LOCUS       NM_001108619            2438 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Rattus norvegicus inosine monophosphate dehydrogenase 1 (Impdh1),
            transcript variant 1, mRNA.
ACCESSION   NM_001108619 XM_001063757 XM_342650
VERSION     NM_001108619.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2438)
  AUTHORS   Tam,L.C., Kiang,A.S., Kennan,A., Kenna,P.F., Chadderton,N.,
            Ader,M., Palfi,A., Aherne,A., Ayuso,C., Campbell,M., Reynolds,A.,
            McKee,A., Humphries,M.M., Farrar,G.J. and Humphries,P.
  TITLE     Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1
            transcripts in a murine model of autosomal dominant retinitis
            pigmentosa (RP10)
  JOURNAL   Hum Mol Genet 17 (14), 2084-2100 (2008)
   PUBMED   18385099
REFERENCE   2  (bases 1 to 2438)
  AUTHORS   Watanabe,M., Yamamoto,T., Kakuhata,R., Okada,N., Kajimoto,K.,
            Yamazaki,N., Kataoka,M., Baba,Y., Tamaki,T. and Shinohara,Y.
  TITLE     Synchronized changes in transcript levels of genes activating cold
            exposure-induced thermogenesis in brown adipose tissue of
            experimental animals
  JOURNAL   Biochim Biophys Acta 1777 (1), 104-112 (2008)
   PUBMED   18036333
REFERENCE   3  (bases 1 to 2438)
  AUTHORS   Gunter,J.H., Thomas,E.C., Lengefeld,N., Kruger,S.J., Worton,L.,
            Gardiner,E.M., Jones,A., Barnett,N.L. and Whitehead,J.P.
  TITLE     Characterisation of inosine monophosphate dehydrogenase expression
            during retinal development: differences between variants and
            isoforms
  JOURNAL   Int J Biochem Cell Biol 40 (9), 1716-1728 (2008)
   PUBMED   18295529
REFERENCE   4  (bases 1 to 2438)
  AUTHORS   McLean,J.E., Hamaguchi,N., Belenky,P., Mortimer,S.E., Stanton,M.
            and Hedstrom,L.
  TITLE     Inosine 5'-monophosphate dehydrogenase binds nucleic acids in vitro
            and in vivo
  JOURNAL   Biochem J 379 (Pt 2), 243-251 (2004)
   PUBMED   14766016
REFERENCE   5  (bases 1 to 2438)
  AUTHORS   Aherne,A., Kennan,A., Kenna,P.F., McNally,N., Lloyd,D.G.,
            Alberts,I.L., Kiang,A.S., Humphries,M.M., Ayuso,C., Engel,P.C.,
            Gu,J.J., Mitchell,B.S., Farrar,G.J. and Humphries,P.
  TITLE     On the molecular pathology of neurodegeneration in IMPDH1-based
            retinitis pigmentosa
  JOURNAL   Hum Mol Genet 13 (6), 641-650 (2004)
   PUBMED   14981049
REFERENCE   6  (bases 1 to 2438)
  AUTHORS   Gu,J.J., Tolin,A.K., Jain,J., Huang,H., Santiago,L. and
            Mitchell,B.S.
  TITLE     Targeted disruption of the inosine 5'-monophosphate dehydrogenase
            type I gene in mice
  JOURNAL   Mol Cell Biol 23 (18), 6702-6712 (2003)
   PUBMED   12944494
REFERENCE   7  (bases 1 to 2438)
  AUTHORS   Bowne,S.J., Sullivan,L.S., Blanton,S.H., Cepko,C.L., Blackshaw,S.,
            Birch,D.G., Hughbanks-Wheaton,D., Heckenlively,J.R. and Daiger,S.P.
  TITLE     Mutations in the inosine monophosphate dehydrogenase 1 gene
            (IMPDH1) cause the RP10 form of autosomal dominant retinitis
            pigmentosa
  JOURNAL   Hum Mol Genet 11 (5), 559-568 (2002)
   PUBMED   11875050
REFERENCE   8  (bases 1 to 2438)
  AUTHORS   Kennan,A., Aherne,A., Palfi,A., Humphries,M., McKee,A., Stitt,A.,
            Simpson,D.A., Demtroder,K., Orntoft,T., Ayuso,C., Kenna,P.F.,
            Farrar,G.J. and Humphries,P.
  TITLE     Identification of an IMPDH1 mutation in autosomal dominant
            retinitis pigmentosa (RP10) revealed following comparative
            microarray analysis of transcripts derived from retinas of
            wild-type and Rho(-/-) mice
  JOURNAL   Hum Mol Genet 11 (5), 547-557 (2002)
   PUBMED   11875049
REFERENCE   9  (bases 1 to 2438)
  AUTHORS   Hager,P.W., Collart,F.R., Huberman,E. and Mitchell,B.S.
  TITLE     Recombinant human inosine monophosphate dehydrogenase type I and
            type II proteins. Purification and characterization of inhibitor
            binding
  JOURNAL   Biochem Pharmacol 49 (9), 1323-1329 (1995)
   PUBMED   7763314
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473959.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342650.3, XM_001063757.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2438
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..2438
                     /gene="Impdh1"
                     /gene_synonym="IMPD 1; IMPDH 1"
                     /note="inosine monophosphate dehydrogenase 1"
                     /db_xref="GeneID:362329"
                     /db_xref="RGD:1311108"
     exon            1..206
                     /gene="Impdh1"
                     /gene_synonym="IMPD 1; IMPDH 1"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1683
                     /gene="Impdh1"
                     /gene_synonym="IMPD 1; IMPDH 1"
                     /EC_number="1.1.1.205"
                     /note="isoform 1 is encoded by transcript variant 1;
                     inosine 5'-phosphate dehydrogenase 1; IMP (inosine
                     monophosphate) dehydrogenase 1; IMP dehydrogenase 1; IMP
                     (inosine 5'-monophosphate) dehydrogenase 1;
                     inosine-5'-monophosphate dehydrogenase 1"
                     /codon_start=1
                     /product="inosine-5'-monophosphate dehydrogenase 1 isoform
                     1"
                     /protein_id="NP_001102089.1"
                     /db_xref="GeneID:362329"
                     /db_xref="RGD:1311108"
                     /translation="MEEPLSPPPESGLLSPLLQGGGAAAAPEPGARQHPGHETAAQRY
                     SARLLQAGYEPESMADYLISGGTGYVPEDGLTAQQLFANADGLTYNDFLILPGFIDFI
                     ADEVDLTSALTRKITLKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANE
                     VRKVKKFEQGFITDPVVLSPSHTVGDVLEAKIQHGFSGIPITATGTMGSKLVMTPRIE
                     LVVAPAGVTLKEANEILQRSKKGKLPIVNDQDELVAIIARTDLKKNRDYPLASKDSHK
                     QLLCGAAVGTREDDKYRLDLLTQAGADVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVI
                     GGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFG
                     VPVIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGS
                     LDAMEKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGAQ
                     SLSVLRSMMYSGELKFEKRTMSAQIEGGVHGLHSYEKRLY"
     exon            207..305
                     /gene="Impdh1"
                     /gene_synonym="IMPD 1; IMPDH 1"
                     /inference="alignment:Splign:2.1.0"
     exon            306..354
                     /gene="Impdh1"
                     /gene_synonym="IMPD 1; IMPDH 1"
                     /inference="alignment:Splign:2.1.0"
     exon            355..456
                     /gene="Impdh1"
                     /gene_synonym="IMPD 1; IMPDH 1"
                     /inference="alignment:Splign:2.1.0"
     exon            457..531
                     /gene="Impdh1"
                     /gene_synonym="IMPD 1; IMPDH 1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..669
                     /gene="Impdh1"
                     /gene_synonym="IMPD 1; IMPDH 1"
                     /inference="alignment:Splign:2.1.0"
     exon            670..757
                     /gene="Impdh1"
                     /gene_synonym="IMPD 1; IMPDH 1"
                     /inference="alignment:Splign:2.1.0"
     exon            758..957
                     /gene="Impdh1"
                     /gene_synonym="IMPD 1; IMPDH 1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1048
                     /gene="Impdh1"
                     /gene_synonym="IMPD 1; IMPDH 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1144
                     /gene="Impdh1"
                     /gene_synonym="IMPD 1; IMPDH 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1288
                     /gene="Impdh1"
                     /gene_synonym="IMPD 1; IMPDH 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1433
                     /gene="Impdh1"
                     /gene_synonym="IMPD 1; IMPDH 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1577
                     /gene="Impdh1"
                     /gene_synonym="IMPD 1; IMPDH 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1661
                     /gene="Impdh1"
                     /gene_synonym="IMPD 1; IMPDH 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..2438
                     /gene="Impdh1"
                     /gene_synonym="IMPD 1; IMPDH 1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctcccgcc gcccagagct gcggcctccg catggcatgg aggaaccgct ctcaccccca
       61 ccggagtccg ggctactctc gccgctgctg cagggaggcg gagccgctgc tgctccagag
      121 cccggagccc ggcaacaccc gggacatgag accgcggcgc agcggtacag cgcccgcctg
      181 ctgcaggccg gctacgagcc ggagagcatg gcggactacc tgatcagcgg cggcaccggc
      241 tacgttcccg aggatgggct caccgcgcag cagctcttcg ccaacgcgga tggcctcacc
      301 tacaacgatt tcctgatcct cccaggattc atagacttca tagctgatga agtggacctg
      361 acatcagccc tgacccggaa gatcacactg aagacaccac tgatctcgtc tcccatggat
      421 accgtgacag aggctgacat ggccattgca atggctctca tgggaggaat tggtttcatt
      481 caccacaact gtaccccaga gttccaggcc aatgaggtgc ggaaggtcaa gaagtttgag
      541 caaggcttca tcacagaccc tgtggtcctg agcccttcac ataccgtggg tgatgttctg
      601 gaggccaaga tacagcatgg cttctctggt atccctatca ccgcaacggg caccatgggg
      661 agcaagctgg tgatgacgcc gaggatcgag ctggtggtgg ctccagcagg tgtgacattg
      721 aaagaggcaa atgagatttt gcagcgcagc aagaaaggga agctgcccat agtcaacgat
      781 caagacgagc tggtagccat tattgcacgc acagacctga agaagaacag agactaccct
      841 ctggcctcca aagactccca caaacagctg ttgtgtgggg cagctgtggg cacccgtgag
      901 gatgacaaat accgtctgga tttgctcact caggccggtg ctgacgtcat agtactagat
      961 tcatcccagg ggaactcagt atatcagatc gccatggtgc actatatcaa gcagaagtac
     1021 ccccacctcc aggtgattgg gggaaacgtg gtgacagcgg cccaggccaa gaacttgatc
     1081 gatgccggtg tggatgggct tcgtgtgggc atgggctgtg gctccatctg catcactcag
     1141 gaagtgatgg cctgtggccg accccagggc actgctgtct acaaggtggc tgagtatgcc
     1201 cggcgctttg gggtgccggt aatagctgat ggtggtatcc agactgtggg ccatgtggtc
     1261 aaagccctgg cgctcggagc ctctacagtg atgatgggct ccttgctggc tgctaccacg
     1321 gaggcccctg gtgaatactt cttctcagac ggggtgaggc ttaagaagta ccgaggcatg
     1381 ggttccctgg acgccatgga gaagagcagc agcagccaga agcgatactt cagtgagggg
     1441 gacaaagtga agatcgcaca gggtgtctcg ggctccatcc aggataaagg ctccattcag
     1501 aagtttgtgc cctacctcat agcagggatc cagcatggct gtcaggatat tggggcccaa
     1561 agcctgtctg tcctgcgatc catgatgtac tcaggagagc tcaagtttga gaagcggacc
     1621 atgtcagccc agatagaggg cggtgtgcac ggcctacact cttacgagaa gcggctgtac
     1681 tgaggacagc ggcggcggcg gccaaggcag tggaggggga gaaccccggg gttccactcc
     1741 gggaacagct cccctccata actgagtggt ccatagattt gcactacggg ttccccagct
     1801 cctttccagg gagaggagtg gagtccctga ggggactgtg gcccctctct gggcaactcc
     1861 acagagtcag gtagccccct gtgccaggct gccccgtgag atcttctggg ttcccccttc
     1921 ctcagccccc tgagcccagt cagccttggt tctcaggccc tgtgcctgcc tcaggtcttt
     1981 cttgctgcag cctgctctgg cccagtatcc aactctgacc cctggggaag gtagcccctc
     2041 ctggcttctc ctatagggca cctctctctc gctgccccct tcctcccagg aaatggtgct
     2101 ctcctgaccc tgcctctgac ccatccttgg agtgctgtcc tctcagccat gtggcactgt
     2161 gggttctgac cctaggccag ggggaggtct ctgccccctt cctctggctt gaggctccca
     2221 tggggcctgc tcctcagcct agttccccgt ctctgagccc agggagggcc tgatgatgac
     2281 cgcctgccct tcattcctga ctcaccattg tccccaggtg taccgtccct gccctctctt
     2341 ctcagctgca gctgaaggct ttaactttgc acactttggg gtcacaatcg tgtcattata
     2401 tattaaataa tctgaataaa tcaagcagtt atcaatgc
//
