LOCUS       NM_199099               1693 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus inosine monophosphate dehydrogenase 2 (Impdh2),
            mRNA.
ACCESSION   NM_199099 XM_217266
VERSION     NM_199099.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1693)
  AUTHORS   Lin,R., Mo,Y., Zha,H., Qu,Z., Xie,P., Zhu,Z.J., Xu,Y., Xiong,Y. and
            Guan,K.L.
  TITLE     CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis
  JOURNAL   Mol Cell 68 (1), 198-209 (2017)
   PUBMED   28985504
REFERENCE   2  (bases 1 to 1693)
  AUTHORS   Bharti,P., Schliebs,W., Schievelbusch,T., Neuhaus,A., David,C.,
            Kock,K., Herrmann,C., Meyer,H.E., Wiese,S., Warscheid,B., Theiss,C.
            and Erdmann,R.
  TITLE     PEX14 is required for microtubule-based peroxisome motility in
            human cells
  JOURNAL   J Cell Sci 124 (Pt 10), 1759-1768 (2011)
   PUBMED   21525035
REFERENCE   3  (bases 1 to 1693)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 1693)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 1693)
  AUTHORS   Gunter,J.H., Thomas,E.C., Lengefeld,N., Kruger,S.J., Worton,L.,
            Gardiner,E.M., Jones,A., Barnett,N.L. and Whitehead,J.P.
  TITLE     Characterisation of inosine monophosphate dehydrogenase expression
            during retinal development: differences between variants and
            isoforms
  JOURNAL   Int J Biochem Cell Biol 40 (9), 1716-1728 (2008)
   PUBMED   18295529
REFERENCE   6  (bases 1 to 1693)
  AUTHORS   McLean,J.E., Hamaguchi,N., Belenky,P., Mortimer,S.E., Stanton,M.
            and Hedstrom,L.
  TITLE     Inosine 5'-monophosphate dehydrogenase binds nucleic acids in vitro
            and in vivo
  JOURNAL   Biochem J 379 (Pt 2), 243-251 (2004)
   PUBMED   14766016
REFERENCE   7  (bases 1 to 1693)
  AUTHORS   Gu,J.J., Tolin,A.K., Jain,J., Huang,H., Santiago,L. and
            Mitchell,B.S.
  TITLE     Targeted disruption of the inosine 5'-monophosphate dehydrogenase
            type I gene in mice
  JOURNAL   Mol Cell Biol 23 (18), 6702-6712 (2003)
   PUBMED   12944494
REFERENCE   8  (bases 1 to 1693)
  AUTHORS   Chu,C.C. and Paul,W.E.
  TITLE     Expressed genes in interleukin-4 treated B cells identified by cDNA
            representational difference analysis
  JOURNAL   Mol Immunol 35 (8), 487-502 (1998)
   PUBMED   9798653
REFERENCE   9  (bases 1 to 1693)
  AUTHORS   Hager,P.W., Collart,F.R., Huberman,E. and Mitchell,B.S.
  TITLE     Recombinant human inosine monophosphate dehydrogenase type I and
            type II proteins. Purification and characterization of inhibitor
            binding
  JOURNAL   Biochem Pharmacol 49 (9), 1323-1329 (1995)
   PUBMED   7763314
REFERENCE   10 (bases 1 to 1693)
  AUTHORS   Yamada,Y., Natsumeda,Y. and Weber,G.
  TITLE     Action of the active metabolites of tiazofurin and ribavirin on
            purified IMP dehydrogenase
  JOURNAL   Biochemistry 27 (6), 2193-2196 (1988)
   PUBMED   2897864
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 18, 2021 this sequence version replaced NM_199099.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060585.1, SRR26360190.1173272.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               JAXUCZ010000008.1  118135257-118135440
            185-233             JAXUCZ010000008.1  118135845-118135893
            234-335             JAXUCZ010000008.1  118136267-118136368
            336-410             JAXUCZ010000008.1  118136446-118136520
            411-617             JAXUCZ010000008.1  118136800-118137006
            618-705             JAXUCZ010000008.1  118137323-118137410
            706-905             JAXUCZ010000008.1  118137487-118137686
            906-996             JAXUCZ010000008.1  118137769-118137859
            997-1092            JAXUCZ010000008.1  118137946-118138041
            1093-1236           JAXUCZ010000008.1  118138951-118139094
            1237-1381           JAXUCZ010000008.1  118139181-118139325
            1382-1525           JAXUCZ010000008.1  118139413-118139556
            1526-1609           JAXUCZ010000008.1  118139640-118139723
            1610-1693           JAXUCZ010000008.1  118139809-118139892
FEATURES             Location/Qualifiers
     source          1..1693
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1693
                     /gene="Impdh2"
                     /gene_synonym="IMPD 2; IMPDH 2"
                     /note="inosine monophosphate dehydrogenase 2"
                     /db_xref="GeneID:301005"
                     /db_xref="RGD:735092"
     exon            1..184
                     /gene="Impdh2"
                     /gene_synonym="IMPD 2; IMPDH 2"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1631
                     /gene="Impdh2"
                     /gene_synonym="IMPD 2; IMPDH 2"
                     /EC_number="1.1.1.205"
                     /note="inosine 5'-phosphate dehydrogenase 2; inosine
                     5-monophosphate dehydrogenase 2; IMP (inosine
                     monophosphate) dehydrogenase 2; IMP dehydrogenase 2; IMP
                     (inosine 5'-monophosphate) dehydrogenase 2"
                     /codon_start=1
                     /product="inosine-5'-monophosphate dehydrogenase 2"
                     /protein_id="NP_954530.2"
                     /db_xref="GeneID:301005"
                     /db_xref="RGD:735092"
                     /translation="MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDF
                     TADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQAN
                     EVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISS
                     RDIDFLKEEEHDRFLEEIMTKREDLVVAPAGVTLKEANEILQRSKKGKLPIVNESDEL
                     VAIIARTDLKKNRDYPLASKDTKKQLLCGAAIGTHEDDKYRLDLLALAGVDVVVLDSS
                     QGNSIFQINMIKYIKEKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQ
                     EVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAA
                     TTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDK
                     GSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHGLHS
                     YEKRLF"
     exon            185..233
                     /gene="Impdh2"
                     /gene_synonym="IMPD 2; IMPDH 2"
                     /inference="alignment:Splign:2.1.0"
     exon            234..335
                     /gene="Impdh2"
                     /gene_synonym="IMPD 2; IMPDH 2"
                     /inference="alignment:Splign:2.1.0"
     exon            336..410
                     /gene="Impdh2"
                     /gene_synonym="IMPD 2; IMPDH 2"
                     /inference="alignment:Splign:2.1.0"
     exon            411..617
                     /gene="Impdh2"
                     /gene_synonym="IMPD 2; IMPDH 2"
                     /inference="alignment:Splign:2.1.0"
     exon            618..705
                     /gene="Impdh2"
                     /gene_synonym="IMPD 2; IMPDH 2"
                     /inference="alignment:Splign:2.1.0"
     exon            706..905
                     /gene="Impdh2"
                     /gene_synonym="IMPD 2; IMPDH 2"
                     /inference="alignment:Splign:2.1.0"
     exon            906..996
                     /gene="Impdh2"
                     /gene_synonym="IMPD 2; IMPDH 2"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1092
                     /gene="Impdh2"
                     /gene_synonym="IMPD 2; IMPDH 2"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1236
                     /gene="Impdh2"
                     /gene_synonym="IMPD 2; IMPDH 2"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1381
                     /gene="Impdh2"
                     /gene_synonym="IMPD 2; IMPDH 2"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1525
                     /gene="Impdh2"
                     /gene_synonym="IMPD 2; IMPDH 2"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1609
                     /gene="Impdh2"
                     /gene_synonym="IMPD 2; IMPDH 2"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1693
                     /gene="Impdh2"
                     /gene_synonym="IMPD 2; IMPDH 2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctagttt atattggcgc ggtccagaag gcagaggcct ctgcggcgcg gtcctctgag
       61 gcacgcgtcc gtgttcctcg ttggtcatgg cggactacct gattagcgga ggcacttctt
      121 acgtgccaga cgacgggctc accgcacagc agctcttcaa ctgcggggac ggcctgacct
      181 acaatgactt tctcattctt cctggatata tcgacttcac tgcggaccag gtggacttga
      241 cctctgctct aaccaagaag attactctga agaccccctt ggtttcctca cctatggaca
      301 ctgtcacgga ggctggaatg gccatcgcaa tggcgcttac aggaggcatt ggcttcatcc
      361 accacaactg cacacctgaa ttccaggcca atgaagttcg gaaagtgaag aaatatgaac
      421 agggattcat cactgaccct gtggtcctta gccccaagga tcgtgtgcgc gatgtttttg
      481 aggccaaagc caggcatggc ttctgtggta tccccatcac agataccggc cggatgggga
      541 gtcgattggt gggcatcatc tcctcgaggg acattgactt cctcaaggag gaagagcatg
      601 atcgcttctt ggaagagatc atgactaaga gagaagattt agtggtagcc cctgccggcg
      661 tcactctaaa agaagcaaat gaaattctgc agcgcagtaa aaagggaaag ttgcccattg
      721 tgaatgagag tgatgagctg gtagccatca tcgcccggac agacctcaag aagaatcgtg
      781 actacccact ggcttccaaa gataccaaaa agcaactact gtgtggggca gccattggca
      841 cccatgagga tgacaagtat cggctggact tactggccct tgctggtgtg gatgtggtag
      901 ttttggactc ttcccaggga aactccattt tccaaatcaa tatgatcaag tacatcaagg
      961 aaaaataccc caatctccag gtcatcggag gcaatgtagt cactgctgct caagccaaga
     1021 acctcatcga cgcaggtgtg gacgctctgc gagtcggcat gggaagtggt tccatctgca
     1081 tcacccagga agtgttggcc tgtgggcgac cccaagcaac agcagtatac aaggtctctg
     1141 agtatgcccg tcgcttcggt gtccctgtta ttgctgatgg aggaatccag aatgtgggtc
     1201 atattgccaa agctttggct cttggggcct ctacagtcat gatgggctcc ctcttggctg
     1261 ccaccactga ggcccctggt gagtacttct tctccgatgg gatccggctg aagaagtatc
     1321 gtggtatggg ctctcttgat gccatggaca aacacctcag cagccagaac cgatatttca
     1381 gtgaagctga caagatcaaa gtggcccaag gagtttcagg ggcagtgcag gacaaagggt
     1441 ctatccacaa gtttgtccct tatttgattg ctggcatcca gcattcctgt caggacattg
     1501 gtgccaagag cttaacccaa gtcagagcca tgatgtactc gggggaactt aaatttgaga
     1561 agagaacgtc ctcagctcag gtggaaggtg gcgttcacgg cctccattcg tatgagaaac
     1621 ggctcttctg aaaacagatc cagtatatgc cttgaatttt tcaataaaag tttgaaaaaa
     1681 caagtggcaa ctg
//
