LOCUS       NM_022606               1319 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ILK associated serine/threonine phosphatase
            (Ilkap), mRNA.
ACCESSION   NM_022606
VERSION     NM_022606.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1319)
  AUTHORS   Legate,K.R., Montanez,E., Kudlacek,O. and Fassler,R.
  TITLE     ILK, PINCH and parvin: the tIPP of integrin signalling
  JOURNAL   Nat Rev Mol Cell Biol 7 (1), 20-31 (2006)
   PUBMED   16493410
  REMARK    Review article
REFERENCE   2  (bases 1 to 1319)
  AUTHORS   Flajolet,M., Rakhilin,S., Wang,H., Starkova,N., Nuangchamnong,N.,
            Nairn,A.C. and Greengard,P.
  TITLE     Protein phosphatase 2C binds selectively to and dephosphorylates
            metabotropic glutamate receptor 3
  JOURNAL   Proc Natl Acad Sci U S A 100 (26), 16006-16011 (2003)
   PUBMED   14663150
  REMARK    GeneRIF: distinct functions for mGluR2 and mGluR3 and dynamic
            regulation of mGluR3 by PP2C
REFERENCE   3  (bases 1 to 1319)
  AUTHORS   Tong,Y., Quirion,R. and Shen,S.H.
  TITLE     Cloning and characterization of a novel mammalian PP2C isozyme
  JOURNAL   J Biol Chem 273 (52), 35282-35290 (1998)
   PUBMED   9857069
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 26, 2020 this sequence version replaced NM_022606.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF095927.1, BC062010.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               JAXUCZ010000009.1  99436162-99436262   c
            102-167             JAXUCZ010000009.1  99428211-99428276   c
            168-224             JAXUCZ010000009.1  99427686-99427742   c
            225-344             JAXUCZ010000009.1  99425553-99425672   c
            345-471             JAXUCZ010000009.1  99424383-99424509   c
            472-578             JAXUCZ010000009.1  99421787-99421893   c
            579-672             JAXUCZ010000009.1  99421126-99421219   c
            673-760             JAXUCZ010000009.1  99419859-99419946   c
            761-882             JAXUCZ010000009.1  99418618-99418739   c
            883-1002            JAXUCZ010000009.1  99415801-99415920   c
            1003-1084           JAXUCZ010000009.1  99414467-99414548   c
            1085-1319           JAXUCZ010000009.1  99413998-99414232   c
FEATURES             Location/Qualifiers
     source          1..1319
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..1319
                     /gene="Ilkap"
                     /note="ILK associated serine/threonine phosphatase"
                     /db_xref="GeneID:64538"
                     /db_xref="RGD:620128"
     exon            1..101
                     /gene="Ilkap"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1225
                     /gene="Ilkap"
                     /EC_number="3.1.3.16"
                     /note="PP2Cdelta; protein phosphatase 2C"
                     /codon_start=1
                     /product="integrin-linked kinase-associated
                     serine/threonine phosphatase 2C"
                     /protein_id="NP_072128.2"
                     /db_xref="GeneID:64538"
                     /db_xref="RGD:620128"
                     /translation="MDLFGDLPEPERAPRPSAGKEAQEGPVLFEDLPPTSSTDSGSGG
                     PLLFDGLPPAGSGNSGSLATSGSQVVKNEGKGAKRKAPEEEKNGGEELVEKKVCKASS
                     VIFGLKGYVAERKGEREEMQDAHVILNDITQECNPPSSLITRVSYFAVFDGHGGIRAS
                     KFAAQNLHQNLIRKFPKGDVISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGST
                     ATCVLAVDNILYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGG
                     NVRDGRVLGVLEVSRSIGDGQYKRCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTP
                     EEAVNFILSCLEDEKIQTREGKPAVDARYEAACNRLANKAVQRGSADNVTVMVVRIGH
                     "
     exon            102..167
                     /gene="Ilkap"
                     /inference="alignment:Splign:2.1.0"
     exon            168..224
                     /gene="Ilkap"
                     /inference="alignment:Splign:2.1.0"
     exon            225..344
                     /gene="Ilkap"
                     /inference="alignment:Splign:2.1.0"
     exon            345..471
                     /gene="Ilkap"
                     /inference="alignment:Splign:2.1.0"
     exon            472..578
                     /gene="Ilkap"
                     /inference="alignment:Splign:2.1.0"
     exon            579..672
                     /gene="Ilkap"
                     /inference="alignment:Splign:2.1.0"
     exon            673..760
                     /gene="Ilkap"
                     /inference="alignment:Splign:2.1.0"
     exon            761..882
                     /gene="Ilkap"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1002
                     /gene="Ilkap"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1084
                     /gene="Ilkap"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1319
                     /gene="Ilkap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgcccag gctagcgcgg agcctccgct ccatcgcccc gccgccatgg acctattcgg
       61 ggacttgccg gagcccgagc gcgcgccgcg gccgtctgcc gggaaagaag cacaggaagg
      121 acccgtgctc ttcgaggacc tgcccccgac cagcagtact gactcaggat ctgggggacc
      181 tttactcttt gatggtcttc cacctgctgg cagcggcaat tcaggttctc ttgccacatc
      241 aggctcccag gtggtgaaga acgaaggaaa aggagcaaag aggaaagccc ctgaggaaga
      301 gaagaatggc ggtgaagagc ttgtggaaaa gaaagtttgt aaagcctctt cggtgatctt
      361 tggtttgaaa ggctacgtgg cagagcggaa gggtgagagg gaggagatgc aggacgccca
      421 tgtcatcctg aatgatatca ctcaggagtg taatcctcca tcatctctca ttactcgggt
      481 ttcatacttt gctgtttttg atggacatgg aggaattcga gcctcgaaat ttgctgcaca
      541 gaatttgcac cagaacttaa tcaggaaatt tcctaaagga gatgtaatca gtgtggagaa
      601 gactgtgaag aggtgcctgc tagatacttt taagcacacc gatgaagagt tcctgaaaca
      661 ggcttcaagc cagaagcctg cctggaaaga cgggtccact gccacgtgtg tcctggctgt
      721 ggacaacatc ctgtatatcg ccaaccttgg agatagtcgg gcaatcctgt gtcgatataa
      781 cgaggaaagt caaaagcatg cagccttaag cctcagcaaa gagcacaatc caactcagta
      841 tgaagagcgc atgaggatac agaaggctgg aggcaatgtc agagatggcc gtgtcttggg
      901 tgtgctggag gtatcccgct ccattggaga tgggcagtac aagcgttgcg gggtcacatc
      961 cgtgcctgat atcagacgct gccagttgac ccccaatgac aggttcattt tgctggcttg
     1021 tgatgggctc ttcaaggtct ttaccccaga agaagctgtg aacttcatct tgtcctgcct
     1081 tgaggatgag aagatccaga cccgagaagg gaagcctgct gttgatgccc gctatgaagc
     1141 tgcatgcaac aggctggcta acaaggcagt gcagcggggc tcggcagata acgtgacggt
     1201 gatggtggtg aggataggac actgaggccg cacactgcac gtgtgctctt gacttgcagg
     1261 ttcatcttgt ttgtgcacgc tgtgtgtact cctgtggggc ttctatggtt gtaaataaa
//
