 3827)
  AUTHORS   Matzaris,M., O'Malley,C.J., Badger,A., Speed,C.J., Bird,P.I. and
            Mitchell,C.A.
  TITLE     Distinct membrane and cytosolic forms of inositol polyphosphate
            5-phosphatase II. Efficient membrane localization requires two
            discrete domains
  JOURNAL   J Biol Chem 273 (14), 8256-8267 (1998)
   PUBMED   9525932
REFERENCE   4  (bases 1 to 3827)
  AUTHORS   Jefferson,A.B. and Majerus,P.W.
  TITLE     Properties of type II inositol polyphosphate 5-phosphatase
  JOURNAL   J Biol Chem 270 (16), 9370-9377 (1995)
   PUBMED   7721860
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB611564.1, JAXUCZ010000005.1, CB748743.1, BC098852.1 and
            CB324491.1.
            
            On or before May 22, 2010 this sequence version replaced
            XM_001056372.2, XM_342909.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-546               CB611564.1         1-546
            547-599             JAXUCZ010000005.1  142286566-142286618
            600-1040            CB748743.1         1-441
            1041-3804           BC098852.1         188-2951
            3805-3827           CB324491.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..3827
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3827
                     /gene="Inpp5b"
                     /note="inositol polyphosphate-5-phosphatase B"
                     /db_xref="GeneID:362590"
                     /db_xref="RGD:1311511"
     exon            1..50
                     /gene="Inpp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            51..433
                     /gene="Inpp5b"
                     /inference="alignment:Splign:2.1.0"
     CDS             377..3127
                     /gene="Inpp5b"
                     /EC_number="3.1.3.36"
                     /note="type II inositol 1,4,5-trisphosphate
                     5-phosphatase-like"
                     /codon_start=1
                     /product="type II inositol 1,4,5-trisphosphate
                     5-phosphatase"
                     /protein_id="NP_001094225.1"
                     /db_xref="GeneID:362590"
                     /db_xref="RGD:1311511"
                     /translation="MDQSVAIQETLVEGEYCVIAVQGVLCKGDSRQSRLLGLVRYRLE
                     NDVQEHALFLYTHRRMAITGDDVALDQIVPLSKDFMLEEVSPDGELYILGSDVTVQLT
                     TAELRLVFQLPFGSHTRTFLQEVARACPGFDPETRDPEFLWLCRHRCAESEAESPKPR
                     EWNSDPGTRSGFAPIGGGGYNVDSSRPNGRGLLPLDQSSGARCPDKPENSLTRQNRSK
                     AEITDMVRSSTITVSDKAHILSMQKFGLRDTMVRSHLLQKEGEYTYIQNFRFFVGTYN
                     VNGQSPKECLRPWLSSDTKAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSESLH
                     PDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQL
                     HNTSICVVNSHLAAHTEEYERRNQDYRDICSRMQFSQVDPSLPPLTISKHDVILWLGD
                     LNYRIEELDVEKVKKLVEEKAFHTLYAHDQLKIQVAAKTVFEGFTEGEITFQPTYKYD
                     TGSDNWDTSEKCRAPAWCDRVLWRGKNISQLSYQSHMSLKTSDHKPVSSVFEIGVRVV
                     NEELYRKTLEEIVRSLDKMENANIPSVTLSKREFCFENVKYMQLQTATFTIHNGQVPC
                     EFEFINKPDEETYCKQWLTAKPSRGFLLPDSHVEIELELFVNKATATKLNSGKDTIED
                     ILVLHLHRGKDYFLSVTGNYLPSCFGSPIHTLCYMREPILDLPLKIVNELTLMTVQTA
                     DDRSQLEKPMEIPKELWMMVDYLYRNAVQQEDLFQQPGLRPEFEHIRDCLDTGMIDHL
                     CANNHSVAEALLLFLESLPEPVICYSAYHSCLECSGSHTASKQVISTLPTFHKNVFSY
                     LMAFLQELLKNSAKNHLDENILASIFGSLLLRSPAGHRKLDMAEKKKAQEFIHHFLCN
                     PL"
     exon            434..528
                     /gene="Inpp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            529..626
                     /gene="Inpp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            627..656
                     /gene="Inpp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            657..767
                     /gene="Inpp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            768..908
                     /gene="Inpp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1014
                     /gene="Inpp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1182
                     /gene="Inpp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1284
                     /gene="Inpp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1399
                     /gene="Inpp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1516
                     /gene="Inpp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1704
                     /gene="Inpp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1816
                     /gene="Inpp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1926
                     /gene="Inpp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2062
                     /gene="Inpp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2173
                     /gene="Inpp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2336
                     /gene="Inpp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2572
                     /gene="Inpp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2686
                     /gene="Inpp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2771
                     /gene="Inpp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            2772..2899
                     /gene="Inpp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..3011
                     /gene="Inpp5b"
                     /inference="alignment:Splign:2.1.0"
     exon            3012..3809
                     /gene="Inpp5b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggcctggg acgtcggtgt cctgcaggcc taccggtgac agctcaggag agaagagcca
       61 gacggaccat aactgctccc tgaagagggc atcagagata tacccagaag caaggagacg
      121 ggcaagcata ctgaacccca ctgggaacat ctggggcaac atccagcaag gagcagagag
      181 gtggaaaccc attttctgga aacgttgaga ggcccattgt aggaaagagg gggaaggacc
      241 ggaaggagaa gcaagacgac caggctctct cttttccctc cacaaacgcc tcctccatcc
      301 ccgcagtgcc gtgaagcagc tctaatacag catgggaggt tcccaacttc tctatcccag
      361 ggtttgacag atcagcatgg accagtctgt ggcaatccag gagaccctgg ttgaggggga
      421 atactgcgtc atcgcagtac aaggtgtgct gtgtaaggga gacagcaggc agagtcgcct
      481 gctcgggctg gtgcgatacc ggctggaaaa tgacgtccag gagcatgccc tcttcctgta
      541 tacacaccgg aggatggcca tcacaggaga cgatgtagct ctggaccaga tagtgccact
      601 ctccaaagac tttatgctgg aagaagtgtc cccagacggt gaactctaca tcctcggctc
      661 tgatgtgacg gtacaactga ccacagctga actcaggctt gtattccaac taccctttgg
      721 ttcacacacc agaacattcc tccaggaagt tgccagagcc tgcccaggtt tcgaccctga
      781 gacgcgggat cccgagttcc tgtggctgtg cagacaccgg tgcgcggagt ccgaagcaga
      841 gtcgccgaaa ccccgcgagt ggaattcgga cccgggtacc cggagtggct tcgcgcccat
      901 tggaggaggt ggttataacg ttgacagctc gaggccaaat gggagaggcc tgctgccttt
      961 ggaccaaagc tctggggcca ggtgtccgga taaaccagaa aactctctca caagacagaa
     1021 tagatcgaag gctgaaatta ctgacatggt tcgctcctcc acgatcacgg tatcggacaa
     1081 ggctcacatt ttatccatgc agaagttcgg gctgcgagac acaatggtga ggtcacacct
     1141 cctgcagaag gaaggggagt atacctacat ccagaacttc aggttttttg tgggaacata
     1201 caatgtgaac ggacagtccc ccaaagaatg cctccggccc tggctgagct ccgacaccaa
     1261 ggccccagat gtgtactgtg tagggttcca ggaactcgat ctgagtaagg aggccttctt
     1321 ctttcatgat accccaaagg aggaggagtg gtttaaggct gtgtcagaaa gccttcaccc
     1381 agatgccaag tacgcaaagg tgaagctcat ccggctggtt gggattatgt tgctgttgta
     1441 tgtcaaacag gagcacgcag cctatatctc agaggtggaa gctgagactg tggggacagg
     1501 aatcatggga aggatgggga acaaaggagg agtggccatc aggttccagc tgcacaacac
     1561 cagcatctgc gttgtcaatt cccacctggc agcccacaca gaggagtacg agaggaggaa
     1621 ccaggactat agagacattt gttctcgaat gcagttctct caggtggacc cgagcctccc
     1681 ccctctcacc attagcaagc acgatgtgat cttgtggctg ggggacctca actacagaat
     1741 agaagagctg gatgtggaaa aggtgaaaaa gctcgtggaa gagaaggcct tccacaccct
     1801 gtatgcgcac gaccagctga aaatccaggt ggctgccaag accgtctttg aaggcttcac
     1861 cgagggtgag attacattcc agcctactta caagtacgat actggctctg acaactggga
     1921 taccagtgag aagtgtcgcg cgcctgcctg gtgtgaccga gtcctgtgga ggggaaagaa
     1981 catcagtcag ctgagttacc agagccacat gtccttgaag accagtgacc acaagcccgt
     2041 cagctcagtg tttgagattg gggtgagggt tgtcaatgaa gaactctacc ggaagaccct
     2101 ggaggaaatc gtacgctccc tggataaaat ggaaaatgcc aacattcctt ctgtgacact
     2161 ctccaagcgg gagttctgtt ttgaaaatgt gaagtacatg cagttgcaaa ccgcaacctt
     2221 cacgattcat aatggccaag tgccctgtga gtttgaattc atcaacaagc ctgatgagga
     2281 gacctactgt aagcagtggc tgacggccaa acccagcagg ggcttcctcc tgccagattc
     2341 tcatgtcgag attgaactgg agctctttgt aaataaggct accgccacaa aactcaactc
     2401 aggcaaggac accattgaag acattctggt tttacacttg catcggggaa aggattactt
     2461 tttgtccgtg accgggaact acctgcccag ctgtttcggg tctcccatcc atacattgtg
     2521 ctacatgaga gagcccatct tggatctacc actgaaaatt gttaacgagc tgaccttgat
     2581 gacagtgcag actgcagatg acagaagcca gttggagaaa cccatggaaa tccccaaaga
     2641 actctggatg atggtcgatt acctatatag aaatgctgtc cagcaggaag atctgtttca
     2701 gcagccaggc ctgaggccag agtttgagca cataagggac tgtttagata ctggaatgat
     2761 cgatcacctc tgcgctaaca accactctgt agccgaagcc ttgctgcttt tcctagagag
     2821 cctgccggag cccgtcatct gctacagcgc ctaccacagc tgcttggagt gttctggcag
     2881 tcacacagcg agcaaacagg tcatttccac tctccccacc ttccacaaaa atgtcttcag
     2941 ctacttgatg gcgtttttgc aagaactgct gaaaaattca gcaaaaaatc atttggatga
     3001 gaatatttta gctagcatat ttggcagctt attgctccga agcccagctg gtcaccgaaa
     3061 acttgacatg gcagagaaga agaaggccca agagtttatt caccactttc tctgcaatcc
     3121 actctgagcc tcagtactcc tcctgttttc ctcaaggcag ccacaactgt cagccccaca
     3181 tgtttcagct cacgacctgc cttaggatgg cctgaggcca gctggaagaa tggcagctac
     3241 ctgtttcttg aacctagacc tgtcccttac ccatgccgtt gtcttgcaca cccgtgctga
     3301 tttatgaaga catgggggaa atccaccgta atagaactga cgttccatgt tcaattttag
     3361 ttatttaacg caaatagatc tctattcatt tttatttaaa aagttttaag taactgtact
     3421 ttgccttatt caacctgcct ccaggacatg cagtcagtga gttccccata ttctgtactg
     3481 agcatctcat ggtcagacac ttggactaac cgaagtcctt aagggaaaat ggcttagaca
     3541 gcaggacttt gcttagatgt ccctggataa acaactttag tcatcccaga tgcttccact
     3601 gtccaagctg aggacatgta catgcatagg gcaactgtaa cctttctact caactccaag
     3661 gcctctcagt cacccctaaa agcactgaag aaagggggtt ctggtgaaac aagtgggatt
     3721 ttgtaggctc tccagtcctc ccaactgtat ataagctcac ctttcataat gtaatatatt
     3781 ttaatgataa atgtattttt aacagtggta aaaaaaaaaa aaaaaaa
//
