LOCUS       NM_080771               3133 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus inhibin subunit beta B (Inhbb), mRNA.
ACCESSION   NM_080771 XM_001053684 XM_344130
VERSION     NM_080771.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3133)
  AUTHORS   Szabo,Z., Vainio,L., Lin,R., Swan,J., Hulmi,J.J., Rahtu-Korpela,L.,
            Serpi,R., Laitinen,M., Pasternack,A., Ritvos,O., Kerkela,R. and
            Magga,J.
  TITLE     Systemic blockade of ACVR2B ligands attenuates muscle wasting in
            ischemic heart failure without compromising cardiac function
  JOURNAL   FASEB J 34 (8), 9911-9924 (2020)
   PUBMED   32427381
REFERENCE   2  (bases 1 to 3133)
  AUTHORS   Palin,N.K., Savikko,J., Pasternack,A., Rintala,J.M., Kalra,B.,
            Mistry,S., Kumar,A., Roth,M.P., Helin,H. and Ritvos,O.
  TITLE     Activin inhibition limits early innate immune response in rat
            kidney allografts-a pilot study
  JOURNAL   Transpl Int 30 (1), 96-107 (2017)
   PUBMED   27732750
REFERENCE   3  (bases 1 to 3133)
  AUTHORS   Wang,X., Tang,P., Guo,F., Zhang,M., Chen,Y., Yan,Y., Tian,Z.,
            Xu,P., Zhang,L., Zhang,L. and Zhang,L.
  TITLE     RhoA regulates Activin B-induced stress fiber formation and
            migration of bone marrow-derived mesenchymal stromal cell through
            distinct signaling
  JOURNAL   Biochim Biophys Acta Gen Subj 1861 (1 Pt A), 3011-3018 (2017)
   PUBMED   27693126
  REMARK    GeneRIF: RhoA regulates Activin B-induced stress fiber formation
            and migration of Bone marrow-derived mesenchymal stem cells.
REFERENCE   4  (bases 1 to 3133)
  AUTHORS   Kanamori,Y., Sugiyama,M., Hashimoto,O., Murakami,M., Matsui,T. and
            Funaba,M.
  TITLE     Regulation of hepcidin expression by inflammation-induced activin B
  JOURNAL   Sci Rep 6, 38702 (2016)
   PUBMED   27922109
  REMARK    GeneRIF: Activin B induced phosphorylation and activation of
            Smad1/5/8, the BMP-regulated (BR)-Smads. The stimulation of
            hepcidin transcription by activin B was mediated by ALK2 and
            ActRIIA, receptors for the TGF-beta family.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3133)
  AUTHORS   Hayes,H.L., Zhang,L., Becker,T.C., Haldeman,J.M., Stephens,S.B.,
            Arlotto,M., Moss,L.G., Newgard,C.B. and Hohmeier,H.E.
  TITLE     A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell
            Proliferation
  JOURNAL   Mol Cell Biol 36 (23), 2918-2930 (2016)
   PUBMED   27620967
  REMARK    GeneRIF: Results identified Inhbb as one factor mediating the
            proliferative effect of Pdx-1 on islet cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3133)
  AUTHORS   Kaipia,A., Penttila,T.L., Shimasaki,S., Ling,N., Parvinen,M. and
            Toppari,J.
  TITLE     Expression of inhibin beta A and beta B, follistatin and activin-A
            receptor messenger ribonucleic acids in the rat seminiferous
            epithelium
  JOURNAL   Endocrinology 131 (6), 2703-2710 (1992)
   PUBMED   1332846
REFERENCE   7  (bases 1 to 3133)
  AUTHORS   Klaij,I.A., Timmerman,M.A., Blok,L.J., Grootegoed,J.A. and de
            Jong,F.H.
  TITLE     Regulation of inhibin beta B-subunit mRNA expression in rat Sertoli
            cells: consequences for the production of bioactive and
            immunoreactive inhibin
  JOURNAL   Mol Cell Endocrinol 85 (3), 237-246 (1992)
   PUBMED   1634019
REFERENCE   8  (bases 1 to 3133)
  AUTHORS   Shaha,C., Morris,P.L., Chen,C.L., Vale,W. and Bardin,C.W.
  TITLE     Immunostainable inhibin subunits are in multiple types of
            testicular cells
  JOURNAL   Endocrinology 125 (4), 1941-1950 (1989)
   PUBMED   2477225
REFERENCE   9  (bases 1 to 3133)
  AUTHORS   Mason,A.J., Berkemeier,L.M., Schmelzer,C.H. and Schwall,R.H.
  TITLE     Activin B: precursor sequences, genomic structure and in vitro
            activities
  JOURNAL   Mol Endocrinol 3 (9), 1352-1358 (1989)
   PUBMED   2575216
REFERENCE   10 (bases 1 to 3133)
  AUTHORS   Esch,F.S., Shimasaki,S., Cooksey,K., Mercado,M., Mason,A.J.,
            Ying,S.Y., Ueno,N. and Ling,N.
  TITLE     Complementary deoxyribonucleic acid (cDNA) cloning and DNA sequence
            analysis of rat ovarian inhibins
  JOURNAL   Mol Endocrinol 1 (5), 388-396 (1987)
   PUBMED   2484214
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000242.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_080771.3.
            
            On Mar 5, 2021 this sequence version replaced NM_080771.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence because no single transcript was available for the
            full length of the gene. The extent of this transcript is supported
            by orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760434,
                              SAMN12840132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-460               JACYVU010000242.1  16897377-16897836   c
            461-3133            JACYVU010000242.1  16892130-16894802   c
FEATURES             Location/Qualifiers
     source          1..3133
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q11"
     gene            1..3133
                     /gene="Inhbb"
                     /note="inhibin subunit beta B"
                     /db_xref="GeneID:25196"
                     /db_xref="RGD:2913"
     CDS             1..1236
                     /gene="Inhbb"
                     /note="inhibin beta B chain; activin betaB; inhibin beta
                     subunit B; activin beta-B chain; inhibin beta-B; inhibin
                     beta B subunit"
                     /codon_start=1
                     /product="inhibin beta B chain precursor"
                     /protein_id="NP_542949.1"
                     /db_xref="GeneID:25196"
                     /db_xref="RGD:2913"
                     /translation="MDGLPGRALGAACLLLLAAGWLGPEAWGSPTPPPSPAAPPPPPP
                     PGAPGGSQDTCTSCGGGGGGFRRPEELGRVDGDFLEAVKRHILSRLQLRGRPNITHAV
                     PKAAMVTALRKLHAGKVREDGRVEIPHLDGHASPGADGQERVSEIISFAETDGLASSR
                     VRLYFFVSNEGNQNLFVVQASLWLYLKLLPYVLEKGSRRKVRVKVYFQEQGHGDRWNV
                     VEKKVDLKRSGWHTFPITEAIQALFERGERRLNLDVQCDSCQELAVVPVFVDPGEESH
                     RPFVVVQARLGDSRHRIRKRGLECDGRTSLCCRQQFFIDFRLIGWNDWIIAPTGYYGN
                     YCEGSCPAYLAGVPGSASSFHTAVVNQYRMRGLNPGPVNSCCIPTKLSSMSMLYFDDE
                     YNIVKRDVPNMIVEECGCA"
     exon            1..460
                     /gene="Inhbb"
                     /inference="alignment:Splign:2.1.0"
     exon            461..3133
                     /gene="Inhbb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggacgggc tgcccggtcg ggcgttgggg gccgcctgcc ttctgcttct ggcggccggc
       61 tggttgggac ccgaggcctg gggctctccc acacccccgc cgtcgcccgc tgcgccgccc
      121 ccgcccccgc cacccggagc tccgggcggc tcgcaggaca cctgtacgtc gtgcggcggc
      181 ggcggcggcg gcttccggcg gcccgaggag ctgggccggg tggacggtga cttcctggag
      241 gcggtgaaga gacacatctt gagccgcctg cagttgcggg gccggcccaa catcacgcac
      301 gctgtcccca aggccgccat ggtcacggcc ctgcgcaagc tgcacgccgg caaggtgcgc
      361 gaggacggcc gcgtggagat cccgcacctc gacggccacg ctagcccggg cgccgacggc
      421 caggagcgcg tctctgagat catcagcttt gcagagacag atggcctcgc ctcctcccgg
      481 gtccgcctgt acttcttcgt ctctaacgaa ggcaaccaga acctatttgt ggtgcaggcc
      541 agcctgtggc tgtacctgaa actgctcccc tatgtcctgg agaagggcag ccggaggaag
      601 gtacgggtca aggtgtactt ccaagaacag ggtcacggtg acaggtggaa tgtggtggag
      661 aagaaggtgg acctaaaacg tagtggctgg cataccttcc ccattacaga ggccatccag
      721 gccttgtttg agcgaggcga gagacgcctt aacctggatg ttcagtgtga cagctgccag
      781 gagctggccg tggtgcctgt gttcgtggac cccggtgagg agtcacaccg gccctttgta
      841 gtggtgcagg cccggctggg cgatagcaga catcgcatcc gaaaacgggg cctggagtgt
      901 gacgggcgga ccagcctctg ttgcaggcaa cagttcttca tcgactttcg gctcatcggc
      961 tggaacgact ggatcattgc acccactggc tactacggga actactgtga gggcagctgc
     1021 ccggcctacc tggctggggt ccctggttca gcctcctcct tccacacggc tgtggtgaac
     1081 cagtaccgca tgcgtggcct gaaccctggg ccggtgaact cttgctgcat ccccaccaag
     1141 ctgagttcta tgtctatgct ctactttgat gacgagtaca acatcgtcaa gcgggacgtg
     1201 cccaacatga tcgtggagga gtgtggctgc gcctgacaga ggcgatgggg cggagcacag
     1261 gcctgtgggt ctttgaggga gcaggagagg caggtgggct gagtgtggtt gttcattggg
     1321 ttgtgaagag tgccaaggtg aggcctgaca gaacgttctc ccgcttcaca gaagaccagt
     1381 cagaaccaga gggagaaccc ttctgtgaca ccagagactc ctaactgcac acatagacac
     1441 gcatagccag actcatacgg tctgccaccc acacagcggc ctccgggata ccagcaaacg
     1501 gatgcggtga caaaccggca gctcagctac caaggcctgt cagtcggaaa gaatgggggt
     1561 gagcagccac cattcccacc agctggctgg gcactctgaa tcgcgccttc tgagtacaca
     1621 caaaagcaca caaagacgga ggacacagag agagtgagcc agagagccac caagaggaaa
     1681 agccgggtgg gagcacaggc gggtggaggg ccacgtatcc ctgacttgtc ccgggtcttc
     1741 accacagcgc ctggcacagt cctgcctgct cactccccgc ctgcctggca tcctccgtgc
     1801 ttcgaggcca gcagagcttt gccgcccctg ttcttggaga gggcaagtag cccaggaggg
     1861 actcgcctgt cacagagacc atggagcagg gacagtgacc ctttgactgt ctgtcacttg
     1921 ggtccctggt gggactggtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     1981 ttcagggttg tttggggagg gagagaataa gggtcttaat tttatgcttt aaactcatct
     2041 ccaacaactg acaggttatt tggtgccagt tgcagaattg aaaaggagcc agcctatcag
     2101 ctatgacctt tgaagcggaa aggccaaacg aatcgaagtg agaaggaaag aataatgttg
     2161 caatcggtgc cctttgctgg ggacatcctc ctagtgccct gctgagatgg gcagggatgg
     2221 ccattaggca atgggaagag accagggagg cagtggtaga gcggaggtgt tctgaggcgc
     2281 tgctcagctg gtcttgggga gagagggaga gctttcagtt gctttgcaga agttgtccct
     2341 gtgggtgggc cccggcttca gggttgtccg tggacatggc tcctgcccac ttcaagtgcc
     2401 ctcctgcctg ctccacaaag cacttgcggt cctgcgtgaa tgcacaccac aatagcactt
     2461 gcaggtctac gtgtgtccag aagtggccct ggggcaagag ctgacatggc agtcctcgtg
     2521 gatgcccaag tgccacgtga actatgcaat ttaaagggtt gacccacact aggcgaaact
     2581 ggactcgtac gactctttta tatttttata cttgaaatga aatcttttgc ttcttttcta
     2641 agcgaatgat tgctttcaat gtttgcactg atctagttgc atggttagtc agaaactgcc
     2701 atttgaaaaa aagttatttt tatagctgca gaaaaatgaa tacagttaaa tgtattatac
     2761 ataattttgg aaccaaagag gccagcggat cagttttaat ttttattaga cggtgaggcc
     2821 atcttctatg aggtagatgt tctaaacagc cctttgagtg gcctgccagc gattcagggt
     2881 ataaatgatt ttttttttat tcagttgatg tgtcttctct gtccttatac acccagaagg
     2941 tagagtaaaa taaatgactg gtggagtgga ggtatgtact gtaagtcctc atctttagtt
     3001 tatttaataa agccctcctt aggttctgtt tcataataac ttaaaaccaa acaattcccc
     3061 ccacagactg gctgtcttaa gtatttcaca ttcgtgtaca gtttaagaca ataaaagatg
     3121 gagtgccacg ggc
//
