LOCUS       NM_019128               3323 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus internexin neuronal intermediate filament
            protein, alpha (Ina), mRNA.
ACCESSION   NM_019128
VERSION     NM_019128.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3323)
  AUTHORS   Mages,B., Aleithe,S., Altmann,S., Blietz,A., Nitzsche,B.,
            Barthel,H., Horn,A.K.E., Hobusch,C., Hartig,W., Krueger,M. and
            Michalski,D.
  TITLE     Impaired Neurofilament Integrity and Neuronal Morphology in
            Different Models of Focal Cerebral Ischemia and Human Stroke Tissue
  JOURNAL   Front Cell Neurosci 12, 161 (2018)
   PUBMED   29967576
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3323)
  AUTHORS   Yuan,A., Sershen,H., Veeranna, Basavarajappa,B.S., Kumar,A.,
            Hashim,A., Berg,M., Lee,J.H., Sato,Y., Rao,M.V., Mohan,P.S.,
            Dyakin,V., Julien,J.P., Lee,V.M. and Nixon,R.A.
  TITLE     Neurofilament subunits are integral components of synapses and
            modulate neurotransmission and behavior in vivo
  JOURNAL   Mol Psychiatry 20 (8), 986-994 (2015)
   PUBMED   25869803
REFERENCE   3  (bases 1 to 3323)
  AUTHORS   Karpova,A., Mikhaylova,M., Bera,S., Bar,J., Reddy,P.P.,
            Behnisch,T., Rankovic,V., Spilker,C., Bethge,P., Sahin,J.,
            Kaushik,R., Zuschratter,W., Kahne,T., Naumann,M., Gundelfinger,E.D.
            and Kreutz,M.R.
  TITLE     Encoding and transducing the synaptic or extrasynaptic origin of
            NMDA receptor signals to the nucleus
  JOURNAL   Cell 152 (5), 1119-1133 (2013)
   PUBMED   23452857
REFERENCE   4  (bases 1 to 3323)
  AUTHORS   Chen,S., Lu,F.F., Seeman,P. and Liu,F.
  TITLE     Quantitative proteomic analysis of human substantia nigra in
            Alzheimer's disease, Huntington's disease and Multiple sclerosis
  JOURNAL   Neurochem Res 37 (12), 2805-2813 (2012)
   PUBMED   22926577
REFERENCE   5  (bases 1 to 3323)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   6  (bases 1 to 3323)
  AUTHORS   Faussone-Pellegrini,M.S., Matini,P. and DeFelici,M.
  TITLE     The cytoskeleton of the myenteric neurons during murine embryonic
            life
  JOURNAL   Anat Embryol (Berl) 199 (5), 459-469 (1999)
   PUBMED   10221457
REFERENCE   7  (bases 1 to 3323)
  AUTHORS   Athlan,E.S. and Mushynski,W.E.
  TITLE     Heterodimeric associations between neuronal intermediate filament
            proteins
  JOURNAL   J Biol Chem 272 (49), 31073-31078 (1997)
   PUBMED   9388258
REFERENCE   8  (bases 1 to 3323)
  AUTHORS   Suzuki,T., Mitake,S., Okumura-Noji,K., Shimizu,H., Tada,T. and
            Fujii,T.
  TITLE     Excitable membranes and synaptic transmission: postsynaptic
            mechanisms. Localization of alpha-internexin in the postsynaptic
            density of the rat brain
  JOURNAL   Brain Res 765 (1), 74-80 (1997)
   PUBMED   9310396
REFERENCE   9  (bases 1 to 3323)
  AUTHORS   Ching,G.Y. and Liem,R.K.
  TITLE     Structure of the gene for the neuronal intermediate filament
            protein alpha-internexin and functional analysis of its promoter
  JOURNAL   J Biol Chem 266 (29), 19459-19468 (1991)
   PUBMED   1717465
REFERENCE   10 (bases 1 to 3323)
  AUTHORS   Fliegner,K.H., Ching,G.Y. and Liem,R.K.
  TITLE     The predicted amino acid sequence of alpha-internexin is that of a
            novel neuronal intermediate filament protein
  JOURNAL   EMBO J 9 (3), 749-755 (1990)
   PUBMED   2311576
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Sep 1, 2015 this sequence version replaced NM_019128.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.8416.1,
                                           SRR26643288.7480.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1139              JAXUCZ010000001.1  255838129-255839267
            1140-1264           JAXUCZ010000001.1  255845465-255845589
            1265-3323           JAXUCZ010000001.1  255847622-255849680
FEATURES             Location/Qualifiers
     source          1..3323
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..3323
                     /gene="Ina"
                     /gene_synonym="alpha-Inx; Inexa; Intlaa; Nf66"
                     /note="internexin neuronal intermediate filament protein,
                     alpha"
                     /db_xref="GeneID:24503"
                     /db_xref="RGD:2911"
     exon            1..1139
                     /gene="Ina"
                     /gene_synonym="alpha-Inx; Inexa; Intlaa; Nf66"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1595
                     /gene="Ina"
                     /gene_synonym="alpha-Inx; Inexa; Intlaa; Nf66"
                     /codon_start=1
                     /product="alpha-internexin"
                     /protein_id="NP_062001.2"
                     /db_xref="GeneID:24503"
                     /db_xref="RGD:2911"
                     /translation="MSFGSEHYLCSASSYRKVFGDGSRLSARLSGPGGSGSFRSQSLS
                     RSNVASTAACSSASSLGLGLAYRRLPASDGLDLSQAAARTNEYKIIRTNEKEQLQGLN
                     DRFAVFIEKVHQLETQNRALEAELAALRQRHAEPSRVGELFQRELRELRAQLEEASSA
                     RAQALLERDGLAEEVQRLRARCEEESRGREGAERALKAQQRDVDGATLARLDLEKKVE
                     SLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVAVAKPDLTSALREIRAQYESLA
                     AKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEIEGLRGANE
                     SLERQILELEERHSAEVAGYQDSIGQLESDLRNTKSEMARHLREYQDLLNVKMALDIE
                     IAAYRKLLEGEETRFSTSGLSISGLNPLPNPSYLLPPRILSSTTSKVSSAGLSLKKEE
                     EEEEEEEEEGASKEVTKKTSKVGESFEETLEETVVSTKKTEKSTIEEITTSSNQKM"
     exon            1140..1264
                     /gene="Ina"
                     /gene_synonym="alpha-Inx; Inexa; Intlaa; Nf66"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..3323
                     /gene="Ina"
                     /gene_synonym="alpha-Inx; Inexa; Intlaa; Nf66"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acccagcctt gccgcacctt cgcgtcctcg ccaggtcccg ccgcagccgc gcacccggcc
       61 ccgaccccgg caccatgagc ttcggatcag agcactactt gtgctccgcc tcctcctacc
      121 gcaaggtgtt cggggatggc tcgcgcctgt ctgcgcgcct gtccgggccg ggaggctccg
      181 gcagctttcg ctcgcagtcg ctgtcccgca gcaatgtggc ctccacggcc gcttgctcct
      241 cggcctcgtc tctcggcctg ggcctggcct accgccgcct gccggcctcc gacgggctgg
      301 acctgagcca agcagcggcg cgcaccaacg agtacaagat catccgcact aacgagaagg
      361 agcagctgca gggcctcaac gaccgcttcg cggtgttcat cgaaaaggtg caccagctgg
      421 agacgcagaa ccgcgcgctc gaggccgagc tggccgcgct gcgccagcgc cacgccgagc
      481 cgtcgcgcgt cggcgagctc ttccagcgcg agctgcgcga gctgcgcgcg cagctggagg
      541 aggcgagctc cgcgcgcgcg caggccctgc tggagcgcga cgggctggcc gaggaggtgc
      601 agcgactgcg ggcgcgctgc gaggaggaga gccgcgggcg cgaaggcgcg gagcgcgccc
      661 tgaaggcgca gcagcgcgac gtggacggcg ccactctggc ccgcctggat ctggagaaga
      721 aggtggagtc gctgctggac gagctggcct tcgtgcgcca ggtgcacgac gaggaggtgg
      781 ccgagctcct ggccacgctg caggcgtctt cgcaagccgc cgccgaggtg gacgtggctg
      841 tggctaaacc agacctgact tcggcgctga gggagatccg cgcccagtat gagtccttgg
      901 ccgctaagaa cctgcagtcg gccgaggagt ggtacaagtc caagttcgcc aacctgaacg
      961 agcaggctgc gcgcagcacg gaagccatcc gagccagccg agaggagatc cacgagtacc
     1021 ggcgccagct ccaggctcgt accattgaga tagagggcct gcgcggagcc aatgaatccc
     1081 tggagaggca gatcttggaa ctggaggagc ggcacagcgc tgaggtggcc ggctaccagg
     1141 atagcattgg gcagctggag agtgacctga ggaacaccaa gagcgagatg gcccgccacc
     1201 ttcgggaata ccaggacttg ctcaatgtca aaatggctct tgacattgag atagcagctt
     1261 acaggaagct gctggaaggt gaagagacac gatttagcac cagcgggtta agcatctcag
     1321 ggctgaatcc acttcccaat cccagttatt tgctccctcc tagaatcctt agttctacaa
     1381 cctccaaagt ctcatccgct gggctgtccc tgaaaaagga ggaggaggag gaggaggagg
     1441 aagaggaaga aggggcttct aaggaagtca ctaagaaaac atccaaggta ggggaaagtt
     1501 tcgaagaaac actggaggaa acggtggtat ctacgaagaa aaccgaaaag tcaactatag
     1561 aagaaatcac caccagttcc aaccaaaaaa tgtaatgctg ttgcttaaaa aaaaaaacaa
     1621 aaaaaggcga tgcctaagag ggaatgcact tggcttattc acagcttact cctgaaccac
     1681 acctaccacc gctatagaat gtcttcaagg cttcaatgtc atagtctgta ccgaatcctc
     1741 gctctctcca gtaggaaggc cactgtagct gggagcaaac tgcagtgctg gaggaggagc
     1801 aggaggagct ctctaagatc acagctttcc tacctacagc tcaggcctca tagtgacagg
     1861 tgacccaggt gcagaggagg ctcaaacgaa ggtgctaaat ctggtcatcg ctcgctgtga
     1921 gctgaaatcg aaacctgttt ctccaccgta ccccgccagt acccagccat agaacctcac
     1981 tgtagatgtc taaaaatata cagtcactgc cgaggacaag ctagtgctcc agacaccatt
     2041 ctcccatccc cctctgatag agctgagtca caaaacgacg gtcgtctctc atgggcaggt
     2101 ttccttcctc tctcttcaat cccgtattgc catttctccc acctgagagg aaggaacaaa
     2161 gtttagtgtg gtatcccctt ctagacacgc atagaactta cgccctttag tcctccactc
     2221 cgtgggtaaa ttagatgcat gttgaccatt cccgtgattt gtataacgca cccttgtcca
     2281 tttcatgacc tttcatgtcc gtagcttaaa aaatagaaag tgattaatga taatggcagt
     2341 gattggtttt aagggttttc ctaaaataat actaattata ataataatca taaaagggat
     2401 ctctagactt taggctttca gcttatccag atccacttaa ttagagagga aaaaaattac
     2461 cttaaatgat gtagcatttc accttaaatt tagaggcacg gtgatagttg ccctactctg
     2521 cgcttaagct gaccttagac ctcgtatcgt aagtagagtg agtgagtgag tgctctgaag
     2581 ggaaagaaca aggtctcctc tgtgttggtt tctatgtagt gctatagaat tagctttctc
     2641 atacccttgc cctaggatct acataattcc cttcccatta gggtagtatg ctatgtatag
     2701 gacattttat caccagacac aacgctactg cccaaaagtg aaaaacacac acttctggtc
     2761 aatcaacacc accagcaaat atttaaaaaa aataaaaaag gaaaggaaga aagaaagaaa
     2821 gaaagaaaga gagagagaga gagaaagaaa gaaagagaaa gattgattct cagagtcttt
     2881 tcctaacagg gttacattgc ttcagttggt ggatgtccct cccctgaagg aaagacagaa
     2941 acattattca gggtccagga ggggtatgca cacttctccc ccacctcaag aaggcaggct
     3001 ggaaagtcag ctcttcgtgc actcaactgt ggcatccaca tgacctgtct gcctcgcgtg
     3061 ccaaacttga tgcagggttt gccctgtctc tgctcactcc caccaagctg tagaactgtc
     3121 tgtcctgtcc ccgcccaccc catccgcaag ctctgtgctg ataaggacat gatgcttcta
     3181 ctgaattcac attctagcac gtgcttcaat atagctcaag gaaccggaaa gacacttcgt
     3241 ttttcctgac ccatcccctc ttgacccccc ccccacactg taagacatta gtaatattaa
     3301 gaaattaaaa gtcattaatc cta
//
