LOCUS       NM_017020               4529 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus interleukin 6 receptor (Il6r), mRNA.
ACCESSION   NM_017020
VERSION     NM_017020.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4529)
  AUTHORS   He,Q., Lin,Y., Liao,B., Zhou,L., Ai,J., Jin,X., Li,H. and Wang,K.
  TITLE     The role of interleukin-6/interleukin-6 receptor signaling in the
            mechanical stress-induced extracellular matrix remodeling of
            bladder smooth muscle
  JOURNAL   Arch Biochem Biophys 702, 108674 (2021)
   PUBMED   33189652
  REMARK    GeneRIF: The role of interleukin-6/interleukin-6 receptor signaling
            in the mechanical stress-induced extracellular matrix remodeling of
            bladder smooth muscle.
REFERENCE   2  (bases 1 to 4529)
  AUTHORS   Leo,A., Nesci,V., Tallarico,M., Amodio,N., Gallo Cantafio,E.M., De
            Sarro,G., Constanti,A., Russo,E. and Citraro,R.
  TITLE     IL-6 Receptor Blockade by Tocilizumab Has Anti-absence and
            Anti-epileptogenic Effects in the WAG/Rij Rat Model of Absence
            Epilepsy
  JOURNAL   Neurotherapeutics 17 (4), 2004-2014 (2020)
   PUBMED   32681356
  REMARK    GeneRIF: IL-6 Receptor Blockade by Tocilizumab Has Anti-absence and
            Anti-epileptogenic Effects in the WAG/Rij Rat Model of Absence
            Epilepsy.
REFERENCE   3  (bases 1 to 4529)
  AUTHORS   Zhang,D., Mou,J.Y., Wang,F., Liu,J. and Hu,X.
  TITLE     CRNDE enhances neuropathic pain via modulating miR-136/IL6R axis in
            CCI rat models
  JOURNAL   J Cell Physiol 234 (12), 22234-22241 (2019)
   PUBMED   31131445
  REMARK    GeneRIF: CRNDE could induce interleukin 6 receptor (IL6R)
            expression positively.
REFERENCE   4  (bases 1 to 4529)
  AUTHORS   Li,N.C., Wei,X.X., Hu,Y.L., Hou,X. and Xu,H.
  TITLE     Aerobic exercise blocks interleukin-6 levels and germ cell
            apoptosis in obese rats
  JOURNAL   Andrologia 50 (2) (2018)
   PUBMED   28776758
  REMARK    GeneRIF: Aerobic exercise improves the lipid metabolism disorder
            and interferes with germ cell apoptosis by reducing interleukin-6
            and interleukin-6 receptor expression in nutritional obesity rat
            model.
REFERENCE   5  (bases 1 to 4529)
  AUTHORS   Zhang,J.Z., Liu,C.M., Peng,H.P. and Zhang,Y.
  TITLE     Association of genetic variations in IL-6/IL-6R pathway genes with
            gastric cancer risk in a Chinese population
  JOURNAL   Gene 623, 1-4 (2017)
   PUBMED   28442395
REFERENCE   6  (bases 1 to 4529)
  AUTHORS   Watanabe,D., Yoshimura,R., Khalil,M., Yoshida,K., Kishimoto,T.,
            Taga,T. and Kiyama,H.
  TITLE     Characteristic localization of gp130 (the signal-transducing
            receptor component used in common for IL-6/IL-11/CNTF/LIF/OSM) in
            the rat brain
  JOURNAL   Eur J Neurosci 8 (8), 1630-1640 (1996)
   PUBMED   8921254
REFERENCE   7  (bases 1 to 4529)
  AUTHORS   Hoffmann,R., Henninger,H.P., Schulze-Specking,A. and Decker,K.
  TITLE     Regulation of interleukin-6 receptor expression in rat Kupffer
            cells: modulation by cytokines, dexamethasone and prostaglandin E2
  JOURNAL   J Hepatol 21 (4), 543-550 (1994)
   PUBMED   7814800
REFERENCE   8  (bases 1 to 4529)
  AUTHORS   Fiorillo,M.T., Toniatti,C., Van Snick,J. and Ciliberto,G.
  TITLE     Expression of the murine interleukin 6 receptor in hepatoma cells:
            the intracytoplasmic domain is not required for interleukin 6
            signal transduction
  JOURNAL   Eur J Immunol 22 (3), 799-804 (1992)
   PUBMED   1312474
REFERENCE   9  (bases 1 to 4529)
  AUTHORS   Hibi,M., Murakami,M., Saito,M., Hirano,T., Taga,T. and Kishimoto,T.
  TITLE     Molecular cloning and expression of an IL-6 signal transducer,
            gp130
  JOURNAL   Cell 63 (6), 1149-1157 (1990)
   PUBMED   2261637
REFERENCE   10 (bases 1 to 4529)
  AUTHORS   Baumann,M., Baumann,H. and Fey,G.H.
  TITLE     Molecular cloning, characterization and functional expression of
            the rat liver interleukin 6 receptor
  JOURNAL   J Biol Chem 265 (32), 19853-19862 (1990)
   PUBMED   2174054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jan 1, 2008 this sequence version replaced NM_017020.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M58587.1, SRR22582416.948486.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               JAXUCZ010000002.1  177645106-177645209 c
            105-341             JAXUCZ010000002.1  177621396-177621632 c
            342-465             JAXUCZ010000002.1  177620360-177620483 c
            466-650             JAXUCZ010000002.1  177618193-177618377 c
            651-817             JAXUCZ010000002.1  177617718-177617884 c
            818-959             JAXUCZ010000002.1  177617094-177617235 c
            960-1006            JAXUCZ010000002.1  177606598-177606644 c
            1007-1076           JAXUCZ010000002.1  177605559-177605628 c
            1077-1176           JAXUCZ010000002.1  177604518-177604617 c
            1177-4529           JAXUCZ010000002.1  177596360-177599712 c
FEATURES             Location/Qualifiers
     source          1..4529
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..4529
                     /gene="Il6r"
                     /gene_synonym="IL6R1; Il6ra"
                     /note="interleukin 6 receptor"
                     /db_xref="GeneID:24499"
                     /db_xref="RGD:2902"
     exon            1..104
                     /gene="Il6r"
                     /gene_synonym="IL6R1; Il6ra"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..1408
                     /gene="Il6r"
                     /gene_synonym="IL6R1; Il6ra"
                     /note="interleukin-6 receptor subunit alpha; IL-6R 1;
                     IL-6R-alpha; IL-6RA; IL-6R subunit alpha; IL-6 receptor
                     subunit alpha; interleukin 6 receptor, alpha"
                     /codon_start=1
                     /product="interleukin-6 receptor subunit alpha precursor"
                     /protein_id="NP_058716.2"
                     /db_xref="GeneID:24499"
                     /db_xref="RGD:2902"
                     /translation="MLAVGCTLLVALLAAPAVALVLGSCRALEVANGTVTSLPGATVT
                     LICPGKEAAGNATIHWVYSGSQSREWTTTGNTLVLRAVQVNDTGHYLCFLDDHLVGTV
                     PLLVDVPPEEPKLSCFRKNPLVNAFCEWHPSSTPSPTTKAVMFAKKINTTNGKSDFQV
                     PCQYSQQLKSFSCEVEILEGDKVYHIVSLCVANSVGSRSSHNVVFQSLKMVQPDPPAN
                     LVVSAIPGRPRWLKVSWQDPESWDPSYYLLQFELRYRPVWSKTFTVWPLQVAQHQCVI
                     HDALRGVKHVVQVRGKEEFDIGQWSKWSPEVTGTPWLAEPRTTPAGIPGNPTQVSVED
                     YDNHEDQYGSSTEATSVLAPVQGSSPIPLPTFLVAGGSLAFGLLLCVFIILRLKKKWK
                     SQAEKESKTTSPPPYPLGPLKPTFLLVPLLTPSGSHNSSGTDNTGSHSCLGVRDPQCP
                     NDNSNRDYLFPR"
     exon            105..341
                     /gene="Il6r"
                     /gene_synonym="IL6R1; Il6ra"
                     /inference="alignment:Splign:2.1.0"
     exon            342..465
                     /gene="Il6r"
                     /gene_synonym="IL6R1; Il6ra"
                     /inference="alignment:Splign:2.1.0"
     exon            466..650
                     /gene="Il6r"
                     /gene_synonym="IL6R1; Il6ra"
                     /inference="alignment:Splign:2.1.0"
     exon            651..817
                     /gene="Il6r"
                     /gene_synonym="IL6R1; Il6ra"
                     /inference="alignment:Splign:2.1.0"
     exon            818..959
                     /gene="Il6r"
                     /gene_synonym="IL6R1; Il6ra"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1006
                     /gene="Il6r"
                     /gene_synonym="IL6R1; Il6ra"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1076
                     /gene="Il6r"
                     /gene_synonym="IL6R1; Il6ra"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1176
                     /gene="Il6r"
                     /gene_synonym="IL6R1; Il6ra"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..4529
                     /gene="Il6r"
                     /gene_synonym="IL6R1; Il6ra"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccccacgta gaaggaacca tgctggccgt cggctgcacc ctgctggtcg ccctgctggc
       61 cgcgcccgca gtcgcgctgg tccttgggag ctgccgcgcg ctggaggtgg caaatggtac
      121 ggtgacgagc ctgccagggg ccactgttac cctgatctgc cctgggaagg aagcagcagg
      181 caatgctacc attcactggg tgtactcagg ctcacagagc agagaatgga ctaccacggg
      241 aaacacactg gttctgaggg ccgtgcaggt caacgacact gggcactatt tgtgcttcct
      301 ggatgatcat ctggttggga ctgtgccctt gctggtggat gttcccccag aggagcccaa
      361 gctctcctgc ttccggaaga acccccttgt aaatgccttt tgtgagtggc atccaagcag
      421 cactccctct ccaaccacga aggctgtgat gtttgcaaag aaaatcaaca ccaccaatgg
      481 gaagagtgac ttccaggtgc cttgccagta ttctcagcag ctgaaaagct tctcctgcga
      541 ggtggagatc ctggagggtg acaaagtgta ccacatagtg tcactgtgcg ttgcaaacag
      601 tgtcggaagc aggtccagcc acaatgtagt atttcagagt ttaaaaatgg tgcagccgga
      661 tccacctgcc aaccttgtgg tatcagccat acctggaagg cctcgttggc tcaaagtcag
      721 ttggcaagac cctgagtcct gggacccaag ttactacttg ttgcaattcg agcttcgata
      781 ccgacctgta tggtcaaaga cgttcacggt gtggccgctc caggtggccc agcatcaatg
      841 tgtcatccat gatgccttgc gaggagtaaa gcatgtggtg caggtccgag ggaaggagga
      901 gtttgacatt ggccagtgga gcaaatggtc cccggaggtc acaggcactc cttggctagc
      961 agagcccagg accactccgg cagggatccc ggggaacccc acacaggtct ctgttgaaga
     1021 ctatgacaac cacgaggatc agtacggaag ttctacagaa gcaacgagtg tcctcgcccc
     1081 agtgcaagga tcctcgccta tacccctgcc cacattcctg gtagctggag gaagcctggc
     1141 gtttggattg cttctctgtg tcttcatcat cttgagactc aagaagaaat ggaagtcaca
     1201 ggctgagaag gaaagcaaga cgacttctcc cccaccgtat cccttgggac cgctgaagcc
     1261 gaccttcctc ctggttcctc tcctcacccc atcagggtcc cataacagct ctgggactga
     1321 caacaccgga agccacagct gcctgggtgt cagggaccca cagtgcccta atgacaacag
     1381 caacagagac tacttattcc ccagataatt gtctggaggg tacctggcag ctggcacgca
     1441 agtttctcac tgccggcccc gtccaccagg gctgggggcg gggtgggcgg ggctgcagct
     1501 tcacgatccc acaggagcct tgcaaaggtt ctgagtggga gaagactggt gtgctgcacg
     1561 ggcttcgaaa gaaggggctg tgaggagcac gagccatcat gaagagagcc tgtgatgact
     1621 ctgaatagag acgcccgccc atcagctaca cacctgatgg tggctctcaa gctatcctct
     1681 caggaagcct ctgggagggg cgacaaaggc tgccccagtt gcctagctct ggctcactgg
     1741 cccaagctgc cttttagctt gaactcctaa aatccaagca ccttggccat tctcttccta
     1801 ggccaccgag gccgcgggga agcttggttc tactttcctt ctcaacacct ggagaagcag
     1861 ctgcccggtg gtggtgacta acgtatcagg gcctgatggc ttatgaggaa tgacaattaa
     1921 ttcctcataa gcagttttta aatgtgaata gtaatcctag gcactgctga cttgaggttt
     1981 tattttcttc aatctcagga cttcaggaga gaagcagagc agaagtagag agaggatggg
     2041 tgtccattgt ccgtgtggta cttgaggggg atacagcctg gaaaacacgt ttcctgtccc
     2101 cctactctcc cagaagaggt agggggtggc gcctcttcca gggcagagag tataactact
     2161 ttacctggcc ttgcccatac tggtttcaac tggacttgag ctactaggaa aaatgacatt
     2221 catgcaaaaa gaaaacttta actagcaaga atgcacttcc actttggttt ctagaggact
     2281 gttgctcctc ttgagacgct ggaagaggcc gctcactgta ccctggtgta tgagccctca
     2341 ccccccaccc cagggtaagt gcagtaactt tagtctaaac accgagtcag gtaaaaatcg
     2401 aggaaaaaac aaccctgttt cctgtaacag aaaagccttt ggtttcgttt tgtattttga
     2461 tttttttttt gtcttaaaaa gtgtaaaaat agtctgtcca tactctgctt cagggaatga
     2521 cctgtgaata ctccccaggc gtgggcagga agggtgtctg cttcctgcta cacctcactg
     2581 ccacctcggc cttccttgct ttacattcaa ctgagttgcc tcagctgctt tcccctgggg
     2641 cgctgaaaaa gccagtgatg ttggtggtca ccgagaagac cacagagcca cagagtaatg
     2701 ctgtgattga agcgagttac gcaaccacag caccccacat ttgctgtatt atagaactat
     2761 gctaggagct tgccttttca caaaatacca ccaccacgag acgtggcaga gctcggaagc
     2821 tgtcaccttg tgccatctgc ttgccagctc caaggggcca ctgacttaag cagttatttt
     2881 ctttgtgggc tttgttcatt tcagggcctg ttgctgtctt agaaaaagct ctgtcggttg
     2941 acaaaaacat cagacaggta gtcatgttta tttatttttt ttccttcttt gctaagtctt
     3001 tgggactcaa gggtagtaaa aaatgctgtg aaaagggaaa cattagaaac agcgatcttc
     3061 ggggaatagg tgactgtgcc cacgcactgt tcttcagtcc ctcacgtggc tctgcccgag
     3121 tgctgttcca agccaggcag agcaggctgg cggaagattg aaatccagat agttcgttat
     3181 ctctgagagc taaatagctt tgatctccaa gctgttattg ctttcactat tgtaacagga
     3241 tagcctcccc cccccatgtc aaaaggatgc ttttcccttt tgacttttta taagctaagt
     3301 cagtgaagtc tgtttcatct gagctccagc ttcgttcagt tcgcacaggt gtatgccctc
     3361 agctgcttcg ggcctcagat ctgtgctagt tgaatggttg tcccatcctt gggtcatcct
     3421 taccagagtt tctgcagccc acaggtctgc cttgtcaaca gtaccactta acaccagcat
     3481 tcagtgccca ggcagccaga tgtggagggt ttacccagag atgatttaaa catgacctta
     3541 aacgtgtatg gtagaacgag gggaacccat accagctcag gttctaaaga gatctttgat
     3601 tcttctggca ttagtgaaat agctttaaac tatttcaagg aagaagcctt ggccacaccc
     3661 acgacatttg gtgacaatcc tttctctcca tgagccttgt ctttacacct tctcacctgg
     3721 ctgaaagctc acactgaatc tttcctatgt ccctggtgtc ttgggagaaa ggaaactggt
     3781 atgggcttca ctgctggaat tggcttggag ccagcgtgtg gcgcagcgcc tggcagggtg
     3841 ggccaggctt agttatggtg tgctggttta aggaatgcct ggcttgcctg gttgcttggg
     3901 ttctgagctg cagagtttcc tagcagttct ttatggctga cctagttggg gaagattccc
     3961 acactcaact gcaggtggag gtggtgagaa agctgttttc atttggagag gcaggatcag
     4021 cccaagaagc tttcagtggg agagcctaca gtgaggctgt acctcactgt gggaggaggc
     4081 aggccagctg gctcaggtcc tgggactggc actggggagg gtctgccaaa ggtccctcca
     4141 gcctgtagtc ctagcatagt cgggtgccag ttccaggaag tttctatggc aaccttagtg
     4201 ctcattaagg aacattgtca gttttgtgaa catatgctca gatggagatc ttgttttcag
     4261 agaaaggact ggtacagtgt gtaacaagct ggagcagaca gagagacttt ttggcaagag
     4321 atcacatccg ttaagcagaa tacctcagtg ctacatgttt ttgtctttga gacaatgttt
     4381 ttaaggtttt tatgctctgt tacctgtaag ctgataccta aaactttctg caaagtcagg
     4441 gtttttcaat gccttttttt tttttttgcc attgtttgct ttaaagtgaa gattgtaact
     4501 gtttgaaata aataatttct aaaactgca
//
