LOCUS       NM_053917               4392 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Rattus norvegicus inositol polyphosphate-4-phosphatase type II B
            (Inpp4b), transcript variant 1, mRNA.
ACCESSION   NM_053917
VERSION     NM_053917.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4392)
  AUTHORS   Balakrishnan,A. and Chaillet,J.R.
  TITLE     Role of the inositol polyphosphate-4-phosphatase type II Inpp4b in
            the generation of ovarian teratomas
  JOURNAL   Dev Biol 373 (1), 118-129 (2013)
   PUBMED   23078915
REFERENCE   2  (bases 1 to 4392)
  AUTHORS   Ferron,M., Boudiffa,M., Arsenault,M., Rached,M., Pata,M.,
            Giroux,S., Elfassihi,L., Kisseleva,M., Majerus,P.W., Rousseau,F.
            and Vacher,J.
  TITLE     Inositol polyphosphate 4-phosphatase B as a regulator of bone mass
            in mice and humans
  JOURNAL   Cell Metab 14 (4), 466-477 (2011)
   PUBMED   21982707
REFERENCE   3  (bases 1 to 4392)
  AUTHORS   Ferron,M. and Vacher,J.
  TITLE     Characterization of the murine Inpp4b gene and identification of a
            novel isoform
  JOURNAL   Gene 376 (1), 152-161 (2006)
   PUBMED   16631325
REFERENCE   4  (bases 1 to 4392)
  AUTHORS   Norris,F.A., Atkins,R.C. and Majerus,P.W.
  TITLE     The cDNA cloning and characterization of inositol polyphosphate
            4-phosphatase type II. Evidence for conserved alternative splicing
            in the 4-phosphatase family
  JOURNAL   J Biol Chem 272 (38), 23859-23864 (1997)
   PUBMED   9295334
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053917.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U96921.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               JAXUCZ010000019.1  43574219-43574411   c
            194-256             JAXUCZ010000019.1  43440504-43440566   c
            257-465             JAXUCZ010000019.1  43184881-43185089   c
            466-510             JAXUCZ010000019.1  43182631-43182675   c
            511-629             JAXUCZ010000019.1  43152488-43152606   c
            630-746             JAXUCZ010000019.1  43149943-43150059   c
            747-797             JAXUCZ010000019.1  43077934-43077984   c
            798-877             JAXUCZ010000019.1  43066973-43067052   c
            878-989             JAXUCZ010000019.1  43037485-43037596   c
            990-1062            JAXUCZ010000019.1  43029853-43029925   c
            1063-1210           JAXUCZ010000019.1  43015894-43016041   c
            1211-1341           JAXUCZ010000019.1  42976148-42976278   c
            1342-1446           JAXUCZ010000019.1  42975684-42975788   c
            1447-1555           JAXUCZ010000019.1  42964806-42964914   c
            1556-1733           JAXUCZ010000019.1  42948699-42948876   c
            1734-1940           JAXUCZ010000019.1  42936083-42936289   c
            1941-2106           JAXUCZ010000019.1  42923376-42923541   c
            2107-2279           JAXUCZ010000019.1  42903688-42903860   c
            2280-2403           JAXUCZ010000019.1  42902436-42902559   c
            2404-2521           JAXUCZ010000019.1  42901260-42901377   c
            2522-2662           JAXUCZ010000019.1  42898515-42898655   c
            2663-2760           JAXUCZ010000019.1  42896402-42896499   c
            2761-2873           JAXUCZ010000019.1  42877164-42877276   c
            2874-3028           JAXUCZ010000019.1  42874276-42874430   c
            3029-4392           JAXUCZ010000019.1  42830100-42831463   c
FEATURES             Location/Qualifiers
     source          1..4392
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..4392
                     /gene="Inpp4b"
                     /note="inositol polyphosphate-4-phosphatase type II B"
                     /db_xref="GeneID:116699"
                     /db_xref="RGD:620470"
     exon            1..193
                     /gene="Inpp4b"
                     /inference="alignment:Splign:2.1.0"
     exon            194..256
                     /gene="Inpp4b"
                     /inference="alignment:Splign:2.1.0"
     exon            257..465
                     /gene="Inpp4b"
                     /inference="alignment:Splign:2.1.0"
     CDS             375..3203
                     /gene="Inpp4b"
                     /EC_number="3.1.3.66"
                     /note="inositol polyphosphate 4-phosphatase type II;
                     inositol polyphosphate-4-phosphatase, type II, 105kD"
                     /codon_start=1
                     /product="type II inositol 3,4-bisphosphate 4-phosphatase"
                     /protein_id="NP_446369.1"
                     /db_xref="GeneID:116699"
                     /db_xref="RGD:620470"
                     /translation="MEIKEEGTSEEGQHFLPAAQANDPEDIQFTSIQKSPNEPQLEFI
                     LACKDLVAPVSDRKLNTVVQVSVIHPVEQTLTRYSSTEIVEGTKDPLFLTGVTFPSDY
                     PIYEETRIKLTVYDVKDKPHDTIRTSVLPEHKDPPPEVARSFLGCASFKVGELLKSKE
                     QLLSLSLRTSDGGKVVGTIEVSLVKMGEIEDGDTDHITTDVQGQKCALVYDSTAPESL
                     SGKENLPFMNAVLRNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKED
                     LCRNQELKELGDLSPHWDNLRNNVLSHCDQMVTMYQDILTELSKETGSSFKSSSSKGE
                     KTLEFVPINLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETER
                     RNTGYQFIYYSPENTAKAKEVLSSINQLQPLVATHADLLLTSASQHSPDSLRSSLKLL
                     SEKTELFVHAFKDQLVRSALLALYTARPGGILRKPPSPKVSTEEKSSQHDSPQQLRRQ
                     DSIPHHSDYDEEEWDRVWANVGKSLNCIIAKVDKLIERDSRNDKSTGGDSSKDGDADP
                     NLEDSLTSHPREDWYEQLHPLILTLKECMAEVVNRAKQSLTFVLLQELAYSLPQCLML
                     TLRRDIVFSQALAGLVCGFIIKLHTSLHDPGFLQQLHTVGLIVQYEGLLSTYSDEIGM
                     LEDMAVGISDLRKVAFKITEATSNDVLPVLTGRREHYVVEVKLPATVFESLPLQIKEG
                     QLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELVQEYYSIFMEKMPPDYIS
                     HFQEQNDLKGLLDNLHQNIQAKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMS
                     VTLEQCSILRDEHQLHKDFFIRALDCMRSRQTQGALNESDDPETGCLSDNKPTSRHFY
                     PVALLLVSSHLLVVWLILSLALLLAKYQ"
     exon            466..510
                     /gene="Inpp4b"
                     /inference="alignment:Splign:2.1.0"
     exon            511..629
                     /gene="Inpp4b"
                     /inference="alignment:Splign:2.1.0"
     exon            630..746
                     /gene="Inpp4b"
                     /inference="alignment:Splign:2.1.0"
     exon            747..797
                     /gene="Inpp4b"
                     /inference="alignment:Splign:2.1.0"
     exon            798..877
                     /gene="Inpp4b"
                     /inference="alignment:Splign:2.1.0"
     exon            878..989
                     /gene="Inpp4b"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1062
                     /gene="Inpp4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1210
                     /gene="Inpp4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1341
                     /gene="Inpp4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1446
                     /gene="Inpp4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1555
                     /gene="Inpp4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1733
                     /gene="Inpp4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1940
                     /gene="Inpp4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2106
                     /gene="Inpp4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2279
                     /gene="Inpp4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2403
                     /gene="Inpp4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2521
                     /gene="Inpp4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2662
                     /gene="Inpp4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2760
                     /gene="Inpp4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..2873
                     /gene="Inpp4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..3028
                     /gene="Inpp4b"
                     /inference="alignment:Splign:2.1.0"
     exon            3029..4392
                     /gene="Inpp4b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagccgggag gctcggtcgg cgccctgcac gcaaccatcc tccgggttcc cagccccggg
       61 tgctgagctc gccgctataa atagcaggtt acagcttctg cttgggcgca ctcgctctca
      121 ctggagaagg ctggaaagtc aacctgaaaa gtgtctgccg ctgctatcgc cccctactca
      181 gcctctgcaa gagaacccaa agaaatggtg tcacctggca agaggtctgc cgctttttat
      241 gaaaaatcag ctcaagaatc tcgcagtgga ctattagatc attaatgtga agatacatca
      301 acgtcaaacc ggaacattat ctggtaccat ttggaaaaga cactgtggag aataagtcag
      361 ttgtgaggtg gatcatggaa atcaaagagg aaggaacgtc agaagaaggc cagcattttc
      421 ttccagcagc tcaggcaaat gaccctgagg acattcagtt taccagcatc cagaagagtc
      481 ccaatgagcc acagttggaa ttcattcttg cctgcaagga ccttgtggct cctgtcagtg
      541 atcggaaact gaatacagta gtacaggtct cagtaatcca ccccgtggag cagaccctga
      601 cgaggtactc cagcacagaa attgtggagg gaacaaaaga cccactgttc ctgacaggcg
      661 tcacattccc atccgactac cccatctatg aagagacaag aataaaactg acagtctatg
      721 atgtcaagga taagccgcat gatactattc gaaccagtgt ccttccggaa cacaaggatc
      781 ccccgccaga agttgcgaga agcttcctgg gctgtgccag ctttaaagtc ggggagctgc
      841 tgaagtccaa ggagcaactg ctgtccctga gcctgaggac ctcagatggt ggcaaagtgg
      901 tcggcaccat agaagtcagc ctcgtgaaga tgggggagat tgaggatggg gacaccgacc
      961 acatcacaac agacgtgcag ggacaaaagt gtgccctagt gtatgattct accgcaccag
     1021 agagtctgag tgggaaggaa aacttacctt tcatgaacgc agtgttaagg aatcctgtgt
     1081 gtaaactgta cagattcccc acgtctgaca ataagtggat gcgaatccgt gagcagatgt
     1141 cagaaagcat cctttctttt catattccta aggaattgat ttcccttcac atcaaagaag
     1201 acctatgcag aaaccaggag ttaaaagaac ttggtgacct ttctccacac tgggacaacc
     1261 tacggaacaa tgtcctttct cactgtgatc aaatggtgac tatgtaccaa gatattctga
     1321 cagaactttc caaggaaacg gggtcctcct tcaaatccag cagcagcaaa ggagagaaaa
     1381 cattagaatt tgttccaata aacctgcact tgcaacggat gcaggtgcac agccctcacc
     1441 tgaaagatgc tctctatgat gtcatcactg tgggggcccc agctgcccat tttcagggat
     1501 tcaagaatgg tggtcttcga aaactactcc atagatttga gacagagaga aggaacaccg
     1561 ggtaccagtt tatttattat tcgcccgaga acacggccaa ggcaaaggaa gttctcagca
     1621 gcatcaatca gctgcaacct ctcgtagcga ctcatgcgga cctgctgcta acctctgcca
     1681 gccagcattc tcctgacagc ctgaggagtt ctttaaagct gctttcagaa aaaaccgagc
     1741 tttttgtgca tgccttcaag gaccagctgg tcaggagtgc tctcttagct ctctacactg
     1801 cgaggccagg aggtatcctt aggaagccac cttctcctaa ggtcagcaca gaggagaaaa
     1861 gtagccagca tgatagcccg cagcagctta gaagacaaga ctccatacca catcactctg
     1921 actatgatga ggaagagtgg gacagggtgt gggccaacgt gggaaagagc ctaaactgta
     1981 ttatcgctaa agttgacaaa ctgatcgaga gagacagtcg caacgacaaa agtactggag
     2041 gcgacagtag caaggacgga gatgcggacc ctaacctgga agattccctc acatcccacc
     2101 caagggagga ctggtatgaa cagctgcacc cactcatcct taccttgaag gagtgcatgg
     2161 cagaagtggt gaaccgagcg aagcaatccc tgacatttgt gctgcttcag gaactcgcct
     2221 acagtctgcc ccagtgtttg atgctgactc tgaggagaga catcgtcttc agtcaggcgc
     2281 ttgctggatt ggtttgtggt tttatcatca aactacacac aagtttgcac gaccctggct
     2341 tcctccagca gcttcacaca gtgggcttga tagtgcagta cgaagggctg ctaagcactt
     2401 acagtgacga aatcggaatg ctggaggaca tggctgtcgg catttcagac ttaaggaagg
     2461 tcgctttcaa aataacggaa gccacatcca atgatgtcct ccctgttctc acaggaaggc
     2521 gcgaacacta cgtggtggag gtcaagcttc cagcgacagt gtttgagtcg ctccctctgc
     2581 aaattaaaga aggccagttg cttcatgtgt atcctgttct gtttaacgtt ggaatcaatg
     2641 agcagcagac tctggccgag aggttcggag atgtttcttt gcaagaaagt attaatcaag
     2701 aaaattttga gcttgtacaa gaatattatt caatatttat ggaaaagatg ccgcctgatt
     2761 atatttcaca ttttcaagaa caaaatgatt taaaaggact gttggacaat ctccaccaaa
     2821 atatccaagc caagaaaaga aaaaatgtag aaatcatgtg gctggcagca acgatttgtc
     2881 gcaaactcaa tggcattcgt tttacctgct gcaaaagtgc caaagacagg acatcaatgt
     2941 cagtgacgct ggaacagtgc tccatcctga gagacgagca tcagctccac aaagactttt
     3001 tcatcagagc attagattgc atgaggagca gacaaaccca gggggccttg aatgagtcgg
     3061 atgatcctga gacaggctgc ctaagcgata acaagccgac ttctcgacac ttctaccctg
     3121 tcgccctgct tcttgtcagt tcacatctgc tagttgtgtg gctcatttta agtcttgctt
     3181 tactcttagc caaataccaa taagttttat gctatgttcc ttgcttttct acaagagaca
     3241 atggacttta attctctaca agagacaatg ttgtaagatt tctacatttt cagattcaca
     3301 gaatttaaaa aaaaattaga agaagaaatg tttgaattgt ggttttgttt tgttcttgat
     3361 tttgtttttc cctaaaacct aaaaggcaaa aaaaggtact atgcattgag tggattcttt
     3421 tgctcttttg tttatggaaa agtgctttcc cgccattaaa tagctaaaga caagttttta
     3481 acttgctgtc tttggagtaa gacaaagaat agaatcctgc aagcttgaag ttctgaacct
     3541 cctcatcccg ggtcattcac taaagaaatt aggtcggaca ttgcgcagcg gttaaacccc
     3601 caagacactc gggaagtggt ggttgcagac tttctttcca ctgtgctaat attaacagag
     3661 ttgccgtcag ctaatagaaa tgtgtctgct tttcttactc tgttcctaat catcccttac
     3721 ccattcatgt gcttaacctt ctttgtcaag tgactttatg aaaaggatgg ctatttctgt
     3781 tttgtaatta aattaacctg tttgtaacta ttgtttgggt tgatttggct ttcagactac
     3841 ttttctattc tttttaacaa ggtctcattt gtgtcttgat gcgccatttt tagcacctgt
     3901 gacttttgta ctgtggtaga ggggacaggc tcttcagaaa gccatctcct ctctgcactg
     3961 catagctaaa acagtgaggt aaaataggga tggaacttcc tttaaaaaaa atctataggg
     4021 ccagacttaa taaattaaat gccttattcc tagaactgca tccttagggc tacatgtaga
     4081 ttttaatgtg ttttaaggga cagatagtta atttgtggaa aagctataca aaggcagata
     4141 tatttatgaa attaaagtaa agttgtattg tggagcaaat tatatttaaa gagtttatta
     4201 aaagttaaat atctgttaag aaacttaatc atatctttcc gaaggcaata atggtattgg
     4261 gcctggccta ggatttaatt ttgtaagatg tatcatcact tgtggaaaaa gaaatgtaga
     4321 gttgaatctt ggttattttt acttggactg ttgctgcaac tctgcactga acaaataaag
     4381 catatttatt ta
//
