LOCUS       NM_031815               2616 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus inhibin subunit beta E (Inhbe), mRNA.
ACCESSION   NM_031815 XM_346794
VERSION     NM_031815.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2616)
  AUTHORS   Grusch,M., Drucker,C., Peter-Vorosmarty,B., Erlach,N., Lackner,A.,
            Losert,A., Macheiner,D., Schneider,W.J., Hermann,M., Groome,N.P.,
            Parzefall,W., Berger,W., Grasl-Kraupp,B. and Schulte-Hermann,R.
  TITLE     Deregulation of the activin/follistatin system in
            hepatocarcinogenesis
  JOURNAL   J Hepatol 45 (5), 673-680 (2006)
   PUBMED   16935389
  REMARK    GeneRIF: Follistatin was overexpressed while both activin subunits
            were downregulated in the majority of rat and human liver tumours
REFERENCE   2  (bases 1 to 2616)
  AUTHORS   Chabicovsky,M., Herkner,K. and Rossmanith,W.
  TITLE     Overexpression of activin beta(C) or activin beta(E) in the mouse
            liver inhibits regenerative deoxyribonucleic acid synthesis of
            hepatic cells
  JOURNAL   Endocrinology 144 (8), 3497-3504 (2003)
   PUBMED   12865331
  REMARK    GeneRIF: first report of a biological activity of activin C and E
            supports an involvement in liver tissue homeostasis
REFERENCE   3  (bases 1 to 2616)
  AUTHORS   Vejda,S., Cranfield,M., Peter,B., Mellor,S.L., Groome,N.,
            Schulte-Hermann,R. and Rossmanith,W.
  TITLE     Expression and dimerization of the rat activin subunits betaC and
            betaE: evidence for the ormation of novel activin dimers
  JOURNAL   J Mol Endocrinol 28 (2), 137-148 (2002)
   PUBMED   11932210
  REMARK    GeneRIF: Expression and dimerization of the rat activin subunits
            betaC and betaE: evidence for the ormation of novel activin dimers.
REFERENCE   4  (bases 1 to 2616)
  AUTHORS   O'Bryan,M.K., Sebire,K.L., Gerdprasert,O., Hedger,M.P., Hearn,M.T.
            and de Kretser,D.M.
  TITLE     Cloning and regulation of the rat activin betaE subunit
  JOURNAL   J Mol Endocrinol 24 (3), 409-418 (2000)
   PUBMED   10828834
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Oct 13, 2022 this sequence version replaced NM_031815.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF089825.1, AF140032.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-524               JAXUCZ010000007.1  65063996-65064519   c
            525-2616            JAXUCZ010000007.1  65061531-65063622   c
FEATURES             Location/Qualifiers
     source          1..2616
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2616
                     /gene="Inhbe"
                     /note="inhibin subunit beta E"
                     /db_xref="GeneID:83711"
                     /db_xref="RGD:621196"
     exon            1..524
                     /gene="Inhbe"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..1279
                     /gene="Inhbe"
                     /note="inhibin beta E chain; activin beta-E chain; activin
                     beta E; inhibin beta E subunit"
                     /codon_start=1
                     /product="inhibin beta E chain precursor"
                     /protein_id="NP_114003.2"
                     /db_xref="GeneID:83711"
                     /db_xref="RGD:621196"
                     /translation="MGLSNVQLWTILLWALAWVQSTRSACPSCGAPTLTPQGERALVL
                     ELAKQQILEGLHLTSRPRITRPLPQAALTRALRRLQPRSMVPGNREKVISFATSIDKS
                     TSTYRSVLTFQLSPLWSHHLYHARLWLHVPPSFPATLYLRIFGCGTTRCRGSRTFLAD
                     YQTTSSGWHALTLPSSGLRSEESGVTKLQLEFRPLDLNSTTARLPRLLLDTAGQQRPF
                     LELKIRANEPGAGRARRRTPTCESETPLCCRRDHYVDFQELGWRDWILQPEGYQLNYC
                     SGQCPPHLAGSPGIAASFHSAVFSLLKANNPWPAGSSCCVPTARRPLSLLYLDHNGNV
                     VKTDVPDMVVEACGCS"
     exon            525..2616
                     /gene="Inhbe"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaactgtg agggtcgaac atagctaccc atcagatgat ctactctcag gcttcctgag
       61 tcacaggcta ccaaggacaa gtagctctgt ctgccctttg ttgaggggag ctgtgacact
      121 ggtttgctgc tgctgctgct gctgctgctg catcttcttt gggaaatcag actcaataaa
      181 ctgccatcca tctgaggttc tcaactcaga gccatctacc tggagcatgg gactttcaaa
      241 tgtccagctc tggacaatac tgctgtgggc attggcatgg gtgcagagta caagatctgc
      301 gtgcccgtcc tgtggggccc caactctgac accccaagga gaacgcgctc tggtcctaga
      361 gctagccaag cagcaaatcc tggaggggct gcacctaacc agccgtccca gaataactcg
      421 tcctctgccc caggcagcac tgaccagagc cctccggaga ctgcagccca ggagcatggt
      481 ccctggcaac cgagagaaag tcatcagctt tgctaccagc atagacaaat ccacttcaac
      541 ctaccgctcc gtgctcacct tccaactgtc ccctctttgg tcccaccacc tgtaccatgc
      601 ccgcctctgg ctgcacgtgc ccccctcttt tccggccact ctgtatctga ggatcttcgg
      661 ttgcggtacc acgaggtgca gaggatcccg cacgttccta gctgattacc aaaccacttc
      721 ctccggctgg cacgccctga ctctgccctc tagcggcttg cggagtgagg aatctggagt
      781 cacaaaactc caactggaat tcagacctct ggaccttaac agcactactg ccagactgcc
      841 acggctgctg ttggacacag cgggacagca gcgtcccttc ttggaactta agatccgagc
      901 taatgaaccc ggagcaggcc gggccaggag gaggactccc acctgtgagt ctgagacccc
      961 cttatgttgt agacgagacc actatgtcga tttccaggag ctggggtgga gagactggat
     1021 cctgcagccg gagggatacc agctgaatta ctgcagtggg cagtgcccgc cccacctggc
     1081 tggcagccct ggcattgctg cttccttcca ttctgctgtc tttagcctcc tcaaagccaa
     1141 caacccttgg cctgcgggtt cttcctgctg tgtccccacc gcgcgaaggc ctctctccct
     1201 cctctacctt gaccataatg gcaatgtggt caagaccgat gtgccagaca tggttgtaga
     1261 ggcctgtggc tgcagctagc aagaggacct gaaggttttg agtgaagttc aaggttcaag
     1321 ttgggggttc ccaagcaaaa gggtcctgtg tctggaagca caagttccgg atccatactg
     1381 acacccaaca agctgtgtag cagtatgcct gagtttgacc cctgtggaac tcaaatgggc
     1441 atttttcttg tcccagattc tggcctattt caggctgttt caaatgtgga cagatgggta
     1501 aaacgtttcc tttcgagaaa ctgcctggcc agcaccattt cctacatcaa gccctgttcc
     1561 aggacagcag gggatgccgt gggagggaag gaagaatgca gggaaaacta cttagtctct
     1621 cccgaaaaag aagttcctca agtaataaag gaggaagtag aagggtgggc agattgggga
     1681 aaggtataca ggctaagaac agggactgtt gcctgctttg agcaaggtca agaggaagat
     1741 gagcaggcac tgaggtggga gagctgttag gaggccctgg aattgagagt cagtaaaaag
     1801 gggtgctgaa cccataagtt ctctagcttc cccttgggga gaggacccat gtaaatgaca
     1861 tacgtttata ttttcttaat aaaaaggaga aagaaaagca acagtgtgta aggggttgtt
     1921 aaaatgagcc agaaacaaag tgtggtctgg ggacctctgt gcttcggggc cttttcaagg
     1981 ggttttcaaa actatttgca taatcacata gagaagttat ttgtcattta ctatcattat
     2041 tttttcattg ttctgtggga acagggttta cacttataac tacagccctc aggaggctga
     2101 gacaggagga tcgccgtgag ttcaagacca gccttcatag tgaatgctgg gctagcctga
     2161 gctatggagt gagatcctgt ctcaaagcaa aagaaacaaa caaaacaaca aagaaagtac
     2221 tgtgagtctt tccagagtgt attatatgat acagccgatg acattgtggc ttatatattc
     2281 tcctttctct cctttaaaca attttattta tttttattgt atgtgtatga tgagtcttag
     2341 gcctgcaccg gcttgcagtg cccatagagg tcagaagagg acgctggatc cttggaacta
     2401 aagttagagc agtgtgagct gcctgtgtct gttaacagaa ctcaggtcca cagtaagaga
     2461 aacaaacaat taaaggctga gctacctctc cacctgagac atgtgcacac acagtcacac
     2521 attgttttgt tttgtttgga aacagcccac gctatcttgg aactctcaat cctcctgcct
     2581 cagaccctcc tgccctggaa ttaaaggcat aaacca
//
