LOCUS       NM_001079887            1615 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus inhibitor of growth family, member 4 (Ing4),
            mRNA.
ACCESSION   NM_001079887 XM_001064956 XM_216265
VERSION     NM_001079887.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1615)
  AUTHORS   Zhang X, Lin DH, Jin Y, Wang KS, Zhang Y, Babilonia E, Wang Z, Wang
            Z, Giebisch G, Han ZG and Wang WH.
  TITLE     Inhibitor of growth 4 (ING4) is up-regulated by a low K intake and
            suppresses renal outer medullary K channels (ROMK) by MAPK
            stimulation
  JOURNAL   Proc Natl Acad Sci U S A 104 (22), 9517-9522 (2007)
   PUBMED   17517644
  REMARK    GeneRIF: provide evidence for the role of ING4 in mediating the
            effect of low K intake on renal outer medullary K channel activity
            by stimulation of p38 and ERK mitogen-activated protein kinase
REFERENCE   2  (bases 1 to 1615)
  AUTHORS   Shi X, Hong T, Walter KL, Ewalt M, Michishita E, Hung T, Carney D,
            Pena P, Lan F, Kaadige MR, Lacoste N, Cayrou C, Davrazou F, Saha A,
            Cairns BR, Ayer DE, Kutateladze TG, Shi Y, Cote J, Chua KF and
            Gozani O.
  TITLE     ING2 PHD domain links histone H3 lysine 4 methylation to active
            gene repression
  JOURNAL   Nature 442 (7098), 96-99 (2006)
   PUBMED   16728974
REFERENCE   3  (bases 1 to 1615)
  AUTHORS   Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS,
            Tan S, Yang XJ and Cote J.
  TITLE     ING tumor suppressor proteins are critical regulators of chromatin
            acetylation required for genome expression and perpetuation
  JOURNAL   Mol Cell 21 (1), 51-64 (2006)
   PUBMED   16387653
REFERENCE   4  (bases 1 to 1615)
  AUTHORS   Zhang X, Xu LS, Wang ZQ, Wang KS, Li N, Cheng ZH, Huang SZ, Wei DZ
            and Han ZG.
  TITLE     ING4 induces G2/M cell cycle arrest and enhances the
            chemosensitivity to DNA-damage agents in HepG2 cells
  JOURNAL   FEBS Lett 570 (1-3), 7-12 (2004)
   PUBMED   15251430
REFERENCE   5  (bases 1 to 1615)
  AUTHORS   Garkavtsev I, Kozin SV, Chernova O, Xu L, Winkler F, Brown E,
            Barnett GH and Jain RK.
  TITLE     The candidate tumour suppressor protein ING4 regulates brain tumour
            growth and angiogenesis
  JOURNAL   Nature 428 (6980), 328-332 (2004)
   PUBMED   15029197
REFERENCE   6  (bases 1 to 1615)
  AUTHORS   Shiseki M, Nagashima M, Pedeux RM, Kitahama-Shiseki M, Miura K,
            Okamura S, Onogi H, Higashimoto Y, Appella E, Yokota J and Harris
            CC.
  TITLE     p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity
  JOURNAL   Cancer Res 63 (10), 2373-2378 (2003)
   PUBMED   12750254
REFERENCE   7  (bases 1 to 1615)
  AUTHORS   Ha S, Lee S, Chung M and Choi Y.
  TITLE     Mouse ING1 homologue, a protein interacting with A1, enhances cell
            death and is inhibited by A1 in mammary epithelial cells
  JOURNAL   Cancer Res 62 (5), 1275-1278 (2002)
   PUBMED   11888890
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC127511.1.
            
            On or before Jan 5, 2007 this sequence version replaced
            XM_216265.4, XM_001064956.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127511.1, EV771700.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1615
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1615
                     /gene="Ing4"
                     /note="inhibitor of growth family, member 4"
                     /db_xref="GeneID:297597"
                     /db_xref="RGD:1309407"
     exon            1..41
                     /gene="Ing4"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..742
                     /gene="Ing4"
                     /codon_start=1
                     /product="inhibitor of growth protein 4"
                     /protein_id="NP_001073356.1"
                     /db_xref="GeneID:297597"
                     /db_xref="RGD:1309407"
                     /translation="MAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEDLKAEIDK
                     LATEYMSSARSLSSEEKLALLRQIQEAYGKCKEFGDDKVQLAMQTYEMVDKHIRRLDT
                     DLARFEADLKEKQIESSDYDSSSSKGRTQKEKKAARARSKGKNSDEEAPKAAQKKLKL
                     VRTSPEYGMPSVTFGSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCDNPDCSIEWF
                     HFACVGLTTKPRGKWFCPRCSQERKKK"
     exon            42..113
                     /gene="Ing4"
                     /inference="alignment:Splign:2.1.0"
     exon            114..280
                     /gene="Ing4"
                     /inference="alignment:Splign:2.1.0"
     exon            281..386
                     /gene="Ing4"
                     /inference="alignment:Splign:2.1.0"
     exon            387..492
                     /gene="Ing4"
                     /inference="alignment:Splign:2.1.0"
     exon            493..640
                     /gene="Ing4"
                     /inference="alignment:Splign:2.1.0"
     exon            641..702
                     /gene="Ing4"
                     /inference="alignment:Splign:2.1.0"
     exon            703..1590
                     /gene="Ing4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caagatggct gctgggatgt atttggaaca ttatctggac agtattgaaa acctcccgtt
       61 tgaattgcag agaaactttc agctcatgag ggacctagac caaaggacag aggacctgaa
      121 ggctgaaatt gacaagttgg ccactgaata tatgagtagc gcccgcagcc tgagctccga
      181 ggaaaaactg gcccttctca gacagatcca ggaggcctat ggcaaatgca aggaatttgg
      241 tgacgacaag gtgcagctgg ccatgcagac ctatgagatg gtggacaaac acattcggcg
      301 gctggacaca gacctggccc gttttgaggc tgatctgaag gaaaaacaga tcgagtcaag
      361 tgactatgac agctcttcca gcaaaggccg gacccaaaag gagaaaaaag ctgcccgtgc
      421 ccgttccaaa gggaaaaact cagatgaaga agcccccaag gctgcccaga aaaagttaaa
      481 acttgtgcgc acaagtcctg agtatgggat gccctcagtg acctttggca gtgtccaccc
      541 ctctgatgtg ttggatatgc ctgtggatcc caacgaaccc acatattgcc tttgtcacca
      601 ggtctcctat ggagagatga ttggctgtga caacccagac tgttccattg agtggttcca
      661 ctttgcctgt gtggggctga caaccaagcc tcgagggaaa tggttttgcc cacgctgctc
      721 ccaagaacgg aagaagaaat aggtttcctt ggattccatc agagacttct tctgaatccc
      781 cctgacctgg gctagtggac agagaggggt gcctgtgctg gggatggggg tccagggaga
      841 tggggacagt gcagtaccgt catcccttct cccttctccc cattcggtgc tgaggctgca
      901 tccaaacccc agtagagaag gtgccacagc cactgacggg atgtgctctc cttccccgcc
      961 tcgccctcag aggaagtagt cccactcact gtccttttgc ctccgtgggg aggttggtgc
     1021 tgtgtttcag agggagggtc ctcttcattc cccttgcttt gacttagaag tgggcagtgg
     1081 agtgggcact ctcccagtcc cctcaatcct ccttccccca ttgggaacta ggtaggacag
     1141 actgccttct ctgtgctctt ccttttctcc atggggaggg tcttctaggt catttgggct
     1201 gtggcctagt tgagtggtta ccccaacctc tatggcccgg ggaattctgc tgactttgaa
     1261 tgggagaggg aaggtggagc ccagatagct cacatgtaaa gggagtcggg gtagtaaata
     1321 aaagctatcc acgctagcct ctgtgtttat tgtagagact gtttacgtat atgtggtaag
     1381 cattcttttt gcattctctg gattggatga gaggcaggag gatggcttgc cagaaatagg
     1441 acaagacata aaacccaaaa tggtctttgt cctgtggtat cctcagcttc tccacctgga
     1501 gggtgccggc atcggggact cagaactttg taattacgag tacgcgctcc gcgaaacacc
     1561 tttcactcaa taaatcatgt atttgcttta aaaaaaaaaa aaaaaaaaaa aaaaa
//
