LOCUS       NM_017128               1552 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus inhibin subunit beta A (Inhba), mRNA.
ACCESSION   NM_017128
VERSION     NM_017128.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1552)
  AUTHORS   Zheng,J., Zhang,T., Han,S., Liu,C., Liu,M., Li,S. and Li,J.
  TITLE     Activin A improves the neurological outcome after ischemic stroke
            in mice by promoting oligodendroglial ACVR1B-mediated white matter
            remyelination
  JOURNAL   Exp Neurol 337, 113574 (2021)
   PUBMED   33345977
REFERENCE   2  (bases 1 to 1552)
  AUTHORS   Xian,S., Chen,A., Wu,X., Lu,C., Wu,Y., Huang,F. and Zeng,Z.
  TITLE     Activation of activin/Smad2 and 3 signaling pathway and
            the&nbsp;potential involvement of endothelial-mesenchymal
            transition in the valvular damage due to rheumatic heart disease
  JOURNAL   Mol Med Rep 23 (1) (2021)
   PUBMED   33179113
REFERENCE   3  (bases 1 to 1552)
  AUTHORS   Wang,Y., Shuang,L., Yujie,S., Xiaohui,M., Wei,W. and Jidong,W.
  TITLE     Activin A overexpression promotes rat follicular development
            through SCF-kit-mediated cell signals
  JOURNAL   Gynecol Endocrinol 36 (12), 1070-1073 (2020)
   PUBMED   32133888
  REMARK    GeneRIF: Activin A overexpression promotes rat follicular
            development through SCF-kit-mediated cell signals.
REFERENCE   4  (bases 1 to 1552)
  AUTHORS   Szabo,Z., Vainio,L., Lin,R., Swan,J., Hulmi,J.J., Rahtu-Korpela,L.,
            Serpi,R., Laitinen,M., Pasternack,A., Ritvos,O., Kerkela,R. and
            Magga,J.
  TITLE     Systemic blockade of ACVR2B ligands attenuates muscle wasting in
            ischemic heart failure without compromising cardiac function
  JOURNAL   FASEB J 34 (8), 9911-9924 (2020)
   PUBMED   32427381
REFERENCE   5  (bases 1 to 1552)
  AUTHORS   Magga,J., Vainio,L., Kilpio,T., Hulmi,J.J., Taponen,S., Lin,R.,
            Rasanen,M., Szabo,Z., Gao,E., Rahtu-Korpela,L., Alakoski,T.,
            Ulvila,J., Laitinen,M., Pasternack,A., Koch,W.J., Alitalo,K.,
            Kivela,R., Ritvos,O. and Kerkela,R.
  TITLE     Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute
            Ischemia-Reperfusion Injury
  JOURNAL   Mol Ther 27 (3), 600-610 (2019)
   PUBMED   30765322
REFERENCE   6  (bases 1 to 1552)
  AUTHORS   Verschueren,K., Dewulf,N., Goumans,M.J., Lonnoy,O., Feijen,A.,
            Grimsby,S., Vandi Spiegle,K., ten Dijke,P., Moren,A.,
            Vanscheeuwijck,P., Heldin,C.H., Miyazono,K., Mummery,C., Van Den
            Eijnden-Van Raaij,J. and Huylebroeck,D.
  TITLE     Expression of type I and type IB receptors for activin in
            midgestation mouse embryos suggests distinct functions in
            organogenesis
  JOURNAL   Mech Dev 52 (1), 109-123 (1995)
   PUBMED   7577669
REFERENCE   7  (bases 1 to 1552)
  AUTHORS   Shao,L., Frigon,N.L. Jr., Young,A.L., Yu,A.L., Mathews,L.S.,
            Vaughan,J., Vale,W. and Yu,J.
  TITLE     Effect of activin A on globin gene expression in purified human
            erythroid progenitors
  JOURNAL   Blood 79 (3), 773-781 (1992)
   PUBMED   1310063
REFERENCE   8  (bases 1 to 1552)
  AUTHORS   Mathews,L.S. and Vale,W.W.
  TITLE     Expression cloning of an activin receptor, a predicted
            transmembrane serine kinase
  JOURNAL   Cell 65 (6), 973-982 (1991)
   PUBMED   1646080
REFERENCE   9  (bases 1 to 1552)
  AUTHORS   Mason,A.J., Berkemeier,L.M., Schmelzer,C.H. and Schwall,R.H.
  TITLE     Activin B: precursor sequences, genomic structure and in vitro
            activities
  JOURNAL   Mol Endocrinol 3 (9), 1352-1358 (1989)
   PUBMED   2575216
REFERENCE   10 (bases 1 to 1552)
  AUTHORS   Woodruff,T.K., Meunier,H., Jones,P.B., Hsueh,A.J. and Mayo,K.E.
  TITLE     Rat inhibin: molecular cloning of alpha- and beta-subunit
            complementary deoxyribonucleic acids and expression in the ovary
  JOURNAL   Mol Endocrinol 1 (8), 561-568 (1987)
   PUBMED   3153478
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Mar 25, 2010 this sequence version replaced NM_017128.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M37482.1, SRR26643285.48847.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840129, SAMN16093046
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                JAXUCZ010000017.1  53804452-53804508   c
            58-558              JAXUCZ010000017.1  53801378-53801878   c
            559-1552            JAXUCZ010000017.1  53791436-53792429   c
FEATURES             Location/Qualifiers
     source          1..1552
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.1"
     gene            1..1552
                     /gene="Inhba"
                     /note="inhibin subunit beta A"
                     /db_xref="GeneID:29200"
                     /db_xref="RGD:62074"
     exon            1..57
                     /gene="Inhba"
                     /inference="alignment:Splign:2.1.0"
     exon            58..558
                     /gene="Inhba"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1445
                     /gene="Inhba"
                     /note="inhibin beta A chain; activin beta-A chain; activin
                     A; inhibin beta-A; inhibin beta A subunit"
                     /codon_start=1
                     /product="inhibin beta A chain preproprotein"
                     /protein_id="NP_058824.1"
                     /db_xref="GeneID:29200"
                     /db_xref="RGD:62074"
                     /translation="MPLLWLRGFLLASCWIIVRSSPTPGSEGHGAAPDCPSCALATLP
                     KDGPNSQPEMVEAVKKHILNMLHLKKRPDVTQPVPKAALLNAIRKLHVGKVGENGYVE
                     IEDDIGRRAEMNELMEQTSEIITFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLK
                     VPKANRTRTKVTIRLFQQQKHPQGSLDMGDEAEEMGLKGERSELLLSEKVVDARKSTW
                     HIFPVSSSIQRLLDQGKSSLDVRIACEQCQESGASLVLLGKKKKKEVDGDGKKKDGSD
                     GGLEEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKVNICCKKQFFVSFKDIGWN
                     DWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPT
                     KLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS"
     exon            559..1552
                     /gene="Inhba"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacagctctg acctcatgag acaagagccg gctggcaaaa cagaagggac ccgaaagaga
       61 atttgctgaa gaggagaagg aaaaaaaaag tccaaaaaac ctgtacgtga ggggtgggga
      121 ggaaaagcag ggcctttaaa gaaggcaacc acacgacttt tgctgccagg atgcccttgc
      181 tttggctgag aggatttctg ttggcaagtt gctggattat agtgaggagt tcccccaccc
      241 caggatccga ggggcacggc gcagccccgg actgcccgtc ctgtgcgctg gccacccttc
      301 cgaaggatgg acctaactct cagccagaga tggtagaggc tgtcaagaag cacatcttaa
      361 acatgctgca cttgaagaag agacccgatg tcacccagcc ggtacccaag gcggcgcttc
      421 tcaacgcgat cagaaagctt catgtgggta aagtggggga aaacgggtat gtggagatag
      481 aggacgacat tggcaggagg gccgaaatga atgaactcat ggagcagacc tcggagatca
      541 tcacctttgc cgagtcaggc acagccagga agacactgca ttttgagatt tccaaggaag
      601 gcagtgacct gtcagtcgtg gagcgtgcag aagtctggct cttcctgaaa gtccccaagg
      661 ccaacaggac caggaccaaa gtcaccatcc gtctgtttca gcagcagaag catccacagg
      721 gcagcttgga catgggggat gaggccgagg aaatgggctt gaagggggag aggagtgaac
      781 tgttgctatc agagaaagtg gtagatgctc ggaagagtac ttggcacatc ttcccagtgt
      841 ctagcagcat ccagcgcctg ctggaccagg ggaagagttc cctggatgtg cggattgctt
      901 gtgaacagtg ccaggagagc ggtgccagcc tagtgctcct gggcaagaag aagaagaaag
      961 aggtggatgg agacgggaag aagaaagacg gaagtgacgg agggctggaa gaggaaaaag
     1021 aacagtcaca cagacctttc ctcatgctgc aggctaggca gtctgaagac catcctcacc
     1081 gcaggcgtag gcggggcttg gagtgtgatg gcaaggtcaa catttgctgt aagaaacagt
     1141 tctttgtcag cttcaaggat attggctgga atgactggat cattgctccc tctggctatc
     1201 atgccaacta ttgtgagggt gagtgcccga gccacatagc aggcacctct gggtcctcac
     1261 tctccttcca ctcaacagtc attaaccact accgcatgag gggtcacagc ccctttgcca
     1321 accttaagtc atgctgtgtg cccaccaagc tgagacccat gtccatgctg tattatgatg
     1381 atggtcaaaa cattatcaaa aaggacattc agaacatgat tgtggaggag tgtggctgct
     1441 cctagagttg ccaggtccca gagcaaatgg atctagggtg tccagaaaag acagtggcaa
     1501 atgaagaaaa aatatataag atttctgaac taaacaagac aaccagaaaa at
//
