LOCUS       NM_032057               2043 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus inositol monophosphatase 1 (Impa1), mRNA.
ACCESSION   NM_032057 XM_001055877
VERSION     NM_032057.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2043)
  AUTHORS   Andreassi,C., Luisier,R., Crerar,H., Darsinou,M.,
            Blokzijl-Franke,S., Lenn,T., Luscombe,N.M., Cuda,G., Gaspari,M.,
            Saiardi,A. and Riccio,A.
  TITLE     Cytoplasmic cleavage of IMPA1 3' UTR is necessary for maintaining
            axon integrity
  JOURNAL   Cell Rep 34 (8), 108778 (2021)
   PUBMED   33626357
  REMARK    GeneRIF: Cytoplasmic cleavage of IMPA1 3' UTR is necessary for
            maintaining axon integrity.
REFERENCE   2  (bases 1 to 2043)
  AUTHORS   Jupp,B., Sawiak,S.J., van der Veen,B., Lemstra,S., Toschi,C.,
            Barlow,R.L., Pekcec,A., Bretschneider,T., Nicholson,J.R.,
            Robbins,T.W. and Dalley,J.W.
  TITLE     Diminished Myoinositol in Ventromedial Prefrontal Cortex Modulates
            the Endophenotype of Impulsivity
  JOURNAL   Cereb Cortex 30 (5), 3392-3402 (2020)
   PUBMED   31897490
  REMARK    GeneRIF: Diminished Myoinositol in Ventromedial Prefrontal Cortex
            Modulates the Endophenotype of Impulsivity.
REFERENCE   3  (bases 1 to 2043)
  AUTHORS   Rafikov,R., McBride,M.L., Zemskova,M., Kurdyukov,S., McClain,N.,
            Niihori,M., Langlais,P.R. and Rafikova,O.
  TITLE     Inositol monophosphatase 1 as a novel interacting partner of RAGE
            in pulmonary hypertension
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 316 (3), L428-L444 (2019)
   PUBMED   30604625
  REMARK    GeneRIF: conclude that the formation of the newly discovered
            RAGE-IMPA1 complex could be responsible for the stimulation of
            inositol pathways and activation of Akt signaling in pulmonary
            arterial hypertension
REFERENCE   4  (bases 1 to 2043)
  AUTHORS   Figueiredo,T., Melo,U.S., Pessoa,A.L., Nobrega,P.R., Kitajima,J.P.,
            Rusch,H., Vaz,F., Lucato,L.T., Zatz,M., Kok,F. and Santos,S.
  TITLE     A homozygous loss-of-function mutation in inositol monophosphatase
            1 (IMPA1) causes severe intellectual disability
  JOURNAL   Mol Psychiatry 21 (8), 1125-1129 (2016)
   PUBMED   26416544
REFERENCE   5  (bases 1 to 2043)
  AUTHORS   Singh,N., Halliday,A.C., Knight,M., Lack,N.A., Lowe,E. and
            Churchill,G.C.
  TITLE     Cloning, expression, purification, crystallization and X-ray
            analysis of inositol monophosphatase from Mus musculus and Homo
            sapiens
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 68 (Pt 10),
            1149-1152 (2012)
   PUBMED   23027737
REFERENCE   6  (bases 1 to 2043)
  AUTHORS   Shamir,A., Shaltiel,G. and Agam,G.
  TITLE     Intracerebroventricular antisense to inositol monophosphatase-1
            reduces enzyme activity but does not affect Li-sensitive behavior
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 26 (1), 103-106 (2002)
   PUBMED   11853098
REFERENCE   7  (bases 1 to 2043)
  AUTHORS   Adams,L.D., Lemire,J.M. and Schwartz,S.M.
  TITLE     A systematic analysis of 40 random genes in cultured vascular
            smooth muscle subtypes reveals a heterogeneity of gene expression
            and identifies the tight junction gene zonula occludens 2 as a
            marker of epithelioid 'pup' smooth muscle cells and a participant
            in carotid neointimal formation
  JOURNAL   Arterioscler Thromb Vasc Biol 19 (11), 2600-2608 (1999)
   PUBMED   10559001
REFERENCE   8  (bases 1 to 2043)
  AUTHORS   Parthasarathy,R., Parthasarathy,L. and Vadnal,R.
  TITLE     Brain inositol monophosphatase identified as a galactose
            1-phosphatase
  JOURNAL   Brain Res 778 (1), 99-106 (1997)
   PUBMED   9462881
REFERENCE   9  (bases 1 to 2043)
  AUTHORS   Parthasarathy,L., Parthasarathy,R. and Vadnal,R.
  TITLE     Molecular characterization of coding and untranslated regions of
            rat cortex lithium-sensitive myo-inositol monophosphatase cDNA
  JOURNAL   Gene 191 (1), 81-87 (1997)
   PUBMED   9210592
REFERENCE   10 (bases 1 to 2043)
  AUTHORS   McAllister,G., Whiting,P., Hammond,E.A., Knowles,M.R., Atack,J.R.,
            Bailey,F.J., Maigetter,R. and Ragan,C.I.
  TITLE     cDNA cloning of human and rat brain myo-inositol monophosphatase.
            Expression and characterization of the human recombinant enzyme
  JOURNAL   Biochem J 284 (Pt 3) (Pt 3), 749-754 (1992)
   PUBMED   1377913
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_032057.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U84038.2, SRR26643287.5177.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                JAXUCZ010000002.1  93370200-93370277
            79-144              JAXUCZ010000002.1  93372535-93372600
            145-278             JAXUCZ010000002.1  93373380-93373513
            279-383             JAXUCZ010000002.1  93375554-93375658
            384-429             JAXUCZ010000002.1  93377641-93377686
            430-538             JAXUCZ010000002.1  93378734-93378842
            539-647             JAXUCZ010000002.1  93380358-93380466
            648-799             JAXUCZ010000002.1  93388592-93388743
            800-2043            JAXUCZ010000002.1  93390106-93391349
FEATURES             Location/Qualifiers
     source          1..2043
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q23"
     gene            1..2043
                     /gene="Impa1"
                     /gene_synonym="Impa1-L"
                     /note="inositol monophosphatase 1"
                     /db_xref="GeneID:83523"
                     /db_xref="RGD:69254"
     exon            1..78
                     /gene="Impa1"
                     /gene_synonym="Impa1-L"
                     /inference="alignment:Splign:2.1.0"
     exon            79..144
                     /gene="Impa1"
                     /gene_synonym="Impa1-L"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..915
                     /gene="Impa1"
                     /gene_synonym="Impa1-L"
                     /EC_number="3.1.3.25"
                     /EC_number="3.1.3.94"
                     /note="lithium-sensitive myo-inositol monophosphatase A1;
                     IMP 1; IMPase 1; inositol-1(or 4)-monophosphatase 1;
                     D-galactose 1-phosphate phosphatase; Inositol (myo)-1(or
                     4)-monophosphatase 1"
                     /codon_start=1
                     /product="inositol monophosphatase 1"
                     /protein_id="NP_114446.2"
                     /db_xref="GeneID:83523"
                     /db_xref="RGD:69254"
                     /translation="MADPWQECMDYAVILARQAGEMIREALKNKMDVMIKSSPADLVT
                     VTDQKVEKMLMSSIKEKYPYHSFIGEESVAAGEKTVFTEQPTWIIDPIDGTTNFVHRF
                     PFVAVSIGFVVNKEMEFGVVYSCVEDKMYTGRKGKGAFCNGQKLRVSQQEDITKSLLV
                     TELGSSRKPETLRIVLSNMERLCSIPIHGIRSVGTAAVNMCLVATGGADAYYEMGIHC
                     WDMAGAGIIVIEAGGVLLDVTGGPFDLMSRRIIAASNIALAERIAKELEIIPLQRDDE
                     S"
     exon            145..278
                     /gene="Impa1"
                     /gene_synonym="Impa1-L"
                     /inference="alignment:Splign:2.1.0"
     exon            279..383
                     /gene="Impa1"
                     /gene_synonym="Impa1-L"
                     /inference="alignment:Splign:2.1.0"
     exon            384..429
                     /gene="Impa1"
                     /gene_synonym="Impa1-L"
                     /inference="alignment:Splign:2.1.0"
     exon            430..538
                     /gene="Impa1"
                     /gene_synonym="Impa1-L"
                     /inference="alignment:Splign:2.1.0"
     exon            539..647
                     /gene="Impa1"
                     /gene_synonym="Impa1-L"
                     /inference="alignment:Splign:2.1.0"
     exon            648..799
                     /gene="Impa1"
                     /gene_synonym="Impa1-L"
                     /inference="alignment:Splign:2.1.0"
     exon            800..2043
                     /gene="Impa1"
                     /gene_synonym="Impa1-L"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgttacctcc ggaagagccg aagaaccgag ccctcggacg ccagcggttg agcatcgatt
       61 gcggtgcgct cgcgcgagat aatggcagac ccttggcagg agtgcatgga ttatgcagtg
      121 atcctcgcaa gacaagctgg agagatgatt cgtgaagctc taaaaaataa gatggatgtc
      181 atgattaaaa gttctccagc cgacttggta acagttactg accaaaaagt tgaaaaaatg
      241 cttatgtctt ctataaagga aaaataccca tatcacagtt tcattggtga agaatctgtg
      301 gcagccgggg aaaagacagt cttcacagag cagcccacgt ggatcattga tcccattgac
      361 gggacgacca actttgtgca ccggtttccc tttgtagctg tttcgattgg cttcgttgta
      421 aataaagaga tggagtttgg agttgtatac agctgtgtgg aagataagat gtatacgggc
      481 aggaaaggaa aaggcgcctt ttgtaacggt cagaagcttc gggtctcgca gcaggaagac
      541 attaccaaat cactcttggt gaccgagctg ggctcgtcca gaaagccgga gactttgcgg
      601 attgttctct ccaacatgga aaggctttgc tccattccta tccatggaat ccggagtgtt
      661 gggacagcgg ctgttaatat gtgccttgtg gcaacgggag gagcggatgc ctattacgag
      721 atggggatcc actgctggga catggctgga gctggcatca tcgtcataga ggctggcgga
      781 gtgctgctgg atgtgacagg tggaccattc gatttgatgt ctcggagaat aattgctgca
      841 agtaatatag cattagcaga aagaatagcc aaagaacttg agataatacc tttacaacga
      901 gacgacgaaa gttaggcacg tagaaccgca tccagctccg tcacacctgc tctccctggg
      961 atgtttaaag atgtatgatg tcactgattt aaatttaact ttgcagtcct gatttttaag
     1021 cgggaacttt tttttacaga tgacatgttc aaaagtagat ggaatatttg attattgaaa
     1081 gaaaatttgc atgtaataat atccttgggg aaaatataca ggaagtataa ttaatgaact
     1141 agccattgaa atagtcccca gcccatatga tccctttcaa cttaatttac tatttatatg
     1201 cacagttctt aactagaaag ttttcttttt tgtaagcggt tttctctttg ttccaaaagc
     1261 catatttgat taagtctgta aggctgtaac cagcaggctc tccctgtgca gagggccttc
     1321 gtgttttatt aatcactgta atacagcacc tagtgcagag ccagtcagac agtaggcgat
     1381 ctccaatcga cacctcacac tgagtgcttg aagctgcaat tcctgcttct aatgtgtcag
     1441 aataagataa ccattctact gtggcttcct gttttgaagt aaaagtttcc tcactgtcct
     1501 tttacatttc atattgttgt gccatttcat agggccaccc tgccagaggc cattgcttct
     1561 agttggcatt tctgcagtta gtatactgct gtgtgttgta ggttctgttt ggagccccca
     1621 cgctagagag aaatttccac agacgtcttc catgtacctg gtgcagttag tggcagtgtg
     1681 acgttttagg aaatgcagta ttcacattca gatccatacc gtggtgttgg ctggtgtgac
     1741 ctgtgtattg tggcgttcat ggtgaacttt ttgatttctt tcaaaacttg ctgaatttca
     1801 ccactgctct ctttggctat tctataaggt cttgggcctc tcaaacacaa gaaaatgcaa
     1861 tgactcctat tccttttcaa aggattaatt cattgtccag ccttggcgct tggcatagga
     1921 gcagactttg ttcttagtat gtttgaacct tgcgttggat aaaatgaggt gttcttgtaa
     1981 agttccaagg cagttattac cttgttgttg gacgatttga tatattaaat ctatatgata
     2041 ctc
//
