LOCUS       NM_013110               1110 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus interleukin 7 (Il7), mRNA.
ACCESSION   NM_013110 XM_579371
VERSION     NM_013110.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1110)
  AUTHORS   Huang,C., Wang,Y., Li,X., Ren,L., Zhao,J., Hu,Y., Zhang,L., Fan,G.,
            Xu,J., Gu,X., Cheng,Z., Yu,T., Xia,J., Wei,Y., Wu,W., Xie,X.,
            Yin,W., Li,H., Liu,M., Xiao,Y., Gao,H., Guo,L., Xie,J., Wang,G.,
            Jiang,R., Gao,Z., Jin,Q., Wang,J. and Cao,B.
  TITLE     Clinical features of patients infected with 2019 novel coronavirus
            in Wuhan, China
  JOURNAL   Lancet 395 (10223), 497-506 (2020)
   PUBMED   31986264
  REMARK    Erratum:[Lancet. 2020 Feb 15;395(10223):496. doi:
            10.1016/S0140-6736(20)30252-X.. PMID: 32007144]
REFERENCE   2  (bases 1 to 1110)
  AUTHORS   Aiello,F.B., Guszczynski,T., Li,W., Hixon,J.A., Jiang,Q.,
            Hodge,D.L., Massignan,T., Di Lisio,C., Merchant,A., Procopio,A.D.,
            Bonetto,V. and Durum,S.K.
  TITLE     IL-7-induced phosphorylation of the adaptor Crk-like and other
            targets
  JOURNAL   Cell Signal 47, 131-141 (2018)
   PUBMED   29581031
REFERENCE   3  (bases 1 to 1110)
  AUTHORS   Chen,X.L., Serrano,D., Ghobadi,F., Mayhue,M., Hoebe,K.,
            Ilangumaran,S. and Ramanathan,S.
  TITLE     TCR and IL-7 Signaling Are Altered in the Absence of Functional
            GTPase of the Immune Associated Nucleotide Binding Protein 5
            (GIMAP5)
  JOURNAL   PLoS One 11 (3), e0151837 (2016)
   PUBMED   27023180
  REMARK    GeneRIF: functional Gimap5 is required for optimal signaling
            through TCR and IL-7R in T cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1110)
  AUTHORS   Habib,R., Haneef,K., Naeem,N., Khan,I., Jamall,S., Atta-Ur-Rahman
            and Salim,A.
  TITLE     Hypoxic stress and IL-7 gene overexpression enhance the fusion
            potential of rat bone marrow mesenchymal stem cells with bovine
            renal epithelial cells
  JOURNAL   Mol Cell Biochem 403 (1-2), 125-137 (2015)
   PUBMED   25666089
  REMARK    GeneRIF: hypoxic stress and IL-7 overexpression can enhance the
            renal regeneration potential of mesenchymal stem cells.
REFERENCE   5  (bases 1 to 1110)
  AUTHORS   Huang,Y.L., Liu,Y.W., Huang,Y.J. and Chiou,W.F.
  TITLE     A Special Ingredient (VtR) Containing Oligostilbenes Isolated from
            Vitis thunbergii Prevents Bone Loss in Ovariectomized Mice: In
            Vitro and In Vivo Study
  JOURNAL   Evid Based Complement Alternat Med 2013, 409421 (2013)
   PUBMED   23662133
REFERENCE   6  (bases 1 to 1110)
  AUTHORS   Kishimoto,H. and Sprent,J.
  TITLE     Several different cell surface molecules control negative selection
            of medullary thymocytes
  JOURNAL   J Exp Med 190 (1), 65-73 (1999)
   PUBMED   10429671
REFERENCE   7  (bases 1 to 1110)
  AUTHORS   Visse,E., Siesjo,P., Widegren,B. and Sjogren,H.O.
  TITLE     Regression of intracerebral rat glioma isografts by therapeutic
            subcutaneous immunization with interferon-gamma, interleukin-7, or
            B7-1-transfected tumor cells
  JOURNAL   Cancer Gene Ther 6 (1), 37-44 (1999)
   PUBMED   10078962
REFERENCE   8  (bases 1 to 1110)
  AUTHORS   von Freeden-Jeffry,U., Solvason,N., Howard,M. and Murray,R.
  TITLE     The earliest T lineage-committed cells depend on IL-7 for Bcl-2
            expression and normal cell cycle progression
  JOURNAL   Immunity 7 (1), 147-154 (1997)
   PUBMED   9252127
REFERENCE   9  (bases 1 to 1110)
  AUTHORS   Lee,S.H., Fujita,N., Mashima,T. and Tsuruo,T.
  TITLE     Interleukin-7 inhibits apoptosis of mouse malignant T-lymphoma
            cells by both suppressing the CPP32-like protease activation and
            inducing the Bcl-2 expression
  JOURNAL   Oncogene 13 (10), 2131-2139 (1996)
   PUBMED   8950980
REFERENCE   10 (bases 1 to 1110)
  AUTHORS   Hardin,J.D., Boast,S., Schwartzberg,P.L., Lee,G., Alt,F.W.,
            Stall,A.M. and Goff,S.P.
  TITLE     Bone marrow B lymphocyte development in c-abl-deficient mice
  JOURNAL   Cell Immunol 165 (1), 44-54 (1995)
   PUBMED   7671324
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_013110.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF367210.1, FQ226549.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                JAXUCZ010000002.1  96142640-96142660
            22-155              JAXUCZ010000002.1  96151159-96151292
            156-236             JAXUCZ010000002.1  96182496-96182576
            237-368             JAXUCZ010000002.1  96183601-96183732
            369-1110            JAXUCZ010000002.1  96185541-96186282
FEATURES             Location/Qualifiers
     source          1..1110
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q23"
     gene            1..1110
                     /gene="Il7"
                     /note="interleukin 7"
                     /db_xref="GeneID:25647"
                     /db_xref="RGD:2904"
     exon            1..21
                     /gene="Il7"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..476
                     /gene="Il7"
                     /note="IL-7"
                     /codon_start=1
                     /product="interleukin-7 precursor"
                     /protein_id="NP_037242.2"
                     /db_xref="GeneID:25647"
                     /db_xref="RGD:2904"
                     /translation="MFHVSFRYIFGIPPLILVLLPVTSSDCHIKDKDGKAFGSVLMIS
                     INQLDKMTGTDSDCPNNEPNFFKKHLCDDTKEAAFLNRAARKLRQFLKMNISEEFNDH
                     LLRVSDGTQTLVNCTSKEEKTIKEQKKNDPCFLKRLLREIKTCWNKILNSSI"
     exon            22..155
                     /gene="Il7"
                     /inference="alignment:Splign:2.1.0"
     exon            156..236
                     /gene="Il7"
                     /inference="alignment:Splign:2.1.0"
     exon            237..368
                     /gene="Il7"
                     /inference="alignment:Splign:2.1.0"
     exon            369..1110
                     /gene="Il7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcccacagac catgttccat gtttctttta gatatatctt tggaattcct cccctgatcc
       61 ttgtgctgct gccggtcaca tcgtctgact gtcacattaa agacaaggac ggtaaagcct
      121 ttgggagtgt gctgatgatc agcatcaatc aactggacaa aatgacagga actgatagtg
      181 attgcccaaa taatgaacca aactttttta aaaaacatct atgtgatgat acaaaggaag
      241 ctgcttttct aaatcgtgct gctcgcaagt tgaggcaatt tcttaaaatg aatatcagtg
      301 aggaattcaa tgaccattta ctaagagttt cagacggcac acaaacactg gtgaactgca
      361 caagcaagga agaaaaaacc ataaaggaac agaaaaagaa tgatccatgt ttcctaaaga
      421 gactactgag agagataaaa acttgttgga ataaaatctt gaacagcagt atataaacag
      481 aaaatgtagt agcaacctcc aagaaactac tgccttgcat acttggagag tttgaaaccc
      541 tcccagaagt ttctggatgc ctcctggtca aataaagcaa gcaactggga aatctacagt
      601 gatagacata agaaatgcaa ctgactcctg cggtcagcat atgcctatgg aaatttatca
      661 acagtactga ttttgtaaag caaccctgtc atctgcaatg cttttaaagc ctttccaagt
      721 gtttctacca ttatccagtc tacaaacaag gctctgaaga ttcagagtcg ccactgtttt
      781 gttagcaacc atgcattggt gaaccactgg gggagtggaa ctgtcctgtg gaagactgca
      841 gatacaggag ggctcctggt gatggataat gctcttgaaa acgagagtca catcttaaag
      901 cagcagcagc agcagcagca aaaagaaggt taaggcatca acaaatgtag ttaaatatga
      961 atgtataaca catagcttca gtacagagca tagcagatat ttttaaataa aagtattctt
     1021 aaaaatagaa atgcacttag ttcaaagata ctgaacctta gtattcagtc acttttgtca
     1081 tatatgtata ataaagctta tataactgaa
//
