LOCUS       NM_012589               1045 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus interleukin 6 (Il6), mRNA.
ACCESSION   NM_012589
VERSION     NM_012589.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1045)
  AUTHORS   Roy,A., Segond von Banchet,G., Gimeno-Ferrer,F., Konig,C.,
            Eitner,A., Ebersberger,A., Ebbinghaus,M., Leuchtweis,J. and
            Schaible,H.G.
  TITLE     Impact of Interleukin-6 Activation and Arthritis on Epidermal
            Growth Factor Receptor (EGFR) Activation in Sensory Neurons and the
            Spinal Cord
  JOURNAL   Int J Mol Sci 25 (13), 7168 (2024)
   PUBMED   39000275
  REMARK    GeneRIF: Impact of Interleukin-6 Activation and Arthritis on
            Epidermal Growth Factor Receptor (EGFR) Activation in Sensory
            Neurons and the Spinal Cord.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1045)
  AUTHORS   Ishibashi,T., Inagaki,T., Okazawa,M., Yamagishi,A., Ohta-Ogo,K.,
            Asano,R., Masaki,T., Kotani,Y., Ding,X., Chikaishi-Kirino,T.,
            Maedera,N., Shirai,M., Hatakeyama,K., Kubota,Y., Kishimoto,T. and
            Nakaoka,Y.
  TITLE     IL-6/gp130 signaling in CD4+ T cells drives the pathogenesis of
            pulmonary hypertension
  JOURNAL   Proc Natl Acad Sci U S A 121 (16), e2315123121 (2024)
   PUBMED   38602915
  REMARK    GeneRIF: IL-6/gp130 signaling in CD4[+] T cells drives the
            pathogenesis of pulmonary hypertension.
REFERENCE   3  (bases 1 to 1045)
  AUTHORS   Crews,F.T., Fisher,R.P., Qin,L. and Vetreno,R.P.
  TITLE     HMGB1 neuroimmune signaling and REST-G9a gene repression contribute
            to ethanol-induced reversible suppression of the cholinergic neuron
            phenotype
  JOURNAL   Mol Psychiatry 28 (12), 5159-5172 (2023)
   PUBMED   37402853
REFERENCE   4  (bases 1 to 1045)
  AUTHORS   Zhang,L., Shi,W., Liu,J., Chen,K., Zhang,G., Zhang,S., Cong,B. and
            Li,Y.
  TITLE     Interleukin 6 (IL-6) Regulates GABAA Receptors in the Dorsomedial
            Hypothalamus Nucleus (DMH) through Activation of the JAK/STAT
            Pathway to Affect Heart Rate Variability in Stressed Rats
  JOURNAL   Int J Mol Sci 24 (16), 12985 (2023)
   PUBMED   37629166
  REMARK    GeneRIF: Interleukin 6 (IL-6) Regulates GABAA Receptors in the
            Dorsomedial Hypothalamus Nucleus (DMH) through Activation of the
            JAK/STAT Pathway to Affect Heart Rate Variability in Stressed Rats.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1045)
  AUTHORS   Abdel-Hamid,M.S., Mansour,A.M., Hassan,M.H., Abdelhady,R.,
            Elsadek,B.E.M., El-Sayed,E.M. and Salama,S.A.
  TITLE     Estrogen Attenuates Diethylnitrosamine-Induced Hepatocellular
            Carcinoma in Female Rats via Modulation of Estrogen
            Receptor/FASN/CD36/IL-6 Axis
  JOURNAL   Biol Pharm Bull 46 (11), 1558-1568 (2023)
   PUBMED   37914358
  REMARK    GeneRIF: Estrogen Attenuates Diethylnitrosamine-Induced
            Hepatocellular Carcinoma in Female Rats via Modulation of Estrogen
            Receptor/FASN/CD36/IL-6 Axis.
REFERENCE   6  (bases 1 to 1045)
  AUTHORS   Heremans,H., Dillen,C., Put,W., Van Damme,J. and Billiau,A.
  TITLE     Protective effect of anti-interleukin (IL)-6 antibody against
            endotoxin, associated with paradoxically increased IL-6 levels
  JOURNAL   Eur J Immunol 22 (9), 2395-2401 (1992)
   PUBMED   1381315
REFERENCE   7  (bases 1 to 1045)
  AUTHORS   De,M., Sanford,T.R. and Wood,G.W.
  TITLE     Interleukin-1, interleukin-6, and tumor necrosis factor alpha are
            produced in the mouse uterus during the estrous cycle and are
            induced by estrogen and progesterone
  JOURNAL   Dev Biol 151 (1), 297-305 (1992)
   PUBMED   1577194
REFERENCE   8  (bases 1 to 1045)
  AUTHORS   Itoh,Y., Maruyama,N., Kitamura,M., Shirasawa,T., Shigemoto,K. and
            Koike,T.
  TITLE     Induction of endogenous retroviral gene product (SU) as an
            acute-phase protein by IL-6 in murine hepatocytes
  JOURNAL   Clin Exp Immunol 88 (2), 356-359 (1992)
   PUBMED   1373998
REFERENCE   9  (bases 1 to 1045)
  AUTHORS   Hoekzema,R., Verhagen,C., van Haren,M. and Kijlstra,A.
  TITLE     Endotoxin-induced uveitis in the rat. The significance of
            intraocular interleukin-6
  JOURNAL   Invest Ophthalmol Vis Sci 33 (3), 532-539 (1992)
   PUBMED   1544781
REFERENCE   10 (bases 1 to 1045)
  AUTHORS   Fiorillo,M.T., Toniatti,C., Van Snick,J. and Ciliberto,G.
  TITLE     Expression of the murine interleukin 6 receptor in hepatoma cells:
            the intracytoplasmic domain is not required for interleukin 6
            signal transduction
  JOURNAL   Eur J Immunol 22 (3), 799-804 (1992)
   PUBMED   1312474
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M26744.1.
            
            On Feb 21, 2013 this sequence version replaced NM_012589.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M26744.1, CB578190.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093048, SAMN16093049
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1045              M26744.1           1-1045
FEATURES             Location/Qualifiers
     source          1..1045
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="F344"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..1045
                     /gene="Il6"
                     /gene_synonym="Ifnb2; ILg6"
                     /note="interleukin 6"
                     /db_xref="GeneID:24498"
                     /db_xref="RGD:2901"
     exon            1..83
                     /gene="Il6"
                     /gene_synonym="Ifnb2; ILg6"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..700
                     /gene="Il6"
                     /gene_synonym="Ifnb2; ILg6"
                     /note="IL-6; Interleukin 6 (interferon, beta 2)"
                     /codon_start=1
                     /product="interleukin-6 precursor"
                     /protein_id="NP_036721.1"
                     /db_xref="GeneID:24498"
                     /db_xref="RGD:2901"
                     /translation="MKFLSARDFQPVAFLGLMLLTATAFPTSQVRRGDFTEDTTHNRP
                     VYTTSQVGGLITYVLREILEMRKELCNGNSDCMNSDDALSENNLKLPEIQRNDGCFQT
                     GYNQEICLLKICSGLLEFRFYLEFVKNNLQDNKKDKARVIQSNTETLVHIFKQEIKDS
                     YKIVLPTPTSNALLMEKLESQKEWLRTKTIQLILKALEEFLKVTMRSTRQT"
     exon            84..268
                     /gene="Il6"
                     /gene_synonym="Ifnb2; ILg6"
                     /inference="alignment:Splign:2.1.0"
     exon            269..382
                     /gene="Il6"
                     /gene_synonym="Ifnb2; ILg6"
                     /inference="alignment:Splign:2.1.0"
     exon            383..532
                     /gene="Il6"
                     /gene_synonym="Ifnb2; ILg6"
                     /inference="alignment:Splign:2.1.0"
     exon            533..1045
                     /gene="Il6"
                     /gene_synonym="Ifnb2; ILg6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctcattct gtctcgagcc caccaggaac gaaagtcaac tccatctgcc cttcaggaac
       61 agctatgaag tttctctccg caagagactt ccagccagtt gccttcttgg gactgatgtt
      121 gttgacagcc actgccttcc ctacttcaca agtccggaga ggagacttca cagaggatac
      181 cacccacaac agaccagtat ataccacttc acaagtcgga ggcttaatta catatgttct
      241 cagggagatc ttggaaatga gaaaagagtt gtgcaatggc aattctgatt gtatgaacag
      301 cgatgatgca ctgtcagaaa acaatctgaa acttccagaa atacaaagaa atgatggatg
      361 cttccaaact ggatataacc aggaaatttg cctattgaaa atctgctctg gtcttctgga
      421 gttccgtttc tacctggagt ttgtgaagaa caacttacaa gataacaaga aagacaaagc
      481 cagagtcatt cagagcaata ctgaaaccct agttcatatc ttcaaacaag agataaaaga
      541 ctcatataaa atagtccttc ctaccccaac ttccaatgct ctcctaatgg agaagttaga
      601 gtcacagaag gagtggctaa ggaccaagac catccaactc atcttgaaag cacttgaaga
      661 atttctaaag gtcactatga ggtctactcg gcaaacctag tgtgctatgc ctaagcatat
      721 cagtttgtgg acattcctca ctgtggtcag aaaatatatc ctgtcgatgg gtatctaaat
      781 tatgttgttc tctacgaaga actggcaata tgaatgttga aacactattt taattatttt
      841 taatttattg ataatttaaa taagtaaact ataagttaat ttatgattga tatttatact
      901 ttttatgaag tgtcacttga aatattatgt tatagttttg aaaagataat ataaaaatct
      961 atttgatatg aatattctct tacctagcca gatggtttct tgcaatatat aagtttacct
     1021 caatgaattg ctaatttaaa ttttt
//
