LOCUS       NM_053645               1245 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus interleukin 5 receptor subunit alpha (Il5ra),
            mRNA.
ACCESSION   NM_053645
VERSION     NM_053645.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1245)
  AUTHORS   Zhou,Y., Li,C., Li,D., Zheng,Y. and Wang,J.
  TITLE     IL-5 blocks apoptosis and tau hyperphosphorylation induced by
            Abeta25-35 peptide in PC12 cells
  JOURNAL   J Physiol Biochem 73 (2), 259-266 (2017)
   PUBMED   28132394
  REMARK    GeneRIF: Data suggest that IL5/IL5Ra signaling activates JAK2 in
            neurons down-regulating cell apoptosis and down-regulating
            hyperphosphorylation of Tau [up-regulated in Alzheimer disease via
            amyloid-beta(25-35) peptide]. [IL5 = interleukin-5 ; IL5Ra =
            interleukin-5 receptor, alpha subunit; JAK2 = Janus kinase 2]
REFERENCE   2  (bases 1 to 1245)
  AUTHORS   Wilson,T.M., Maric,I., Shukla,J., Brown,M., Santos,C., Simakova,O.,
            Khoury,P., Fay,M.P., Kozhich,A., Kolbeck,R., Metcalfe,D.D. and
            Klion,A.D.
  TITLE     IL-5 receptor alpha levels in patients with marked eosinophilia or
            mastocytosis
  JOURNAL   J Allergy Clin Immunol 128 (5), 1086-92 (2011)
   PUBMED   21762978
REFERENCE   3  (bases 1 to 1245)
  AUTHORS   Park,C.S.
  TITLE     Eosinophilic bronchitis, eosinophilia associated genetic variants,
            and notch signaling in asthma
  JOURNAL   Allergy Asthma Immunol Res 2 (3), 188-194 (2010)
   PUBMED   20592918
REFERENCE   4  (bases 1 to 1245)
  AUTHORS   Busse,W.W., Katial,R., Gossage,D., Sari,S., Wang,B., Kolbeck,R.,
            Coyle,A.J., Koike,M., Spitalny,G.L., Kiener,P.A., Geba,G.P. and
            Molfino,N.A.
  TITLE     Safety profile, pharmacokinetics, and biologic activity of
            MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study
            of subjects with mild asthma
  JOURNAL   J Allergy Clin Immunol 125 (6), 1237-1244 (2010)
   PUBMED   20513521
REFERENCE   5  (bases 1 to 1245)
  AUTHORS   Mao,H., Wen,F.Q., Liu,C.T., Liang,Z.A., Wang,Z.L. and Yin,K.S.
  TITLE     Effect of interleukin-5 receptor-alpha short hairpin RNA-expressing
            vector on bone marrow eosinophilopoiesis in asthmatic mice
  JOURNAL   Adv Ther 23 (6), 938-956 (2006)
   PUBMED   17276963
REFERENCE   6  (bases 1 to 1245)
  AUTHORS   Gevaert,P., Bachert,C., Holtappels,G., Novo,C.P., Van der
            Heyden,J., Fransen,L., Depraetere,S., Walter,H., van Cauwenberge,P.
            and Tavernier,J.
  TITLE     Enhanced soluble interleukin-5 receptor alpha expression in nasal
            polyposis
  JOURNAL   Allergy 58 (5), 371-379 (2003)
   PUBMED   12752323
REFERENCE   7  (bases 1 to 1245)
  AUTHORS   Saito,H., Matsumoto,K., Denburg,A.E., Crawford,L., Ellis,R.,
            Inman,M.D., Sehmi,R., Takatsu,K., Matthaei,K.I. and Denburg,J.A.
  TITLE     Pathogenesis of murine experimental allergic rhinitis: a study of
            local and systemic consequences of IL-5 deficiency
  JOURNAL   J Immunol 168 (6), 3017-3023 (2002)
   PUBMED   11884474
REFERENCE   8  (bases 1 to 1245)
  AUTHORS   Pierrot,C., Begue,A., Szpirer,C., Capron,A., Capron,M. and
            Khalife,J.
  TITLE     Cloning of the rat IL-5Ralpha gene: analysis of 5'-upstream region
            and expression by B cells
  JOURNAL   Biochem Biophys Res Commun 288 (2), 328-339 (2001)
   PUBMED   11606047
REFERENCE   9  (bases 1 to 1245)
  AUTHORS   Tanaka,H., Kawada,N., Yamada,T., Kawada,K., Takatsu,K. and Nagai,H.
  TITLE     Allergen-induced airway inflammation and bronchial responsiveness
            in interleukin-5 receptor alpha chain-deficient mice
  JOURNAL   Clin Exp Allergy 30 (6), 874-881 (2000)
   PUBMED   10848907
REFERENCE   10 (bases 1 to 1245)
  AUTHORS   Denburg,J.A., Sehmi,R., Upham,J., Wood,L., Gauvreau,G. and
            O'Byrne,P.
  TITLE     Regulation of IL-5 and IL-5 receptor expression in the bone marrow
            of allergic asthmatics
  JOURNAL   Int Arch Allergy Immunol 118 (2-4), 101-103 (1999)
   PUBMED   10224351
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB056101.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB056101.1, AF324153.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1245
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q41"
     gene            1..1245
                     /gene="Il5ra"
                     /note="interleukin 5 receptor subunit alpha"
                     /db_xref="GeneID:114103"
                     /db_xref="RGD:70938"
     CDS             1..1245
                     /gene="Il5ra"
                     /note="interleukin 5 receptor, alpha"
                     /codon_start=1
                     /product="interleukin-5 receptor subunit alpha precursor"
                     /protein_id="NP_446097.1"
                     /db_xref="GeneID:114103"
                     /db_xref="RGD:70938"
                     /translation="MVPVLLILMGASATLHADLLSPEKFLLLPPVNFTIKATGLAQVL
                     LHWDPNPDQDPVDLEYHVKINVPQEDEYDTKNTESKCVTPLHECFAASVRTILKSIHS
                     PLASSWVSAELKAPPGSSGTSVMNLTCTTNTVKSSHTHFRPYQVSLRCTWLVGKDAPE
                     DTQYFLYYRFSVWTEECQEYSRDALNRNIACWFPRTFINSKGFEQLAVHINGSSKHAA
                     TKPLDQLFTLYAIDQVNPPMNVTVEIENNSLYIQWGKPLSAFPVHCFKYKLKIYNTKN
                     GYSQMENLVTNKFISKIDDVSTYSIQVRAAVSSPCRMSGSWGEWSQPIYVGKKKKPLV
                     EWHLIVLPTAICFILLIFSLICRVYHLWTRLFPPVPAPKSSIKDLPVVTEYEKPPWNE
                     TKIEIVHFVEEDGFEVMENSLF"
     exon            1..73
                     /gene="Il5ra"
                     /inference="alignment:Splign:2.1.0"
     exon            74..213
                     /gene="Il5ra"
                     /inference="alignment:Splign:2.1.0"
     exon            214..352
                     /gene="Il5ra"
                     /inference="alignment:Splign:2.1.0"
     exon            353..506
                     /gene="Il5ra"
                     /inference="alignment:Splign:2.1.0"
     exon            507..694
                     /gene="Il5ra"
                     /inference="alignment:Splign:2.1.0"
     exon            695..840
                     /gene="Il5ra"
                     /inference="alignment:Splign:2.1.0"
     exon            841..979
                     /gene="Il5ra"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1073
                     /gene="Il5ra"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1158
                     /gene="Il5ra"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1245
                     /gene="Il5ra"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggtgcctg tgttactaat tcttatggga gcttcggcaa cactgcatgc tgacttactt
       61 tctcctgaaa agtttttact tctgccacct gtcaatttta ccattaaagc caccggatta
      121 gctcaagttc ttttacactg ggacccaaat cctgaccaag atcctgtgga tctagagtac
      181 catgtgaaaa taaatgttcc acaagaagac gaatatgata ctaaaaatac tgaaagcaaa
      241 tgcgtgaccc cacttcatga atgctttgca gcgagtgtaa ggaccattct gaagagcatc
      301 cactctcccc tggccagcag ctgggtttct gctgaactca aagctccacc aggatcttct
      361 ggcacctcgg ttatgaattt aacttgtacc acaaacactg tcaaaagtag ccacacccac
      421 ttcaggccat accaagtttc tcttcgttgc acctggcttg ttggcaagga tgcccctgag
      481 gacacacagt atttcctata ctataggttt agtgtttgga ctgaagaatg ccaagaatac
      541 agcagagatg cactgaacag aaatattgca tgctggttcc ccaggacatt tatcaacagc
      601 aaagggtttg aacagcttgc tgtgcacatt aatggttcaa gcaagcacgc tgcaaccaag
      661 cccttggatc agctgttcac tctatatgcc attgatcaag tgaatcctcc aatgaatgtc
      721 acagtggaaa ttgaaaacaa ttctctctat atacaatggg gaaaaccact ttctgccttt
      781 ccagtccatt gctttaagta taaactgaaa atttacaaca caaaaaatgg ttactctcag
      841 atggaaaacc tggtcaccaa taagttcatc tcaaaaattg atgatgtttc tacatattcc
      901 attcaagtga gagcagctgt gagctcacct tgcaggatgt caggaagctg gggcgagtgg
      961 agtcaaccga tttatgtggg aaagaaaaag aagcccttgg tagaatggca tctcatcgtg
     1021 ctcccaacag ccatctgctt catcttgtta atcttctcac tcatctgcag agtgtatcac
     1081 ctatggacaa ggttgtttcc accagttccg gcgccaaaga gtagcatcaa agatctccct
     1141 gtggtgactg aatatgagaa acctccttgg aatgaaacca aaattgaaat cgtacatttt
     1201 gtagaagagg atggatttga agtcatggaa aattccctgt tttga
//
