LOCUS       NM_022614               2022 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus inhibin subunit beta C (Inhbc), mRNA.
ACCESSION   NM_022614
VERSION     NM_022614.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2022)
  AUTHORS   Du,X.Y., Zheng,B.T., Pang,Y., Zhang,W., Liu,M., Xu,X.L. and
            Zhou,S.J.
  TITLE     The potential mechanism of INHBC and CSF1R in diabetic nephropathy
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (4), 1970-1978 (2020)
   PUBMED   32141565
  REMARK    GeneRIF: The potential mechanism of INHBC and CSF1R in diabetic
            nephropathy.
REFERENCE   2  (bases 1 to 2022)
  AUTHORS   Wada,W., Medina,J., Hasegawa,Y., Kuwano,H. and Kojima,I.
  TITLE     Adenovirus-mediated overexpression of the activin betaC subunit
            accelerates liver regeneration in partially hepatectomized rats
  JOURNAL   J Hepatol 43 (5), 823-828 (2005)
   PUBMED   16085335
  REMARK    GeneRIF: These results indicate that liver regeneration is
            accelerated in activin betaC-overexpressing liver, and that betaC
            may function to promote replication of hepatocytes during liver
            regeneration.
REFERENCE   3  (bases 1 to 2022)
  AUTHORS   Gold,E.J., Zhang,X., Wheatley,A.M., Mellor,S.L., Cranfield,M.,
            Risbridger,G.P., Groome,N.P. and Fleming,J.S.
  TITLE     betaA- and betaC-activin, follistatin, activin receptor mRNA and
            betaC-activin peptide expression during rat liver regeneration
  JOURNAL   J Mol Endocrinol 34 (2), 505-515 (2005)
   PUBMED   15821113
  REMARK    GeneRIF: Data suggest that betaA- and betaC-activin subunit
            proteins and follistatin are autocrine growth regulators in
            regenerating liver and when expressed independently lead to
            hepatocyte apoptosis or mitosis in a subset of hepatocytes.
REFERENCE   4  (bases 1 to 2022)
  AUTHORS   Chabicovsky,M., Herkner,K. and Rossmanith,W.
  TITLE     Overexpression of activin beta(C) or activin beta(E) in the mouse
            liver inhibits regenerative deoxyribonucleic acid synthesis of
            hepatic cells
  JOURNAL   Endocrinology 144 (8), 3497-3504 (2003)
   PUBMED   12865331
  REMARK    GeneRIF: first report of a biological activity of activin C and E
            supports an involvement in liver tissue homeostasis
REFERENCE   5  (bases 1 to 2022)
  AUTHORS   Vejda,S., Cranfield,M., Peter,B., Mellor,S.L., Groome,N.,
            Schulte-Hermann,R. and Rossmanith,W.
  TITLE     Expression and dimerization of the rat activin subunits betaC and
            betaE: evidence for the ormation of novel activin dimers
  JOURNAL   J Mol Endocrinol 28 (2), 137-148 (2002)
   PUBMED   11932210
  REMARK    GeneRIF: Expression and dimerization of the rat activin subunits
            betaC and betaE: evidence for the ormation of novel activin dimers.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089799.1.
            
            On Feb 13, 2005 this sequence version replaced NM_022614.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089799.1, AF140031.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2022
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2022
                     /gene="Inhbc"
                     /note="inhibin subunit beta C"
                     /db_xref="GeneID:64549"
                     /db_xref="RGD:621194"
     exon            1..406
                     /gene="Inhbc"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1149
                     /gene="Inhbc"
                     /note="inhibin beta C chain; activin beta-C chain;
                     activin/inhibin beta C; inhibin beta C subunit"
                     /codon_start=1
                     /product="inhibin beta C chain precursor"
                     /protein_id="NP_072136.1"
                     /db_xref="GeneID:64549"
                     /db_xref="RGD:621194"
                     /translation="MASSLLLALLFLTLATVVNLKTDGPCPACWGATFDLESHRELLL
                     DLAKKSILDKLHLSQRPILSRPVSREALKTALRRLRGTRAETLLEHDQRQEYEIISFA
                     DTGLSNINQTRLEFHFSDRTTGGVEVLQTRFMFFMQLPPNTTQTMNIRVLVLRPYDTN
                     LTLTSQYMLQVDASGWYQLLLGPEAQAACSQGHLTLELVPESQLAHSSLILDGVSHRP
                     FVAAQVRVEGKHRVRRRGINCQGLSRMCCRQEFFVDFREIGWHDWIIQPEGYAMNFCT
                     GQCPLHVAGMPGISASFHTAVLNLLKANTDAGTARRGSCCVPTSRRPLSLLYYDRDSN
                     IVKTDIPDMVVEACGCS"
     exon            407..1982
                     /gene="Inhbc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagggtccct ggtggccagg acagagttga agctactccc gttgagaccc tgaacacagg
       61 cgttgtgtcc tttaaggaga ccatcctcca gcaatggcct cctccttgct cctggctctt
      121 ctgttcctga ctctagccac agtagtgaac ctcaaaactg atggtccatg tccagcatgt
      181 tggggtgcca cctttgacct ggagagccat cgggagctcc ttctcgattt ggccaagaaa
      241 agcatcctgg acaagctgca cctcagccag cgccccatac tcagtcggcc tgtgtccaga
      301 gaggccctca agaccgcgct gcggcgcctc cgtgggactc gagcggaaac cctgttggag
      361 catgaccaga gacaagaata tgagatcatc agctttgctg acacaggcct ctccaacatc
      421 aaccaaaccc gtcttgaatt ccatttctct gatagaacta ctggtggtgt ggaggtcctg
      481 cagacccgtt tcatgttctt catgcagctc cctcccaaca ccacccagac catgaatata
      541 agagttcttg tgctaaggcc atatgacacc aacctcacct tgacaagcca gtacatgctg
      601 caggtggatg ccagtggctg gtaccagctt ctcctaggac ccgaagctca agctgcttgc
      661 agtcaggggc acctcactct ggagctggtg ccagaaagtc agctggccca cagttccttg
      721 atcctggatg gggtttccca caggcctttt gtggcagccc aggtaagagt tgaaggcaag
      781 catcgggtac gccggcgagg tatcaactgc caggggctgt ccaggatgtg ctgtcggcaa
      841 gagttctttg tggacttccg tgagattggc tggcatgact ggatcatcca gcccgaaggc
      901 tatgccatga acttctgcac tgggcagtgc ccactacatg tggcaggcat gcctggcatc
      961 tctgcgtcct ttcacactgc agtgctgaat ctgctcaaag ccaacacaga tgctggcact
     1021 gcccgcaggg gctcatgctg cgtgcctacg tctcggcgcc ctctgtcttt gctctactat
     1081 gacagggaca gcaacattgt caagacggat atacctgaca tggtggtaga ggcctgtggg
     1141 tgcagttagc ttatgtgtga tataggcagc ctgaggtaga gcagcagcct gaggtagagc
     1201 ggccttcccc aggacggggt gactctgctc tggcttctgt ccagaaagta agcgccttct
     1261 ttctaagcat acagacatcc ctccgttgac tccaggagat ccacctctaa agggagtcac
     1321 tcatgatcaa cagcctttct ctccccttgg acatggttga cccagtatac ccacatcttc
     1381 agctaggcca ggggctaatc cactgccaac cacaagcagt atcatttcat ttccagcaaa
     1441 cacatcctta gttcaccctt agtcaactat gtcacctact ctgcctccct gacctgccac
     1501 ctgaggctcc caccgagatg acgtgcctta gtatctcctc ttgaattcta tggctctccc
     1561 aagagtcctt tcctcagctt cactaaagat tataccgctg tcttccaaag caaggcgcag
     1621 ctctcagatc tcgagaccct cacccagatg tgctgctaaa tgctgtctgc acagcttcca
     1681 gagttctctg ccctcctctg ccctggtggg tggcatacca agactcatca cctgaactct
     1741 cctacccaac tgaacttgac caaagggaga ctcaggttgg aaacaaaatc ccaggatgat
     1801 acacggaaaa actccattag gcacagtgac atacatgtgt aattcaaacg ctgcacttga
     1861 gagactgagg caggaggaga tctatcgaaa ggttgagacc aactagctgt aggctagcct
     1921 gggctatgct gttaagacct tgtcacaaag tacaagaagg gagaataaaa gaatatttcc
     1981 taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
