LOCUS       NM_001106083            2738 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus inhibitor of growth family, member 2 (Ing2),
            mRNA.
ACCESSION   NM_001106083 XM_001059606 XM_214344
VERSION     NM_001106083.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2738)
  AUTHORS   Vicinanza M, Korolchuk VI, Ashkenazi A, Puri C, Menzies FM, Clarke
            JH and Rubinsztein DC.
  TITLE     PI(5)P regulates autophagosome biogenesis
  JOURNAL   Mol Cell 57 (2), 219-234 (2015)
   PUBMED   25578879
REFERENCE   2  (bases 1 to 2738)
  AUTHORS   Patel DJ and Wang Z.
  TITLE     Readout of epigenetic modifications
  JOURNAL   Annu Rev Biochem 82, 81-118 (2013)
   PUBMED   23642229
  REMARK    Review article
REFERENCE   3  (bases 1 to 2738)
  AUTHORS   Saito M, Kumamoto K, Robles AI, Horikawa I, Furusato B, Okamura S,
            Goto A, Yamashita T, Nagashima M, Lee TL, Baxendale VJ, Rennert OM,
            Takenoshita S, Yokota J, Sesterhenn IA, Trivers GE, Hussain SP and
            Harris CC.
  TITLE     Targeted disruption of Ing2 results in defective spermatogenesis
            and development of soft-tissue sarcomas
  JOURNAL   PLoS One 5 (11), e15541 (2010)
   PUBMED   21124965
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2738)
  AUTHORS   Sarker KP, Kataoka H, Chan A, Netherton SJ, Pot I, Huynh MA, Feng
            X, Bonni A, Riabowol K and Bonni S.
  TITLE     ING2 as a novel mediator of transforming growth
            factor-beta-dependent responses in epithelial cells
  JOURNAL   J Biol Chem 283 (19), 13269-13279 (2008)
   PUBMED   18334480
REFERENCE   5  (bases 1 to 2738)
  AUTHORS   Kaadige MR and Ayer DE.
  TITLE     The polybasic region that follows the plant homeodomain zinc finger
            1 of Pf1 is necessary and sufficient for specific phosphoinositide
            binding
  JOURNAL   J Biol Chem 281 (39), 28831-28836 (2006)
   PUBMED   16893883
REFERENCE   6  (bases 1 to 2738)
  AUTHORS   Shi X, Hong T, Walter KL, Ewalt M, Michishita E, Hung T, Carney D,
            Pena P, Lan F, Kaadige MR, Lacoste N, Cayrou C, Davrazou F, Saha A,
            Cairns BR, Ayer DE, Kutateladze TG, Shi Y, Cote J, Chua KF and
            Gozani O.
  TITLE     ING2 PHD domain links histone H3 lysine 4 methylation to active
            gene repression
  JOURNAL   Nature 442 (7098), 96-99 (2006)
   PUBMED   16728974
REFERENCE   7  (bases 1 to 2738)
  AUTHORS   Doyon Y, Cayrou C, Ullah M, Landry AJ, Cote V, Selleck W, Lane WS,
            Tan S, Yang XJ and Cote J.
  TITLE     ING tumor suppressor proteins are critical regulators of chromatin
            acetylation required for genome expression and perpetuation
  JOURNAL   Mol Cell 21 (1), 51-64 (2006)
   PUBMED   16387653
REFERENCE   8  (bases 1 to 2738)
  AUTHORS   Watanabe-Fukunaga R, Iida S, Shimizu Y, Nagata S and Fukunaga R.
  TITLE     SEI family of nuclear factors regulates p53-dependent
            transcriptional activation
  JOURNAL   Genes Cells 10 (8), 851-860 (2005)
   PUBMED   16098148
REFERENCE   9  (bases 1 to 2738)
  AUTHORS   Chattopadhyay C, Hawke D, Kobayashi R and Maity SN.
  TITLE     Human p32, interacts with B subunit of the CCAAT-binding factor,
            CBF/NF-Y, and inhibits CBF-mediated transcription activation in
            vitro
  JOURNAL   Nucleic Acids Res 32 (12), 3632-3641 (2004)
   PUBMED   15243141
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473995.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_214344.4, XM_001059606.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168652.1, CK364787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2738
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q11"
     gene            1..2738
                     /gene="Ing2"
                     /gene_synonym="Ing1l"
                     /note="inhibitor of growth family, member 2"
                     /db_xref="GeneID:290744"
                     /db_xref="RGD:1307347"
     exon            1..614
                     /gene="Ing2"
                     /gene_synonym="Ing1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             446..1285
                     /gene="Ing2"
                     /gene_synonym="Ing1l"
                     /note="inhibitor of growth family, member 1-like"
                     /codon_start=1
                     /product="inhibitor of growth protein 2"
                     /protein_id="NP_001099553.1"
                     /db_xref="GeneID:290744"
                     /db_xref="RGD:1307347"
                     /translation="MLGQQQQLYSSAALLTGERSRLLTCYVQDYLECVESLPHDMQRN
                     VSVLRELDNKYQETLKEIDDVYEKYKKEDDSNQKKRLQQHLQRALINSQELGDEKIQI
                     VTQMLELVENRARQMELHSQCFQDPAESERASDKSKMDSSQPERSSRRPRRQRTSESR
                     DLCHMTNGIDDCDDQPPKEKKSKSAKKKKRSKAKQEREASPVEFAIDPNEPTYCLCNQ
                     VSYGEMIGCDNEQCPIEWFHFSCVSLTYKPKGKWYCPKCRGDSEKTMDKSTEKTRKER
                     RAR"
     exon            615..2738
                     /gene="Ing2"
                     /gene_synonym="Ing1l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcaagtcc actgagactc cgacaggcaa ggaggctgat agcgaggcga gaggatagcg
       61 agggtcttgt cacggggatc cgggcgaccg ggcagctctg gtggtgtctg gggagtccca
      121 ggggggacag ccagtgtcac cgcccgggag cccggcgccg tcggccgcgg ggaaccccgc
      181 tgctctctcc cagcgaggga gggggccgga gggagccccg gtctcgcccc gcccttgggc
      241 ttgttaccgc gggggcgggg agtaagggtt tcttctgggg ggagtggaga tcgggggact
      301 cggcggtgcc ctctcgagcg gcggccgtgt ccccgcggcg ccgggctgcc gagcggagga
      361 gcggcggtcg tggctgttgc atgtgtggct gctggatgcg gaggcggcgg cggcggcggc
      421 ggcgaggagc agcagcggcg gcaggatgtt agggcagcag cagcagctgt actcgtcggc
      481 cgcgctcctg accggagagc ggagccggct gctcacctgc tacgtgcagg actacctgga
      541 gtgtgtggag tcgctgcccc acgacatgca gaggaacgtg tcggtgctgc gggagctgga
      601 caacaaatac caagaaactt taaaggaaat tgatgatgtc tatgaaaaat ataagaaaga
      661 agatgattca aaccagaaaa aacgcctaca gcagcatctc cagagagcat taatcaatag
      721 ccaagaattg ggagatgaaa agattcagat tgtcacacag atgctggaat tggtggaaaa
      781 ccgagccaga caaatggagc tgcattcaca gtgtttccag gatcctgctg aaagtgagcg
      841 ggcctcagac aaatccaaga tggattccag tcaacccgaa agatcttcca gaagacctcg
      901 aagacagcgg accagtgaga gccgtgattt atgtcacatg acaaacggga ttgatgactg
      961 cgatgatcag ccaccgaaag aaaagaaatc caaatccgcc aagaagaaaa agcgctccaa
     1021 ggccaagcag gagagggaag cgtcacctgt tgagtttgcc atagatccca acgagcccac
     1081 ctactgctta tgtaaccaag tgtcttacgg ggagatgata ggctgtgaca atgaacagtg
     1141 tcccattgag tggtttcact tttcctgcgt ttcactcacc tataaaccaa aggggaaatg
     1201 gtattgccca aagtgcaggg gagacagtga gaaaaccatg gacaaaagta ctgaaaagac
     1261 aagaaaggag agaagagcga ggtagtgaag gccatccggt tttaaagggt tctttgtctt
     1321 ttatataatt gctttacttt cagaaaatgt tttagggtaa atgcataaga ctatgcaata
     1381 atttttaatc attagtattg atggtgtatt aaaagttgtt gtactttgtc tgtgacctta
     1441 attttctgca ctgaattacc aaatattttc agccagatag tcttgtgagg acccgatgaa
     1501 aggaacaggc agtttcccaa gccacgccca tcccagcccc acctcgaact cccatgctgg
     1561 ctgggggtgg taaacccaaa agttttgcta acattttatt ttagttctgt atgcttaaga
     1621 atttcatgta ttgttggatt tctctgtcaa attatcttgg taatttcgaa catgaacact
     1681 atcctgttta gagattcttc ctgcctcctt gttttcagat acttgttaaa tctctagtgg
     1741 cccagaaatc ccagaaacag acagagtgat ctgtgcttcc acacgggcta gtgcgctctt
     1801 actggagtat ttgttgctgt atttcctggg tagcttttga tacctgtcag ttgtagtgtc
     1861 tggaaaagcc ctgcttcttt agaacagaca cacctcatct agtgcttaat aagggacttg
     1921 ttttgttttg atcaggacat ataagactag ttagaaatac caagaaacaa aacaaacaaa
     1981 caaaaaaaca acaacaaaaa acgctgcccc tggcaagatt tggattattt agcatcatgg
     2041 ctcaaggttg aacaatttaa aggtgtgtct taatattttc catgtgaccc actgctggga
     2101 tgtttagtca cagacctgtc atgggaaaag ggcatttatt agtctttaga tattgatatt
     2161 gccttttctg ttaaacagtt atttgaaata gtttttctgg gacctagagt ttatttctgt
     2221 ccaaaggaga attatacatt aatttaaata atcacatatt taccctaacc tggtattggt
     2281 gctgttgatg tttcatgttt atggaattaa cttcattata acgataccat caataatgca
     2341 tttgtaaatt gagttttcca agattttcat attctaaggg taagcatctt ggtggatctg
     2401 tgaccatgta ttggagcagt ttttggttat ggtgggcagc agatggacta gtcctttaga
     2461 cttatatgta gcatccgtcc cattcatcat ttctttctaa tctgataatc ttggttcttt
     2521 ttgattaaca tgtgaaaaaa tcctgtctgc ttgtttggaa aagaattttt ttttttcctc
     2581 ttcaagctgt ctgtgtgact tagccatgtc atttcacctt acctgaatgt gaggtcatcg
     2641 acctgggaaa tgagttggtt taaccatccc ccagggtctt cagaaatttc agtgttgtac
     2701 tgttggtgaa agatttttaa caatgaaatg gcttgctt
//
