LOCUS       NP_001094225             916 aa            linear   ROD 31-MAR-2024
DEFINITION  type II inositol 1,4,5-trisphosphate 5-phosphatase [Rattus
            norvegicus].
ACCESSION   NP_001094225 XP_001056372 XP_342910
VERSION     NP_001094225.1
DBSOURCE    REFSEQ: accession NM_001100755.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 916)
  AUTHORS   Bernard,D.J. and Nussbaum,R.L.
  TITLE     X-inactivation analysis of embryonic lethality in Ocrl wt/-;
            Inpp5b-/- mice
  JOURNAL   Mamm Genome 21 (3-4), 186-194 (2010)
   PUBMED   20195868
REFERENCE   2  (residues 1 to 916)
  AUTHORS   Hellsten,E., Evans,J.P., Bernard,D.J., Janne,P.A. and Nussbaum,R.L.
  TITLE     Disrupted sperm function and fertilin beta processing in mice
            deficient in the inositol polyphosphate 5-phosphatase Inpp5b
  JOURNAL   Dev Biol 240 (2), 641-653 (2001)
   PUBMED   11784089
REFERENCE   3  (residues 1 to 916)
  AUTHORS   Matzaris,M., O'Malley,C.J., Badger,A., Speed,C.J., Bird,P.I. and
            Mitchell,C.A.
  TITLE     Distinct membrane and cytosolic forms of inositol polyphosphate
            5-phosphatase II. Efficient membrane localization requires two
            discrete domains
  JOURNAL   J Biol Chem 273 (14), 8256-8267 (1998)
   PUBMED   9525932
REFERENCE   4  (residues 1 to 916)
  AUTHORS   Jefferson,A.B. and Majerus,P.W.
  TITLE     Properties of type II inositol polyphosphate 5-phosphatase
  JOURNAL   J Biol Chem 270 (16), 9370-9377 (1995)
   PUBMED   7721860
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB611564.1, JAXUCZ010000005.1, CB748743.1, BC098852.1 and
            CB324491.1.
            
            On or before May 22, 2010 this sequence version replaced
            XP_001056372.2, XP_342910.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..916
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     Protein         1..916
                     /product="type II inositol 1,4,5-trisphosphate
                     5-phosphatase"
                     /EC_number="3.1.3.36"
                     /note="type II inositol 1,4,5-trisphosphate
                     5-phosphatase-like"
                     /calculated_mol_wt=104281
     Region          1..144
                     /region_name="INPP5B_PH"
                     /note="Type II inositol 1,4,5-trisphosphate 5-phosphatase
                     PH domain; pfam16776"
                     /db_xref="CDD:465268"
     Region          268..561
                     /region_name="INPP5c_INPP5B"
                     /note="Catalytic inositol polyphosphate 5-phosphatase
                     (INPP5c) domain of Type II inositol polyphosphate
                     5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and
                     related proteins; cd09093"
                     /db_xref="CDD:197327"
     Site            order(276,278,306,309,311,314,376,382..383,403,406..407,
                     450,452,454,505..506,519,521,527,551..552)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:197327"
     Site            order(276,306,403,450,452,527,551..552)
                     /site_type="active"
                     /note="putative catalytic site [active]"
                     /db_xref="CDD:197327"
     Site            order(278,306,551)
                     /site_type="other"
                     /note="Mg binding site [ion binding]"
                     /db_xref="CDD:197327"
     Site            order(306,309,311,314,376,382..383,403,406..407,454,
                     505..506,519,521,551)
                     /site_type="other"
                     /note="putative PI/IP binding site [chemical binding]"
                     /db_xref="CDD:197327"
     Site            order(403,452,552)
                     /site_type="other"
                     /note="putative phosphate binding site [ion binding]"
                     /db_xref="CDD:197327"
     Region          695..915
                     /region_name="RhoGAP_OCRL1"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in OCRL1-like proteins.
                     OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins
                     contain two conserved domains: a central inositol
                     polyphosphate 5-phosphatase domain and...; cd04380"
                     /db_xref="CDD:239845"
     Site            order(775,810,814,877,880..881,906)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239845"
     Site            775
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239845"
     CDS             1..916
                     /gene="Inpp5b"
                     /coded_by="NM_001100755.1:377..3127"
                     /db_xref="GeneID:362590"
                     /db_xref="RGD:1311511"
ORIGIN      
        1 mdqsvaiqet lvegeycvia vqgvlckgds rqsrllglvr yrlendvqeh alflythrrm
       61 aitgddvald qivplskdfm leevspdgel yilgsdvtvq lttaelrlvf qlpfgshtrt
      121 flqevaracp gfdpetrdpe flwlcrhrca eseaespkpr ewnsdpgtrs gfapiggggy
      181 nvdssrpngr gllpldqssg arcpdkpens ltrqnrskae itdmvrssti tvsdkahils
      241 mqkfglrdtm vrshllqkeg eytyiqnfrf fvgtynvngq spkeclrpwl ssdtkapdvy
      301 cvgfqeldls keafffhdtp keeewfkavs eslhpdakya kvklirlvgi mlllyvkqeh
      361 aayiseveae tvgtgimgrm gnkggvairf qlhntsicvv nshlaahtee yerrnqdyrd
      421 icsrmqfsqv dpslppltis khdvilwlgd lnyrieeldv ekvkklveek afhtlyahdq
      481 lkiqvaaktv fegftegeit fqptykydtg sdnwdtsekc rapawcdrvl wrgknisqls
      541 yqshmslkts dhkpvssvfe igvrvvneel yrktleeivr sldkmenani psvtlskref
      601 cfenvkymql qtatftihng qvpcefefin kpdeetyckq wltakpsrgf llpdshveie
      661 lelfvnkata tklnsgkdti edilvlhlhr gkdyflsvtg nylpscfgsp ihtlcymrep
      721 ildlplkivn eltlmtvqta ddrsqlekpm eipkelwmmv dylyrnavqq edlfqqpglr
      781 pefehirdcl dtgmidhlca nnhsvaeall lfleslpepv icysayhscl ecsgshtask
      841 qvistlptfh knvfsylmaf lqellknsak nhldenilas ifgslllrsp aghrkldmae
      901 kkkaqefihh flcnpl
//
