LOCUS       NM_001419098            1075 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus inhibitor of CDK, cyclin A1 interacting protein 1
            (Inca1), mRNA.
ACCESSION   NM_001419098 XM_006246752
VERSION     NM_001419098.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1075)
  AUTHORS   Baumer,N., Tickenbrock,L., Tschanter,P., Lohmeyer,L.,
            Diederichs,S., Baumer,S., Skryabin,B.V., Zhang,F.,
            Agrawal-Singh,S., Kohler,G., Berdel,W.E., Serve,H., Koschmieder,S.
            and Muller-Tidow,C.
  TITLE     Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin
            A1 (INCA1) regulates proliferation and is repressed by oncogenic
            signaling
  JOURNAL   J Biol Chem 286 (32), 28210-28222 (2011)
   PUBMED   21540187
REFERENCE   2  (bases 1 to 1075)
  AUTHORS   Zhang,F., Baumer,N., Rode,M., Ji,P., Zhang,T., Berdel,W.E. and
            Muller-Tidow,C.
  TITLE     The inhibitor of growth protein 5 (ING5) depends on INCA1 as a
            co-factor for its antiproliferative effects
  JOURNAL   PLoS One 6 (7), e21505 (2011)
   PUBMED   21750715
REFERENCE   3  (bases 1 to 1075)
  AUTHORS   Chen,X., Hu,T., Liang,G., Yang,M., Zong,S., Miao,S., Koide,S.S. and
            Wang,L.
  TITLE     A novel testis protein, RSB-66, interacting with INCA1 (inhibitor
            of Cdk interacting with cyclin A1)
  JOURNAL   Biochem Cell Biol 86 (4), 345-351 (2008)
   PUBMED   18756329
  REMARK    GeneRIF: When being transfected into HeLa cells, RSB-66 and INCA1
            were found to be co-localized principally in the cytoplasm. The
            alpha helix in the RSB-66 C terminal and two amino acid residues
            (tyr117 and his119) appear to be crucial for its function
REFERENCE   4  (bases 1 to 1075)
  AUTHORS   Diederichs,S., Baumer,N., Ji,P., Metzelder,S.K., Idos,G.E.,
            Cauvet,T., Wang,W., Moller,M., Pierschalski,S., Gromoll,J.,
            Schrader,M.G., Koeffler,H.P., Berdel,W.E., Serve,H. and
            Muller-Tidow,C.
  TITLE     Identification of interaction partners and substrates of the cyclin
            A1-CDK2 complex
  JOURNAL   J Biol Chem 279 (32), 33727-33741 (2004)
   PUBMED   15159402
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Mar 28, 2023 this sequence version replaced XM_006246752.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2216642.1,
                                           SRR26360181.2661606.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                JAXUCZ010000010.1  55912604-55912698   c
            96-180              JAXUCZ010000010.1  55908772-55908856   c
            181-294             JAXUCZ010000010.1  55902991-55903104   c
            295-334             JAXUCZ010000010.1  55902749-55902788   c
            335-528             JAXUCZ010000010.1  55902309-55902502   c
            529-688             JAXUCZ010000010.1  55901407-55901566   c
            689-1075            JAXUCZ010000010.1  55900610-55900996   c
FEATURES             Location/Qualifiers
     source          1..1075
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..1075
                     /gene="Inca1"
                     /gene_synonym="RGD1306656"
                     /note="inhibitor of CDK, cyclin A1 interacting protein 1"
                     /db_xref="GeneID:360555"
                     /db_xref="RGD:1306656"
     exon            1..95
                     /gene="Inca1"
                     /gene_synonym="RGD1306656"
                     /inference="alignment:Splign:2.1.0"
     exon            96..180
                     /gene="Inca1"
                     /gene_synonym="RGD1306656"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..832
                     /gene="Inca1"
                     /gene_synonym="RGD1306656"
                     /note="inhibitor of CDK interacting with cyclin A1"
                     /codon_start=1
                     /product="protein INCA1"
                     /protein_id="NP_001406027.1"
                     /db_xref="GeneID:360555"
                     /db_xref="RGD:1306656"
                     /translation="MQGQEDGDSILPFAKCSRVVSRSSPCSLPSQKSRPMPQPYGEIF
                     WENLSRRSNSNWMIEQYIPPILRATGCSQPGLHPLEGLPPPEKLWRRKGKKLHLERMQ
                     KGLGSTPARVRAVTYHLEDLRRRQGIINELKKAQWGSSEATPELPVFEEGCELLSTTK
                     YLDVEEERATYPQGENYFVTPRDQLLWSPWTPVGQQGTYASGQLNSLAYSTVTARKNP
                     IYSPQRMELESEE"
     exon            181..294
                     /gene="Inca1"
                     /gene_synonym="RGD1306656"
                     /inference="alignment:Splign:2.1.0"
     exon            295..334
                     /gene="Inca1"
                     /gene_synonym="RGD1306656"
                     /inference="alignment:Splign:2.1.0"
     exon            335..528
                     /gene="Inca1"
                     /gene_synonym="RGD1306656"
                     /inference="alignment:Splign:2.1.0"
     exon            529..688
                     /gene="Inca1"
                     /gene_synonym="RGD1306656"
                     /inference="alignment:Splign:2.1.0"
     exon            689..1075
                     /gene="Inca1"
                     /gene_synonym="RGD1306656"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcgagcca ggcaagtggg gcgacccggg tcactgcaga gccactcctt cctgcccgac
       61 ctgaggttcc agaattcgct tcacagttgc ctcagcatca aggagatcca gtcttgctac
      121 ctagccaagt ccagtcatgc agggtcagga agatggagac agcatccttc cttttgccaa
      181 gtgttccaga gtggtcagcc gatcttcacc ctgcagcctg ccttcccaga agagcagacc
      241 aatgcctcag ccttatggag agatcttctg ggagaatctc agccgaaggt ctaactccaa
      301 ctggatgata gaacagtaca ttccaccaat tctgagggcc acgggttgct cccagcctgg
      361 cctgcaccct cttgaggggc tccctcctcc tgagaagctt tggagaagaa agggaaagaa
      421 gctgcatttg gaaagaatgc aaaagggact tggaagcact ccagcccgtg ttagagcagt
      481 tacttatcat ctggaggacc tgaggaggcg ccagggaatc atcaacgaac tgaagaaggc
      541 ccagtgggga agctcagagg ctacacctga actcccagtg tttgaagagg gctgtgaact
      601 cctcagcact acaaaatacc ttgatgtgga agaagagagg gcaacctatc cacagggaga
      661 gaattatttt gtcactccca gggatcagct gctttggtct ccctggactc ctgtaggcca
      721 gcaggggact tacgcctctg ggcagctaaa ctctctggcc tacagcactg ttacagccag
      781 aaagaaccct atttacagtc cccagaggat ggagttggag tctgaggagt agtgggaaat
      841 catccaggcc caagctacag gacccaagac caattcaaac atcaagactc cccattgcgg
      901 cttcaaggcg gttgttttct ctctcctaac tgttgtctcc atcccatagc gtaggcattc
      961 acaccccact tgagttccta tccaactgtt cggtccactc atagccgggt ttttctctag
     1021 gccagaccct ggtcttgtgt tctgtctgtt ctgttattaa agagccccaa ggaga
//
