LOCUS       NM_001008725            7454 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Rattus norvegicus interleukin 6 cytokine family signal transducer
            (Il6st), mRNA.
ACCESSION   NM_001008725 XM_215483
VERSION     NM_001008725.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7454)
  AUTHORS   Ishibashi,T., Inagaki,T., Okazawa,M., Yamagishi,A., Ohta-Ogo,K.,
            Asano,R., Masaki,T., Kotani,Y., Ding,X., Chikaishi-Kirino,T.,
            Maedera,N., Shirai,M., Hatakeyama,K., Kubota,Y., Kishimoto,T. and
            Nakaoka,Y.
  TITLE     IL-6/gp130 signaling in CD4+ T cells drives the pathogenesis of
            pulmonary hypertension
  JOURNAL   Proc Natl Acad Sci U S A 121 (16), e2315123121 (2024)
   PUBMED   38602915
  REMARK    GeneRIF: IL-6/gp130 signaling in CD4[+] T cells drives the
            pathogenesis of pulmonary hypertension.
REFERENCE   2  (bases 1 to 7454)
  AUTHORS   Gao,M., Yin,D., Chen,J. and Qu,X.
  TITLE     Activating the interleukin-6-Gp130-STAT3 pathway ameliorates
            ventricular electrical stability in myocardial infarction rats by
            modulating neurotransmitters in the paraventricular nucleus
  JOURNAL   BMC Cardiovasc Disord 20 (1), 60 (2020)
   PUBMED   32024466
  REMARK    GeneRIF: Activating the interleukin-6-Gp130-STAT3 pathway
            ameliorates ventricular electrical stability in myocardial
            infarction rats by modulating neurotransmitters in the
            paraventricular nucleus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7454)
  AUTHORS   Tamura,Y., Phan,C., Tu,L., Le Hiress,M., Thuillet,R., Jutant,E.M.,
            Fadel,E., Savale,L., Huertas,A., Humbert,M. and Guignabert,C.
  TITLE     Ectopic upregulation of membrane-bound IL6R drives vascular
            remodeling in pulmonary arterial hypertension
  JOURNAL   J Clin Invest 128 (5), 1956-1970 (2018)
   PUBMED   29629897
  REMARK    GeneRIF: Ectopic upregulation of membrane-bound IL6R drives
            vascular remodeling in pulmonary arterial hypertension.
REFERENCE   4  (bases 1 to 7454)
  AUTHORS   Thompson,L.C., Holland,N.A., Snyder,R.J., Luo,B., Becak,D.P.,
            Odom,J.T., Harrison,B.S., Brown,J.M., Gowdy,K.M. and Wingard,C.J.
  TITLE     Pulmonary instillation of MWCNT increases lung permeability,
            decreases gp130 expression in the lungs, and initiates
            cardiovascular IL-6 transsignaling
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 310 (2), L142-L154 (2016)
   PUBMED   26589480
  REMARK    GeneRIF: pulmonary exposure to MWCNT can manifest as a reduced
            epithelial barrier and activator of vascular gp130-associated
            transsignaling that may promote susceptibility to cardiovascular
            derangements
REFERENCE   5  (bases 1 to 7454)
  AUTHORS   Bradesi,S., Karagiannides,I., Bakirtzi,K., Joshi,S.M., Koukos,G.,
            Iliopoulos,D., Pothoulakis,C. and Mayer,E.A.
  TITLE     Identification of Spinal Cord MicroRNA and Gene Signatures in a
            Model of Chronic Stress-Induced Visceral Hyperalgesia in Rat
  JOURNAL   PLoS One 10 (7), e0130938 (2015)
   PUBMED   26222740
  REMARK    GeneRIF: findings suggest a link between miR-17-5p increased
            expression and gp130/STAT3 activation providing new insight into
            the possible mechanisms mediating the effect of chronic stress on
            neuroinflammation
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7454)
  AUTHORS   Hilton,D.J., Hilton,A.A., Raicevic,A., Rakar,S., Harrison-Smith,M.,
            Gough,N.M., Begley,C.G., Metcalf,D., Nicola,N.A. and Willson,T.A.
  TITLE     Cloning of a murine IL-11 receptor alpha-chain; requirement for
            gp130 for high affinity binding and signal transduction
  JOURNAL   EMBO J 13 (20), 4765-4775 (1994)
   PUBMED   7957045
REFERENCE   7  (bases 1 to 7454)
  AUTHORS   Narazaki,M., Yasukawa,K., Saito,T., Ohsugi,Y., Fukui,H.,
            Koishihara,Y., Yancopoulos,G.D., Taga,T. and Kishimoto,T.
  TITLE     Soluble forms of the interleukin-6 signal-transducing receptor
            component gp130 in human serum possessing a potential to inhibit
            signals through membrane-anchored gp130
  JOURNAL   Blood 82 (4), 1120-1126 (1993)
   PUBMED   8353278
REFERENCE   8  (bases 1 to 7454)
  AUTHORS   Stahl,N., Davis,S., Wong,V., Taga,T., Kishimoto,T., Ip,N.Y. and
            Yancopoulos,G.D.
  TITLE     Cross-linking identifies leukemia inhibitory factor-binding protein
            as a ciliary neurotrophic factor receptor component
  JOURNAL   J Biol Chem 268 (11), 7628-7631 (1993)
   PUBMED   8385113
REFERENCE   9  (bases 1 to 7454)
  AUTHORS   Wang,Y., Nesbitt,J.E., Fuentes,N.L. and Fuller,G.M.
  TITLE     Molecular cloning and characterization of the rat liver IL-6 signal
            transducing molecule, gp130
  JOURNAL   Genomics 14 (3), 666-672 (1992)
   PUBMED   1427893
REFERENCE   10 (bases 1 to 7454)
  AUTHORS   Hibi,M., Murakami,M., Saito,M., Hirano,T., Taga,T. and Kishimoto,T.
  TITLE     Molecular cloning and expression of an IL-6 signal transducer,
            gp130
  JOURNAL   Cell 63 (6), 1149-1157 (1990)
   PUBMED   2261637
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jul 8, 2010 this sequence version replaced NM_001008725.2.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M92340.1, JQ013730.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                JAXUCZ010000002.1  45810232-45810311
            81-386              JAXUCZ010000002.1  45813136-45813441
            387-507             JAXUCZ010000002.1  45814474-45814594
            508-671             JAXUCZ010000002.1  45817280-45817443
            672-826             JAXUCZ010000002.1  45818091-45818245
            827-986             JAXUCZ010000002.1  45820039-45820198
            987-1069            JAXUCZ010000002.1  45823725-45823807
            1070-1280           JAXUCZ010000002.1  45824673-45824883
            1281-1463           JAXUCZ010000002.1  45825304-45825486
            1464-1565           JAXUCZ010000002.1  45827310-45827411
            1566-1712           JAXUCZ010000002.1  45827588-45827734
            1713-1853           JAXUCZ010000002.1  45828659-45828799
            1854-1950           JAXUCZ010000002.1  45831596-45831692
            1951-2032           JAXUCZ010000002.1  45833143-45833224
            2033-7454           JAXUCZ010000002.1  45834080-45839501
FEATURES             Location/Qualifiers
     source          1..7454
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q14"
     gene            1..7454
                     /gene="Il6st"
                     /gene_synonym="Ac1055; Gp130; Il-6rb"
                     /note="interleukin 6 cytokine family signal transducer"
                     /db_xref="GeneID:25205"
                     /db_xref="RGD:2903"
     exon            1..80
                     /gene="Il6st"
                     /gene_synonym="Ac1055; Gp130; Il-6rb"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..2773
                     /gene="Il6st"
                     /gene_synonym="Ac1055; Gp130; Il-6rb"
                     /note="membrane glycoprotein 130; oncostatin-M receptor
                     subunit alpha; IL-6R subunit beta; IL-6 receptor subunit
                     beta; interleukin 6 signal transducer"
                     /codon_start=1
                     /product="interleukin-6 receptor subunit beta precursor"
                     /protein_id="NP_001008725.2"
                     /db_xref="GeneID:25205"
                     /db_xref="RGD:2903"
                     /translation="MSALRIWLMQALLIFLTTESIGQLVEPCGYIYPEFPVVQRGSNF
                     TATCVLKEKCLQVYSVNATYIVWKTNHVAVPKEQVTVINRTASSVTFTDVVFQNVQLT
                     CNILSFGQIEQNVYGITILSGYPPDIPTNLSCIVNEGKNMLCQWDPGRETYLETNYTL
                     KSEWATEKFPDCRTKHGTSSCMMGYTPIYFVNIEVWVEAENALGNVSSEPINFDPVDK
                     VKPSPPHNLSVTNSEELSSILKLAWVNSGLDSILRLKSDIQYRTKDASTWIQVPLEDT
                     VSPRTSFTVQDLKPFTEYVFRIRSIKENGKGYWSDWSEEASGTTYEDRPSKAPSFWYK
                     VNANHPQEYRSARLIWKTLPLSEANGKILDYEVVLTQSKSVSQTYTVNGTELIVNLTN
                     NRYVASLAARNVVGKSPATVLTIPGSHFKASHPVVDLKAFPKDNLLWVEWTPPSKPVN
                     KYILEWCVLSENSPCIPDWQQEDGTVNRTHLRGSLLESKCYLITVTPVFPGGPGSPES
                     MKAYLKQAAPSKGPTVRTKKVGKNEAVLEWDHLPVDVQNGFIRNYSISYRTSVGKEMV
                     VRVDSSHTEYTLSSLSSDTLYMVHMAAYTEEGGKDGPEFTFTTLKFAQGEIEAIVVPV
                     CLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSKSHIAQWSPHTPPRHNFNSKDQMY
                     SDANFTDVSVVEIEANNKKPCPDDLKSLDLFKKEKISTEGHSSGIGGSSCMSSSRPSI
                     SSSEENESAQSTASTVQYSTVVHSGYRHQVPSVQVFSRSESTQPLLDSEERPEDLQLV
                     DSVDSGDEILPRQQYFKQSCSQPGASPDVSHFERSSQVPSGSEEDFVRLKQQQVSDHI
                     SEPYGSEQRRLFQEGSVADALGTGTDGQIERFESVGMETAMDEDISKSYLPQTVRQGG
                     YMPQ"
     exon            81..386
                     /gene="Il6st"
                     /gene_synonym="Ac1055; Gp130; Il-6rb"
                     /inference="alignment:Splign:2.1.0"
     exon            387..507
                     /gene="Il6st"
                     /gene_synonym="Ac1055; Gp130; Il-6rb"
                     /inference="alignment:Splign:2.1.0"
     exon            508..671
                     /gene="Il6st"
                     /gene_synonym="Ac1055; Gp130; Il-6rb"
                     /inference="alignment:Splign:2.1.0"
     exon            672..826
                     /gene="Il6st"
                     /gene_synonym="Ac1055; Gp130; Il-6rb"
                     /inference="alignment:Splign:2.1.0"
     exon            827..986
                     /gene="Il6st"
                     /gene_synonym="Ac1055; Gp130; Il-6rb"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1069
                     /gene="Il6st"
                     /gene_synonym="Ac1055; Gp130; Il-6rb"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1280
                     /gene="Il6st"
                     /gene_synonym="Ac1055; Gp130; Il-6rb"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1463
                     /gene="Il6st"
                     /gene_synonym="Ac1055; Gp130; Il-6rb"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1565
                     /gene="Il6st"
                     /gene_synonym="Ac1055; Gp130; Il-6rb"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1712
                     /gene="Il6st"
                     /gene_synonym="Ac1055; Gp130; Il-6rb"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1853
                     /gene="Il6st"
                     /gene_synonym="Ac1055; Gp130; Il-6rb"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1950
                     /gene="Il6st"
                     /gene_synonym="Ac1055; Gp130; Il-6rb"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2032
                     /gene="Il6st"
                     /gene_synonym="Ac1055; Gp130; Il-6rb"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..7454
                     /gene="Il6st"
                     /gene_synonym="Ac1055; Gp130; Il-6rb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcatccct tgcaagatgt ccgcactaag gatctggcta atgcaagctt tgcttatttt
       61 cctcactact gagtctatag gtcaacttgt ggaaccatgt ggttatatct accctgagtt
      121 tccagttgtc cagcgtggct ctaacttcac tgccacttgt gtgctaaagg agaagtgtct
      181 gcaggtgtac tccgtgaatg ccacttacat cgtgtggaag acaaaccatg ttgccgttcc
      241 taaggagcag gtcacagtca tcaacagaac ggcatccagt gtcacattca cagacgtggt
      301 ctttcagaac gtccagctca cctgcaatat cctgtcattt ggacagatcg agcagaatgt
      361 gtatggaatc accatacttt caggctatcc tccagatata cctacaaatt tgagttgcat
      421 tgtgaatgag gggaagaaca tgctgtgtca gtgggaccca ggaagggaga cataccttga
      481 aacaaactac actttgaagt cagagtgggc aacagagaag tttcctgatt gtcgaacaaa
      541 gcatggcacg agctcctgca tgatgggcta tacccccatc tattttgtca acatcgaggt
      601 ctgggtggag gccgagaatg cccttgggaa tgtctcctca gagcctatca attttgaccc
      661 cgtggataaa gtgaaaccca gcccacctca taatttgtca gtgaccaact cagaagaatt
      721 atccagtata ttaaaactag catgggtcaa ttcaggtttg gacagtattt taaggctgaa
      781 gtcggacatc caatatagga ccaaagatgc ctcaacttgg attcaggtcc ctcttgaaga
      841 tacagtgtct ccccggactt cgttcactgt tcaggatctc aagcctttta cagaatatgt
      901 gtttaggatt cggtccatta aggagaatgg gaagggctac tggagtgact ggagtgagga
      961 ggcgagcggg accacatatg aagacagacc atccaaagcg ccaagtttct ggtataaggt
     1021 aaatgcaaac catccacagg agtataggtc tgcacggctc atatggaaga cattgcccct
     1081 ttctgaagcc aatgggaaga tcttggatta tgaagtggtt cttacacagt ccaagtcagt
     1141 ttcgcaaact tacacagtta acggcacaga gttgatagta aacctcacca ataaccgcta
     1201 tgtagcgtct ctagcagcaa gaaatgtggt cggcaagtcc cctgcaaccg tcctcaccat
     1261 ccccggctcc cacttcaaag cttctcaccc cgtagtggat cttaaagcat ttccaaaaga
     1321 taacctgctc tgggtagaat ggacaccgcc atctaaacct gtgaacaaat acatactaga
     1381 gtggtgtgtg ttgtcagaga actcaccctg catcccagac tggcagcaag aagatggcac
     1441 tgtgaatcgg acccacttaa gaggaagcct actggagagc aagtgctatc tgatcacagt
     1501 aaccccagtg tttcccggtg ggcctggaag ccctgagtcc atgaaggcgt acctcaaaca
     1561 agcagctcct tctaaaggac cgactgttcg gacaaagaaa gtggggaaaa atgaagctgt
     1621 cttagagtgg gaccatcttc ctgttgatgt ccagaacgga ttcattagaa actactccat
     1681 atcttataga accagtgttg gaaaagaaat ggttgtgcgt gtggattctt ctcacacaga
     1741 atacacactg tcctctttga gtagcgatac actgtacatg gtccacatgg cagcatacac
     1801 agaagaaggt gggaaggatg ggccggaatt cacttttaca acactaaagt ttgctcaagg
     1861 agaaatcgaa gccatagtcg tgcctgtgtg cttagctttc ctcctgacaa cgctgctggg
     1921 agtcttgttc tgctttaata aacgagacct aattaaaaaa cacatctggc cgaatgtccc
     1981 agatccttca aagagtcata ttgcccagtg gtcacctcac acccccccaa ggcacaattt
     2041 taactccaaa gatcagatgt actcagatgc caatttcact gacgtaagcg ttgtggaaat
     2101 agaagcaaac aacaaaaagc cttgtccaga tgacctgaaa tccttggacc tgttcaagaa
     2161 ggagaaaata agtacagaag ggcacagcag tggcattggg gggtcctcgt gcatgtcctc
     2221 ttctaggccc agcatctcca gcagtgagga gaacgagtct gctcagagca ccgcaagcac
     2281 ggtgcagtac tccaccgtgg tgcacagcgg ctacaggcac caggtgccgt cagtgcaagt
     2341 gttctcaagg tctgagtcca cccagcccct gctagactcc gaggagcggc cagaggacct
     2401 gcagctggtg gatagtgtgg acagcggtga cgagatctta cccaggcaac agtatttcaa
     2461 acaaagctgc agtcagcctg gagccagtcc agatgtttca cacttcgaaa ggtcaagcca
     2521 ggttccgtca ggcagtgagg aggattttgt cagactgaaa cagcagcagg tttcagatca
     2581 catttcagag ccctatggct ccgagcaacg gaggctgttt caggaaggtt ctgtggcaga
     2641 tgctcttggc acagggactg atggacagat agagagattc gaatctgttg gaatggagac
     2701 agcgatggat gaagacattt ccaaaagtta cttgccacag actgtaagac aaggtggcta
     2761 catgccacag tgagggaccg gctcctgcgg gacctcagcg ggactgcgaa gtaaagctaa
     2821 aatgctcgtg acttcagatg ggaaataatc ttcagtccct gatgataacc attgccttta
     2881 aggacaaagt cacaactggg ccatctccat tccagagtat ctgggattct ccttcaagca
     2941 ctacatgaac tgactttatc ctctgaatag ctggaggact ctgcgctgtt tcagaatgtt
     3001 tgcactgctg aaaactaagt gtgtctgagt ttgtaaagct tttgttttgc tccatagaaa
     3061 gtggggaatt taaatgagcc gagccgagcc atggcgtcgc tcagctgtgc tggtggtgag
     3121 actgaccatt cagatgccgg gagcaaaggt ctaaccctcc tcagccagca gcttcatgtc
     3181 agagttcccc gggcagactg cccagattgt gtcacctatc aaaaaaaaaa aaaaaagagt
     3241 ggagggggca gggtggctca tttctgggtt tgttattaga gaatcttggc ttgtttggtg
     3301 ccgttggtat cgatgcttcc agttattact gaagaaaagg acgaactttc aagagaagca
     3361 gcatagaaga acccattacc ttatattcac ctaaaacctc acagaaacct gcttattagt
     3421 gataacattt ttcaaagtca gtttcaccaa cactctagtg gaccgggctg gcctcaaact
     3481 cacagagatt tgtctgcctc agcctccgga gtactggggt taaaggcatg taccaccacc
     3541 accacttgac ttaaaaattt gctgttttta aagacttaag ttgctgacat ttttctgaac
     3601 gtatataaac acaccaggga cagatgattc cagatgttgg tggaggaagc actttatcca
     3661 gaatgtcttc aactgtacat tactttaatt gactccacct tgtttttgtt tttaagacta
     3721 gcaaggtgtt tgctgaaggg tggcattgcc cagaggctca ggcgagtccc agagctcacg
     3781 caccgatgtc tgtgaccacc accgtggcag aagtcctcct acaaagctga cgaagccgtg
     3841 agggttttgt tagtttgctg ggcggggatt gagcccacag ccttgtacat gctagacact
     3901 accactgagc tcacctacac atctcactat gttatgtagg ctcaagcgat cctcctgtct
     3961 cagcttcctg agtgttggga cttcgggtgt gcgctgccac acacccgacc aggtagtttt
     4021 aatatctgcc atttatgagg tagagtttta cacaggattt aggactatct taaacctgtt
     4081 ccttaggttg ctttgttaag gaatagcctg gacatccggt gtttagcact aaagccatta
     4141 tgtatgcgcc taactttcca gtgacatgtc ctgggtgggc aggagttgac tgagcgccat
     4201 tagtggttga ttaccaccaa gtgtgcgcac aggaaaagga ttaaagtttc agaacatggc
     4261 ccttaatcat tcatagccgc tgccccacgg tggctgagga ggagttgatg tgcactgagc
     4321 tggatgtggt tttgccgttc actcagagga ctgtttatac tctacttgtg atgtgttatc
     4381 gttatatttt tatactaggt aatcctgttc tgagtccttt cacgtgtata atcctcatgg
     4441 gactgtacgt gctttgctct ggtattcagt tgccttcttg gcaaaaccag cctagaattg
     4501 ctaaaatgcc aggattgaag ttagatgatg aaagtcgggc acaggaaggc caggtcaggg
     4561 tcagagagac cagaattcac actacaaggc tggcaccatc accattcaag ttgggcatgg
     4621 aagcctgggc ccggcaggac tgagctccct atgtatgtgt atctgccagg aaattaacac
     4681 ttgctaaatt tcccatcctc tcacagcgag cagtgtacct gtgcgctgct gtgaacgttg
     4741 tagtgtgaag tctgtcctgg ggtagggagt taccagcgtg aggtcaggga tgaacacagc
     4801 tcactgaaga cgagcctggt ggaagagagt ttgccattgt gcccactgca tgaacattcc
     4861 ctcgggggat gtatcatgga gcacctctct ttgctctaag aaagagtctt agaattcatc
     4921 ttaaatacag actttgctac agcatgttta agaataatct ggatgcacgt aacttgtatt
     4981 ttaggtaggc agagaaacta atctggctgc tttctgtaaa accagtctaa taaagctaat
     5041 tctatacatg ttcttttctt ctctcgtgtg taaaactgta gtttaaggca atcagaaaac
     5101 aacctatctt gtggccaaaa ctagttcact gtagtttaag gcaatcagaa aacaacctat
     5161 cttgtggcca aaactagttc actgcttctg atgcagttgc ctgcttagga gtcatagaca
     5221 aagaaggttt aatgtaatca atattaccaa acagagttcc catcttttac tcaccaaaca
     5281 aagtcagtcc ttcgaaaagc ataagtcagt actggcggac acagagaagc caaagtagga
     5341 aaagtgcaac cccatcctgg ttctcctgtc tacagttcat tcagcttctg catagttcct
     5401 gaactgtagg gttttttgct tttcgggttt tttttgtttt gttttggggt ttgtttgttt
     5461 gttttgtttt tggggatttt gggggggtgt ttttggtttt ttaagatagg gtttctctgt
     5521 gtggccttgg ctgtcctgga tctgccagcc tggtgtgcca ccactgtctg gtgagaccat
     5581 agttcttact gtgaacttaa agggctgaag aggtagaagg gcttatggga cggactgcag
     5641 cttctaattt tttctcaacc ctactttaat aatggttctt aaatgcttta accttccttc
     5701 tagcccacca cccattaggg gtagtggaaa agagaggata caggtgaagt ggacctgttt
     5761 agaaatggtt ctttggagca aatcctgtct gcactgtcag gaaatcagca gttcggttca
     5821 ctggtcagca gtggcagccc cactcgagaa cacacttcct ggatgcacca gcagtccagt
     5881 tcagtagtgt cgggagagca gcagcggtgg cccgacctag caggagtggc caggcctcag
     5941 cctcagcaca agtcagcaga aagaaccaga agttctcagc tgtgcctctc agtgaaatga
     6001 aaatatccaa gactgttgag tcctatatat actgcctcca aatatcatgt gtccgtgggt
     6061 gtggtctccc cacgtgtctt gcctcagtat gtgagtctgt atcagctgac atgactgcca
     6121 atcgacccag gtcaaggaat tcgcaagaag ccaccagaac acacgttttt tggtgtttct
     6181 ctttatggag tcctgacaaa tggcgcacaa tgatacatgt gaggcaaacc aatatgtgtg
     6241 ttattacaaa gaatccttca tcatgtgtcc tttcgaatgc tttctgtagc aaaatatcct
     6301 ttcacctgtg tctgctttag caaaacaccg tccaacacaa ctgactttcc aaagaacctt
     6361 aagtttccat tccacaggac actgtcaaag ccaggactgc taacgtccca ttagacatcg
     6421 cactgttttt aaagctgtct tctttttcct gcccacagaa ttagagctac agcattcctc
     6481 agtgtttgtc atagacatgt attaaccagg tagaacaagc caggaggttt tagactatta
     6541 agtttactct cctgcttcat gttactgagt ttcctttaaa agcaagcttt taacacaact
     6601 tctggttagt agagattttc atgacatgag tagaatcagt gagctgcaaa aaaaagtgta
     6661 aaggtgaatt gttaaaaata accccttggg ctagctctgc tctaggcact gttgttacat
     6721 tacccaggta agattacgtt ttaaaatgtg cctttctatg agttagaaaa cacactatat
     6781 ggcaaactat ataattaatt catagacaaa gtcttctcaa gccagatgta ctatctctca
     6841 ggttcatggt ttgttctgtc acatgcaggt tagcctatgc tcactccggt aaagctaaaa
     6901 cggtgatggc tgtaggtgtt actcgctcta acttttttag ggctttttgt caccagtaag
     6961 ctcccacaga ctggtcagtt ttttgtttgt tttttgtttg tttgttttaa ttagttgtca
     7021 acaccagtga gggggtcagc atgaaaacgc accaggccgg ttgggtagag attcttagtc
     7081 ctgtgatcac cagcttagtc tggtaaccac agactgcaaa tgctgttacg taactagaaa
     7141 catgggacgt atcagaacaa ggggatgcta cacaggtgtt tgtgtaatat acagtgcacc
     7201 ttgctgctag tgtgacagta ggcattccct gtggcccctt atgcctttgc tctcctgtac
     7261 tccacgtgag ccctgttctc tcaactctgc cccacccacc catgcagctt cacatgggaa
     7321 gcttgcccgt gttagcgctg tagtaagttg catgtgctga gtataaccaa agctatcatt
     7381 tttatgttga ccctgtcata aatgtcttac tatatcagct ctaatccttt ttaaataaat
     7441 ttgagaaaga aact
//
