LOCUS       NM_001034928            2580 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus inner membrane mitochondrial protein (Immt),
            mRNA.
ACCESSION   NM_001034928 XM_008762987 XM_232055
VERSION     NM_001034928.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2580)
  AUTHORS   Deng,R., Wang,W., Xu,X., Ding,J., Wang,J., Yang,S., Li,H., Shen,H.,
            Li,X. and Chen,G.
  TITLE     Loss of MIC60 Aggravates Neuronal Death by Inducing Mitochondrial
            Dysfunction in a Rat Model of Intracerebral Hemorrhage
  JOURNAL   Mol Neurobiol 58 (10), 4999-5013 (2021)
   PUBMED   34232477
  REMARK    GeneRIF: Loss of MIC60 Aggravates Neuronal Death by Inducing
            Mitochondrial Dysfunction in a Rat Model of Intracerebral
            Hemorrhage.
REFERENCE   2  (bases 1 to 2580)
  AUTHORS   Terzenidou,M.E., Segklia,A., Kano,T., Papastefanaki,F.,
            Karakostas,A., Charalambous,M., Ioakeimidis,F., Papadaki,M.,
            Kloukina,I., Chrysanthou-Piterou,M., Samiotaki,M., Panayotou,G.,
            Matsas,R. and Douni,E.
  TITLE     Novel insights into SLC25A46-related pathologies in a genetic mouse
            model
  JOURNAL   PLoS Genet 13 (4), e1006656 (2017)
   PUBMED   28376086
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2580)
  AUTHORS   Van Laar,V.S., Berman,S.B. and Hastings,T.G.
  TITLE     Mic60/mitofilin overexpression alters mitochondrial dynamics and
            attenuates vulnerability of dopaminergic cells to dopamine and
            rotenone
  JOURNAL   Neurobiol Dis 91, 247-261 (2016)
   PUBMED   27001148
  REMARK    GeneRIF: that altering levels of Mic60 in dopaminergic neuronal
            cells significantly affects both mitochondrial homeostasis and
            cellular vulnerability to the PD-relevant stressors dopamine and
            rotenone
REFERENCE   4  (bases 1 to 2580)
  AUTHORS   Guarani,V., McNeill,E.M., Paulo,J.A., Huttlin,E.L., Frohlich,F.,
            Gygi,S.P., Van Vactor,D. and Harper,J.W.
  TITLE     QIL1 is a novel mitochondrial protein required for MICOS complex
            stability and cristae morphology
  JOURNAL   Elife 4, e06265 (2015)
   PUBMED   25997101
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2580)
  AUTHORS   Ott,C., Dorsch,E., Fraunholz,M., Straub,S. and Kozjak-Pavlovic,V.
  TITLE     Detailed analysis of the human mitochondrial contact site complex
            indicate a hierarchy of subunits
  JOURNAL   PLoS One 10 (3), e0120213 (2015)
   PUBMED   25781180
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2580)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 2580)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   8  (bases 1 to 2580)
  AUTHORS   Navet,R., Mathy,G., Douette,P., Dobson,R.L., Leprince,P., De
            Pauw,E., Sluse-Goffart,C. and Sluse,F.E.
  TITLE     Mitoproteome plasticity of rat brown adipocytes in response to cold
            acclimation
  JOURNAL   J Proteome Res 6 (1), 25-33 (2007)
   PUBMED   17203945
REFERENCE   9  (bases 1 to 2580)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 2580)
  AUTHORS   Gieffers,C., Korioth,F., Heimann,P., Ungermann,C. and Frey,J.
  TITLE     Mitofilin is a transmembrane protein of the inner mitochondrial
            membrane expressed as two isoforms
  JOURNAL   Exp Cell Res 232 (2), 395-399 (1997)
   PUBMED   9168817
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Mar 8, 2021 this sequence version replaced
            XM_008762987.3, NM_001034928.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105841.1, SRR22399489.2407828.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               JAXUCZ010000004.1  105438800-105438963
            165-238             JAXUCZ010000004.1  105447802-105447875
            239-428             JAXUCZ010000004.1  105450014-105450203
            429-537             JAXUCZ010000004.1  105453284-105453392
            538-630             JAXUCZ010000004.1  105454274-105454366
            631-767             JAXUCZ010000004.1  105458192-105458328
            768-871             JAXUCZ010000004.1  105461992-105462095
            872-1007            JAXUCZ010000004.1  105463072-105463207
            1008-1137           JAXUCZ010000004.1  105464155-105464284
            1138-1152           JAXUCZ010000004.1  105467339-105467353
            1153-1376           JAXUCZ010000004.1  105468748-105468971
            1377-1508           JAXUCZ010000004.1  105471150-105471281
            1509-1638           JAXUCZ010000004.1  105472588-105472717
            1639-2580           JAXUCZ010000004.1  105474025-105474966
FEATURES             Location/Qualifiers
     source          1..2580
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q32"
     gene            1..2580
                     /gene="Immt"
                     /note="inner membrane mitochondrial protein"
                     /db_xref="GeneID:312444"
                     /db_xref="RGD:1310684"
     exon            1..164
                     /gene="Immt"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..2252
                     /gene="Immt"
                     /note="mitofilin; mitochondrial inner membrane protein;
                     inner membrane protein, mitochondrial"
                     /codon_start=1
                     /product="MICOS complex subunit Mic60"
                     /protein_id="NP_001030100.2"
                     /db_xref="GeneID:312444"
                     /db_xref="RGD:1310684"
                     /translation="MLRACQLSGVTVAAQSCLCGKFVLRPLRPCRRYSTSSSSGVTAG
                     KIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPLPKK
                     PIQSGPLKISSVSEVMTDSELPMAQTQETNGDTPASAAGDPAPEVEHEDTINTECPNT
                     DEGTSTFVTAALAKSLEDALNQTATVTRQTITAQNAAVQAVKAHSSTLKTAMDNSEIA
                     GEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKREIAGATPYI
                     TAAEEKLHSMIVDLDSVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITP
                     GWKGMSISDLAGTLSTDDLNALIAHAHRRIDQLNRELAQQKATEKQHIELALERQKLE
                     EKRAFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVL
                     KVQEQELKFEFEQDLSEKLSEQELEFHRRSQEQMDNFTLDINTAYARLRGIEQAVQSH
                     AVAEEEARKAHQLWLSVEALKYSMKTSSAEMPTIPLGSAVEAIRVSCSDNEFTQALTA
                     AIPPESLTRGVYSEETLRARFYAVQKLAGRVAMIDETKNSLYQYFLSYLQSLLLFPPK
                     QLKPPAELYPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARM
                     TLETKQIVEILTTYASAVGIGTTQVQQE"
     exon            165..238
                     /gene="Immt"
                     /inference="alignment:Splign:2.1.0"
     exon            239..428
                     /gene="Immt"
                     /inference="alignment:Splign:2.1.0"
     exon            429..537
                     /gene="Immt"
                     /inference="alignment:Splign:2.1.0"
     exon            538..630
                     /gene="Immt"
                     /inference="alignment:Splign:2.1.0"
     exon            631..767
                     /gene="Immt"
                     /inference="alignment:Splign:2.1.0"
     exon            768..871
                     /gene="Immt"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1007
                     /gene="Immt"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1137
                     /gene="Immt"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1152
                     /gene="Immt"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1376
                     /gene="Immt"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1508
                     /gene="Immt"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1638
                     /gene="Immt"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..2580
                     /gene="Immt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggtgcgcc ggacgcagag gctgtacaga cgcgggcacg cacaggaaca cgcacgccct
       61 tctctcgtgc cgccgcggtc gttcccgcgt acaccagcag cgccgtcact tcggcagaga
      121 tgctgcgggc ctgtcagtta tccggcgtga ccgtcgcggc ccagagttgt ctgtgtggga
      181 agtttgtcct ccgcccacta cgaccatgcc gtagatactc cacttcaagc agttctgggg
      241 tgactgctgg taaaattgct ggagctggcc ttttgtttgt tggtggaggg attggtggca
      301 ctatcctgta tgccaaatgg gattcccatt tccgggaaag tgtagaaaaa actattcctt
      361 attcagacaa gctctttggg atggttcttg gctctgcacc ttatactgtt ccattgccaa
      421 agaaaccgat tcagtctggt ccactaaaaa tctccagcgt atcagaggtg atgacagact
      481 ctgaactgcc catggcacag acccaggaaa cgaacgggga tactccagct tcagcagcag
      541 gtgatccggc ccctgaggtt gagcatgagg acactataaa caccgaatgt cccaacactg
      601 atgaaggaac atctacattc gtaactgcag ctctagccaa gagtttagaa gatgctctga
      661 accagactgc aaccgtcact cggcagacta ttacagccca gaatgctgca gttcaggctg
      721 tcaaggcaca ctccagcaca ctgaaaacag ccatggacaa ttctgagatt gcaggtgaga
      781 agaagtcagc ccagtggcga acagtggagg gtgcgttgaa ggagcgaaga aaggcagttg
      841 acgaagctgc tgatgccctt ctcaaagcca aagaagagtt agagaagatg aaaactataa
      901 ttgaagatgc aaagaaaaga gagattgctg gggccacccc ttatataact gctgcagagg
      961 agaaactgca cagcatgata gtggatctgg atagcgtggt caaaaaggtc caggctgctc
     1021 agtcagaggc taaggtggtg tctcaatatc atgaacttgt ggtccaagca agggatgact
     1081 ttagaaaaga gctggacagc atcactccag acatcactcc tggatggaaa gggatgagta
     1141 tttctgacct agctggcaca ctctccactg acgacctgaa cgcgctcatt gctcatgccc
     1201 accgtcgcat tgatcagctc aacagagagc tagcgcaaca gaaagccaca gagaagcagc
     1261 acatcgagct agccctggaa aggcaaaagc tagaagaaaa gcgagccttt gactctgcgg
     1321 tggcaaaagc gttggagcac catagaagtg aaattcaggc tgagcaagac agaaaggtag
     1381 aggaagtcag agatgccatg gagaatgaaa tgcggaccca acttcgacga caggcagctg
     1441 cccacactga tcatttgcga gatgtcctca aggtgcaaga acaggaactg aagtttgaat
     1501 ttgaacagga cctgtctgag aaattgtctg agcaagaatt agagtttcat cgtcgcagtc
     1561 aagaacaaat ggacaacttt actctggaca taaatactgc ctatgcaagg ttgagaggaa
     1621 ttgagcaggc tgttcagagt catgcagttg ctgaagaaga agccagaaaa gcccaccagc
     1681 tctggctttc agtggaggca ttaaagtaca gcatgaagac ctcatctgca gaaatgccta
     1741 ccatcccact ggggagtgca gttgaggcca tcagagtcag ctgttctgat aatgaattta
     1801 cccaggcttt aactgcagcc attcctccag agtccctgac ccggggggta tacagtgaag
     1861 agaccctaag agcccgtttc tatgctgttc aaaaactagc tggaagggta gcgatgattg
     1921 atgaaaccaa aaatagcctg taccaatact tcctttccta cttacagtcc ctacttttgt
     1981 tcccgcctaa gcaactgaag cctccggcag agctctaccc tgaagatata aatacattta
     2041 aattgctctc atatgcctcc tattgtattg agcatggtga cctggagctg gccgcaaagt
     2101 ttgtcaatca gctaaaaggg gagtccagaa gagtggcaca ggactggctg aaggaggccc
     2161 gaatgacctt agaaactaag cagatagtgg agatcctgac tacatacgcc agcgccgtag
     2221 gaataggaac cactcaagtg cagcaagagt aaggcctagg aagagttgtg taatgtcata
     2281 tttcatatca aagaaaatca gcattggtat ctgcagggtt tgcaacaagg gtcccagaat
     2341 tgtccagaag tgagcaggtt ccaagtcctg tgtgagatgt taacacctgt tgcatttacc
     2401 gtccttacac tgctatcatg ccaatgaact ccaggagact ttatttgcaa cttgtgtaac
     2461 acttcctgtt ttttaggttt tactgatcag gcttgtgagc cactcaaaat aatgtttgtg
     2521 atccctacta ttgattctgc ccttggagca aactgaataa agctacacaa tgaaaactga
//
