LOCUS       NM_031002               5630 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus inositol polyphosphate-4-phosphatase type I A
            (Inpp4a), mRNA.
ACCESSION   NM_031002
VERSION     NM_031002.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5630)
  AUTHORS   Chaudhuri,R., Khanna,K., Koundinya,D., Pattnaik,B., Vatsa,D.,
            Agrawal,A. and Ghosh,B.
  TITLE     Novel nuclear translocation of inositol polyphosphate 4-phosphatase
            is associated with cell cycle, proliferation and survival
  JOURNAL   Biochim Biophys Acta Mol Cell Res (2018) In press
   PUBMED   30071275
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 5630)
  AUTHORS   Sasaki,J., Kofuji,S., Itoh,R., Momiyama,T., Takayama,K.,
            Murakami,H., Chida,S., Tsuya,Y., Takasuga,S., Eguchi,S.,
            Asanuma,K., Horie,Y., Miura,K., Davies,E.M., Mitchell,C.,
            Yamazaki,M., Hirai,H., Takenawa,T., Suzuki,A. and Sasaki,T.
  TITLE     The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of
            excitotoxic neuronal death
  JOURNAL   Nature 465 (7297), 497-501 (2010)
   PUBMED   20463662
REFERENCE   3  (bases 1 to 5630)
  AUTHORS   Norris,F.A., Auethavekiat,V. and Majerus,P.W.
  TITLE     The isolation and characterization of cDNA encoding human and rat
            brain inositol polyphosphate 4-phosphatase
  JOURNAL   J Biol Chem 270 (27), 16128-16133 (1995)
   PUBMED   7608176
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Mar 8, 2021 this sequence version replaced NM_031002.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760433,
                              SAMN12840105 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               JAXUCZ010000009.1  47024492-47024610
            120-181             JAXUCZ010000009.1  47086607-47086668
            182-389             JAXUCZ010000009.1  47087471-47087678
            390-434             JAXUCZ010000009.1  47088117-47088161
            435-553             JAXUCZ010000009.1  47096542-47096660
            554-670             JAXUCZ010000009.1  47098516-47098632
            671-750             JAXUCZ010000009.1  47098892-47098971
            751-862             JAXUCZ010000009.1  47099228-47099339
            863-953             JAXUCZ010000009.1  47100179-47100269
            954-1101            JAXUCZ010000009.1  47100649-47100796
            1102-1232           JAXUCZ010000009.1  47102489-47102619
            1233-1337           JAXUCZ010000009.1  47104582-47104686
            1338-1446           JAXUCZ010000009.1  47105158-47105266
            1447-1464           JAXUCZ010000009.1  47107076-47107093
            1465-1648           JAXUCZ010000009.1  47110622-47110805
            1649-1867           JAXUCZ010000009.1  47112098-47112316
            1868-2006           JAXUCZ010000009.1  47113173-47113311
            2007-2039           JAXUCZ010000009.1  47115950-47115982
            2040-2212           JAXUCZ010000009.1  47119964-47120136
            2213-2336           JAXUCZ010000009.1  47121006-47121129
            2337-2463           JAXUCZ010000009.1  47121257-47121383
            2464-2604           JAXUCZ010000009.1  47121675-47121815
            2605-2702           JAXUCZ010000009.1  47123805-47123902
            2703-2815           JAXUCZ010000009.1  47127218-47127330
            2816-2970           JAXUCZ010000009.1  47130479-47130633
            2971-5630           JAXUCZ010000009.1  47139732-47142391
FEATURES             Location/Qualifiers
     source          1..5630
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q21"
     gene            1..5630
                     /gene="Inpp4a"
                     /note="inositol polyphosphate-4-phosphatase type I A"
                     /db_xref="GeneID:80849"
                     /db_xref="RGD:68386"
     exon            1..119
                     /gene="Inpp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            120..181
                     /gene="Inpp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            182..389
                     /gene="Inpp4a"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..3103
                     /gene="Inpp4a"
                     /EC_number="3.1.3.66"
                     /note="inositol polyphosphate-4-phosphatase, type I,
                     107kD; inositol polyphosphate 4-phosphatase type I; type I
                     inositol 3,4-bisphosphate 4-phosphatase; inositol
                     polyphosphate-4-phosphatase, type 1"
                     /codon_start=1
                     /product="inositol polyphosphate-4-phosphatase type I A"
                     /protein_id="NP_112264.4"
                     /db_xref="GeneID:80849"
                     /db_xref="RGD:68386"
                     /translation="MTAREHSPRHGARARAMQRASTIDVTADMVGLSLAGNIQDPDEP
                     ILEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIA
                     FFQDSLINQMTQIKLSVYDVKDRSQGTMYLLGSGTFVVKDLLQDRHHRLHLTLRSAES
                     DRVGNITVIGWQMEEKSDQQPPVTRSLDTVNGRMVLPVDESLTEALGIRSKYASLRKD
                     SLLKAVFGGAICRMYRFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCE
                     LEELGELSPCWESLRRQIVTQYQTIILTYQENLTDLHQYKGPSFKASSLKADKKLEFV
                     PTNLHIQRMRVQDDGGSDQNYDVVTIGAPAAHCQGFKSGGLRKKLHKFEEAKKHSFEE
                     CCTSSTCQSIIYIPQDVVRAKEIIAQINTLKTQVSYYAERLSRAAKDRSATGLERTLA
                     ILADKTRQLVTVCDCKLLANSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMA
                     RWAGRSSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKERLHGEGGEDVFPC
                     SSTCSSKKDCSPPPEESSPGEWSEALYPLLTTLTDCVAMMSDKAKAAMVFLLMQDSAP
                     TIASYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDGGFLRQLYTIGLLAQFESLLS
                     TYGEELAMLEDMSLGIMDLRNVTFKVTQATSNASSDMLPVITGNRDGFNVRIPLPGPL
                     FDSLPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYFEQ
                     FKEVLPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEVCRRLNGVRFTS
                     CKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYA
                     FNSLQLKAFPKHYRPPEGTYGKVET"
     exon            390..434
                     /gene="Inpp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            435..553
                     /gene="Inpp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            554..670
                     /gene="Inpp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            671..750
                     /gene="Inpp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            751..862
                     /gene="Inpp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            863..953
                     /gene="Inpp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1101
                     /gene="Inpp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1232
                     /gene="Inpp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1337
                     /gene="Inpp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1446
                     /gene="Inpp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1464
                     /gene="Inpp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1648
                     /gene="Inpp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1867
                     /gene="Inpp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2006
                     /gene="Inpp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2039
                     /gene="Inpp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2212
                     /gene="Inpp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2336
                     /gene="Inpp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2463
                     /gene="Inpp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2604
                     /gene="Inpp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2702
                     /gene="Inpp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..2815
                     /gene="Inpp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2970
                     /gene="Inpp4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2971..5630
                     /gene="Inpp4a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggcttct cggggagctc tgtgatgctc tacatcgagc ctgccggcag catctctact
       61 ggatcccaca ggcatccaac gctggaggcc tcgcggtatc tcgggtgtca acacaccgga
      121 tgatggatct gtttgtcctt ccgtgacgca atgccatgta gtccaacggc aagcatgtat
      181 gggatactgc cattgtaggg atccagggcc tggagacggc tctgctttgg ggaatcaggt
      241 gaggtgacca aggaacaaga agcataccct caccaatgac atcatgacag caagagagca
      301 cagccctcgc catggtgcca gggcccgtgc gatgcagcgg gcttccacca ttgacgtgac
      361 agccgacatg gtgggcctct ctctggcagg aaacatccaa gacccagatg agcccatttt
      421 agagttcagc ttagcttgca gtgagcttca cactccatcg ctagatcgaa aaccaaatag
      481 ttttgtggct gtgagtgtca ccacccctcc acaggcattc tggacgaagc acgcgcagac
      541 ggagatcatc gagggaacca acaaccctat ctttctgagc agcattgcct tctttcaaga
      601 ctctctcatc aatcagatga cccagatcaa gctgtcagtg tacgacgtca aagacagatc
      661 tcagggaaca atgtacttgc tgggctctgg aacattcgtg gtcaaagacc tgctccagga
      721 caggcatcac cgattgcatc tgacactgag gtctgcagag agtgaccgag tcggtaacat
      781 aactgtgatc ggctggcaga tggaggagaa gtcagaccag cagccccctg tgacccggtc
      841 tctggacact gtcaatggca ggatggtttt gcccgttgac gagagcttga ccgaggcctt
      901 gggaatccga tccaaatatg cttctttgcg aaaagacagc ttactgaaag cggtgtttgg
      961 tggtgccatc tgccgcatgt accgcttccc aaccaccgat ggcaaccacc tacggatcct
     1021 ggagcagatg gcagagagcg tcctctcgct gcacgtgcct cggcagtttg tgaagctcct
     1081 gctggaagaa gatgcagcca gagtctgtga gttggaagag ttgggggagc tgtccccttg
     1141 ctgggagagc ctccggcgcc agattgtcac ccagtatcag actatcatcc tcacctacca
     1201 ggagaacctg actgacctcc atcagtacaa aggtccttcg tttaaagcaa gcagcttgaa
     1261 agcagataaa aagttagaat tcgttcccac aaacctgcac atacagagga tgcgagttca
     1321 ggacgacggc ggctcagatc agaactacga cgtcgtcact attggagccc cagcagcaca
     1381 ctgccaaggt tttaagtcag gaggtcttcg aaaaaagctg cacaagtttg aagaggccaa
     1441 gaagcacagt tttgaggagt gttgtacatc ttctacctgc cagtccataa tctacatacc
     1501 acaggatgtc gtccgggcca aggagatcat tgctcagatc aacaccctga aaacccaagt
     1561 gagctactat gcagaacggc tctcaagggc ggcgaaggac aggtctgcca ctggccttga
     1621 gaggactctc gccatcttgg cagacaagac tcggcagttg gtgactgtct gtgactgtaa
     1681 gctgttggcc aactccatcc atgggctgaa tgcagcacgg cctgactaca tcgcttccaa
     1741 ggcctcccct acctcgactg aggaggagca ggtgatgctt cggaatgacc aggacaccct
     1801 catggccagg tgggcaggga ggagcagccg gtcttccctg caggtggact ggcatgagga
     1861 agagtgggag aaagtgtggc tgaatgtgga caagagcctg gagtgcatca ttcagcgggt
     1921 ggacaagctg ctgcagaagg aacgtctgca tggggagggc ggcgaggatg ttttcccctg
     1981 ttcaagcacc tgttccagca agaaagattg cagcccccct cctgaagagt ccagtccagg
     2041 tgagtggagc gaggcccttt accctctgct gaccaccctc acagactgtg tggccatgat
     2101 gagcgacaag gccaaggcag ccatggtctt cctgctcatg caggacagcg cccccacaat
     2161 cgcctcttac ctcagcctgc agtatcgccg tgacgtcgtc ttctgccaaa ccctgaccgc
     2221 cctcatctgt ggctttatca tcaagctgag gaactgcctg cacgatggtg gcttcctacg
     2281 gcagctctat accatcgggc tcctggccca gtttgagagc ctgctgagca cctatggaga
     2341 ggagttggcc atgttggagg acatgagcct tgggatcatg gacctgagga atgtgacctt
     2401 taaagtcact caggccactt cgaatgcttc tagtgacatg ctgccagtca tcacaggaaa
     2461 ccgggatggc tttaacgtgc ggattcctct gccaggccca ctgtttgact ctctccccag
     2521 agagatccag agcggcatgc tgctgcgggt gcagcccgtc ctcttcaacg tgggcatcaa
     2581 tgagcaacag acactggccg agaggtttgg agacacatcc ctacaagaag tcatcaatgt
     2641 ggagagcctg gtgcggctga attcctactt tgagcagttc aaggaggttt tgccagagga
     2701 ctgtctacct cgatctcgga gtcagacctg ccttccagag ctgctgcggt ttctaggaca
     2761 gaatgtccat gcacgcaaga ataagaatgt ggacatcctc tggcaagctg ctgaggtctg
     2821 tcgccgcctt aatggggtcc gattcaccag ctgcaagagt gccaaggacc gcacagccat
     2881 gtcggtgacc ctggagcagt gtctgatcct gcagcatgag cacggcatgg ccccgcaggt
     2941 cttcacacaa gccctggagt gcatgcgcag tgagggttgt cggcgagaaa acacaatgaa
     3001 gaatgttgga agtcgcaaat atgcatttaa ctccctgcag ctgaaggcct tccccaagca
     3061 ttacaggcct ccagaaggga cttacggaaa agttgagaca tgaacacacg gtgtcctcta
     3121 attagctgtc atgtaatcaa tgtgggtccc tctagtgtca catacgattc ttcaagaaga
     3181 cctgaaggat tggtttttat ttctgtgttt ttaaagacat gtcactggag agtccacgga
     3241 gcatgatttt gtgctggaat ctgtagggtt acgtgtgggt cgatagcgtg gatagcaaca
     3301 gccgccctca accacagctt tcagctgtaa ctgtacagtt aatgtcatag ttcctagaag
     3361 atgccagcta ggtctcatac aactccagca ggctttctca aatagccact taggccctgc
     3421 tcaccccctt tacctttcta ttcagtaact cacaagtgag cactgactta aaatcttctt
     3481 tcaaaaagac tgactataaa gcaggaagta cctaacctgt gcacttcagg tcccaggtag
     3541 agcagcaggt agagcagcag gtagagcagc aggtagagca gcaggtagag cagcaggtag
     3601 atgctgactc agctggggga gaacctccat gctatgacag gctggtgctc gtggccctaa
     3661 aaggccacca agctctgtga accgaaagtg gaaggaaagc ttggttggtc acaccaggag
     3721 ctcacacacc tggagccaca ctgttcctgc ccctcacaag tcatggatga gtgtctgctt
     3781 aagatgtaaa gccagtattg aggtccctgg actctgcccc caccccaccc ccaccccacc
     3841 ccacccccac cccaccccca ccccaccccc accccacccc caccccaccc caccccggat
     3901 gctccgtgta tgtttagccc taccccacag ggtgtttctc cctttgttct ccagcagtca
     3961 ggaccttcaa tgtggcttgt caggtgtctg ggatttaggg ccagagagac agtagaaact
     4021 tagatatttt caaagtagat gttcttctgg gagcttcgta atagtcttct agaagaccat
     4081 aaatcatgtt tgaatgtcta gagaaagcat cttagtttct ggtttgcaat gatggttacg
     4141 gtcccccttc tgtttcacgg ctattgataa acagttgaaa ctgtccccta ccttgagagt
     4201 ctgagatgag attatggaac agggaatgag ggattttgta gacactgtaa tctgctcatc
     4261 ttttacaagg tgacggtgag tcttgtctgc acgtggcaga tttttttcct tagagattta
     4321 tatgtttata agttctgttc accgtaattc tgtttacatg ttatttaaaa ggctgtaaaa
     4381 agaaatgtat atgaactgta ttcgtgacac tgatactaat gacctgtgac caccatggga
     4441 actcgtaggc aagtctaggt agttttcttt tggctccttt agaaaaacag ctaacagctt
     4501 ggatctgagg catttgaggt atcaatagga ccagtcttgg caagagacag ggagggtgcg
     4561 ggcatccctc taccccagtg tgcagacagc ctcctgtctc tggtgcctgc tgggaggaag
     4621 atgtgccctg ctaaggggtg gtgtggctca ctgccccacc ctcaaggcaa ggcactgtgg
     4681 aaggtgagtg gctaagctct ctttacccaa cccttccctc gggtctgctc tgctggtctc
     4741 acattgtcct gaagcctcag gccctgatca aagatggctg agtctcagtg cggcgggcta
     4801 agccttttaa cttgttgttg gttcacttac tcttagcttt tagtttttgt tcgttcattt
     4861 ttttcttatt ttgacatcac tgccttttaa aaatatttct tcagatttta gaatgaaatg
     4921 tttcccatgt tctccagcgt tcctttctgt ccacagggca tttgacttgt ccacagggca
     4981 tttgacctgt ccacatttat aaagggaaca ggcgaagctg acttatttgt cagcttctgc
     5041 atgtgaattc ttgtctcagt ttctgtttat aatatgaatc actgtaaaac tctaagactt
     5101 ggctaatcac gtaaaagatt gtggcttcag tgttttctct gaaggcattg tgactggctt
     5161 ccagagcatc acacacgccc cagaagggtc atctcgcaca gcacaggctc agcaaggccc
     5221 tgggccgctc acaggaggcc gaactgttcc ctgtgggagg aaaacagttc tacagctttc
     5281 cagtgaacag acgttccgtc cggcaccttt ccccatttag gaaggaatgt gcagtctctg
     5341 ggcggtgggc atgccgtgcg gatcctgtca gagctcctgc agcacatctg cctttactgt
     5401 cctttaagga tgtataaatg ctgtacagtg ctgttgtatc tcccgacacg tgttttcgct
     5461 cagcttagtg catttaaata cttgtattta tttatttgtt tgggacagta ttaatatata
     5521 tgaacatata gttactgttt tatatattat tagcttattc aaagccatgt atgctgtaaa
     5581 tgtgcttgtc tttagaatga taaataataa aaactgacaa gaacattgaa
//
