LOCUS       NP_112264                939 aa            linear   ROD 31-MAR-2024
DEFINITION  inositol polyphosphate-4-phosphatase type I A [Rattus norvegicus].
ACCESSION   NP_112264
VERSION     NP_112264.4
DBSOURCE    REFSEQ: accession NM_031002.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 939)
  AUTHORS   Chaudhuri,R., Khanna,K., Koundinya,D., Pattnaik,B., Vatsa,D.,
            Agrawal,A. and Ghosh,B.
  TITLE     Novel nuclear translocation of inositol polyphosphate 4-phosphatase
            is associated with cell cycle, proliferation and survival
  JOURNAL   Biochim Biophys Acta Mol Cell Res (2018) In press
   PUBMED   30071275
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 939)
  AUTHORS   Sasaki,J., Kofuji,S., Itoh,R., Momiyama,T., Takayama,K.,
            Murakami,H., Chida,S., Tsuya,Y., Takasuga,S., Eguchi,S.,
            Asanuma,K., Horie,Y., Miura,K., Davies,E.M., Mitchell,C.,
            Yamazaki,M., Hirai,H., Takenawa,T., Suzuki,A. and Sasaki,T.
  TITLE     The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of
            excitotoxic neuronal death
  JOURNAL   Nature 465 (7297), 497-501 (2010)
   PUBMED   20463662
REFERENCE   3  (residues 1 to 939)
  AUTHORS   Norris,F.A., Auethavekiat,V. and Majerus,P.W.
  TITLE     The isolation and characterization of cDNA encoding human and rat
            brain inositol polyphosphate 4-phosphatase
  JOURNAL   J Biol Chem 270 (27), 16128-16133 (1995)
   PUBMED   7608176
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Mar 8, 2021 this sequence version replaced NP_112264.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760433,
                              SAMN12840105 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..939
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q21"
     Protein         1..939
                     /product="inositol polyphosphate-4-phosphatase type I A"
                     /EC_number="3.1.3.66"
                     /note="inositol polyphosphate-4-phosphatase, type I,
                     107kD; inositol polyphosphate 4-phosphatase type I; type I
                     inositol 3,4-bisphosphate 4-phosphatase; inositol
                     polyphosphate-4-phosphatase, type 1"
                     /calculated_mol_wt=105472
     Region          44..157
                     /region_name="C2A_Copine"
                     /note="C2 domain first repeat in Copine; cd04048"
                     /db_xref="CDD:176013"
     Site            order(59,65,121,123,131)
                     /site_type="other"
                     /note="putative Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176013"
     Site            355
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q96PE3; propagated from
                     UniProtKB/Swiss-Prot (Q62784.1)"
     Site            488
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q62784.1)"
     CDS             1..939
                     /gene="Inpp4a"
                     /coded_by="NM_031002.4:284..3103"
                     /db_xref="GeneID:80849"
                     /db_xref="RGD:68386"
ORIGIN      
        1 mtarehsprh gararamqra stidvtadmv glslagniqd pdepilefsl acselhtpsl
       61 drkpnsfvav svttppqafw tkhaqteiie gtnnpiflss iaffqdslin qmtqiklsvy
      121 dvkdrsqgtm yllgsgtfvv kdllqdrhhr lhltlrsaes drvgnitvig wqmeeksdqq
      181 ppvtrsldtv ngrmvlpvde sltealgirs kyaslrkdsl lkavfggaic rmyrfpttdg
      241 nhlrileqma esvlslhvpr qfvkllleed aarvceleel gelspcwesl rrqivtqyqt
      301 iiltyqenlt dlhqykgpsf kasslkadkk lefvptnlhi qrmrvqddgg sdqnydvvti
      361 gapaahcqgf ksgglrkklh kfeeakkhsf eecctsstcq siiyipqdvv rakeiiaqin
      421 tlktqvsyya erlsraakdr satglertla iladktrqlv tvcdckllan sihglnaarp
      481 dyiaskaspt steeeqvmlr ndqdtlmarw agrssrsslq vdwheeewek vwlnvdksle
      541 ciiqrvdkll qkerlhgegg edvfpcsstc sskkdcsppp eesspgewse alypllttlt
      601 dcvammsdka kaamvfllmq dsaptiasyl slqyrrdvvf cqtltalicg fiiklrnclh
      661 dggflrqlyt igllaqfesl lstygeelam ledmslgimd lrnvtfkvtq atsnassdml
      721 pvitgnrdgf nvriplpgpl fdslpreiqs gmllrvqpvl fnvgineqqt laerfgdtsl
      781 qevinveslv rlnsyfeqfk evlpedclpr srsqtclpel lrflgqnvha rknknvdilw
      841 qaaevcrrln gvrftscksa kdrtamsvtl eqclilqheh gmapqvftqa lecmrsegcr
      901 rentmknvgs rkyafnslql kafpkhyrpp egtygkvet
//
