LOCUS       NM_001134502            2977 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus innate immunity activator (Inava), mRNA.
ACCESSION   NM_001134502 XM_001063937 XM_213984
VERSION     NM_001134502.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2977)
  AUTHORS   Mohanan,V., Nakata,T., Desch,A.N., Levesque,C., Boroughs,A.,
            Guzman,G., Cao,Z., Creasey,E., Yao,J., Boucher,G., Charron,G.,
            Bhan,A.K., Schenone,M., Carr,S.A., Reinecker,H.C., Daly,M.J.,
            Rioux,J.D., Lassen,K.G. and Xavier,R.J.
  TITLE     C1orf106 is a colitis risk gene that regulates stability of
            epithelial adherens junctions
  JOURNAL   Science 359 (6380), 1161-1166 (2018)
   PUBMED   29420262
REFERENCE   2  (bases 1 to 2977)
  AUTHORS   Yan,J., Hedl,M. and Abraham,C.
  TITLE     An inflammatory bowel disease-risk variant in INAVA decreases
            pattern recognition receptor-induced outcomes
  JOURNAL   J Clin Invest 127 (6), 2192-2205 (2017)
   PUBMED   28436939
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473958.2.
            
            [WARNING] On Oct 24, 2024 this sequence was replaced by
            NM_001134502.2.
            
            On or before Sep 4, 2008 this sequence version replaced
            XM_213984.4, XM_001063937.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760494 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2977
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..2977
                     /gene="Inava"
                     /gene_synonym="RGD1311892"
                     /note="innate immunity activator"
                     /db_xref="GeneID:289399"
                     /db_xref="RGD:1311892"
     exon            1..378
                     /gene="Inava"
                     /gene_synonym="RGD1311892"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..2209
                     /gene="Inava"
                     /gene_synonym="RGD1311892"
                     /note="uncharacterized protein C1orf106 homolog"
                     /codon_start=1
                     /product="innate immunity activator protein"
                     /protein_id="NP_001127974.1"
                     /db_xref="GeneID:289399"
                     /db_xref="RGD:1311892"
                     /translation="MPQGTDVLGSLTFGMLQMPKLNEIPPGRGGPGEPWGEGRWAGPT
                     GPEAARRAQGARGQARGARARWDSWENSRLPTHPGPGWDRRSPSFLAAPSSQKLIMES
                     KDEVSDSDSGIILQSGPDSPVSPMKELTNAVRKQQRALEARLEACLEELRRLCLREAE
                     LTGTLPAEYPLKPGEKAPKVRRRIGAAYKLDEWALHREDPLSSLERQLALQLQITEAA
                     RRLCAEENLSRQARRQRKHAALQEEKKLRDLQRCLGDRRRNSEPPPSTVPSLGRELSA
                     SDDSSLSDGLLLEEEDSQAPKPPPESPAPPSRPLPPQSLEGLQPTGPESGGLERAPIQ
                     NSPWKETSLDHPYEKPRKSSELSSESSSPATTPQDQPSPSNLWVLDAASYQVVPIRNV
                     PGQRQGRTSAPATPEMQGRRGQSQSLRVDSFRAGAEGRGRSAFPRRRPTHYTVTVPDS
                     CFTPSKPPLPHPACHSCSEDSGSDVSSISHPTSPGSSSPDISFLRPLCPPETPRHRGA
                     WGPACGRELVTHYPKLLLPAGYFPTGRYVMVAEGHLPPGEWELCRAAVGAAYDEEGAP
                     LRYQRLVPSHSRIVRTPSLKDCPAGRALSKAAVSEELKWWHERARLRSSRPHSLDRQG
                     AFRVRSLPPGRESFGRASVPRTQVPPVCVLRRSPDGAPVQVFVPENGEIISQV"
     exon            379..527
                     /gene="Inava"
                     /gene_synonym="RGD1311892"
                     /inference="alignment:Splign:2.1.0"
     exon            528..652
                     /gene="Inava"
                     /gene_synonym="RGD1311892"
                     /inference="alignment:Splign:2.1.0"
     exon            653..769
                     /gene="Inava"
                     /gene_synonym="RGD1311892"
                     /inference="alignment:Splign:2.1.0"
     exon            770..992
                     /gene="Inava"
                     /gene_synonym="RGD1311892"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1046
                     /gene="Inava"
                     /gene_synonym="RGD1311892"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1257
                     /gene="Inava"
                     /gene_synonym="RGD1311892"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1431
                     /gene="Inava"
                     /gene_synonym="RGD1311892"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..2116
                     /gene="Inava"
                     /gene_synonym="RGD1311892"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2977
                     /gene="Inava"
                     /gene_synonym="RGD1311892"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggctgccc gaatgcggga gatagggggc agcgtcgtcc ctcgcgatgt tgctcccgca
       61 gggtgcacac tggggctggc accgttccaa cacaacgtga ggccccgccc cgtctcttgg
      121 atcagaatct cgaatctctt ctagcatttt cccctctctc cacagggcct ttggtatgcc
      181 ccaggggaca gatgtcttgg gatctttaac atttgggatg ctgcaaatgc cgaagttaaa
      241 tgaaatacct ccggggaggg gaggaccggg ggagccttgg ggagagggaa gatgggcggg
      301 accaacaggt cctgaagctg cgcgacgggc tcagggggcg cgggggcagg cgcggggcgc
      361 cagagctcgg tgggacagct gggaaaactc cagactacct acacatcctg gcccaggctg
      421 ggaccggcgc agcccctcct tcctcgctgc cccctcctcc cagaaactca tcatggagag
      481 taaggatgaa gtcagtgact ctgacagcgg catcatcctg cagtctggcc cagacagccc
      541 tgtctctcca atgaaagagc tgaccaacgc cgtgcgcaag cagcaaaggg ctctggaagc
      601 aaggctggag gcctgcttgg aggagctgcg cagactctgc ctgagggagg cggagctgac
      661 cggtactttg ccggcagagt atcctcttaa gccaggcgag aaagccccca aggtccggcg
      721 caggatcgga gcagcataca aactggacga gtgggccctg cacagagagg atcccctgag
      781 cagcctggag cgccagttgg ctctgcagct tcagatcacc gaggcggctc gcaggctctg
      841 cgcagaggag aaccttagca ggcaggcacg caggcagcgg aagcacgctg cgctgcagga
      901 ggagaagaag ctgcgggacc ttcagcgctg cctgggtgat cggcggcgga acagtgagcc
      961 ccctccttcc actgtgccct ccctgggcag agagctcagt gcctctgatg acagctccct
     1021 gtcagacggg ctactcctgg aggaagaaga ctcccaagcg ccaaaacctc ccccagagtc
     1081 accggcacca ccttcacggc ctctcccacc ccagagcctt gagggcctgc agccaacagg
     1141 acctgaatct ggcggcctgg aacgagcccc catccaaaac agtccctgga aggagaccag
     1201 cttggaccac ccctatgaga agccacggaa gtcttccgag ctcagtagcg agtccagcag
     1261 cccagctacc actcctcagg accagcccag cccctccaac ctgtgggtgc tggatgctgc
     1321 ctcctaccag gtggtcccca tccgaaatgt tcctggccag cgtcagggcc gcaccagtgc
     1381 cccagccacc cctgagatgc agggcaggag gggccagtcc cagtctctga gggtggactc
     1441 cttccgagca ggtgcggagg gccgaggtcg cagtgccttt ccccgccgcc gccccactca
     1501 ttacacagtg acggtgccag actcctgctt cacacccagc aagcccccac tgccgcaccc
     1561 tgcctgccat tcctgttctg aagacagcgg ctctgatgtc tccagcatct cccatcccac
     1621 ctcacccggc agcagcagtc cagacatctc ctttctgagg cccctctgtc cccctgagac
     1681 tcctcgccac cgtggagcct ggggcccagc ctgtggcaga gagctggtca ctcattaccc
     1741 taaacttctg ctgcccgctg ggtacttccc aaccgggcgc tatgtgatgg tggctgaggg
     1801 ccacctgccg ccgggcgagt gggagctgtg tcgtgcagct gtgggtgccg cctatgacga
     1861 ggaaggtgca cccctacgtt accagcggct ggtgccctcc catagccgca ttgtgcgcac
     1921 accctcacta aaggactgtc ctgcgggccg ggcactcagc aaggcagctg tgtcagagga
     1981 gctcaagtgg tggcatgagc gtgcacgtct ccggagcagc cgcccccact cgctcgaccg
     2041 ccaaggggct ttccgtgtta ggagtctgcc tcctgggagg gagagcttcg ggcgggcctc
     2101 cgtaccccgg acacaggtgc ccccagtgtg tgtacttcgg aggtcgccag acggggcccc
     2161 cgtgcaagtc tttgtgcctg agaatggaga gatcatcagc caagtgtaac tcctctgaaa
     2221 gccttgccca gtactggaaa agacttaata ttggagctgg gatcgaggac cccatcactc
     2281 ttaagtgctt ctttcggctc tcttaccgtc gtcgccggcc gatgacccag agctgaaacc
     2341 tttgtttttt acgtgttttc cagaagtccg gacctgaagc tttacatctg tgatttgtct
     2401 tcatggttct tataatatga tcatgcttta tcccccagag tctggccttt tggattaatg
     2461 tcgcgctgga ctaatcgaca gcacttgtct ccttatgcag ggcaagtggc atagagggcc
     2521 ctttgaggct tgggccttct ttctgagata gctgctgctt cttgctggag gcaggatgtg
     2581 gttcttcctc aacagagact cgtttccctt gtttcccaga tgccaggcag gactctcctt
     2641 tatatgctct gtgacgtaca cccagggcac agggcatttc tgtcagtgtt cttcccacac
     2701 cctatagtag tcccacctcc acttgccata ttatatggct tctgagcccc ttccccagtg
     2761 tatagatgcc ctaccctgac cccagtgtat tctctggatc cctaagtgcc ttagattctg
     2821 agtcacagag cagggagatt tctgagtgct ggtacctccc atgcgtgacc atccctcaca
     2881 ttaacttatt ggtcttacct aacagctatc tcgtggttgc acagtggtag tgccaaatac
     2941 gtcaataaaa tctgattggc ccagctgagg atgaagg
//
