LOCUS       NP_001030100             710 aa            linear   ROD 27-MAR-2024
DEFINITION  MICOS complex subunit Mic60 [Rattus norvegicus].
ACCESSION   NP_001030100 XP_008761209 XP_232055
VERSION     NP_001030100.2
DBSOURCE    REFSEQ: accession NM_001034928.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 710)
  AUTHORS   Deng,R., Wang,W., Xu,X., Ding,J., Wang,J., Yang,S., Li,H., Shen,H.,
            Li,X. and Chen,G.
  TITLE     Loss of MIC60 Aggravates Neuronal Death by Inducing Mitochondrial
            Dysfunction in a Rat Model of Intracerebral Hemorrhage
  JOURNAL   Mol Neurobiol 58 (10), 4999-5013 (2021)
   PUBMED   34232477
  REMARK    GeneRIF: Loss of MIC60 Aggravates Neuronal Death by Inducing
            Mitochondrial Dysfunction in a Rat Model of Intracerebral
            Hemorrhage.
REFERENCE   2  (residues 1 to 710)
  AUTHORS   Terzenidou,M.E., Segklia,A., Kano,T., Papastefanaki,F.,
            Karakostas,A., Charalambous,M., Ioakeimidis,F., Papadaki,M.,
            Kloukina,I., Chrysanthou-Piterou,M., Samiotaki,M., Panayotou,G.,
            Matsas,R. and Douni,E.
  TITLE     Novel insights into SLC25A46-related pathologies in a genetic mouse
            model
  JOURNAL   PLoS Genet 13 (4), e1006656 (2017)
   PUBMED   28376086
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 710)
  AUTHORS   Van Laar,V.S., Berman,S.B. and Hastings,T.G.
  TITLE     Mic60/mitofilin overexpression alters mitochondrial dynamics and
            attenuates vulnerability of dopaminergic cells to dopamine and
            rotenone
  JOURNAL   Neurobiol Dis 91, 247-261 (2016)
   PUBMED   27001148
  REMARK    GeneRIF: that altering levels of Mic60 in dopaminergic neuronal
            cells significantly affects both mitochondrial homeostasis and
            cellular vulnerability to the PD-relevant stressors dopamine and
            rotenone
REFERENCE   4  (residues 1 to 710)
  AUTHORS   Guarani,V., McNeill,E.M., Paulo,J.A., Huttlin,E.L., Frohlich,F.,
            Gygi,S.P., Van Vactor,D. and Harper,J.W.
  TITLE     QIL1 is a novel mitochondrial protein required for MICOS complex
            stability and cristae morphology
  JOURNAL   Elife 4, e06265 (2015)
   PUBMED   25997101
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 710)
  AUTHORS   Ott,C., Dorsch,E., Fraunholz,M., Straub,S. and Kozjak-Pavlovic,V.
  TITLE     Detailed analysis of the human mitochondrial contact site complex
            indicate a hierarchy of subunits
  JOURNAL   PLoS One 10 (3), e0120213 (2015)
   PUBMED   25781180
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 710)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (residues 1 to 710)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   8  (residues 1 to 710)
  AUTHORS   Navet,R., Mathy,G., Douette,P., Dobson,R.L., Leprince,P., De
            Pauw,E., Sluse-Goffart,C. and Sluse,F.E.
  TITLE     Mitoproteome plasticity of rat brown adipocytes in response to cold
            acclimation
  JOURNAL   J Proteome Res 6 (1), 25-33 (2007)
   PUBMED   17203945
REFERENCE   9  (residues 1 to 710)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (residues 1 to 710)
  AUTHORS   Gieffers,C., Korioth,F., Heimann,P., Ungermann,C. and Frey,J.
  TITLE     Mitofilin is a transmembrane protein of the inner mitochondrial
            membrane expressed as two isoforms
  JOURNAL   Exp Cell Res 232 (2), 395-399 (1997)
   PUBMED   9168817
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Mar 8, 2021 this sequence version replaced
            XP_008761209.1, NP_001030100.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105841.1, SRR22399489.2407828.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..710
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q32"
     Protein         1..710
                     /product="MICOS complex subunit Mic60"
                     /note="mitofilin; mitochondrial inner membrane protein;
                     inner membrane protein, mitochondrial"
                     /calculated_mol_wt=75021
     transit_peptide 1..33
                     /note="Mitochondrion. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (Q3KR86.1)"
                     /calculated_mol_wt=3698
     Region          43..698
                     /region_name="Mitofilin"
                     /note="Mitochondrial inner membrane protein; pfam09731"
                     /db_xref="CDD:430783"
     Site            46..65
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3KR86.1)"
     Site            112
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q16891; propagated from
                     UniProtKB/Swiss-Prot (Q3KR86.1)"
     Site            113
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q16891; propagated from
                     UniProtKB/Swiss-Prot (Q3KR86.1)"
     Region          127..162
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3KR86.1)"
     Site            174
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q16891; propagated from
                     UniProtKB/Swiss-Prot (Q3KR86.1)"
     Site            175
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q3KR86.1)"
     Site            340
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q16891; propagated from
                     UniProtKB/Swiss-Prot (Q3KR86.1)"
     Site            342
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q16891; propagated from
                     UniProtKB/Swiss-Prot (Q3KR86.1)"
     Site            403
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q16891; propagated from
                     UniProtKB/Swiss-Prot (Q3KR86.1)"
     CDS             1..710
                     /gene="Immt"
                     /coded_by="NM_001034928.2:120..2252"
                     /db_xref="GeneID:312444"
                     /db_xref="RGD:1310684"
ORIGIN      
        1 mlracqlsgv tvaaqsclcg kfvlrplrpc rrystssssg vtagkiagag llfvgggigg
       61 tilyakwdsh fresvektip ysdklfgmvl gsapytvplp kkpiqsgplk issvsevmtd
      121 selpmaqtqe tngdtpasaa gdpapevehe dtintecpnt degtstfvta alaksledal
      181 nqtatvtrqt itaqnaavqa vkahsstlkt amdnseiage kksaqwrtve galkerrkav
      241 deaadallka keelekmkti iedakkreia gatpyitaae eklhsmivdl dsvvkkvqaa
      301 qseakvvsqy helvvqardd frkeldsitp ditpgwkgms isdlagtlst ddlnaliaha
      361 hrridqlnre laqqkatekq hielalerqk leekrafdsa vakalehhrs eiqaeqdrkv
      421 eevrdamene mrtqlrrqaa ahtdhlrdvl kvqeqelkfe feqdlsekls eqelefhrrs
      481 qeqmdnftld intayarlrg ieqavqshav aeeearkahq lwlsvealky smktssaemp
      541 tiplgsavea irvscsdnef tqaltaaipp esltrgvyse etlrarfyav qklagrvami
      601 detknslyqy flsylqslll fppkqlkppa elypedintf kllsyasyci ehgdlelaak
      661 fvnqlkgesr rvaqdwlkea rmtletkqiv eilttyasav gigttqvqqe
//
