LOCUS       NM_001034107            2163 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus inhibitor of growth family, member 3 (Ing3),
            mRNA.
ACCESSION   NM_001034107 XM_231552
VERSION     NM_001034107.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2163)
  AUTHORS   Ahmed,H.H., Khalil,W.K. and Hamza,A.H.
  TITLE     Molecular mechanisms of nano-selenium in mitigating hepatocellular
            carcinoma induced by N-nitrosodiethylamine (NDEA) in rats
  JOURNAL   Toxicol Mech Methods 24 (8), 593-602 (2014)
   PUBMED   25156538
REFERENCE   2  (bases 1 to 2163)
  AUTHORS   Wang,J., Liu,Z., Feng,X., Gao,S., Xu,S. and Liu,P.
  TITLE     Tumor suppressor gene ING3 induces cardiomyocyte hypertrophy via
            inhibition of AMPK and activation of p38 MAPK signaling
  JOURNAL   Arch Biochem Biophys 562, 22-30 (2014)
   PUBMED   25151306
  REMARK    GeneRIF: ING3 bas a role in inducing cardiomyocyte hypertrophy via
            inhibition of AMPK and activation of p38 MAPK signaling
REFERENCE   3  (bases 1 to 2163)
  AUTHORS   Obri,A., Ouararhni,K., Papin,C., Diebold,M.L., Padmanabhan,K.,
            Marek,M., Stoll,I., Roy,L., Reilly,P.T., Mak,T.W., Dimitrov,S.,
            Romier,C. and Hamiche,A.
  TITLE     ANP32E is a histone chaperone that removes H2A.Z from chromatin
  JOURNAL   Nature 505 (7485), 648-653 (2014)
   PUBMED   24463511
REFERENCE   4  (bases 1 to 2163)
  AUTHORS   Watanabe,S. and Peterson,C.L.
  TITLE     The INO80 family of chromatin-remodeling enzymes: regulators of
            histone variant dynamics
  JOURNAL   Cold Spring Harb Symp Quant Biol 75, 35-42 (2010)
   PUBMED   21502417
  REMARK    Review article
REFERENCE   5  (bases 1 to 2163)
  AUTHORS   Lee,W.Y., Lee,D., Chung,W.I. and Kwon,C.S.
  TITLE     Arabidopsis ING and Alfin1-like protein families localize to the
            nucleus and bind to H3K4me3/2 via plant homeodomain fingers
  JOURNAL   Plant J 58 (3), 511-524 (2009)
   PUBMED   19154204
REFERENCE   6  (bases 1 to 2163)
  AUTHORS   Shi,X., Hong,T., Walter,K.L., Ewalt,M., Michishita,E., Hung,T.,
            Carney,D., Pena,P., Lan,F., Kaadige,M.R., Lacoste,N., Cayrou,C.,
            Davrazou,F., Saha,A., Cairns,B.R., Ayer,D.E., Kutateladze,T.G.,
            Shi,Y., Cote,J., Chua,K.F. and Gozani,O.
  TITLE     ING2 PHD domain links histone H3 lysine 4 methylation to active
            gene repression
  JOURNAL   Nature 442 (7098), 96-99 (2006)
   PUBMED   16728974
REFERENCE   7  (bases 1 to 2163)
  AUTHORS   Doyon,Y., Cayrou,C., Ullah,M., Landry,A.J., Cote,V., Selleck,W.,
            Lane,W.S., Tan,S., Yang,X.J. and Cote,J.
  TITLE     ING tumor suppressor proteins are critical regulators of chromatin
            acetylation required for genome expression and perpetuation
  JOURNAL   Mol Cell 21 (1), 51-64 (2006)
   PUBMED   16387653
REFERENCE   8  (bases 1 to 2163)
  AUTHORS   Doyon,Y., Selleck,W., Lane,W.S., Tan,S. and Cote,J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001034107.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100082.1, SRR26360186.1177443.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                JAXUCZ010000004.1  51443811-51443906
            97-168              JAXUCZ010000004.1  51444144-51444215
            169-269             JAXUCZ010000004.1  51446266-51446366
            270-335             JAXUCZ010000004.1  51447876-51447941
            336-432             JAXUCZ010000004.1  51459649-51459745
            433-504             JAXUCZ010000004.1  51461612-51461683
            505-624             JAXUCZ010000004.1  51462399-51462518
            625-782             JAXUCZ010000004.1  51462788-51462945
            783-976             JAXUCZ010000004.1  51463431-51463624
            977-1178            JAXUCZ010000004.1  51464946-51465147
            1179-1217           JAXUCZ010000004.1  51466712-51466750
            1218-2163           JAXUCZ010000004.1  51468554-51469499
FEATURES             Location/Qualifiers
     source          1..2163
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..2163
                     /gene="Ing3"
                     /note="inhibitor of growth family, member 3"
                     /db_xref="GeneID:312154"
                     /db_xref="RGD:1310556"
     exon            1..96
                     /gene="Ing3"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1334
                     /gene="Ing3"
                     /codon_start=1
                     /product="inhibitor of growth protein 3"
                     /protein_id="NP_001029279.1"
                     /db_xref="GeneID:312154"
                     /db_xref="RGD:1310556"
                     /translation="MLYLEDYLEMIEQLPMDLRDRFTEMREMDLQVQNAMDQLEQRVS
                     EFFMNAKKNKPEWREEQMASIKKDYYKALEDADEKVQLANQIYDLVDRHLRKLDQELA
                     KFKMELEADNAGITEILERRSLELDAPSQPVNNHHAHSHTPVEKRKYNPTSHHTATDH
                     IPEKKFKSEALLSTLTSDASKENTLGCRNNNSTASCNNAYNVNSSQPLASYNIGSLSS
                     GAGAGAITMAAAQAVQATAQMKEGRRTSSLKASYEAFKNNDFQLGKEFSMPRETAGYS
                     SSSALMTTLTQNASSSAADSRSGRKSKNNTKSSSQQSSSSSSSSSSSSLSLCSSSSTV
                     VQEVSQQTTVVPESDSNSQVDWTYDPNEPRYCICNQVSYGEMVGCDNQDCPIEWFHYG
                     CVGLTEAPKGKWFCPQCTAAMKRRGSRHK"
     exon            97..168
                     /gene="Ing3"
                     /inference="alignment:Splign:2.1.0"
     exon            169..269
                     /gene="Ing3"
                     /inference="alignment:Splign:2.1.0"
     exon            270..335
                     /gene="Ing3"
                     /inference="alignment:Splign:2.1.0"
     exon            336..432
                     /gene="Ing3"
                     /inference="alignment:Splign:2.1.0"
     exon            433..504
                     /gene="Ing3"
                     /inference="alignment:Splign:2.1.0"
     exon            505..624
                     /gene="Ing3"
                     /inference="alignment:Splign:2.1.0"
     exon            625..782
                     /gene="Ing3"
                     /inference="alignment:Splign:2.1.0"
     exon            783..976
                     /gene="Ing3"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1178
                     /gene="Ing3"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1217
                     /gene="Ing3"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..2163
                     /gene="Ing3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccggcgac agcgagtgac acaaataaac ccctggaccc gttcgtctcc gcagcactca
       61 gggccgcgat gttgtaccta gaagactatt tggaaatgat tgagcagctt ccgatggacc
      121 tgcgggaccg cttcacggag atgcgcgaga tggatctgca ggtgcagaat gcaatggatc
      181 aactagaaca aagagtcagt gaattcttta tgaatgcaaa gaagaataaa cccgagtggc
      241 gagaagaaca gatggcatcc atcaaaaaag actactataa agctttggaa gatgcagatg
      301 agaaagtaca gttggcgaac caaatttatg atttggtaga tcgccacttg agaaagctgg
      361 accaggagct ggctaagttt aaaatggagc tggaagctga taatgctgga attacggaaa
      421 tattggagag gcgatctttg gaattagatg ctccttcgca gccagtgaac aatcaccacg
      481 ctcattcaca tactcctgtg gaaaaaagga aatataatcc aacttctcac catacagcaa
      541 cagaccatat ccccgaaaag aaattcaaat ccgaagctct cctgtccacc cttacatctg
      601 atgcttctaa ggagaacacg ctgggctgtc gaaataataa ttccacagct tcctgcaaca
      661 atgcttacaa tgtgaactcg tcccaacccc tggcatccta caatattggt tcattatctt
      721 caggggctgg cgcaggggcc atcaccatgg cagcagctca ggcagtgcaa gcaacagcac
      781 agatgaaaga aggacgaaga acatcgagtt taaaagccag ttatgaagcg tttaagaata
      841 atgacttcca gctgggaaaa gaattctcca tgcccagaga gacagcaggc tattcctcct
      901 cgtcggcact catgacaacc ttaacacaga atgccagctc ctcggccgcc gactctcgca
      961 gtggcaggaa gagcaaaaat aacaccaagt cttcaagcca gcagtcctcc tcctcatcct
     1021 catcctcgtc ctcctcctcc ttatctctgt gttcgtcatc ttcaactgta gtacaagaag
     1081 tttcccagca aacaacggta gtgcccgaat ctgattccaa cagtcaggtc gattggactt
     1141 acgacccaaa tgaaccccgg tattgcatct gtaatcaggt atcctatgga gagatggtgg
     1201 gatgtgataa ccaagactgt ccaatagagt ggttccacta tgggtgtgtc ggcttgacag
     1261 aagcaccgaa ggggaagtgg ttctgtccgc agtgcacggc tgccatgaag agaagaggca
     1321 gtcgacacaa atagagaggg gcttcaccgc aggaagggag agcttcagct cggcatttta
     1381 tacgggactc tagaaggaac gacacgagga cgaagaaaca actcatttcc aggcgaccac
     1441 ttaaaggatt acatagacaa tcctataaga tcttgaactt gaattttatg agttgtattt
     1501 taataatgta agtaaattat ttatgcactc ctggtgtgct atgaatatta ttccagttag
     1561 ccttggatta tttctgtggc caacatatgc agacatttgt actcctcaac cattttctca
     1621 aagtaatggg cattctataa tttaaacttc aaagaattcc aacgatgaag attttaagaa
     1681 agaattttat attcaacagg tatattctgc tgcatgtact gtactccaga gctgttatgt
     1741 tacactgtat ataaatggtt gcaaaaaaaa acaaaaaaca aaaaacaaac aaaaaaagtc
     1801 agtccttcga aaaaggatta agataatggt ttttaagatg cctttataat aagctttgtt
     1861 tctttgtgaa actcattcag caggctgaag ggattggttt atgtgataaa gtgggctgag
     1921 gtcctctaga gtacctgggt acataaacag aaactcctgt aggtaaaccc gatccgtgcc
     1981 attagtctac atgtttctgc atccagatag aatgccgctc aagctcaagg gggtgggggt
     2041 ggggcctctg ggggaaaggg cgttaaagtg atacattttt ataccaaatg tgtttatttt
     2101 tttgtgcgag taatccttaa attggaattg tattaggtgt taaaataaag ttttttaaaa
     2161 aaa
//
