LOCUS       NM_001106418            3124 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus interleukin 7 receptor (Il7r), mRNA.
ACCESSION   NM_001106418 XM_001057658 XM_226824
VERSION     NM_001106418.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3124)
  AUTHORS   Yu X, Zeng K, Liu X, Peng Y, Li C, Fu K and Liang H.
  TITLE     Increased expression of thymic stromal lymphopoietin receptor in a
            rat model of middle cerebral artery occlusion
  JOURNAL   Neuroreport 30 (3), 182-187 (2019)
   PUBMED   30676545
REFERENCE   2  (bases 1 to 3124)
  AUTHORS   Oliveira DM, Santamaria G, Laudanna C, Migliozzi S, Zoppoli P,
            Quist M, Grasso C, Mignogna C, Elia L, Faniello MC, Marinaro C,
            Sacco R, Corcione F, Viglietto G, Malanga D and Rizzuto A.
  TITLE     Identification of copy number alterations in colon cancer from
            analysis of amplicon-based next generation sequencing data
  JOURNAL   Oncotarget 9 (29), 20409-20425 (2018)
   PUBMED   29755661
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3124)
  AUTHORS   Ujiie H, Kadota K, Nitadori JI, Aerts JG, Woo KM, Sima CS, Travis
            WD, Jones DR, Krug LM and Adusumilli PS.
  TITLE     The tumoral and stromal immune microenvironment in malignant
            pleural mesothelioma: A comprehensive analysis reveals prognostic
            immune markers
  JOURNAL   Oncoimmunology 4 (6), e1009285 (2015)
   PUBMED   26155428
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3124)
  AUTHORS   MING J, ZHANG Q, JIANG Y, QIU X and BAI X.
  TITLE     [The expressions of IL-7 and IL-7R and the relationship between
            them with lymph node metastasis and prognosis in non-small cell
            lung cancer]
  JOURNAL   Zhongguo Fei Ai Za Zhi 13 (12), 1101-1106 (2010)
   PUBMED   21159243
REFERENCE   5  (bases 1 to 3124)
  AUTHORS   Hosoya T, Kuroha T, Moriguchi T, Cummings D, Maillard I, Lim KC and
            Engel JD.
  TITLE     GATA-3 is required for early T lineage progenitor development
  JOURNAL   J Exp Med 206 (13), 2987-3000 (2009)
   PUBMED   19934022
REFERENCE   6  (bases 1 to 3124)
  AUTHORS   Nemeth MJ, Curtis DJ, Kirby MR, Garrett-Beal LJ, Seidel NE, Cline
            AP and Bodine DM.
  TITLE     Hmgb3: an HMG-box family member expressed in primitive
            hematopoietic cells that inhibits myeloid and B-cell
            differentiation
  JOURNAL   Blood 102 (4), 1298-1306 (2003)
   PUBMED   12714519
REFERENCE   7  (bases 1 to 3124)
  AUTHORS   Reche PA, Soumelis V, Gorman DM, Clifford T, Liu Mr, Travis M,
            Zurawski SM, Johnston J, Liu YJ, Spits H, de Waal Malefyt R,
            Kastelein RA and Bazan JF.
  TITLE     Human thymic stromal lymphopoietin preferentially stimulates
            myeloid cells
  JOURNAL   J Immunol 167 (1), 336-343 (2001)
   PUBMED   11418668
REFERENCE   8  (bases 1 to 3124)
  AUTHORS   Puel A, Ziegler SF, Buckley RH and Leonard WJ.
  TITLE     Defective IL7R expression in T(-)B(+)NK(+) severe combined
            immunodeficiency
  JOURNAL   Nat Genet 20 (4), 394-397 (1998)
   PUBMED   9843216
REFERENCE   9  (bases 1 to 3124)
  AUTHORS   Akashi K, Kondo M, von Freeden-Jeffry U, Murray R and Weissman IL.
  TITLE     Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient
            mice
  JOURNAL   Cell 89 (7), 1033-1041 (1997)
   PUBMED   9215626
REFERENCE   10 (bases 1 to 3124)
  AUTHORS   Maraskovsky E, O'Reilly LA, Teepe M, Corcoran LM, Peschon JJ and
            Strasser A.
  TITLE     Bcl-2 can rescue T lymphocyte development in interleukin-7
            receptor-deficient mice but not in mutant rag-1-/- mice
  JOURNAL   Cell 89 (7), 1011-1019 (1997)
   PUBMED   9215624
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474048.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_226824.4, XM_001057658.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5756307, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3124
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..3124
                     /gene="Il7r"
                     /note="interleukin 7 receptor"
                     /db_xref="GeneID:294797"
                     /db_xref="RGD:1309776"
     exon            1..158
                     /gene="Il7r"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1450
                     /gene="Il7r"
                     /note="interleukin-7 receptor subunit alpha"
                     /codon_start=1
                     /product="interleukin-7 receptor subunit alpha precursor"
                     /protein_id="NP_001099888.1"
                     /db_xref="GeneID:294797"
                     /db_xref="RGD:1309776"
                     /translation="MMALGRAFAIVFCLLQAASGESGNAQDGDLEDAEPDDHSFWCHS
                     QLEVDGNQHSLTCAFNDPDIKTTNLEFQICGALLGIDCLTLNKLREMYFIKTSKFLLI
                     GNSSVCVKLGKMDVICKILDISTIVKPEAPSNLKVVYRKEANDFLVTFNTSHSTKKYV
                     TALKHDVAYRPERGESNWTHVYLFHTRTTILQRKLQPKAVYEIKVRSIPNHEYFKGFW
                     SEWSPSSTFETPDSKYQGGWDPVLPSIILLSLFSMVLLVILAHVLWKKRIKPVVWPSL
                     PDHKKTLEQLCKKPKKNLNVSFNPESFLDCQIHEVNGIQARDEVESFLQNDLPPRPGE
                     LEKQGHRATVHGANWPSEISGSTPETFRRESPLRCLARNLSTCNTPAFLSSRSPDYRE
                     GDGNRSHVYQDLLPSSRNTNGTVPQPFPLQSGILIPVSQGQPISTSSVLNQEEAYVTM
                     SSFYQNK"
     exon            159..297
                     /gene="Il7r"
                     /inference="alignment:Splign:2.1.0"
     exon            298..455
                     /gene="Il7r"
                     /inference="alignment:Splign:2.1.0"
     exon            456..613
                     /gene="Il7r"
                     /inference="alignment:Splign:2.1.0"
     exon            614..782
                     /gene="Il7r"
                     /inference="alignment:Splign:2.1.0"
     exon            783..876
                     /gene="Il7r"
                     /inference="alignment:Splign:2.1.0"
     exon            877..952
                     /gene="Il7r"
                     /inference="alignment:Splign:2.1.0"
     exon            953..3124
                     /gene="Il7r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagctgggt ttggtctccc cctctctcat tcacttgcgc acacaagtgt gcttcttctc
       61 tcttctctct ctcagaatga tggctctggg tagagctttc gctatagttt tctgcttact
      121 tcaagctgct tctggagaaa gtggcaatgc ccaggatgga gatctagagg atgcggaacc
      181 agatgatcac tccttctggt gccacagcca gctggaagtg gatggaaatc agcactcact
      241 gacgtgtgct tttaatgacc cagacatcaa aaccactaat ctggaatttc aaatatgtgg
      301 ggctcttcta ggcatagatt gcctaactct taataagcta cgagagatgt attttataaa
      361 gacatcaaaa ttcttactga ttggtaacag cagtgtatgt gtgaagcttg gaaaaatgga
      421 tgtaatttgc aaaattttgg acataagcac aatagttaaa cctgaggcgc cttctaacct
      481 gaaagtagtt tatcgaaaag aagcaaatga ctttttggta acatttaata catctcactc
      541 aacaaagaaa tatgtaacag cattaaagca tgatgtggcc taccgcccag aaaggggtga
      601 aagtaactgg acgcatgtat atttattcca tacaagaaca acaatcctac agagaaaact
      661 acaaccaaaa gcagtgtatg aaatcaaagt ccgatccatt cccaatcatg aatacttcaa
      721 aggcttctgg agtgagtgga gtccaagttc tacctttgaa acaccagatt ccaagtatca
      781 agggggatgg gatccggttt tgccaagtat catccttctg agtttgttct ctatggtttt
      841 gttggtcatt ttagcccatg tgctatggaa aaaaaggatt aaacctgttg tatggcctag
      901 tcttcctgat cataagaaaa ctctggaaca actatgtaag aagccaaaaa agaatttgaa
      961 tgtgagtttc aatcctgaaa gtttcctgga ctgccagatt catgaggtga atggcattca
     1021 agccagggat gaagtggaaa gctttctgca aaatgatctt cctccacggc ctggggagct
     1081 ggagaagcag ggacatagag caactgtaca cggtgcaaac tggccatctg agatttcagg
     1141 cagcacacca gaaacgttcc gaagagaatc acccctaaga tgcctggcta gaaatctaag
     1201 cacatgcaat acccctgcat tcctttcctc taggtcccct gactacagag aaggtgacgg
     1261 aaataggtct catgtgtatc aagacttgct gccaagctcc agaaacacaa atggcactgt
     1321 ccctcaacca tttcctctcc agtcaggaat cctgatacca gtttctcaag gacagcccat
     1381 ctctacttct tcagtattga atcaagaaga agcatatgtc actatgtcta gcttttacca
     1441 aaacaaatga attataagaa acctgagacc ccttccacag aaaaccaaat gatcactgag
     1501 atggaaagtc tggaatgctt gtctccctca tagctcttag aagagaaagt caacatggac
     1561 ttgctacaca tcttcagcat tctaagaaat cattttgatc tcctagctca aaagcattta
     1621 ttcaaagcag gaagaatctg ctttcccctt gttggattag tcatatgagt acaaatgacc
     1681 caattaaaat tgtaaaactc aattaaatga agagtaaagg gaaagataga aggaggtgaa
     1741 tacaggaaga agagaaggat gtcagtggtg ggtctatcat taggacttac tatatatcca
     1801 gcagtacaca acggctctca tttcttcctc acaataatac tacaatgtgg gttcatccat
     1861 tagaattgtt attttctttg tcatagatgc tgaagttgaa agtggaaatt tttaagtaat
     1921 gtccaggttt ttcttccagc aacagatgaa gcatgcattc caacttcaac cctccttggc
     1981 catgaacctg tcctactact gagtatcaaa catcaccact aagtgggtgg ttacagtcag
     2041 aatccaaact gggtcatttt ggaaagggaa agttagaaaa aattaatagc aagcataaac
     2101 tgtatctttc ttagagagat gtggatacat ggtcacttca cgtaaagtgt ctatgaggat
     2161 gaacatagag gacaaaatac acttatggga gtgaaatacc gtgaccatgt gtcaaaggaa
     2221 gtgggagaaa gaaaaaaggc accaagctca tttgattttg ttttctttca tttgaaaacg
     2281 aacccaaaaa gtaataagtt ataagtcaag aagttccaga gtcagttatc tagaccatga
     2341 tcttcctgct gctattaccc atcggcttcc ctgtgagatc gtatggggag ctatggccaa
     2401 cctacatcag agcaacattt aacagtgagt agatgtctcc tcctgtgaca ccattacacc
     2461 ttaccccaag ttctacagcc ttggatattg cctaaactac aggaagaaag ggctgtgcac
     2521 acctcagtga ttatcccaac tgaaactatg tttgtggaag cataaagaag atgggtaagt
     2581 tactcaaatg caaatgttga ttcatgactg caagccacaa ttttgaatcc ctgctgtgta
     2641 tggccagtct cctaaagaaa acaacaaata actgaaagac accgtgattg ggtgccttag
     2701 cattaaaatt ctttgtttca gtgttgacat tggttgttta aatcggtgtg tctcttcggt
     2761 catgtattat atctatgcat tatattcaga taactacaac tgctgctaat gcttgattat
     2821 atactcagga accacatgcc atgtaacatt actggtttgt tctgccattt ttcctcttga
     2881 tatttagaaa ggaagaccaa aactcttggc cagagacagt atgcaaaaca gagatgtcaa
     2941 gaactatgtc taaataatgt gaaatacaat gagaaatagg taacaaattt atcaaccaac
     3001 tatgtctgga tccagagaat ctctagttat tcaatttatt ttctataagc ctttgtctct
     3061 ctcttcatcc agacttccat gggaattttt gccttcaaat aaaagaatgg gcaaatttct
     3121 ggaa
//
