LOCUS       NM_053412               3167 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus interleukin enhancer binding factor 3 (Ilf3),
            mRNA.
ACCESSION   NM_053412
VERSION     NM_053412.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3167)
  AUTHORS   Tan,X., Ye,P., Li,W.Y., Gao,Y., Leng,Y.Q., Duan,W., Wang,Y.K. and
            Wang,W.Z.
  TITLE     The interleukin-enhanced binding factor 3-mediated inhibition of
            nitric oxide production via phosphoinositide 3-kinase/protein
            kinase B pathway contributes to central cardiovascular regulation
            in the rostral ventrolateral medulla in hypertension
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 323 (6), R861-R874 (2022)
   PUBMED   36222883
  REMARK    GeneRIF: The interleukin-enhanced binding factor 3-mediated
            inhibition of nitric oxide production via phosphoinositide
            3-kinase/protein kinase B pathway contributes to central
            cardiovascular regulation in the rostral ventrolateral medulla in
            hypertension.
REFERENCE   2  (bases 1 to 3167)
  AUTHORS   Zhang,J.Y., Yang,Z., Fang,K., Shi,Z.L., Ren,D.H. and Sun,J.
  TITLE     Long noncoding RNA ILF3-AS1 regulates myocardial infarction via the
            miR-212-3p/SIRT1 axis and PI3K/Akt signaling pathway
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (5), 2647-2658 (2020)
   PUBMED   32196615
  REMARK    GeneRIF: Long noncoding RNA ILF3-AS1 regulates myocardial
            infarction via the miR-212-3p/SIRT1 axis and PI3K/Akt signaling
            pathway.
REFERENCE   3  (bases 1 to 3167)
  AUTHORS   Yang,R.H., Tan,X., Ge,L.J., Sun,J.C., Peng,X.D. and Wang,W.Z.
  TITLE     Interleukin enhancement binding factor 3 inhibits cardiac
            hypertrophy by targeting asymmetric dimethylarginine-nitric oxide
  JOURNAL   Nitric Oxide 93, 44-52 (2019)
   PUBMED   31536826
  REMARK    GeneRIF: ILF3 protein inhibits cardiac hypertrophy by targeting
            asymmetric dimethylarginine-nitric oxide.  Its expression is
            regulated by angiotensin II.
REFERENCE   4  (bases 1 to 3167)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 3167)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 3167)
  AUTHORS   Reichman,T.W., Muniz,L.C. and Mathews,M.B.
  TITLE     The RNA binding protein nuclear factor 90 functions as both a
            positive and negative regulator of gene expression in mammalian
            cells
  JOURNAL   Mol Cell Biol 22 (1), 343-356 (2002)
   PUBMED   11739746
REFERENCE   7  (bases 1 to 3167)
  AUTHORS   Tang,J., Kao,P.N. and Herschman,H.R.
  TITLE     Protein-arginine methyltransferase I, the predominant
            protein-arginine methyltransferase in cells, interacts with and is
            regulated by interleukin enhancer-binding factor 3
  JOURNAL   J Biol Chem 275 (26), 19866-19876 (2000)
   PUBMED   10749851
REFERENCE   8  (bases 1 to 3167)
  AUTHORS   Satoh,M., Shaheen,V.M., Kao,P.N., Okano,T., Shaw,M., Yoshida,H.,
            Richards,H.B. and Reeves,W.H.
  TITLE     Autoantibodies define a family of proteins with conserved
            double-stranded RNA-binding domains as well as DNA binding activity
  JOURNAL   J Biol Chem 274 (49), 34598-34604 (1999)
   PUBMED   10574923
REFERENCE   9  (bases 1 to 3167)
  AUTHORS   Matsumoto-Taniura,N., Pirollet,F., Monroe,R., Gerace,L. and
            Westendorf,J.M.
  TITLE     Identification of novel M phase phosphoproteins by expression
            cloning
  JOURNAL   Mol Biol Cell 7 (9), 1455-1469 (1996)
   PUBMED   8885239
REFERENCE   10 (bases 1 to 3167)
  AUTHORS   Kao,P.N., Chen,L., Brock,G., Ng,J., Kenny,J., Smith,A.J. and
            Corthesy,B.
  TITLE     Cloning and expression of cyclosporin A- and FK506-sensitive
            nuclear factor of activated T-cells: NF45 and NF90
  JOURNAL   J Biol Chem 269 (32), 20691-20699 (1994)
   PUBMED   7519613
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            [WARNING] On Mar 12, 2025 this sequence was replaced by
            NM_053412.3.
            
            On Nov 26, 2020 this sequence version replaced NM_053412.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF220102.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                JAXUCZ010000008.1  28209010-28209099
            91-188              JAXUCZ010000008.1  28219161-28219258
            189-227             JAXUCZ010000008.1  28219581-28219619
            228-457             JAXUCZ010000008.1  28220002-28220231
            458-635             JAXUCZ010000008.1  28220683-28220860
            636-783             JAXUCZ010000008.1  28223540-28223687
            784-875             JAXUCZ010000008.1  28224972-28225063
            876-971             JAXUCZ010000008.1  28225440-28225535
            972-1083            JAXUCZ010000008.1  28226074-28226185
            1084-1181           JAXUCZ010000008.1  28226611-28226708
            1182-1293           JAXUCZ010000008.1  28227262-28227373
            1294-1404           JAXUCZ010000008.1  28227460-28227570
            1405-1604           JAXUCZ010000008.1  28228703-28228902
            1605-1772           JAXUCZ010000008.1  28229217-28229384
            1773-1898           JAXUCZ010000008.1  28230380-28230505
            1899-2075           JAXUCZ010000008.1  28230664-28230840
            2076-2232           JAXUCZ010000008.1  28230937-28231093
            2233-2286           JAXUCZ010000008.1  28231210-28231263
            2287-2652           JAXUCZ010000008.1  28234392-28234757
            2653-2781           JAXUCZ010000008.1  28235346-28235474
            2782-3167           JAXUCZ010000008.1  28235924-28236309
FEATURES             Location/Qualifiers
     source          1..3167
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..3167
                     /gene="Ilf3"
                     /note="interleukin enhancer binding factor 3"
                     /db_xref="GeneID:84472"
                     /db_xref="RGD:619734"
     exon            1..90
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            91..188
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..2918
                     /gene="Ilf3"
                     /note="M phase phosphoprotein 4"
                     /codon_start=1
                     /product="interleukin enhancer-binding factor 3"
                     /protein_id="NP_445864.2"
                     /db_xref="GeneID:84472"
                     /db_xref="RGD:619734"
                     /translation="MALYHHHFITRRRRRPMRIFVNDDRHVMAKHSSVYPTQEELEAV
                     QNMVSHTERALKAVSDWIDEQEKGNSELSEAENMDTPPDDESKEGAGEQKAEHMTRTL
                     RGVMRVGLVAKGLLLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLTTVTEDKYEIL
                     QSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCLA
                     ALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTAN
                     RPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHA
                     LRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGE
                     EKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKLISQTGPVHAPIFTMSVE
                     VDGSTFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEESDGKPAVVAP
                     PPVVEAVSNPSSVFPSDATTEQGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDK
                     RFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDAPLALEANKKKRAPVPVRGG
                     PKFAAKPHNPGFGMGGPMHNEAPPPPNIRGRGRGGNIRGRGRGRGFGGTNHGGGYMNA
                     GAGYGSYGYSSNSATAGYSQFYSNGGHSGNAGGGGSGGGGGSSSYSSYYQGDSYNSPV
                     PPKHAGKKPLHGGQQKPSYSSGYQSHQGQQQPYNQSQYSSYGTPQGKQKGYGHGQGSY
                     SSYSNSYNSPGGGGGSDYSYDSKFNYSGSGGRSGGNSYGSSGSSYNTGSHGGYGAGSG
                     GSSSYQGKQGGYSSQSNYSSPGSSQSYSGPASSYQSSQGGYSRNTEHSMNYQYR"
     exon            189..227
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            228..457
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            458..635
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            636..783
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            784..875
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            876..971
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1083
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1181
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1293
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1404
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1604
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1772
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1898
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2075
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2232
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2286
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2652
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2781
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2782..3167
                     /gene="Ilf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagagggtg tcggccttct tgggacagat gattgtaagc tgcatgtggg tgccaggaac
       61 tgaaccctgg ttcctctgca agagcagtaa atagttgaag tattggtaac accaaggaac
      121 tgtcacaatt tgaaaagata agccaaggct gatttccaga cactacagga aaaaaggagg
      181 ggaaaatggc attgtatcat catcacttca tcacaagaag aagaaggcgt cccatgagaa
      241 tttttgtgaa tgatgatcgc catgtgatgg caaagcattc ttcagtatac ccaacacaag
      301 aggagctgga ggctgtacag aacatggtgt cccacactga gcgggccctc aaggctgtct
      361 ctgactggat tgatgagcag gagaaaggca acagcgagct ctctgaagca gaaaatatgg
      421 acacaccccc agatgatgag agcaaagaag gggctgggga acagaaggcg gaacacatga
      481 ctaggaccct gaggggcgtg atgcgggtcg gcctggtagc caagggtctt ctgctcaagg
      541 gggacttgga tctggagctg gttctgctct gtaaggagaa gcccacaact gcccttctgg
      601 acaaggtggc tgacaacctg gccatccagc ttactactgt aacagaagac aagtatgaaa
      661 tactccaatc tgtggatgat gctgcgattg tgataaaaaa cacaaaagag ccccccttgt
      721 ccttgaccat ccatctgacc tcccctgttg tcagagaaga aatggagaaa gtattagctg
      781 gagaaacgct atcagtcaac gaccccccgg acgttctgga caggcagaaa tgccttgctg
      841 ccttggcgtc cctccgacac gccaagtggt tccaggctag agccaatggg ctgaagtcat
      901 gtgtcattgt catccgtgtc ctaagggact tgtgtacccg agtgcccacc tggggtcctc
      961 tcagaggatg gcctctggag ctgctgtgtg agaagtccat cggcactgcc aataggccaa
     1021 tgggtgctgg tgaagccctg cggagagtac tggagtgcct ggcttccggc atcgtaatgc
     1081 cagatggttc tggcatttat gacccttgtg aaaaagaagc cactgatgct attgggcatc
     1141 tagacagaca gcaacgggaa gatatcacac agagtgcgca gcatgctctg cggcttgctg
     1201 cctttggcca gctccataaa gtactgggaa tggacccact gccttccaaa atgcccaaga
     1261 aaccaaagaa cgagaacccg gtggactata ctgttcaaat cccccccagc accacctacg
     1321 ccatcacacc catgaaacgc cctatggaag aagatgggga ggagaagtct cccagcaaaa
     1381 agaaaaagaa gatccagaag aaagaggaga aggctgagcc tccccaagct atgaatgccc
     1441 tgatgaggtt aaaccagctg aagccagggc tacagtacaa gctgatctcc cagacgggtc
     1501 ctgttcacgc tcccatcttc accatgtctg tggaggtaga cggcagtacc tttgaggcct
     1561 cagggccatc taaaaagacc gccaagctac atgtggctgt gaaggtgtta caggacatgg
     1621 gattgccaac aggcgctgaa ggcagagact ccagcaaggg ggaggactct gctgaggagt
     1681 cagatgggaa gccagcagta gtggccccac cccctgtggt ggaagcagtc tccaacccca
     1741 gttctgtctt cccttcagat gccactactg agcaggggcc gattttgact aagcacggca
     1801 agaatcctgt aatggagctt aatgagaaga gacgtggcct caaatatgag ctcatttctg
     1861 agacaggggg cagccacgac aaacggtttg ttatggaggt tgaggtggac ggacagaagt
     1921 ttcaaggtgc tggctcaaac aaaaaggtag caaaggctta tgctgcactt gccgcattag
     1981 agaagctttt ccctgacgcc cctcttgctc ttgaagccaa caagaagaaa agagcccctg
     2041 tgcctgtccg aggcggaccc aaatttgctg ccaagccaca taaccctggc tttggcatgg
     2101 gaggccccat gcataatgaa gcgcccccac ctcccaacat ccgaggtcgg ggccgaggag
     2161 gtaacatccg agggcgagga cgggggcgag gatttggtgg caccaaccac ggaggaggct
     2221 acatgaatgc tggcgctgga tatggaagct atgggtacag cagcaattcg gccacagcag
     2281 gctacagtca gttctacagc aatggagggc attctgggaa tgccggtggt ggaggcagcg
     2341 ggggaggtgg tggctcgtcc agctacagct cctactacca aggagacagc tacaactcac
     2401 cagtgccccc gaaacatgct gggaagaagc cgctgcatgg gggccagcag aaaccctcct
     2461 acagctcggg ctaccagtcc caccagggcc agcagcaacc ttacaaccag agccagtaca
     2521 gcagctacgg cacgccacag ggcaagcaga aaggctatgg ccatgggcag ggcagctact
     2581 cctcctactc caactcttac aactcccctg gtggtggtgg gggctctgac tacagctacg
     2641 acagcaaatt caactacagt ggtagtggag gccggagtgg agggaacagc tatggctcca
     2701 gcgggtcatc ctacaacaca ggctcacatg ggggttatgg cgcaggttct ggaggcagct
     2761 cttcatacca aggcaaacaa ggaggctact catcacagtc aaactacagc tcccctgggt
     2821 ccagccagag ctacagcggc cccgccagct cctaccagtc ctcacagggt ggctacagtc
     2881 ggaacacaga acacagcatg aactaccagt acagataaag gcccaggctg cccctctcaa
     2941 ccttctgcac ctctgcctcc aacttgtctc gggagattga gtctgcacat caccagttgc
     3001 catgtccact gggccagtgc ccacccgtcc acgttgctga cgttgccacg ctgtgaggcg
     3061 tggtggtccc tgggacccgt gctgtgaccc tatttagctg tgttttggac tcagtgtctt
     3121 cagtggtttg ttagttacca ttacaccttg tctgagtagt gttccga
//
